CA2861592A1 - Albumin variants - Google Patents
Albumin variants Download PDFInfo
- Publication number
- CA2861592A1 CA2861592A1 CA2861592A CA2861592A CA2861592A1 CA 2861592 A1 CA2861592 A1 CA 2861592A1 CA 2861592 A CA2861592 A CA 2861592A CA 2861592 A CA2861592 A CA 2861592A CA 2861592 A1 CA2861592 A1 CA 2861592A1
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- CA
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- Prior art keywords
- albumin
- polypeptide
- seq
- fragment
- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12160007 | 2012-03-16 | ||
| EP12160007.6 | 2012-03-16 | ||
| PCT/EP2012/058206 WO2012150319A1 (en) | 2011-05-05 | 2012-05-04 | Albumin variants |
| EPPCT/EP2012/058206 | 2012-05-04 | ||
| EP12187326.9 | 2012-10-05 | ||
| EP12187326 | 2012-10-05 | ||
| EP12191086 | 2012-11-02 | ||
| EP12191086.3 | 2012-11-02 | ||
| EP12191854.4 | 2012-11-08 | ||
| EP12191854 | 2012-11-08 | ||
| PCT/EP2013/055487 WO2013135896A1 (en) | 2012-03-16 | 2013-03-15 | Albumin variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2861592A1 true CA2861592A1 (en) | 2013-09-19 |
Family
ID=49160283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2861592A Abandoned CA2861592A1 (en) | 2012-03-16 | 2013-03-15 | Albumin variants |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9944691B2 (enExample) |
| EP (2) | EP3330283A3 (enExample) |
| JP (2) | JP6441682B2 (enExample) |
| KR (1) | KR20140136934A (enExample) |
| CN (1) | CN104736559B (enExample) |
| AU (2) | AU2013234299B2 (enExample) |
| BR (1) | BR112014018679A2 (enExample) |
| CA (1) | CA2861592A1 (enExample) |
| DK (1) | DK2825556T3 (enExample) |
| ES (1) | ES2664328T3 (enExample) |
| IL (1) | IL233689A0 (enExample) |
| MX (1) | MX2014010278A (enExample) |
| PL (1) | PL2825556T3 (enExample) |
| WO (1) | WO2013135896A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101722961B1 (ko) | 2009-02-11 | 2017-04-04 | 알부메딕스 에이/에스 | 알부민 변이체 및 접합체 |
| MX2012004793A (es) | 2009-10-30 | 2012-07-20 | Novozymes Biopharma Dk As | Variantes de albumina. |
| JP5969458B2 (ja) | 2010-04-09 | 2016-08-17 | アルブミディクス アクティーゼルスカブ | アルブミン誘導体及び変異体 |
| US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
| DK2825556T3 (en) | 2012-03-16 | 2018-04-16 | Albumedix As | albumin Variants |
| KR20150082422A (ko) * | 2012-11-08 | 2015-07-15 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민 변이체 |
| CN105007722A (zh) | 2013-02-16 | 2015-10-28 | 诺维信生物制药丹麦公司 | 药代动力学动物模型 |
| CN105992770B (zh) | 2013-11-01 | 2021-06-25 | 奥斯陆大学 | 白蛋白的变体及其用途 |
| CA2956471C (en) | 2014-07-31 | 2024-09-10 | Amgen Res Munich Gmbh | OPTIMIZED CONSTRUCTIONS OF SINGLE-CATENAL, BI-SPECIFIC, AND CROSS-SPECIFIC ANTIBODY |
| AU2016250023B2 (en) | 2015-04-17 | 2022-02-24 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs for CDH3 and CD3 |
| TWI717375B (zh) | 2015-07-31 | 2021-02-01 | 德商安美基研究（慕尼黑）公司 | Ｃｄ７０及ｃｄ３抗體構築體 |
| TWI793062B (zh) | 2015-07-31 | 2023-02-21 | 德商安美基研究（慕尼黑）公司 | Ｄｌｌ３及ｃｄ３抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| EP3337816B1 (en) * | 2015-08-20 | 2024-02-14 | Albumedix Ltd | Albumin variants and conjugates |
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2013
- 2013-03-15 DK DK13709457.9T patent/DK2825556T3/en active
- 2013-03-15 BR BR112014018679A patent/BR112014018679A2/pt not_active Application Discontinuation
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| JP6441682B2 (ja) | 2018-12-19 |
| KR20140136934A (ko) | 2014-12-01 |
| US20180265569A1 (en) | 2018-09-20 |
| MX2014010278A (es) | 2015-03-05 |
| US20190315836A1 (en) | 2019-10-17 |
| WO2013135896A1 (en) | 2013-09-19 |
| JP2018138023A (ja) | 2018-09-06 |
| US20150065687A1 (en) | 2015-03-05 |
| JP6657284B2 (ja) | 2020-03-04 |
| EP3330283A2 (en) | 2018-06-06 |
| AU2013234299A1 (en) | 2014-08-14 |
| EP3330283A3 (en) | 2018-07-11 |
| AU2013234299B2 (en) | 2017-06-22 |
| CN104736559B (zh) | 2022-04-08 |
| JP2015512893A (ja) | 2015-04-30 |
| US9944691B2 (en) | 2018-04-17 |
| PL2825556T3 (pl) | 2018-10-31 |
| DK2825556T3 (en) | 2018-04-16 |
| EP2825556A1 (en) | 2015-01-21 |
| ES2664328T3 (es) | 2018-04-19 |
| IL233689A0 (en) | 2014-09-30 |
| CN104736559A (zh) | 2015-06-24 |
| US10329340B2 (en) | 2019-06-25 |
| EP2825556B1 (en) | 2018-01-03 |
| AU2017228726A1 (en) | 2017-10-12 |
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