CA2833389C - Mirna-based universal screening test (ust) - Google Patents
Mirna-based universal screening test (ust) Download PDFInfo
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- CA2833389C CA2833389C CA2833389A CA2833389A CA2833389C CA 2833389 C CA2833389 C CA 2833389C CA 2833389 A CA2833389 A CA 2833389A CA 2833389 A CA2833389 A CA 2833389A CA 2833389 C CA2833389 C CA 2833389C
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- mir
- mirna
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161476591P | 2011-04-18 | 2011-04-18 | |
| US61/476,591 | 2011-04-18 | ||
| US201161478766P | 2011-04-25 | 2011-04-25 | |
| US61/478,766 | 2011-04-25 | ||
| US201161546431P | 2011-10-12 | 2011-10-12 | |
| US61/546,431 | 2011-10-12 | ||
| PCT/US2012/034098 WO2012145409A1 (en) | 2011-04-18 | 2012-04-18 | miRNA-BASED UNIVERSAL SCREENING TEST (UST) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2833389A1 CA2833389A1 (en) | 2012-10-26 |
| CA2833389C true CA2833389C (en) | 2022-01-11 |
Family
ID=47041896
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2833389A Active CA2833389C (en) | 2011-04-18 | 2012-04-18 | Mirna-based universal screening test (ust) |
| CA2833375A Pending CA2833375A1 (en) | 2011-04-18 | 2012-04-18 | Methods of using mirna from bodily fluids for early detection and monitoring of mild cognitive impairment (mci) and alzheimer's disease (ad) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2833375A Pending CA2833375A1 (en) | 2011-04-18 | 2012-04-18 | Methods of using mirna from bodily fluids for early detection and monitoring of mild cognitive impairment (mci) and alzheimer's disease (ad) |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9556487B2 (https=) |
| EP (4) | EP2699697B1 (https=) |
| JP (3) | JP6021893B2 (https=) |
| CN (3) | CN105861712B (https=) |
| AU (2) | AU2012245580B2 (https=) |
| CA (2) | CA2833389C (https=) |
| ES (1) | ES2630602T3 (https=) |
| RU (1) | RU2626540C2 (https=) |
| WO (2) | WO2012145363A1 (https=) |
Families Citing this family (58)
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|---|---|---|---|---|
| RU2626540C2 (ru) | 2011-04-18 | 2017-07-28 | Диамир, Ллс | Способы обнаружения патологических изменений в органе или системе органов |
| US20160289762A1 (en) | 2012-01-27 | 2016-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| US20140087964A1 (en) * | 2012-09-24 | 2014-03-27 | University Of Virginia Patent Foundation | Compositions and methods for detecting aberrant regulation, expression, and levels of hgh |
| WO2014055117A1 (en) * | 2012-10-04 | 2014-04-10 | Asuragen, Inc. | Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions |
| WO2014075822A1 (en) | 2012-11-16 | 2014-05-22 | Siemens Aktiengesellschaft | New diagnostic mirna markers for parkinson disease |
| EP2733219B1 (en) | 2012-11-16 | 2017-09-20 | Siemens Aktiengesellschaft | Diagnostic miRNA markers for Alzheimer |
| EP2733220B1 (en) * | 2012-11-16 | 2017-10-18 | Siemens Aktiengesellschaft | Novel miRNA as a diagnostic marker for Alzheimer's Disease |
| JP2014128249A (ja) * | 2012-12-28 | 2014-07-10 | Hokkaido Univ | 神経変性疾患の検査と治療に対するｍｉＲＮＡ又はその標的遺伝子の利用 |
| CN103805693B (zh) * | 2013-10-29 | 2017-01-11 | 宁夏医科大学 | 微小分子RNA-508-5p作为抗肿瘤标志物的用途 |
| CN105917005B (zh) * | 2013-11-18 | 2020-09-11 | 迪阿米尔有限责任公司 | 使用来自体液的miRNA检测和监控帕金森病(PD)的方法 |
| CA2939343A1 (en) * | 2014-02-18 | 2015-08-27 | Baylor Research Institute | Mir-320e and colorectal cancer |
| US20170032100A1 (en) * | 2014-04-10 | 2017-02-02 | The Trustees Of The University Of Pennslyvania | Use of micro-ribonucleic acid (mirna) to diagnose transplant rejection and tolerance of immunosuppression therapy |
| CN103937888B (zh) * | 2014-04-14 | 2016-08-17 | 上海交通大学 | 鉴别胃癌的血浆microRNA标志物的筛选与应用 |
| CA2946720A1 (en) * | 2014-04-22 | 2015-10-29 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods, processes, devices and kits for the measurement of post traumatic stress disorder microrna markers |
| WO2015181825A1 (en) * | 2014-05-28 | 2015-12-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of glucocorticoid therapy and determining responsiveness thereof |
| BR112016029583A2 (pt) | 2014-06-18 | 2017-10-24 | Nat Cancer Ct | ?kit ou dispositivo para a detecção de câncer esofágico e método de detecção? |
| WO2016138287A1 (en) | 2015-02-25 | 2016-09-01 | Washington University | METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs |
| AU2016267392B2 (en) * | 2015-05-28 | 2021-12-09 | Immunexpress Pty Ltd | Validating biomarker measurement |
| KR20190118688A (ko) | 2015-06-05 | 2019-10-18 | 미라젠 세러퓨틱스 인코포레이티드 | 피부 t 세포 림프종(ctcl) 치료용 mir-155 억제제 |
| CN104940954B (zh) * | 2015-06-23 | 2017-12-26 | 同济大学 | MicroRNA‑7在制备抗胶质化药物中的应用 |
| JP2018526021A (ja) * | 2015-09-11 | 2018-09-13 | コーニング インコーポレイテッド | 血液試料からの核酸精製のための組成物及び方法 |
| EP3184646B1 (de) * | 2015-12-22 | 2019-04-17 | Siemens Aktiengesellschaft | Spezifische signaturen in alzheimer durch multizentrische mirna-profile |
| WO2017120285A1 (en) * | 2016-01-05 | 2017-07-13 | Diamir, Llc | METHODS OF USING miRNA FROM BODILY FLUIDS FOR DIAGNOSIS AND MONITORING OF NEURODEVELOPMENTAL DISORDERS |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| US11149313B2 (en) | 2016-03-21 | 2021-10-19 | Diamir, Llc | Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases |
| WO2017186719A1 (en) * | 2016-04-25 | 2017-11-02 | Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk | Microrna biomarkers in blood for diagnosis of alzheimer's disease |
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| CN106544435A (zh) * | 2016-09-30 | 2017-03-29 | 河北医科大学第医院 | 检测miR‑206所需逆转录引物对在制备预测试剂盒中的应用 |
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| US11492669B2 (en) * | 2017-07-12 | 2022-11-08 | Texas Tech University System | MicroRNA-455-3p as a peripheral biomarker for Alzheimer's disease |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| KR101830583B1 (ko) * | 2017-08-11 | 2018-02-20 | 주식회사 인피니트헬스케어 | Ｗｓｉ 스트리밍 방법 |
| WO2019060298A1 (en) | 2017-09-19 | 2019-03-28 | Neuroenhancement Lab, LLC | METHOD AND APPARATUS FOR NEURO-ACTIVATION |
| CN107811609B (zh) * | 2017-09-22 | 2020-06-09 | 中国医学科学院北京协和医院 | 一种脑老化评估系统 |
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| US11332789B2 (en) | 2018-05-21 | 2022-05-17 | Temple University-Of The Commonwealth System Of Higher Education | Compositions and methods for diagnosing and treating hyperlipidemia-related diseases |
| ES3060495T3 (en) | 2018-06-15 | 2026-03-26 | UNIV AUTòNOMA DE BARCELONA | Circulating mirnas as biomarkers for diagnosis of mild cognitive impairment and alzheimer¿s disease |
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| CN109055541B (zh) * | 2018-09-26 | 2020-08-28 | 上海市精神卫生中心（上海市心理咨询培训中心） | Ad所致mci诊断标志物及其应用 |
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| EP3983549A4 (en) * | 2019-06-17 | 2023-06-28 | Biorchestra Co., Ltd. | Compositions and methods for preparing an alzheimer's disease animal model using microrna |
| US11198908B2 (en) | 2019-06-17 | 2021-12-14 | Biorchestra Co., Ltd. | Method for diagnosis of Alzheimer's disease using microRNA |
| WO2021024331A1 (ja) | 2019-08-02 | 2021-02-11 | 株式会社 東芝 | 分析方法及びキット |
| CA3175419A1 (en) * | 2020-04-23 | 2021-10-28 | Jin-Hyeob RYU | Diagnostic methods using mir-485-3p expression |
| US20220073992A1 (en) * | 2020-11-24 | 2022-03-10 | Hossein Abdul Tehrani Abdul Tehrani | Diagnosis of chronic kidney disease (ckd) and its subgroups |
| CN112562867A (zh) * | 2021-02-22 | 2021-03-26 | 天津迈德新医药科技有限公司 | 一种预测极早期hiv感染风险的装置、存储介质和电子装置 |
| CN112980954B (zh) * | 2021-03-03 | 2022-02-25 | 首都医科大学宣武医院 | 一种预测神经退行性疾病风险的试剂盒及其用途 |
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| WO2025089057A1 (ja) * | 2023-10-24 | 2025-05-01 | アークレイ株式会社 | スモールｒｎａ測定用血液試料の調製方法及び保存方法、スモールｒｎａの発現量の測定方法、疾患の判定方法、検査方法、モデルの生成方法、検査装置、検査システム、検査プログラム、並びに記録媒体 |
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