CA2833706C - Quinazoline derivatives for the treatment of cancer diseases - Google Patents
Quinazoline derivatives for the treatment of cancer diseases Download PDFInfo
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- CA2833706C CA2833706C CA2833706A CA2833706A CA2833706C CA 2833706 C CA2833706 C CA 2833706C CA 2833706 A CA2833706 A CA 2833706A CA 2833706 A CA2833706 A CA 2833706A CA 2833706 C CA2833706 C CA 2833706C
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Inorganic Chemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05110656 | 2005-11-11 | ||
| EP05110656.5 | 2005-11-11 | ||
| CA2629244A CA2629244C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2629244A Division CA2629244C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
Publications (2)
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| CA2833706A1 CA2833706A1 (en) | 2007-05-18 |
| CA2833706C true CA2833706C (en) | 2014-10-21 |
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| CA2833706A Active CA2833706C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
| CA2833852A Active CA2833852C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
| CA2629244A Active CA2629244C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2833852A Active CA2833852C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
| CA2629244A Active CA2629244C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
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| EP (2) | EP3173084B1 (enExample) |
| JP (2) | JP5688877B2 (enExample) |
| CA (3) | CA2833706C (enExample) |
| WO (1) | WO2007054550A1 (enExample) |
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| NZ516633A (en) | 1999-06-21 | 2004-09-24 | Boehringer Ingelheim Pharma | Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| DE10349113A1 (de) * | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| CA2833706C (en) | 2005-11-11 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
| DK1948180T3 (da) * | 2005-11-11 | 2013-05-27 | Boehringer Ingelheim Int | Kombinationsbehandling af cancer omfattende EGFR/HER2 inhibitorer |
| ES2397181T3 (es) | 2006-01-26 | 2013-03-05 | Boehringer Ingelheim International Gmbh | Procedimiento para preparar derivados de quinazolina sustituida con aminocrotonilamino |
| RU2492864C2 (ru) * | 2006-09-18 | 2013-09-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ лечения рака, несущего мутации egfr |
| PE20100252A1 (es) * | 2008-06-06 | 2010-04-12 | Boehringer Ingelheim Int | Nuevas formulaciones farmaceuticas solidas que comprenden dimaleato de 4-[(3-cloro-4-fluorofenil) amino]-6-{[4-(n,n-dimetilamino)-1-oxo-2-buten-1-il] amino}-7-((s)-tetrahidrofuran-3-iloxi)-quinazolina |
| US20120157472A1 (en) * | 2009-01-14 | 2012-06-21 | Boehringer Ingelheim International Gmbh | Method for treating colorectal cancer |
| EP2429520A1 (en) | 2009-05-14 | 2012-03-21 | Boehringer Ingelheim International GmbH | New combination therapy in treatment of oncological and fibrotic diseases |
| PT2451445T (pt) | 2009-07-06 | 2019-07-10 | Boehringer Ingelheim Int | Processo para secagem de bibw2992, dos seus sais e de formulações farmacêuticas sólidas compreendendo este ingrediente ativo |
| US20130012465A1 (en) | 2009-12-07 | 2013-01-10 | Boehringer Ingelheim International Gmbh | Bibw 2992 for use in the treatment of triple negative breast cancer |
| CN102146059A (zh) * | 2010-02-08 | 2011-08-10 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、制备方法及其应用 |
| US20120107304A1 (en) * | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
| PT2608792T (pt) * | 2010-08-26 | 2018-01-15 | Boehringer Ingelheim Int | Métodos de administração de um inibidor de egfr |
| CN102382065B (zh) * | 2010-08-30 | 2014-05-28 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
| CN102382106A (zh) * | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
| CN102452989B (zh) * | 2010-10-19 | 2014-10-22 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
| WO2012122058A2 (en) * | 2011-03-04 | 2012-09-13 | Newgen Therapeutics, Inc. | Alkyne substituted quinazoline compound and methods of use |
| CN102731485B (zh) * | 2011-04-02 | 2016-06-15 | 齐鲁制药有限公司 | 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途 |
| US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| WO2012155339A1 (zh) * | 2011-05-17 | 2012-11-22 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
| US9586939B2 (en) | 2011-05-26 | 2017-03-07 | Xuanzhu Pharma Co., Ltd. | Quinazoline derivative as tyrosine-kinase inhibitor, preparation method therefor and application thereof |
| WO2013135176A1 (zh) * | 2012-03-16 | 2013-09-19 | 苏州迈泰生物技术有限公司 | 氨基喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
| WO2013017637A1 (en) * | 2011-08-02 | 2013-02-07 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Selective inhibition of malt1 protease by phenothiazine derivatives |
| TWI596089B (zh) | 2012-04-17 | 2017-08-21 | 富士軟片股份有限公司 | 含氮雜環化合物或其鹽 |
| US20150368230A1 (en) | 2013-02-01 | 2015-12-24 | Boehringer Ingelheim International Gmbh | Radiolabeled quinazoline derivatives |
| CN104119350B (zh) | 2013-04-28 | 2017-04-12 | 广东东阳光药业有限公司 | 氨基喹唑啉类衍生物及其盐和使用方法 |
| WO2015007206A1 (zh) * | 2013-07-16 | 2015-01-22 | 杭州普晒医药科技有限公司 | 阿法替尼酸加成盐及其晶型、其制备方法及药物组合物 |
| CN105683167B (zh) | 2013-10-16 | 2018-10-23 | 富士胶片株式会社 | 含氮杂环化合物的盐或其结晶、药品组合物及flt3抑制剂 |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| JP6783224B2 (ja) * | 2014-04-04 | 2020-11-11 | デル マー ファーマシューティカルズ | 肺の非小細胞癌腫及び卵巣癌を処置するためのジアンヒドロガラクチトール及びその類縁体又は誘導体の使用 |
| EP3195866B1 (en) | 2014-08-22 | 2020-11-18 | FUJIFILM Corporation | Pharmaceutical composition for treating flt3 mutation-positive cancer, mutant flt3 inhibitor and uses thereof |
| CN105777655B (zh) * | 2014-12-25 | 2018-02-02 | 深圳海王医药科技研究院有限公司 | 萘普替尼对甲苯磺酸盐的α晶型及制备方法和含有其的药物组合物 |
| CN105777656B (zh) * | 2014-12-25 | 2018-02-02 | 深圳海王医药科技研究院有限公司 | 萘普替尼对甲苯磺酸盐的β晶型及制备方法和含有其的药物组合物 |
| CN105801568B (zh) | 2015-01-15 | 2019-07-30 | 杭州普晒医药科技有限公司 | 阿法替尼一马来酸盐晶型及其制备方法和药物组合物 |
| JP6412471B2 (ja) | 2015-07-15 | 2018-10-24 | 富士フイルム株式会社 | 含窒素複素環化合物の製造方法およびその中間体 |
| MX2018004109A (es) | 2015-10-05 | 2018-09-27 | Univ Columbia | Activadores de flujo autofágico y fosfolipasa d y depuración de acumulaciones de proteína que incluyen tau y tratamiento de proteinopatías. |
| CN107721987A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN107721985A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN107721986A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN109265449B (zh) * | 2018-11-07 | 2021-11-23 | 沈阳工业大学 | Egfr和her2双靶点酪氨酸激酶抑制剂及制备方法和用途 |
| TWI820414B (zh) * | 2020-04-17 | 2023-11-01 | 大陸商北京賽特明強醫藥科技有限公司 | 喹唑啉類化合物、製備方法及其應用 |
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-
2006
- 2006-11-09 CA CA2833706A patent/CA2833706C/en active Active
- 2006-11-09 JP JP2008539440A patent/JP5688877B2/ja active Active
- 2006-11-09 CA CA2833852A patent/CA2833852C/en active Active
- 2006-11-09 WO PCT/EP2006/068313 patent/WO2007054550A1/en not_active Ceased
- 2006-11-09 EP EP16201715.6A patent/EP3173084B1/en active Active
- 2006-11-09 EP EP06819379A patent/EP1948179A1/en not_active Ceased
- 2006-11-09 CA CA2629244A patent/CA2629244C/en active Active
- 2006-11-09 US US12/093,321 patent/US8404697B2/en active Active
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2013
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- 2013-02-14 US US13/766,914 patent/US9089571B2/en active Active
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2015
- 2015-06-15 US US14/739,299 patent/US9539258B2/en active Active
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2016
- 2016-10-31 US US15/338,632 patent/US20170112835A1/en not_active Abandoned
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- 2017-12-19 US US15/846,356 patent/US20180360834A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2629244A1 (en) | 2007-05-18 |
| EP3173084B1 (en) | 2019-10-23 |
| US20150272954A1 (en) | 2015-10-01 |
| US20170112835A1 (en) | 2017-04-27 |
| JP2009515851A (ja) | 2009-04-16 |
| CA2833852A1 (en) | 2007-05-18 |
| EP3173084A1 (en) | 2017-05-31 |
| CA2833852C (en) | 2014-10-21 |
| US20130178487A1 (en) | 2013-07-11 |
| CA2833706A1 (en) | 2007-05-18 |
| US9539258B2 (en) | 2017-01-10 |
| JP5688877B2 (ja) | 2015-03-25 |
| CA2629244C (en) | 2014-08-05 |
| JP5695680B2 (ja) | 2015-04-08 |
| JP2013064024A (ja) | 2013-04-11 |
| US20180360834A1 (en) | 2018-12-20 |
| WO2007054550A1 (en) | 2007-05-18 |
| US8404697B2 (en) | 2013-03-26 |
| US20090306044A1 (en) | 2009-12-10 |
| EP1948179A1 (en) | 2008-07-30 |
| US9089571B2 (en) | 2015-07-28 |
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