CA2848463A1 - Gene expression markers for predicting response to chemotherapy - Google Patents
Gene expression markers for predicting response to chemotherapy Download PDFInfo
- Publication number
- CA2848463A1 CA2848463A1 CA2848463A CA2848463A CA2848463A1 CA 2848463 A1 CA2848463 A1 CA 2848463A1 CA 2848463 A CA2848463 A CA 2848463A CA 2848463 A CA2848463 A CA 2848463A CA 2848463 A1 CA2848463 A1 CA 2848463A1
- Authority
- CA
- Canada
- Prior art keywords
- cancer
- expression
- chemotherapy
- catenin
- grb7
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000014509 gene expression Effects 0.000 title claims abstract description 133
- 230000004044 response Effects 0.000 title claims abstract description 57
- 238000002512 chemotherapy Methods 0.000 title claims abstract description 52
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 132
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 102
- 201000011510 cancer Diseases 0.000 claims abstract description 57
- 238000000034 method Methods 0.000 claims description 116
- 230000003247 decreasing effect Effects 0.000 claims description 62
- 108700031843 GRB7 Adaptor Proteins 0.000 claims description 52
- 101150052409 GRB7 gene Proteins 0.000 claims description 52
- 102100033107 Growth factor receptor-bound protein 7 Human genes 0.000 claims description 52
- 210000001519 tissue Anatomy 0.000 claims description 40
- 102000040430 polynucleotide Human genes 0.000 claims description 38
- 108091033319 polynucleotide Proteins 0.000 claims description 38
- 239000002157 polynucleotide Substances 0.000 claims description 37
- WVAKRQOMAINQPU-UHFFFAOYSA-N 2-[4-[2-[5-(2,2-dimethylbutyl)-1h-imidazol-2-yl]ethyl]phenyl]pyridine Chemical compound N1C(CC(C)(C)CC)=CN=C1CCC1=CC=C(C=2N=CC=CC=2)C=C1 WVAKRQOMAINQPU-UHFFFAOYSA-N 0.000 claims description 36
- 102100037152 BAG family molecular chaperone regulator 1 Human genes 0.000 claims description 36
- 102000016362 Catenins Human genes 0.000 claims description 36
- 108010067316 Catenins Proteins 0.000 claims description 36
- 101000740062 Homo sapiens BAG family molecular chaperone regulator 1 Proteins 0.000 claims description 36
- 206010006187 Breast cancer Diseases 0.000 claims description 34
- 208000026310 Breast neoplasm Diseases 0.000 claims description 34
- 239000000523 sample Substances 0.000 claims description 31
- 102100028932 Signal peptide, CUB and EGF-like domain-containing protein 2 Human genes 0.000 claims description 29
- 108700020472 CDC20 Proteins 0.000 claims description 27
- 101150023302 Cdc20 gene Proteins 0.000 claims description 27
- 102100038099 Cell division cycle protein 20 homolog Human genes 0.000 claims description 27
- 102100038595 Estrogen receptor Human genes 0.000 claims description 27
- 101100010298 Schizosaccharomyces pombe (strain 972 / ATCC 24843) pol2 gene Proteins 0.000 claims description 27
- 101001059203 Arabidopsis thaliana Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 1, chloroplastic Proteins 0.000 claims description 26
- 102100025620 Cytochrome b-245 light chain Human genes 0.000 claims description 26
- 102100033720 DNA replication licensing factor MCM6 Human genes 0.000 claims description 26
- 101100457345 Danio rerio mapk14a gene Proteins 0.000 claims description 26
- 101100457347 Danio rerio mapk14b gene Proteins 0.000 claims description 26
- 102100031855 Estrogen-related receptor gamma Human genes 0.000 claims description 26
- 102100039291 Geranylgeranyl pyrophosphate synthase Human genes 0.000 claims description 26
- 102100035688 Guanylate-binding protein 1 Human genes 0.000 claims description 26
- 101000856723 Homo sapiens Cytochrome b-245 light chain Proteins 0.000 claims description 26
- 101001018484 Homo sapiens DNA replication licensing factor MCM6 Proteins 0.000 claims description 26
- 101000920831 Homo sapiens Estrogen-related receptor gamma Proteins 0.000 claims description 26
- 101000888406 Homo sapiens Geranylgeranyl pyrophosphate synthase Proteins 0.000 claims description 26
- 101001001336 Homo sapiens Guanylate-binding protein 1 Proteins 0.000 claims description 26
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims description 26
- 101000998020 Homo sapiens Keratin, type I cytoskeletal 18 Proteins 0.000 claims description 26
- 102100025390 Integrin beta-2 Human genes 0.000 claims description 26
- 102100033421 Keratin, type I cytoskeletal 18 Human genes 0.000 claims description 26
- 108700012928 MAPK14 Proteins 0.000 claims description 26
- 101150003941 Mapk14 gene Proteins 0.000 claims description 26
- 102000054819 Mitogen-activated protein kinase 14 Human genes 0.000 claims description 26
- 101150093699 Scube2 gene Proteins 0.000 claims description 26
- 102100028186 ATP-binding cassette sub-family C member 5 Human genes 0.000 claims description 25
- 108010043471 Core Binding Factor Alpha 2 Subunit Proteins 0.000 claims description 25
- 102100035186 DNA excision repair protein ERCC-1 Human genes 0.000 claims description 25
- 102100037700 DNA mismatch repair protein Msh3 Human genes 0.000 claims description 25
- 102100030960 DNA replication licensing factor MCM2 Human genes 0.000 claims description 25
- 102100028541 Guanylate-binding protein 2 Human genes 0.000 claims description 25
- 101000986622 Homo sapiens ATP-binding cassette sub-family C member 5 Proteins 0.000 claims description 25
- 101000876529 Homo sapiens DNA excision repair protein ERCC-1 Proteins 0.000 claims description 25
- 101001027762 Homo sapiens DNA mismatch repair protein Msh3 Proteins 0.000 claims description 25
- 101000583807 Homo sapiens DNA replication licensing factor MCM2 Proteins 0.000 claims description 25
- 101001018431 Homo sapiens DNA replication licensing factor MCM7 Proteins 0.000 claims description 25
- 101001058858 Homo sapiens Guanylate-binding protein 2 Proteins 0.000 claims description 25
- 101000624631 Homo sapiens M-phase inducer phosphatase 2 Proteins 0.000 claims description 25
- 101000798015 Homo sapiens RAC-beta serine/threonine-protein kinase Proteins 0.000 claims description 25
- 101000584767 Homo sapiens Ras-related protein Rab-6C Proteins 0.000 claims description 25
- 101000650806 Homo sapiens Semaphorin-3F Proteins 0.000 claims description 25
- 102100023325 M-phase inducer phosphatase 2 Human genes 0.000 claims description 25
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims description 25
- 102100032315 RAC-beta serine/threonine-protein kinase Human genes 0.000 claims description 25
- 102100038914 RalA-binding protein 1 Human genes 0.000 claims description 25
- 101150041852 Ralbp1 gene Proteins 0.000 claims description 25
- 102100030021 Ras-related protein Rab-6C Human genes 0.000 claims description 25
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 claims description 25
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims description 25
- 102100027751 Semaphorin-3F Human genes 0.000 claims description 25
- 102100029904 Signal transducer and activator of transcription 1-alpha/beta Human genes 0.000 claims description 25
- 102100021573 Bcl-2-binding component 3, isoforms 3/4 Human genes 0.000 claims description 24
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims description 24
- 102100038503 Cellular retinoic acid-binding protein 1 Human genes 0.000 claims description 24
- 102100036213 Collagen alpha-2(I) chain Human genes 0.000 claims description 24
- 102100023387 Endoribonuclease Dicer Human genes 0.000 claims description 24
- 102000004989 Hepsin Human genes 0.000 claims description 24
- 108090001101 Hepsin Proteins 0.000 claims description 24
- 101000971203 Homo sapiens Bcl-2-binding component 3, isoforms 1/2 Proteins 0.000 claims description 24
- 101000971209 Homo sapiens Bcl-2-binding component 3, isoforms 3/4 Proteins 0.000 claims description 24
- 101001099865 Homo sapiens Cellular retinoic acid-binding protein 1 Proteins 0.000 claims description 24
- 101000875067 Homo sapiens Collagen alpha-2(I) chain Proteins 0.000 claims description 24
- 101001026854 Homo sapiens Protein kinase C delta type Proteins 0.000 claims description 24
- 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 claims description 24
- 101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 claims description 24
- 101000904152 Homo sapiens Transcription factor E2F1 Proteins 0.000 claims description 24
- 101710091439 Major capsid protein 1 Proteins 0.000 claims description 24
- 102100037340 Protein kinase C delta type Human genes 0.000 claims description 24
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims description 24
- 102100021386 Trans-acting T-cell-specific transcription factor GATA-3 Human genes 0.000 claims description 24
- 102100024026 Transcription factor E2F1 Human genes 0.000 claims description 24
- 102100030686 Beta-sarcoglycan Human genes 0.000 claims description 23
- 108010058546 Cyclin D1 Proteins 0.000 claims description 23
- 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 claims description 23
- 101000703495 Homo sapiens Beta-sarcoglycan Proteins 0.000 claims description 23
- 101000907904 Homo sapiens Endoribonuclease Dicer Proteins 0.000 claims description 23
- 101000577881 Homo sapiens Macrophage metalloelastase Proteins 0.000 claims description 23
- 101000712958 Homo sapiens Ras association domain-containing protein 1 Proteins 0.000 claims description 23
- 102100027998 Macrophage metalloelastase Human genes 0.000 claims description 23
- 102100025825 Methylated-DNA-protein-cysteine methyltransferase Human genes 0.000 claims description 23
- 102100033243 Ras association domain-containing protein 1 Human genes 0.000 claims description 23
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims description 23
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 claims description 23
- 108040008770 methylated-DNA-[protein]-cysteine S-methyltransferase activity proteins Proteins 0.000 claims description 23
- 101000934372 Homo sapiens Macrosialin Proteins 0.000 claims description 22
- 101000622304 Homo sapiens Vascular cell adhesion protein 1 Proteins 0.000 claims description 22
- 101000784541 Homo sapiens Zinc finger and SCAN domain-containing protein 21 Proteins 0.000 claims description 22
- 102100025136 Macrosialin Human genes 0.000 claims description 22
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims description 22
- 102100020917 Zinc finger and SCAN domain-containing protein 21 Human genes 0.000 claims description 22
- 102100032311 Aurora kinase A Human genes 0.000 claims description 21
- 102100026540 Cathepsin L2 Human genes 0.000 claims description 21
- 102100033601 Collagen alpha-1(I) chain Human genes 0.000 claims description 21
- 102100032757 Cysteine-rich protein 2 Human genes 0.000 claims description 21
- 102100031242 Deoxyhypusine synthase Human genes 0.000 claims description 21
- 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 claims description 21
- 102100036534 Glutathione S-transferase Mu 1 Human genes 0.000 claims description 21
- 101000798300 Homo sapiens Aurora kinase A Proteins 0.000 claims description 21
- 101000983577 Homo sapiens Cathepsin L2 Proteins 0.000 claims description 21
- 101000942088 Homo sapiens Cysteine-rich protein 2 Proteins 0.000 claims description 21
- 101000844963 Homo sapiens Deoxyhypusine synthase Proteins 0.000 claims description 21
- 101000868643 Homo sapiens G2/mitotic-specific cyclin-B1 Proteins 0.000 claims description 21
- 101001071694 Homo sapiens Glutathione S-transferase Mu 1 Proteins 0.000 claims description 21
- 101001077604 Homo sapiens Insulin receptor substrate 1 Proteins 0.000 claims description 21
- 101000593405 Homo sapiens Myb-related protein B Proteins 0.000 claims description 21
- 101001087388 Homo sapiens Tyrosine-protein phosphatase non-receptor type 21 Proteins 0.000 claims description 21
- 102100025087 Insulin receptor substrate 1 Human genes 0.000 claims description 21
- 102100034670 Myb-related protein B Human genes 0.000 claims description 21
- 102000000504 Tumor Suppressor p53-Binding Protein 1 Human genes 0.000 claims description 21
- 108010041385 Tumor Suppressor p53-Binding Protein 1 Proteins 0.000 claims description 21
- 102100033005 Tyrosine-protein phosphatase non-receptor type 21 Human genes 0.000 claims description 21
- 108010029483 alpha 1 Chain Collagen Type I Proteins 0.000 claims description 21
- 101000577877 Homo sapiens Stromelysin-3 Proteins 0.000 claims description 20
- 102000019149 MAP kinase activity proteins Human genes 0.000 claims description 20
- 108040008097 MAP kinase activity proteins Proteins 0.000 claims description 20
- 102100028847 Stromelysin-3 Human genes 0.000 claims description 20
- 239000002246 antineoplastic agent Substances 0.000 claims description 20
- 102100037674 Bis(5'-adenosyl)-triphosphatase Human genes 0.000 claims description 19
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims description 19
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims description 19
- 108010005713 bis(5'-adenosyl)triphosphatase Proteins 0.000 claims description 19
- 101001027925 Homo sapiens Metastasis-associated protein MTA1 Proteins 0.000 claims description 18
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 18
- 102100037517 Metastasis-associated protein MTA1 Human genes 0.000 claims description 18
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 18
- 101150044980 Akap1 gene Proteins 0.000 claims description 17
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims description 17
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims description 17
- 238000003757 reverse transcription PCR Methods 0.000 claims description 17
- 101000926086 Homo sapiens Rap1 GTPase-GDP dissociation stimulator 1 Proteins 0.000 claims description 15
- 102100034329 Rap1 GTPase-GDP dissociation stimulator 1 Human genes 0.000 claims description 15
- 238000001574 biopsy Methods 0.000 claims description 15
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims description 14
- 108010038795 estrogen receptors Proteins 0.000 claims description 14
- 238000011227 neoadjuvant chemotherapy Methods 0.000 claims description 14
- 108091012583 BCL2 Proteins 0.000 claims description 13
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims description 13
- 101000882584 Homo sapiens Estrogen receptor Proteins 0.000 claims description 13
- 101000840566 Homo sapiens Insulin-like growth factor-binding protein 5 Proteins 0.000 claims description 13
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 13
- 101000945496 Homo sapiens Proliferation marker protein Ki-67 Proteins 0.000 claims description 13
- 102100029225 Insulin-like growth factor-binding protein 5 Human genes 0.000 claims description 13
- 102100034256 Mucin-1 Human genes 0.000 claims description 13
- 102100034836 Proliferation marker protein Ki-67 Human genes 0.000 claims description 13
- 108010002687 Survivin Proteins 0.000 claims description 13
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 12
- 108091034117 Oligonucleotide Proteins 0.000 claims description 10
- 230000001575 pathological effect Effects 0.000 claims description 10
- 238000003556 assay Methods 0.000 claims description 9
- 238000010195 expression analysis Methods 0.000 claims description 9
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 9
- 229940123237 Taxane Drugs 0.000 claims description 8
- 230000009545 invasion Effects 0.000 claims description 7
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 7
- 229930012538 Paclitaxel Natural products 0.000 claims description 6
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 6
- 239000012472 biological sample Substances 0.000 claims description 6
- 229940127089 cytotoxic agent Drugs 0.000 claims description 6
- 229960001592 paclitaxel Drugs 0.000 claims description 6
- 230000035755 proliferation Effects 0.000 claims description 6
- 108020004635 Complementary DNA Proteins 0.000 claims description 5
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 5
- -1 RPLPO Proteins 0.000 claims description 5
- 229960003668 docetaxel Drugs 0.000 claims description 5
- 229960004679 doxorubicin Drugs 0.000 claims description 5
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims description 5
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims description 5
- 238000003364 immunohistochemistry Methods 0.000 claims description 5
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 229940045799 anthracyclines and related substance Drugs 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
- 208000030776 invasive breast carcinoma Diseases 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 238000011277 treatment modality Methods 0.000 claims description 4
- 108010064760 Anidulafungin Proteins 0.000 claims description 3
- 102100026031 Beta-glucuronidase Human genes 0.000 claims description 3
- 101000933465 Homo sapiens Beta-glucuronidase Proteins 0.000 claims description 3
- 101000631713 Homo sapiens Signal peptide, CUB and EGF-like domain-containing protein 2 Proteins 0.000 claims description 3
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims description 3
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims description 3
- 238000011226 adjuvant chemotherapy Methods 0.000 claims description 3
- JHVAMHSQVVQIOT-MFAJLEFUSA-N anidulafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@@H](C)O)[C@H](O)[C@@H](O)C=2C=CC(O)=CC=2)[C@@H](C)O)=O)C=C1 JHVAMHSQVVQIOT-MFAJLEFUSA-N 0.000 claims description 3
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims description 3
- 229940071198 eraxis Drugs 0.000 claims description 3
- 238000005259 measurement Methods 0.000 claims description 3
- 102000003998 progesterone receptors Human genes 0.000 claims description 3
- 108090000468 progesterone receptors Proteins 0.000 claims description 3
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims description 3
- 101000756632 Homo sapiens Actin, cytoplasmic 1 Proteins 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 102100024516 F-box only protein 5 Human genes 0.000 claims 9
- 101150008545 FAS1 gene Proteins 0.000 claims 9
- 101001052797 Homo sapiens F-box only protein 5 Proteins 0.000 claims 9
- 101150017888 Bcl2 gene Proteins 0.000 claims 1
- 101150031726 ERS1 gene Proteins 0.000 claims 1
- 101000741289 Homo sapiens Calreticulin-3 Proteins 0.000 claims 1
- 101000969621 Homo sapiens Monocarboxylate transporter 12 Proteins 0.000 claims 1
- 102100021444 Monocarboxylate transporter 12 Human genes 0.000 claims 1
- 101100204733 Schizosaccharomyces pombe (strain 972 / ATCC 24843) gus1 gene Proteins 0.000 claims 1
- 101150075071 TRS1 gene Proteins 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 26
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 238000004393 prognosis Methods 0.000 abstract description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 61
- 239000000047 product Substances 0.000 description 33
- 108020004414 DNA Proteins 0.000 description 32
- 210000004027 cell Anatomy 0.000 description 22
- 108020004999 messenger RNA Proteins 0.000 description 18
- 229940079593 drug Drugs 0.000 description 14
- 239000003814 drug Substances 0.000 description 14
- 101150089023 FASLG gene Proteins 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 12
- 239000002299 complementary DNA Substances 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 238000009396 hybridization Methods 0.000 description 11
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 10
- 238000001356 surgical procedure Methods 0.000 description 9
- 102000013814 Wnt Human genes 0.000 description 8
- 108050003627 Wnt Proteins 0.000 description 8
- 230000003321 amplification Effects 0.000 description 8
- 238000001514 detection method Methods 0.000 description 8
- 238000011223 gene expression profiling Methods 0.000 description 8
- 238000010606 normalization Methods 0.000 description 8
- 238000003199 nucleic acid amplification method Methods 0.000 description 8
- 238000012163 sequencing technique Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 210000004881 tumor cell Anatomy 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 6
- 102100031901 A-kinase anchor protein 2 Human genes 0.000 description 6
- 101710109888 A-kinase anchor protein 2 Proteins 0.000 description 6
- 101000984190 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 1 Proteins 0.000 description 6
- 102100025584 Leukocyte immunoglobulin-like receptor subfamily B member 1 Human genes 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 101150109862 WNT-5A gene Proteins 0.000 description 6
- 108700020483 Wnt-5a Proteins 0.000 description 6
- 102000043366 Wnt-5a Human genes 0.000 description 6
- 238000004422 calculation algorithm Methods 0.000 description 6
- 239000000975 dye Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000002493 microarray Methods 0.000 description 6
- 238000009099 neoadjuvant therapy Methods 0.000 description 6
- 239000013615 primer Substances 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 238000003196 serial analysis of gene expression Methods 0.000 description 6
- 102000053602 DNA Human genes 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- 239000011325 microbead Substances 0.000 description 5
- 239000001509 sodium citrate Substances 0.000 description 5
- 108091093088 Amplicon Proteins 0.000 description 4
- 102100031780 Endonuclease Human genes 0.000 description 4
- 108700039887 Essential Genes Proteins 0.000 description 4
- 108010006785 Taq Polymerase Proteins 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 230000009274 differential gene expression Effects 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000010839 reverse transcription Methods 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 238000011269 treatment regimen Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- QKYZQKJXAKNEPA-UHFFFAOYSA-N 3-hydroxy-5-methyl-1-phenylthieno[2,3-d]pyrimidine-2,4-dione Chemical compound O=C1N(O)C(=O)C=2C(C)=CSC=2N1C1=CC=CC=C1 QKYZQKJXAKNEPA-UHFFFAOYSA-N 0.000 description 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102100031618 HLA class II histocompatibility antigen, DP beta 1 chain Human genes 0.000 description 3
- 108010045483 HLA-DPB1 antigen Proteins 0.000 description 3
- 101000606537 Homo sapiens Receptor-type tyrosine-protein phosphatase delta Proteins 0.000 description 3
- 206010027476 Metastases Diseases 0.000 description 3
- 101710163270 Nuclease Proteins 0.000 description 3
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 3
- 102100039666 Receptor-type tyrosine-protein phosphatase delta Human genes 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 230000001394 metastastic effect Effects 0.000 description 3
- 206010061289 metastatic neoplasm Diseases 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- RVNZEJNWTUDQSC-JOCHJYFZSA-N (2r)-n-(6-aminohexyl)-1-tridecanoylpyrrolidine-2-carboxamide Chemical compound CCCCCCCCCCCCC(=O)N1CCC[C@@H]1C(=O)NCCCCCCN RVNZEJNWTUDQSC-JOCHJYFZSA-N 0.000 description 2
- OGWKCGZFUXNPDA-CFWMRBGOSA-N 5j49q6b70f Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 OGWKCGZFUXNPDA-CFWMRBGOSA-N 0.000 description 2
- 241000972773 Aulopiformes Species 0.000 description 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
- 239000003298 DNA probe Substances 0.000 description 2
- 101150029707 ERBB2 gene Proteins 0.000 description 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
- 108010010378 HLA-DP Antigens Proteins 0.000 description 2
- 102000015789 HLA-DP Antigens Human genes 0.000 description 2
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 2
- 238000002123 RNA extraction Methods 0.000 description 2
- 238000010802 RNA extraction kit Methods 0.000 description 2
- 238000011529 RT qPCR Methods 0.000 description 2
- 108091006629 SLC13A2 Proteins 0.000 description 2
- 108020004682 Single-Stranded DNA Proteins 0.000 description 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000009098 adjuvant therapy Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 229940044683 chemotherapy drug Drugs 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 229960004397 cyclophosphamide Drugs 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 239000005547 deoxyribonucleotide Substances 0.000 description 2
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 229960000633 dextran sulfate Drugs 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 229960002949 fluorouracil Drugs 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000002962 histologic effect Effects 0.000 description 2
- 229960001330 hydroxycarbamide Drugs 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 238000010841 mRNA extraction Methods 0.000 description 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 238000012775 microarray technology Methods 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 230000009826 neoplastic cell growth Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000000171 quenching effect Effects 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 238000002271 resection Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 235000019515 salmon Nutrition 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- MPPTYPZHFZZRQJ-RUELKSSGSA-N (7s,9s)-7-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione;n,n-bis(2-chloroethyl)-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine Chemical compound ClCCN(CCCl)P1(=O)NCCCO1.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 MPPTYPZHFZZRQJ-RUELKSSGSA-N 0.000 description 1
- SLVOVFVZZFUEAS-UHFFFAOYSA-N 2-[2-[2-[bis(carboxymethyl)amino]ethoxy]ethyl-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCN(CC(O)=O)CC(O)=O SLVOVFVZZFUEAS-UHFFFAOYSA-N 0.000 description 1
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
- 240000005020 Acaciella glauca Species 0.000 description 1
- 101000588924 Anthopleura elegantissima Delta-actitoxin-Ael1a Proteins 0.000 description 1
- 101100099988 Arabidopsis thaliana TPD1 gene Proteins 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 101100322915 Caenorhabditis elegans akt-1 gene Proteins 0.000 description 1
- 101100504320 Caenorhabditis elegans mcp-1 gene Proteins 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 239000003155 DNA primer Substances 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108010042407 Endonucleases Proteins 0.000 description 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 1
- 101001109137 Homo sapiens Receptor-interacting serine/threonine-protein kinase 2 Proteins 0.000 description 1
- 101000733257 Homo sapiens Rho guanine nucleotide exchange factor 28 Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- 102000004371 Insulin-like growth factor binding protein 5 Human genes 0.000 description 1
- 108090000961 Insulin-like growth factor binding protein 5 Proteins 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 238000012773 Laboratory assay Methods 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000713869 Moloney murine leukemia virus Species 0.000 description 1
- 101100226013 Mus musculus Ercc1 gene Proteins 0.000 description 1
- 102000048850 Neoplasm Genes Human genes 0.000 description 1
- 108700019961 Neoplasm Genes Proteins 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 238000009004 PCR Kit Methods 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108010026552 Proteome Proteins 0.000 description 1
- 230000006819 RNA synthesis Effects 0.000 description 1
- 102100022851 Rab5 GDP/GTP exchange factor Human genes 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 101710203837 Replication-associated protein Proteins 0.000 description 1
- 208000007660 Residual Neoplasm Diseases 0.000 description 1
- 102100033204 Rho guanine nucleotide exchange factor 28 Human genes 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 101100336452 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GDS1 gene Proteins 0.000 description 1
- 101100352918 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PTC1 gene Proteins 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 108010020713 Tth polymerase Proteins 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000006593 Urologic Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000011360 adjunctive therapy Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229940009456 adriamycin Drugs 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 229940046836 anti-estrogen Drugs 0.000 description 1
- 230000001833 anti-estrogenic effect Effects 0.000 description 1
- 230000005975 antitumor immune response Effects 0.000 description 1
- 210000001099 axilla Anatomy 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 230000004186 co-expression Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 229960000975 daunorubicin Drugs 0.000 description 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000000432 density-gradient centrifugation Methods 0.000 description 1
- 230000030609 dephosphorylation Effects 0.000 description 1
- 238000006209 dephosphorylation reaction Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 208000028715 ductal breast carcinoma in situ Diseases 0.000 description 1
- 229960001904 epirubicin Drugs 0.000 description 1
- 239000000328 estrogen antagonist Substances 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 229960005420 etoposide Drugs 0.000 description 1
- LIQODXNTTZAGID-OCBXBXKTSA-N etoposide phosphate Chemical compound COC1=C(OP(O)(O)=O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 LIQODXNTTZAGID-OCBXBXKTSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000002795 fluorescence method Methods 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000004547 gene signature Effects 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 230000003118 histopathologic effect Effects 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000012308 immunohistochemistry method Methods 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- QZIQJVCYUQZDIR-UHFFFAOYSA-N mechlorethamine hydrochloride Chemical compound Cl.ClCCN(C)CCCl QZIQJVCYUQZDIR-UHFFFAOYSA-N 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 1
- 229960001428 mercaptopurine Drugs 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 238000010208 microarray analysis Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229940127084 other anti-cancer agent Drugs 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000011518 platinum-based chemotherapy Methods 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000001915 proofreading effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 235000003499 redwood Nutrition 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000012340 reverse transcriptase PCR Methods 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
- G01N2474/20—Immunohistochemistry assay
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56103504P | 2004-04-09 | 2004-04-09 | |
| US60/561,035 | 2004-04-09 | ||
| CA2563074A CA2563074C (en) | 2004-04-09 | 2005-04-07 | Gene expression markers for predicting response to chemotherapy |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2563074A Division CA2563074C (en) | 2004-04-09 | 2005-04-07 | Gene expression markers for predicting response to chemotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2848463A1 true CA2848463A1 (en) | 2005-10-27 |
Family
ID=34981928
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2848463A Abandoned CA2848463A1 (en) | 2004-04-09 | 2005-04-07 | Gene expression markers for predicting response to chemotherapy |
| CA2563074A Expired - Lifetime CA2563074C (en) | 2004-04-09 | 2005-04-07 | Gene expression markers for predicting response to chemotherapy |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2563074A Expired - Lifetime CA2563074C (en) | 2004-04-09 | 2005-04-07 | Gene expression markers for predicting response to chemotherapy |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7871769B2 (enExample) |
| EP (4) | EP1737980A2 (enExample) |
| JP (3) | JP5813908B2 (enExample) |
| AU (2) | AU2005233593B2 (enExample) |
| CA (2) | CA2848463A1 (enExample) |
| DK (1) | DK2163650T3 (enExample) |
| ES (2) | ES2636470T3 (enExample) |
| IL (4) | IL178508A (enExample) |
| WO (1) | WO2005100606A2 (enExample) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2261368A1 (en) * | 2002-03-13 | 2010-12-15 | Genomic Health, Inc. | Gene expression profiling in biopsied tumor tissues |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| WO2005039382A2 (en) * | 2003-06-24 | 2005-05-06 | Genomic Health | Prediction of likelihood of cancer recurrence |
| CA2848463A1 (en) | 2004-04-09 | 2005-10-27 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| US20050260659A1 (en) * | 2004-04-23 | 2005-11-24 | Exagen Diagnostics, Inc. | Compositions and methods for breast cancer prognosis |
| CA3061785A1 (en) * | 2004-11-05 | 2006-05-18 | Genomic Health, Inc. | Predicting response to chemotherapy using gene expression markers |
| JP4939425B2 (ja) * | 2004-11-05 | 2012-05-23 | ジェノミック ヘルス, インコーポレイテッド | 乳癌の治療反応の予後および予測の分子指標 |
| EP2395109A1 (en) * | 2004-12-08 | 2011-12-14 | Aventis Pharmaceuticals Inc. | Method for measuring resistance or sensitivity to docetaxel |
| WO2007013946A2 (en) * | 2005-07-20 | 2007-02-01 | University Of South Florida | Method of predicting responsiveness to chemotherapy and selecting treatments |
| EP1937837A2 (en) * | 2005-07-29 | 2008-07-02 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the prediction of therapeutic success, recurrence free and overall survival in cancer therapies |
| JP5984324B2 (ja) * | 2005-12-01 | 2016-09-06 | メディカル プログノシス インスティテュート エー/エス | 治療反応のバイオマーカーを同定するための方法および装置、ならびに治療効果を推定するためのその使用 |
| US8445198B2 (en) | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| US7892740B2 (en) | 2006-01-19 | 2011-02-22 | The University Of Chicago | Prognosis and therapy predictive markers and methods of use |
| WO2007085497A2 (en) * | 2006-01-30 | 2007-08-02 | Epigenomics Ag | Markers for the prediction of outcome of anthracycline treatment |
| BRPI0711011A2 (pt) | 2006-05-18 | 2011-08-23 | Molecular Profiling Inst Inc | método para a determinação da intervenção médica para um estado de doença, método para a identificação de uma terapia de droga com capacidade de interação com um alvo molecular e sistema para a determinação da intervenção médica individualizada para um estado de doença |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| JP2008017832A (ja) * | 2006-06-13 | 2008-01-31 | Sysmex Corp | がんの転移の判定方法及び判定装置 |
| DK2081950T3 (da) * | 2006-09-21 | 2013-06-03 | Nuclea Biomarkers Llc | Med irinotecanbehandling forbundne ekspressionsprofiler |
| WO2008058018A2 (en) | 2006-11-02 | 2008-05-15 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
| WO2008098086A2 (en) * | 2007-02-06 | 2008-08-14 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | A gene expression profile that predicts ovarian cancer subject response to chemotherapy |
| KR101791981B1 (ko) * | 2007-03-14 | 2017-11-01 | 비온실 에스.알.엘. | 화학요법 약물-내성 상피성 종양을 치료하기 위한 siRNA-매개 유전자 침묵화 |
| CA2680591A1 (en) * | 2007-03-15 | 2008-09-25 | Genomic Health, Inc. | Gene expression markers for prediction of patient response to chemotherapy |
| EP1978106A1 (en) * | 2007-04-07 | 2008-10-08 | Universitätsklinikum Hamburg-Eppendorf | Detection of ESR1 amplification in endometrium cancer and ovary cancer |
| EP2228457A1 (en) * | 2007-08-16 | 2010-09-15 | Genomic Health, Inc. | Gene expression markers of recurrence risk in cancer patients after chemotherapy |
| JP2009050189A (ja) * | 2007-08-24 | 2009-03-12 | Sumitomo Bakelite Co Ltd | 抗癌剤の有効性予測方法 |
| AU2008298560A1 (en) * | 2007-09-14 | 2009-03-19 | Ventana Medical Systems, Inc. | Prostate cancer biomarkers |
| JP5303132B2 (ja) * | 2007-09-20 | 2013-10-02 | シスメックス株式会社 | がん細胞の存否を判定する方法及び装置 |
| GB0720113D0 (en) * | 2007-10-15 | 2007-11-28 | Cambridge Cancer Diagnostics L | Diagnostic, prognostic and predictive testing for cancer |
| BRPI0820707A2 (pt) | 2007-11-07 | 2015-06-16 | Genentech Inc | Métodos e composição para avaliar a responsividade do linfoma de células b para o tratamento com anticorpos anti-cd40 |
| US8168755B2 (en) * | 2008-05-07 | 2012-05-01 | Eutropics Pharmaceuticals, Inc. | Antibodies specific to heterodimers of Bcl-2 family and uses thereof |
| EP2641978A1 (en) * | 2008-05-12 | 2013-09-25 | Genomic Health, Inc. | Tests to predict responsiveness of cancer patients to chemotherapy treatment options |
| EP2806054A1 (en) * | 2008-05-28 | 2014-11-26 | Genomedx Biosciences Inc. | Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer |
| US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
| PL2297359T4 (pl) | 2008-05-30 | 2014-07-31 | Univ North Carolina Chapel Hill | Profile ekspresji genów do przewidywania skutków raka piersi |
| TW201000119A (en) * | 2008-06-10 | 2010-01-01 | Oncotherapy Science Inc | MYBL2 epitope peptides and vaccines containing the same |
| WO2010007083A2 (en) * | 2008-07-15 | 2010-01-21 | Epigenomics Ag | Methods and nucleic acids for analyses of cell proliferative disorders |
| KR100996994B1 (ko) * | 2008-08-18 | 2010-11-25 | 울산대학교 산학협력단 | 간세포암종 수술후 재발 또는 재발 발병 위험성의 진단방법 |
| EP2318553A4 (en) * | 2008-08-20 | 2011-11-02 | Univ Colorado Regents | MARKERS FOR CHECKING THE RECEIVABILITY OF CARCINOMES FOR IGF-1R TREATMENTS |
| JP2010057486A (ja) * | 2008-09-02 | 2010-03-18 | Sysmex Corp | 化学療法に対するがん患者の応答の予測方法 |
| EP3216874A1 (en) | 2008-09-05 | 2017-09-13 | TOMA Biosciences, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| US20130324478A1 (en) * | 2008-09-08 | 2013-12-05 | Laurence Faure | Pharmacodiagnosis Test Targeting Oncology and Neurodegeneration |
| US10359425B2 (en) * | 2008-09-09 | 2019-07-23 | Somalogic, Inc. | Lung cancer biomarkers and uses thereof |
| US20100221752A2 (en) * | 2008-10-06 | 2010-09-02 | Somalogic, Inc. | Ovarian Cancer Biomarkers and Uses Thereof |
| EP3075864A1 (en) * | 2008-10-14 | 2016-10-05 | Caris MPI, Inc. | Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type |
| EP3181705A1 (en) | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| WO2010067316A1 (en) * | 2008-12-10 | 2010-06-17 | Ipsogen | Methods for identifying erbb2 alteration in tumors |
| US20120041274A1 (en) | 2010-01-07 | 2012-02-16 | Myriad Genetics, Incorporated | Cancer biomarkers |
| CA2751688A1 (en) * | 2009-02-06 | 2010-08-12 | Biao He | Emx2 in cancer diagnosis and prognosis |
| US8972899B2 (en) | 2009-02-10 | 2015-03-03 | Ayasdi, Inc. | Systems and methods for visualization of data analysis |
| US9617600B2 (en) | 2009-04-18 | 2017-04-11 | Genentech, Inc. | Methods for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies |
| DK177532B1 (en) | 2009-09-17 | 2013-09-08 | Bio Bedst Aps | Medical use of sPLA2 hydrolysable liposomes |
| CA3256492A1 (en) | 2010-01-11 | 2025-11-29 | Genomic Health Inc | Method to use gene expression to determine likelihood of clinical outcome of renal cancer |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| US9598734B2 (en) | 2010-04-29 | 2017-03-21 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy |
| WO2012000976A1 (en) * | 2010-07-02 | 2012-01-05 | Topogen Inc. | Method for diagnosis of bladder cancer and related kits |
| EP3812469A1 (en) | 2010-07-07 | 2021-04-28 | Myriad Genetics, Inc. | Gene signatures for cancer prognosis |
| MX355020B (es) | 2010-07-09 | 2018-04-02 | Somalogic Inc | Biomarcadores de cancer de pulmon y usos de los mismos. |
| TW201209163A (en) * | 2010-07-12 | 2012-03-01 | Opko Curna Llc | Treatment of BCL2 binding component 3 (BBC3) related diseases by inhibition of natural antisense transcript to BBC3 |
| MX338883B (es) | 2010-07-27 | 2016-05-04 | Genomic Health Inc | Metodo para usar expresion de gen para determinar el pronostico de cancer de prostata. |
| JP5931874B2 (ja) | 2010-08-13 | 2016-06-08 | ソマロジック・インコーポレーテッド | 膵癌バイオマーカーおよびその使用 |
| WO2012030840A2 (en) | 2010-08-30 | 2012-03-08 | Myriad Genetics, Inc. | Gene signatures for cancer diagnosis and prognosis |
| KR20130113447A (ko) | 2010-09-24 | 2013-10-15 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화 |
| EP2619576B1 (en) | 2010-09-24 | 2020-06-10 | Niels Grabe | Means and methods for the prediction of treatment response of a cancer patient |
| US20130267443A1 (en) | 2010-11-19 | 2013-10-10 | The Regents Of The University Of Michigan | ncRNA AND USES THEREOF |
| JP5828446B2 (ja) * | 2011-02-10 | 2015-12-09 | 国立大学法人秋田大学 | 扁平上皮癌組織の放射線感受性マーカー |
| CA2742342A1 (en) * | 2011-02-12 | 2012-08-12 | Baylor Research Institute | Msh3 expression status determines the responsiveness of cancer cells to the chemotherapeutic treatment with parp inhibitors and platinum drugs |
| US20130042333A1 (en) * | 2011-05-06 | 2013-02-14 | Jean-Gabriel JUDDE | Markers for cancer prognosis and therapy and methods of use |
| BR112013031019A2 (pt) * | 2011-06-02 | 2017-03-21 | Almac Diagnostics Ltd | teste diagnóstico molecular para câncer |
| WO2012174203A2 (en) * | 2011-06-14 | 2012-12-20 | Anthony Albino | Methods and kits for the detection and treatment of recurring prostate cancer |
| EP2834640B1 (en) * | 2011-10-04 | 2020-06-17 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Cd247 as a biomarker for assessing the effect of chemotherapeutic and biological drugs |
| EP2766836A4 (en) * | 2011-10-10 | 2015-07-15 | Ayasdi Inc | SYSTEM AND METHOD FOR ALLOCATING NEW PATIENT INFORMATION TO PREVIOUS RESULTS IN SUPPORT OF TREATMENT |
| EP2785873A4 (en) * | 2011-11-30 | 2015-11-11 | Univ North Carolina | METHOD FOR THE TREATMENT OF BREAST CANCER WITH TAXAN THERAPY |
| WO2013090620A1 (en) | 2011-12-13 | 2013-06-20 | Genomedx Biosciences, Inc. | Cancer diagnostics using non-coding transcripts |
| EP2794924B1 (en) | 2011-12-22 | 2019-02-06 | Baylor Research Institute | Identification of mirna signatures in human colorectal cancer |
| WO2013109690A1 (en) * | 2012-01-17 | 2013-07-25 | Myriad Genetics, Inc. | Breast cancer prognosis signatures |
| SG11201404390WA (en) | 2012-01-31 | 2014-08-28 | Genomic Health Inc | Gene expression profile algorithm and test for determining prognosis of prostate cancer |
| FR2987446B1 (fr) * | 2012-02-28 | 2016-01-01 | Univ Nice Sophia Antipolis | Test diagnostic de la resistance a l'azacitidine |
| WO2013170174A1 (en) | 2012-05-10 | 2013-11-14 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Method of diagnosing, treating and determining progression and survival of cancer cells using bcl-2 antagonist of cell death (bad) pathway gene signature |
| IN2014DN11205A (enExample) | 2012-06-20 | 2015-10-02 | Eutropics Pharmaceuticals Inc | |
| ES2945036T3 (es) | 2012-08-16 | 2023-06-28 | Veracyte Sd Inc | Pronóstico del cáncer de próstata mediante biomarcadores |
| WO2014078700A1 (en) | 2012-11-16 | 2014-05-22 | Myriad Genetics, Inc. | Gene signatures for cancer prognosis |
| EP2922544B1 (en) | 2012-11-21 | 2018-08-01 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
| US20140315844A1 (en) * | 2012-11-30 | 2014-10-23 | Celera Corporation | Multi-gene signatures for predicting response to chemotherapy or risk of metastasis for breast cancer |
| US11091809B2 (en) | 2012-12-03 | 2021-08-17 | Almac Diagnostic Services Limited | Molecular diagnostic test for cancer |
| US10240206B2 (en) * | 2013-02-01 | 2019-03-26 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Biomarkers and methods for predicting benefit of adjuvant chemotherapy |
| KR102241063B1 (ko) * | 2013-03-15 | 2021-04-16 | 얀센 파마슈티카 엔.브이. | 예측성 바이오마커에 대한 검정법 |
| ES2829415T3 (es) * | 2013-05-30 | 2021-05-31 | Genomic Health Inc | Algoritmo de perfil de expresión génica para calcular una puntuación de recurrencia para un paciente con cáncer de riñón |
| WO2015017788A1 (en) | 2013-08-01 | 2015-02-05 | Eutropics Pharmaceuticals, Inc. | Method for predicting cancer sensitivity |
| AU2014342269B2 (en) | 2013-10-30 | 2020-02-27 | Eutropics Pharmaceuticals, Inc. | Methods for determining chemosensitivity and chemotoxicity |
| GB201409479D0 (en) | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| EP3134119B1 (en) * | 2014-04-24 | 2018-08-22 | Pfizer Inc | Cancer treatment |
| EP3143160B1 (en) | 2014-05-13 | 2019-11-06 | Myriad Genetics, Inc. | Gene signatures for cancer prognosis |
| CN104004844A (zh) * | 2014-05-28 | 2014-08-27 | 杭州美中疾病基因研究院有限公司 | 乳腺癌21基因联合检测试剂盒及其制备方法 |
| AU2014407088B2 (en) | 2014-09-26 | 2021-09-23 | Somalogic Operating Co., Inc. | Cardiovascular risk event prediction and uses thereof |
| FI3198035T3 (fi) | 2014-09-26 | 2023-01-31 | Menetelmiä lääkevasteen ennustamiseksi | |
| WO2016062892A1 (en) * | 2014-10-24 | 2016-04-28 | Koninklijke Philips N.V. | Medical prognosis and prediction of treatment response using multiple cellular signaling pathway activities |
| AU2015334842B2 (en) * | 2014-10-24 | 2022-02-17 | Koninklijke Philips N.V. | Medical prognosis and prediction of treatment response using multiple cellular signaling pathway activities |
| HK1247250A1 (zh) | 2015-01-12 | 2018-09-21 | Eutropics Pharmaceuticals, Inc. | 用於指导癌症治疗的内容相关的诊断测试 |
| EP3248127A4 (en) | 2015-01-20 | 2018-08-08 | Nantomics, LLC | Systems and methods for response prediction to chemotherapy in high grade bladder cancer |
| KR102755601B1 (ko) | 2015-10-14 | 2025-01-17 | 바이오-패쓰 홀딩스 인크. | 리포좀 제제를 위한 p-에톡시 핵산 |
| WO2017096458A1 (en) * | 2015-12-07 | 2017-06-15 | Ontario Institute For Cancer Research (Oicr) | Immune gene signature predictive of anthracycline benefit |
| EP3387443A4 (en) * | 2015-12-10 | 2019-11-13 | Nantomics, LLC | INTEGRATED ANALYSIS TO DETERMINE PROGNOSIS AFTER THE TREATMENT OF PRIMARY BREAST CANCER |
| US11414708B2 (en) | 2016-08-24 | 2022-08-16 | Decipher Biosciences, Inc. | Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy |
| US10927379B2 (en) | 2016-09-16 | 2021-02-23 | Bio-Path Holdings, Inc. | Combination therapy with liposomal antisense oligonucleotides |
| US9725769B1 (en) | 2016-10-07 | 2017-08-08 | Oncology Venture ApS | Methods for predicting drug responsiveness in cancer patients |
| AU2017258901A1 (en) | 2016-12-30 | 2018-07-19 | Allarity Therapeutics Europe ApS | Methods for predicting drug responsiveness in cancer patients |
| AU2018210695B2 (en) | 2017-01-20 | 2024-07-18 | The University Of British Columbia | Molecular subtyping, prognosis, and treatment of bladder cancer |
| US11873532B2 (en) | 2017-03-09 | 2024-01-16 | Decipher Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
| US11746381B2 (en) | 2017-03-10 | 2023-09-05 | Cancer Diagnostics Research Innvovations, LLC | Methods for diagnosing and treating gastric cancer using miRNA expression |
| US12234457B2 (en) | 2017-04-19 | 2025-02-25 | Bio-Path Holdings, Inc. | P-ethoxy nucleic acids for BCL2 inhibition |
| IL269608B2 (en) | 2017-04-19 | 2024-06-01 | Bio Path Holdings Inc | Compositions comprising p-ethoxy nucleic acids for stat3 inhibition for use in treating cancer or autoimmune disease |
| WO2018205035A1 (en) | 2017-05-12 | 2018-11-15 | Genomedx Biosciences, Inc | Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness |
| RU2675236C1 (ru) * | 2018-02-22 | 2018-12-18 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ прогнозирования развития метастазов у больных раком молочной железы |
| US12174192B2 (en) * | 2018-07-12 | 2024-12-24 | Corvus Pharmaceuticals, Inc. | Methods for detecting and treating cancers having adenosine pathway activation |
| US20220357328A1 (en) * | 2019-09-09 | 2022-11-10 | Oaklabs Gmbh | Superior biomarker signature to predict the response of a breast cancer patient to chemotherapy |
| CN111184865B (zh) * | 2020-03-09 | 2021-11-16 | 复旦大学附属金山医院 | Stat1在耐紫杉醇上皮性卵巢癌治疗中的用途 |
| GB202116745D0 (en) * | 2021-11-19 | 2022-01-05 | Institute Of Cancer Res Royal Cancer Hospital | Prognostic and treatment response predictive method |
| EP4623092A1 (en) * | 2022-11-21 | 2025-10-01 | Merck Sharp & Dohme LLC | Genome wide tumor derived gene expression based signatures associated with poor prognosis for melanoma patients with early stage disease |
Family Cites Families (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE35491E (en) | 1982-11-04 | 1997-04-08 | The Regents Of The University Of California | Methods and compositions for detecting human tumors |
| US4699877A (en) | 1982-11-04 | 1987-10-13 | The Regents Of The University Of California | Methods and compositions for detecting human tumors |
| IE56509B1 (en) | 1982-11-04 | 1991-08-28 | Univ California | Methods for oncogenic detection |
| US7838216B1 (en) | 1986-03-05 | 2010-11-23 | The United States Of America, As Represented By The Department Of Health And Human Services | Human gene related to but distinct from EGF receptor gene |
| US5015568A (en) | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
| US5202429A (en) | 1986-07-09 | 1993-04-13 | The Wistar Institute | DNA molecules having human BCL-2 gene sequences |
| US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
| US5831066A (en) | 1988-12-22 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Regulation of bcl-2 gene expression |
| US7625697B2 (en) * | 1994-06-17 | 2009-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for constructing subarrays and subarrays made thereby |
| US5858678A (en) | 1994-08-02 | 1999-01-12 | St. Louis University | Apoptosis-regulating proteins |
| US5830753A (en) | 1994-09-30 | 1998-11-03 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof. |
| CA2239692C (en) | 1995-12-18 | 2008-12-16 | Sugen, Inc. | Diagnosis and treatment of aur-1 and/or aur-2 related disorders |
| US6716575B2 (en) | 1995-12-18 | 2004-04-06 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
| US5670325A (en) | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| US5741650A (en) | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
| US5821082A (en) | 1996-05-23 | 1998-10-13 | St. Louis University Health Sciences Center | Anti-proliferation domain of a human Bcl-2 and DNA encoding the same |
| US6203993B1 (en) | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
| US6143529A (en) | 1996-08-14 | 2000-11-07 | Exact Laboratories, Inc. | Methods for improving sensitivity and specificity of screening assays |
| US5952178A (en) | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
| US6146828A (en) | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
| US6100029A (en) | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
| US5928870A (en) | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US6020137A (en) | 1996-08-14 | 2000-02-01 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US5861278A (en) | 1996-11-01 | 1999-01-19 | Genetics Institute, Inc. | HNF3δ compositions |
| CA2271783C (en) | 1996-11-20 | 2013-04-16 | Yale University | Survivin, a protein that inhibits cellular apoptosis, and its modulation |
| US5830665A (en) | 1997-03-03 | 1998-11-03 | Exact Laboratories, Inc. | Contiguous genomic sequence scanning |
| US6033893A (en) | 1997-06-26 | 2000-03-07 | Incyte Pharmaceuticals, Inc. | Human cathepsin |
| WO1999002714A1 (en) | 1997-07-07 | 1999-01-21 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the breast |
| US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
| CA2330929A1 (en) | 1998-06-06 | 1999-12-16 | Genostic Pharma Limited | Probes used for genetic profiling |
| US6696558B2 (en) | 1998-09-09 | 2004-02-24 | The Burnham Institute | Bag proteins and nucleic acid molecules encoding them |
| US6331396B1 (en) | 1998-09-23 | 2001-12-18 | The Cleveland Clinic Foundation | Arrays for identifying agents which mimic or inhibit the activity of interferons |
| WO2000040749A2 (en) | 1999-01-06 | 2000-07-13 | Genenews Inc. | Method for the detection of gene transcripts in blood and uses thereof |
| AU3246200A (en) | 1999-02-25 | 2000-09-14 | Boris Bilynsky | Nucleic acid molecules associated with melanoma and thyroid tumors |
| AU3395900A (en) | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| US20020039764A1 (en) | 1999-03-12 | 2002-04-04 | Rosen Craig A. | Nucleic, acids, proteins, and antibodies |
| DE19922052A1 (de) * | 1999-05-14 | 2000-11-16 | Theragen Molekularmedizinische | Verfahren zum Nachweis der Wirkung von unterschiedlichen Chemotherapeutika und/oder einer Strahlentherapie bei malignen Erkrankungen sowie Verfahren zur Auswahl wirkungsvoller therapeutischer Mittel zu deren Therapie |
| US6692916B2 (en) | 1999-06-28 | 2004-02-17 | Source Precision Medicine, Inc. | Systems and methods for characterizing a biological condition or agent using precision gene expression profiles |
| US6960439B2 (en) | 1999-06-28 | 2005-11-01 | Source Precision Medicine, Inc. | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
| US6326148B1 (en) | 1999-07-12 | 2001-12-04 | The Regents Of The University Of California | Detection of copy number changes in colon cancer |
| US6710170B2 (en) | 1999-09-10 | 2004-03-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| US6271002B1 (en) | 1999-10-04 | 2001-08-07 | Rosetta Inpharmatics, Inc. | RNA amplification method |
| AU777096B2 (en) | 1999-10-06 | 2004-09-30 | Regents Of The University Of California, The | Differentially expressed genes associated with Her-2/neu overexpression |
| EP1686134A3 (en) | 1999-12-01 | 2006-08-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6750013B2 (en) | 1999-12-02 | 2004-06-15 | Protein Design Labs, Inc. | Methods for detection and diagnosing of breast cancer |
| US6248535B1 (en) | 1999-12-20 | 2001-06-19 | University Of Southern California | Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens |
| WO2001051661A2 (en) | 2000-01-13 | 2001-07-19 | Amsterdam Support Diagnostics B.V. | A universal nucleic acid amplification system for nucleic acids in a sample |
| US6322986B1 (en) | 2000-01-18 | 2001-11-27 | Albany Medical College | Method for colorectal cancer prognosis and treatment selection |
| WO2001055454A1 (en) | 2000-01-28 | 2001-08-02 | Althea Technologies, Inc. | Methods for analysis of gene expression |
| WO2001055343A1 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| AU4592601A (en) | 2000-03-21 | 2001-10-03 | Millennium Predictive Medicine | Novel genes, compositions, kits, and method for identification, assessment, prevention, and therapy of ovarian cancer |
| WO2001075162A2 (en) | 2000-03-31 | 2001-10-11 | University Of Louisville Research Foundation, Inc. | Microarrays to screen regulatory genes |
| WO2002000677A1 (en) | 2000-06-07 | 2002-01-03 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| MXPA03000575A (es) | 2000-07-21 | 2004-12-13 | Global Genomics Ab | Metodos para analisis e identificacion de genes transcritos e impresion dactilar. |
| AU2001277202A1 (en) | 2000-07-26 | 2002-02-05 | Applied Genomics, Inc. | Bstp-ras/rerg protein and related reagents and methods of use thereof |
| WO2002008260A2 (en) | 2000-07-26 | 2002-01-31 | Stanford University | Bstp-ecg1 protein and related reagents and methods of use thereof |
| WO2002008262A2 (en) | 2000-07-26 | 2002-01-31 | Stanford University | Bstp-5 proteins and related reagents and methods of use thereof |
| WO2002010436A2 (en) * | 2000-07-28 | 2002-02-07 | The Brigham And Women's Hospital, Inc. | Prognostic classification of breast cancer |
| US7795232B1 (en) | 2000-08-25 | 2010-09-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| AU2002214576A1 (en) | 2000-10-13 | 2002-04-22 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Genes related to development of refractory prostate cancer |
| US6602670B2 (en) | 2000-12-01 | 2003-08-05 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
| US6582919B2 (en) | 2001-06-11 | 2003-06-24 | Response Genetics, Inc. | Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates |
| EP1353947A2 (en) | 2000-12-08 | 2003-10-22 | Ipsogen | Gene expression profiling of primary breast carcinomas using arrays of candidate genes |
| WO2002068579A2 (en) | 2001-01-10 | 2002-09-06 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
| WO2002057787A2 (en) | 2001-01-12 | 2002-07-25 | Yale University | Detection of survivin in the biological fluids of cancer patients |
| US7776518B2 (en) | 2001-01-12 | 2010-08-17 | Yale University | Detection of survivin in the biological fluids of cancer patients |
| MXPA03006617A (es) | 2001-01-24 | 2004-12-02 | Protein Design Labs Inc | Metodos de diagnostico de cancer de pecho, composiciones y metodos de rastreo de moduladores de cancer de pecho. |
| ATE325894T1 (de) * | 2001-03-01 | 2006-06-15 | Epigenomics Ag | Verfahren und rechnerprogrammprodukte zur erfassung der biologischen wirkung und/oder aktivität von arzneimitteln, chemischen substanzen und/oder pharmazeuitschen verbindungen auf der basis ihrer effekte auf den methylierungszustand der dna |
| IL157872A0 (en) | 2001-03-12 | 2004-03-28 | Monogen Inc | A panel for detecting a generic disease state containing a plurality of probes and using cell-based diagnosis |
| US20030077582A1 (en) * | 2001-03-27 | 2003-04-24 | Wen-Lin Kuo | Methods for diagnosing and monitoring malignancies by screeining gene copy numbers |
| US6686155B2 (en) * | 2001-06-14 | 2004-02-03 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on glutathione-S-transferase pi expression |
| US7171311B2 (en) * | 2001-06-18 | 2007-01-30 | Rosetta Inpharmatics Llc | Methods of assigning treatment to breast cancer patients |
| DK1410011T3 (da) | 2001-06-18 | 2011-07-18 | Netherlands Cancer Inst | Diagnose og prognose for brystcancerpatienter |
| US7125680B2 (en) | 2001-07-27 | 2006-10-24 | The Regents Of The University Of California | Methods and materials for characterizing and modulating interaction between heregulin and HER3 |
| AU2002343443A1 (en) | 2001-09-28 | 2003-04-14 | Whitehead Institute For Biomedical Research | Classification of lung carcinomas using gene expression analysis |
| US6964850B2 (en) | 2001-11-09 | 2005-11-15 | Source Precision Medicine, Inc. | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
| US20030198972A1 (en) | 2001-12-21 | 2003-10-23 | Erlander Mark G. | Grading of breast cancer |
| US20030124130A1 (en) * | 2002-01-02 | 2003-07-03 | Brown Robert E. | Proteomic analysis of tumors for development of consultative report of therapeutic options |
| EP1466016A2 (en) * | 2002-01-09 | 2004-10-13 | Riken Institute Of Physical And Chemical Research | Cancer profiles |
| US7704700B2 (en) * | 2002-02-12 | 2010-04-27 | Burnham Institute For Medical Research | Methods for determining the prognosis for patients with a prostate neoplastic condition using inhibitor of apoptosis polypeptides |
| EP2261368A1 (en) | 2002-03-13 | 2010-12-15 | Genomic Health, Inc. | Gene expression profiling in biopsied tumor tissues |
| AU2003215460A1 (en) | 2002-03-28 | 2003-10-13 | Qlt Inc. | Cancer associated protein kinases and their uses |
| US20050272052A1 (en) | 2002-04-09 | 2005-12-08 | Affymetrix, Inc. | Molecular genetic profiling of gleason grades 3 and 4/5 prostate cancer |
| EP1900827A3 (en) | 2002-05-21 | 2008-04-16 | Bayer HealthCare AG | Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| CA2516553C (en) | 2003-02-20 | 2013-04-16 | Genomic Health, Inc. | Use of intronic rna to measure gene expression |
| EP1631689A2 (en) * | 2003-05-28 | 2006-03-08 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| WO2005039382A2 (en) | 2003-06-24 | 2005-05-06 | Genomic Health | Prediction of likelihood of cancer recurrence |
| EP1644858B1 (en) | 2003-07-10 | 2017-12-06 | Genomic Health, Inc. | Expression profile algorithm and test for cancer prognosis |
| WO2005015236A2 (en) | 2003-07-18 | 2005-02-17 | Roche Diagnostics Gmbh | A method for predicting the progression of adenocarcinoma |
| EP1522594A3 (en) | 2003-10-06 | 2005-06-22 | Bayer HealthCare AG | Methods and kits for investigating cancer |
| CA2848463A1 (en) | 2004-04-09 | 2005-10-27 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| AU2005245815B2 (en) | 2004-05-07 | 2011-06-09 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer |
| EP1759009A1 (en) * | 2004-05-28 | 2007-03-07 | Board Of Regents, The University Of Texas System | Multigene predictors of response to chemotherapy |
| CA3061785A1 (en) | 2004-11-05 | 2006-05-18 | Genomic Health, Inc. | Predicting response to chemotherapy using gene expression markers |
| JP4939425B2 (ja) | 2004-11-05 | 2012-05-23 | ジェノミック ヘルス, インコーポレイテッド | 乳癌の治療反応の予後および予測の分子指標 |
| JP5904569B2 (ja) | 2005-06-08 | 2016-04-13 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 癌治療を受けている患者の同定、判定および処置のための方法 |
| US20070099209A1 (en) | 2005-06-13 | 2007-05-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2006138275A2 (en) | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| NZ544432A (en) | 2005-12-23 | 2009-07-31 | Pacific Edge Biotechnology Ltd | Prognosis prediction for colorectal cancer using a prognositc signature comprising markers ME2 and FAS |
| KR20090003178A (ko) | 2006-01-11 | 2009-01-09 | 게노믹 헬쓰, 인코포레이티드 | 직장결장암 예후에 대한 유전자 발현 마커 |
| WO2007123772A2 (en) | 2006-03-31 | 2007-11-01 | Genomic Health, Inc. | Genes involved in estrogen metabolism |
| CA2680591A1 (en) | 2007-03-15 | 2008-09-25 | Genomic Health, Inc. | Gene expression markers for prediction of patient response to chemotherapy |
| EP2228457A1 (en) | 2007-08-16 | 2010-09-15 | Genomic Health, Inc. | Gene expression markers of recurrence risk in cancer patients after chemotherapy |
| US8067178B2 (en) | 2008-03-14 | 2011-11-29 | Genomic Health, Inc. | Gene expression markers for prediction of patient response to chemotherapy |
| EP2641978A1 (en) | 2008-05-12 | 2013-09-25 | Genomic Health, Inc. | Tests to predict responsiveness of cancer patients to chemotherapy treatment options |
| CA2742489A1 (en) | 2008-11-14 | 2010-05-20 | Intelligent Oncotherapeutics, Inc. | Methods for identification of tumor phenotype and treatment |
| WO2010065940A1 (en) | 2008-12-04 | 2010-06-10 | The Regents Of The University Of California | Materials and methods for determining diagnosis and prognosis of prostate cancer |
| WO2010127322A1 (en) | 2009-05-01 | 2010-11-04 | Genomic Health Inc. | Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer and response to chemotherapy |
| WO2011063274A2 (en) | 2009-11-23 | 2011-05-26 | Genomic Health, Inc. | Methods to predict clinical outcome of cancer |
-
2005
- 2005-04-07 CA CA2848463A patent/CA2848463A1/en not_active Abandoned
- 2005-04-07 AU AU2005233593A patent/AU2005233593B2/en not_active Expired
- 2005-04-07 EP EP05735478A patent/EP1737980A2/en not_active Withdrawn
- 2005-04-07 WO PCT/US2005/011760 patent/WO2005100606A2/en not_active Ceased
- 2005-04-07 CA CA2563074A patent/CA2563074C/en not_active Expired - Lifetime
- 2005-04-07 ES ES15173816.8T patent/ES2636470T3/es not_active Expired - Lifetime
- 2005-04-07 EP EP09014283.7A patent/EP2163650B1/en not_active Expired - Lifetime
- 2005-04-07 DK DK09014283.7T patent/DK2163650T3/en active
- 2005-04-07 JP JP2007507495A patent/JP5813908B2/ja not_active Expired - Lifetime
- 2005-04-07 EP EP10177408A patent/EP2270232A1/en not_active Withdrawn
- 2005-04-07 US US11/102,228 patent/US7871769B2/en active Active
- 2005-04-07 ES ES09014283.7T patent/ES2550614T3/es not_active Expired - Lifetime
- 2005-04-07 EP EP15173816.8A patent/EP2947160B1/en not_active Expired - Lifetime
-
2006
- 2006-10-05 IL IL178508A patent/IL178508A/en active IP Right Grant
-
2010
- 2010-11-08 US US12/941,877 patent/US9605318B2/en active Active
- 2010-11-18 AU AU2010241525A patent/AU2010241525B2/en not_active Expired
-
2011
- 2011-09-06 IL IL214995A patent/IL214995A/en active IP Right Grant
- 2011-09-06 IL IL214994A patent/IL214994A/en active IP Right Grant
-
2013
- 2013-05-15 JP JP2013103045A patent/JP6130726B2/ja not_active Expired - Lifetime
-
2015
- 2015-10-16 JP JP2015204285A patent/JP6190434B2/ja not_active Expired - Lifetime
-
2016
- 2016-02-23 IL IL244249A patent/IL244249A/en active IP Right Grant
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2563074C (en) | Gene expression markers for predicting response to chemotherapy | |
| AU2004248120B2 (en) | Gene expression markers for predicting response to chemotherapy | |
| EP2775000A1 (en) | Prediction of likelihood of cancer recurrence | |
| EP2226396A1 (en) | Gene expression markers for response to EGFR inhibitor drugs | |
| AU2011204944B2 (en) | Gene expression markers for predicting response to chemotherapy | |
| AU2012200431B2 (en) | Gene expression markers for predicting response to chemotherapy | |
| HK1217737B (en) | Gene expression markers for predicting response to chemotherapy | |
| KR20070022694A (ko) | 화학요법 반응을 예측하기 위한 유전자 발현 마커 | |
| AU2019261715A1 (en) | Prediction of likelihood of cancer recurrence | |
| HK1148320A (en) | Gene expression markers for response to egfr inhibitor drugs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140829 |
|
| FZDE | Discontinued |
Effective date: 20190430 |