CA2783536A1 - Biomarker assay for diagnosis and classification of cardiovascular disease - Google Patents

Biomarker assay for diagnosis and classification of cardiovascular disease Download PDF

Info

Publication number
CA2783536A1
CA2783536A1 CA2783536A CA2783536A CA2783536A1 CA 2783536 A1 CA2783536 A1 CA 2783536A1 CA 2783536 A CA2783536 A CA 2783536A CA 2783536 A CA2783536 A CA 2783536A CA 2783536 A1 CA2783536 A1 CA 2783536A1
Authority
CA
Canada
Prior art keywords
mir
hsa
classification
protein
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2783536A
Other languages
English (en)
French (fr)
Inventor
Doug Harrington
Evangelos Hytopoulos
Bruce Phelps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aviir Inc
Original Assignee
Aviir Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aviir Inc filed Critical Aviir Inc
Publication of CA2783536A1 publication Critical patent/CA2783536A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Data Mining & Analysis (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Databases & Information Systems (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Epidemiology (AREA)
  • Theoretical Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Artificial Intelligence (AREA)
  • Primary Health Care (AREA)
  • Bioethics (AREA)
  • Software Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Cell Biology (AREA)
CA2783536A 2009-12-09 2010-12-09 Biomarker assay for diagnosis and classification of cardiovascular disease Abandoned CA2783536A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28512109P 2009-12-09 2009-12-09
US61/285,121 2009-12-09
PCT/US2010/059781 WO2011072177A2 (en) 2009-12-09 2010-12-09 Biomarker assay for diagnosis and classification of cardiovascular disease

Publications (1)

Publication Number Publication Date
CA2783536A1 true CA2783536A1 (en) 2011-06-16

Family

ID=43587661

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2783536A Abandoned CA2783536A1 (en) 2009-12-09 2010-12-09 Biomarker assay for diagnosis and classification of cardiovascular disease

Country Status (7)

Country Link
US (2) US20110144914A1 (cg-RX-API-DMAC10.html)
EP (1) EP2510116A2 (cg-RX-API-DMAC10.html)
JP (1) JP2013513387A (cg-RX-API-DMAC10.html)
CN (1) CN102762743A (cg-RX-API-DMAC10.html)
AU (1) AU2010328019A1 (cg-RX-API-DMAC10.html)
CA (1) CA2783536A1 (cg-RX-API-DMAC10.html)
WO (1) WO2011072177A2 (cg-RX-API-DMAC10.html)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10359425B2 (en) 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
US8846350B2 (en) * 2009-10-26 2014-09-30 Albert Einstein College Of Medicine Of Yeshiva University MicroRNA affinity assay and uses thereof
EP2561091B1 (en) * 2010-04-20 2014-08-06 Comprehensive Biomarker Center GmbH Complex mirna sets as novel biomarkers for an acute coronary syndrome
JP6055966B2 (ja) * 2010-06-07 2017-01-11 マイクロ‐シグネチャー リミテッド 検出方法
JP5905003B2 (ja) 2010-07-09 2016-04-20 ソマロジック・インコーポレーテッド 肺癌バイオマーカーとその使用
MX350533B (es) 2010-08-13 2017-09-08 Somalogic Inc Biomarcadores de cancer pancreatico y usos de los mismos.
TW201231671A (en) * 2011-01-28 2012-08-01 Univ Kaohsiung Medical Method and kit for in vitro diagnosis of atherosclerosis
BR112013029857A2 (pt) * 2011-05-24 2017-11-28 Mor Research Applic Ltd métodos e composições para determinação de insuficiência cardíaca ou risco de insuficiência cardíaca
US9708643B2 (en) * 2011-06-17 2017-07-18 Affymetrix, Inc. Circulating miRNA biomaker signatures
WO2013023233A1 (en) 2011-08-12 2013-02-21 Alfred Health Method for diagnosis, prognosis or treatment of acute coronary syndrome (acs) comprising measurement of plasma concentration of macrophage migration inhibitory factor (mif)
KR102248900B1 (ko) * 2011-09-30 2021-05-07 소마로직, 인크. 심혈관 위험 사건 예측 및 그것의 용도
EP2771482A1 (en) * 2011-10-27 2014-09-03 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods for the treatment and diagnosis of atherosclerosis
CN103103189B (zh) * 2011-11-14 2015-06-03 中国科学院上海生命科学研究院 过表达单一MicroRNA成熟体序列的新方法
CN103160507B (zh) * 2011-12-19 2017-05-24 上海交通大学医学院附属新华医院 检测肝硬化的miRNA血清标志物及其应用
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
AU2013217935B2 (en) 2012-02-09 2018-05-17 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
US10417575B2 (en) * 2012-12-14 2019-09-17 Microsoft Technology Licensing, Llc Resource allocation for machine learning
DE102012101557A1 (de) * 2012-02-27 2013-08-29 Charité Universitätsmedizin Berlin Verwendung von microRNAs oder Genen als Marker zur Identifizierung, Diagnose und Therapie einzelner nicht-ischämischer Kardiomyopathien oder Speichererkrankungen des Herzens
CN102708384B (zh) * 2012-06-04 2014-01-29 西南交通大学 一种基于随机蕨的自举弱学习方法及其分类器
US9002769B2 (en) * 2012-07-03 2015-04-07 Siemens Aktiengesellschaft Method and system for supporting a clinical diagnosis
US9336302B1 (en) 2012-07-20 2016-05-10 Zuci Realty Llc Insight and algorithmic clustering for automated synthesis
CN102839172B (zh) * 2012-08-24 2013-09-25 中国医科大学附属第一医院 HIV感染疾病进展分子标志物miR-503
US20140087964A1 (en) * 2012-09-24 2014-03-27 University Of Virginia Patent Foundation Compositions and methods for detecting aberrant regulation, expression, and levels of hgh
US9996889B2 (en) * 2012-10-01 2018-06-12 International Business Machines Corporation Identifying group and individual-level risk factors via risk-driven patient stratification
CN102980920A (zh) * 2012-11-14 2013-03-20 华东师范大学 同时检测miRNAs与蛋白标记物的硅纳米线芯片及其检测方法和应用
CN103233007A (zh) * 2013-02-05 2013-08-07 中国科学院广州生物医药与健康研究院 hsa-miR-545miRNA及其应用
EP4365793A3 (en) * 2013-03-04 2024-07-31 Board Of Regents Of the University Of Texas System System and method for determining triage categories
EP2968393A2 (en) * 2013-03-15 2016-01-20 The Hospital For Sick Children Diagnostic and therapeutic methods relating to microrna-144
CN103205505B (zh) * 2013-05-03 2014-11-05 周玲 一种诊断妊娠糖尿病的microRNA分子标志物及其检测试剂盒
KR20150007468A (ko) * 2013-07-11 2015-01-21 (의료)길의료재단 임상의사결정 지원방법 및 그 장치
US9953417B2 (en) * 2013-10-04 2018-04-24 The University Of Manchester Biomarker method
CN104357554B (zh) * 2013-11-26 2016-08-24 上海中医药大学附属岳阳中西医结合医院 微小核苷酸hsa-miR939在高血压诊断中的应用
CN103642914B (zh) * 2013-11-29 2015-02-25 中国人民解放军第四军医大学 与恶性黑素瘤相关的血浆/血清循环microRNA标志物及其应用
US10817791B1 (en) * 2013-12-31 2020-10-27 Google Llc Systems and methods for guided user actions on a computing device
US10138717B1 (en) * 2014-01-07 2018-11-27 Novi Labs, LLC Predicting well performance with feature similarity
CN105993016B (zh) * 2014-02-04 2020-01-10 奥普蒂马塔公司 用于为具有特定疾病的个体规划医疗的计算机化系统
BR112016020987B1 (pt) 2014-03-12 2023-11-14 Western Sydney Local Health District Método de identificação de receptores de aloenxerto renal e método de seleção de receptor do aloenxerto renal
CN104017806B (zh) * 2014-05-08 2017-11-10 复旦大学 microRNA及其在制备活动性结核病检测试剂中的应用
US11017881B2 (en) 2014-05-15 2021-05-25 Codondex Llc Systems, methods, and devices for analysis of genetic material
WO2015175602A1 (en) 2014-05-15 2015-11-19 Codondex Llc Systems, methods, and devices for analysis of genetic material
ES2850281T3 (es) 2014-06-26 2021-08-26 Icahn School Med Mount Sinai Método para diagnosticar el rechazo agudo subclínico y clínico mediante el análisis de conjuntos de genes predictivos, un agente terapéutico para usar en el tratamiento y kits para determinar la expresión
AU2015279621B2 (en) * 2014-06-26 2021-04-08 Icahn School Of Medicine At Mount Sinai Methods for diagnosing risk of renal allograft fibrosis and rejection
WO2016007549A1 (en) 2014-07-07 2016-01-14 Veramarx, Inc. Biomarker signatures for lyme disease and methods of use thereof
RU2730836C2 (ru) 2014-08-14 2020-08-26 Мемед Диагностикс Лтд. Вычислительный анализ биологических данных с применением многообразия и гиперплоскости
US10801066B2 (en) 2014-09-05 2020-10-13 American University Of Beirut Determination of risk for development of cardiovascular disease by measuring urinary levels of podocin and nephrin messenger RNA
BR112017005730B1 (pt) * 2014-09-26 2023-12-12 Somalogic Operating Co., Inc Método para triagem de um indivíduo quanto ao risco de um evento cardiovascular ou para predizer a probabilidade que um indivíduo tenha tal evento
CN104278105A (zh) * 2014-11-07 2015-01-14 雷桅 一种检测冠心病的血清学生物标志物miR-19a及其用途
EP3230740B1 (en) 2014-12-11 2025-05-21 Memed Diagnostics Ltd. Marker combinations for diagnosing infections and methods of use thereof
JP6782405B2 (ja) * 2014-12-15 2020-11-11 学校法人 久留米大学 腎性貧血のバイオマーカーとしての赤血球ａｄｍａの使用
CA3012985A1 (en) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarkers of vascular disease
EP3283649A4 (en) * 2015-04-14 2019-03-20 Ubiome Inc. METHOD AND SYSTEM FOR MICROBIBLE DERIVED CHARACTERIZATION, DIAGNOSTICS AND THERAPEUTICS FOR CARDIOVASCULAR DISEASE STATES
KR101903526B1 (ko) * 2015-08-19 2018-10-05 한국전자통신연구원 바이오 물질의 농도를 기반으로 하는 질환 예측 장치 및 그것의 질환 예측 방법
DE102015216782B3 (de) * 2015-09-02 2017-01-26 Ikdt Institut Kardiale Diagnostik Und Therapie Gmbh Verwendung von im Blutserum oder Blutplasma zirkulierenden microRNAs zur Identifikation biopsiepflichtiger Patienten und als Marker zur Differentialdiagnose einzelner nicht-ischämischer Kardiomyopathien oder Speichererkrankungen des Herzens
CN106609301B (zh) * 2015-10-26 2019-10-25 北京大学人民医院 一种辅助诊断1型糖尿病的试剂盒
WO2017093337A1 (en) * 2015-12-02 2017-06-08 Siemens Healthcare Gmbh Personalized assessment of patients with acute coronary syndrome
EA201600076A1 (ru) * 2015-12-30 2017-07-31 Андрей Владимирович ТИТОВ Способ оценки состояния организма по образцам биологической жидкости, получаемой неинвазивно
US10725038B2 (en) 2016-01-06 2020-07-28 Veramarx, Inc. Biomarker signatures for lyme disease differentiation and methods of use thereof
EP3196317A1 (en) 2016-01-21 2017-07-26 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Predictive methods of atherosclerosis and stenosis
FR3047013A1 (fr) * 2016-01-22 2017-07-28 Univ Montpellier Procede de classification d'un echantillon biologique.
CN105486878B (zh) * 2016-01-22 2018-02-06 徐超 一种临床个体化组合用药的筛选系统及其方法
CN105445408B (zh) * 2016-01-25 2018-06-12 齐炼文 诊断区分冠状动脉粥样硬化和稳定型心绞痛的代谢标志物
CN107194138B (zh) * 2016-01-31 2023-05-16 北京万灵盘古科技有限公司 一种基于体检数据建模的空腹血糖预测方法
US10983135B2 (en) * 2016-02-01 2021-04-20 Prevencio, Inc. Diagnostic and prognostic methods for cardiovascular diseases and events
WO2017149547A1 (en) 2016-03-03 2017-09-08 Memed Diagnostics Ltd. Analyzing rna for diagnosing infection type
CN105713972A (zh) * 2016-03-16 2016-06-29 上海中医药大学 miRNA在制备药物性心脏病生物标志物中的用途
CN109416361B (zh) * 2016-03-31 2022-04-19 雅培制药有限公司 用于估计急性冠状动脉综合征的风险的基于决策树的系统和方法
WO2018011796A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Early diagnosis of infections
WO2018011795A1 (en) * 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
WO2018060998A1 (en) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Methods of prognosis and treatment
US11205103B2 (en) 2016-12-09 2021-12-21 The Research Foundation for the State University Semisupervised autoencoder for sentiment analysis
US20180166170A1 (en) * 2016-12-12 2018-06-14 Konstantinos Theofilatos Generalized computational framework and system for integrative prediction of biomarkers
WO2018127821A1 (en) * 2017-01-06 2018-07-12 Codondex Llc Systems, methods, and devices for analysis of genetic material
WO2018140568A1 (en) * 2017-01-27 2018-08-02 Becton, Dickinson And Company Vertical flow assay device for detecting glucose concentration in a fluid sample
US11634778B2 (en) * 2017-06-29 2023-04-25 Toray Industries, Inc. Kit, device, and method for detecting lung cancer
TWI641963B (zh) * 2017-07-07 2018-11-21 長庚醫療財團法人林口長庚紀念醫院 Method for screening coronary heart disease by cardiovascular marker and mechanical learning algorithm
US11942219B1 (en) * 2017-09-25 2024-03-26 Cerner Innovation, Inc. Determining a cardiovascular ischemic event and decision support tool
EP3688466A4 (en) 2017-09-30 2021-05-19 Alfred Health FORECAST PROCEDURE
JP7372251B2 (ja) * 2017-11-02 2023-10-31 プリベンシオ，インコーポレイテッド 末梢動脈疾患、大動脈弁狭窄症についての診断および予後の方法、ならびにアウトカム
CN109985243B (zh) * 2017-12-29 2021-06-29 中国科学院上海药物研究所 靶向PCSK9的microRNA在治疗LDLC相关代谢性疾病中的应用
CN108004316A (zh) * 2018-01-09 2018-05-08 青岛大学 用于预测急性心肌梗死风险的试剂盒
CN108376564A (zh) * 2018-02-06 2018-08-07 天津艾登科技有限公司 基于随机森林算法的疾病诊断并发症识别方法及系统
CN108070650B (zh) * 2018-02-09 2021-02-12 深圳承启生物科技有限公司 外泌体中microRNA在诊断缺血性脑卒中疾病的用途
US10915729B2 (en) * 2018-02-20 2021-02-09 The Regents Of The University Of Michigan Three-dimensional cell and tissue image analysis for cellular and sub-cellular morphological modeling and classification
CN108492272B (zh) * 2018-03-26 2021-01-19 西安交通大学 基于注意力模型及多任务神经网络的心血管易损斑块识别方法及系统
JP7464279B2 (ja) 2018-04-16 2024-04-09 アイカーン スクール オブ メディスン アット マウント シナイ レシピエント血液における移植前トランスクリプトームシグネチャーを使用した急性拒絶反応および腎臓同種異系移植喪失の予測のための方法およびキット
WO2019217714A1 (en) * 2018-05-09 2019-11-14 The General Hospital Corporation Determination and reduction of risk of sudden cardiac death
RU2677280C1 (ru) * 2018-05-17 2019-01-16 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ диагностики многососудистого атеросклеротического поражения коронарных артерий у больных ишемической болезнью сердца при абдоминальном ожирении
CN108728437A (zh) * 2018-05-25 2018-11-02 中国人民解放军陆军军医大学 促进骨骼肌损伤修复的寡核苷酸、药物及应用
US12292451B2 (en) * 2018-06-08 2025-05-06 Cleveland Clinic Foundation ApoA1 exchange rate assays in serum
CN108803994B (zh) * 2018-06-14 2022-10-14 四川和生视界医药技术开发有限公司 视网膜血管的管理方法及视网膜血管的管理装置
CN109009222A (zh) * 2018-06-19 2018-12-18 杨成伟 面向心脏病类型和严重程度的智能评估诊断方法及系统
CN108796070B (zh) * 2018-07-16 2022-09-30 辽宁中医药大学 miR-125a-3p在制备心血管疾病诊断试剂盒中的用途
CN108998514B (zh) * 2018-08-20 2022-02-01 青岛大学 miRNA-378及其抑制剂的应用和应用其的产品
CN109411015B (zh) * 2018-09-28 2020-12-22 深圳裕策生物科技有限公司 基于循环肿瘤dna的肿瘤突变负荷检测装置及存储介质
US11103171B2 (en) * 2018-10-23 2021-08-31 BlackThor Therapeutics, Ine. Systems and methods for screening, diagnosing, and stratifying patients
US11928985B2 (en) * 2018-10-30 2024-03-12 International Business Machines Corporation Content pre-personalization using biometric data
KR102165841B1 (ko) * 2018-11-05 2020-10-14 순천향대학교 산학협력단 당뇨병 진단을 위한 마이크로RNA let-7b 또는 마이크로RNA-664a 바이오마커 및 이의 용도
US20220015714A1 (en) * 2018-11-29 2022-01-20 Somalogic, Inc. Methods For Determining Disease Risk Combining Downsampling of Class-Imbalanced Sets With Survival Analysis
CN110229893A (zh) * 2019-02-04 2019-09-13 金华市中心医院 用于诊断颈动脉粥样硬化斑块的miRNAs标志物及其应用
CN110082536B (zh) * 2019-04-17 2022-06-10 广州医科大学附属肿瘤医院 一种乳腺癌细胞标志物细胞因子群及其应用
US11030743B2 (en) * 2019-05-16 2021-06-08 Tencent America LLC System and method for coronary calcium deposits detection and labeling
EP3990664A1 (en) * 2019-06-26 2022-05-04 Westfälische Wilhelms-Universität Münster Method for establishing an individual physical activity program for a subject for reducing an individual risk of the subject for developing a cardiovascular disease
CN111154870B (zh) * 2019-08-05 2023-06-23 江苏省肿瘤医院 一种鼻咽癌转移诊断和/或预后评估的生物标记
WO2021062298A1 (en) 2019-09-27 2021-04-01 Arterez, Inc. Biomarker panel targeted to diseases due to multifactorial ontology of glycocalyx disruption
US20220351806A1 (en) * 2019-10-02 2022-11-03 Endpoint Health Inc. Biomarker Panels for Guiding Dysregulated Host Response Therapy
CA3156785A1 (en) * 2019-11-04 2021-05-14 Oxford University Innovation Limited Identification and characterisation of herbicides and plant growth regulators
CN111275125A (zh) * 2020-02-10 2020-06-12 东华大学 一种面向低秩图像特征分析的类别标签恢复方法
US11058710B1 (en) 2020-02-14 2021-07-13 Dasman Diabetes Institute MicroRNA ANGPTL3 inhibitor
CN111718991A (zh) * 2020-07-03 2020-09-29 西安交通大学医学院第一附属医院 血浆miRNA分子标志物在诊断代谢综合征中的应用
CN114058696B (zh) * 2020-07-29 2023-08-18 四川大学华西医院 miR-519e-5p作为甲状腺乳头状癌远处转移检测或治疗靶点中的用途
CN114113624B (zh) * 2020-08-28 2024-08-16 香港城市大学深圳研究院 利用免疫球蛋白关联蛋白质组开发疾病标志物的方法及装置
EP3971909A1 (en) * 2020-09-21 2022-03-23 Thorsten Kaiser Method for predicting markers which are characteristic for at least one medical sample and/or for a patient
CN112280845A (zh) * 2020-09-22 2021-01-29 山东大学第二医院 miR-328-3p在制备脑梗死及脑缺血再灌注预后预测试剂中的应用
CN114520054A (zh) * 2020-11-18 2022-05-20 英业达科技有限公司 心衰竭预测组件及心衰竭预测方法
CN112530595A (zh) * 2020-12-21 2021-03-19 无锡市第二人民医院 一种基于多分支链式神经网络的心血管疾病分类方法和装置
CN112680509A (zh) * 2021-01-20 2021-04-20 河南省中医院（河南中医药大学第二附属医院） 一种评估冠心病预后分子标志物miR-302e及其逆转录引物、扩增引物和应用
CN112904020A (zh) * 2021-01-25 2021-06-04 上海市第六人民医院 Fam172a在筛查和治疗糖尿病大血管病变中的应用
CN112509700A (zh) * 2021-02-05 2021-03-16 中国医学科学院阜外医院 稳定型冠心病的风险预测方法及装置
CN112941167A (zh) * 2021-03-16 2021-06-11 宁夏医科大学 一种心血管疾病诊断用miRNA标志物及其应用
EP4326894A4 (en) * 2021-04-24 2025-06-04 University of Notre Dame du Lac Method and device for detection of myocardial infarction and reperfusion injury
CN113876954A (zh) * 2021-05-31 2022-01-04 烟台金蕊女性用品有限公司 miRNA-550b-2-5p及其抑制剂在制备治疗糖尿病诱导的血管损伤药物中的应用
CN113293207B (zh) * 2021-06-22 2022-09-02 上海市东方医院（同济大学附属东方医院） 外周血miRNA在制备作为心衰诊断或者预后的生物标志物中的用途
CN117916599A (zh) * 2021-09-07 2024-04-19 美国西门子医学诊断股份有限公司 生物标记物组合物及其使用方法
CN113943792A (zh) * 2021-11-02 2022-01-18 石河子大学 检测miRNA表达量的试剂在制备诊断或预后哈萨克族高血压的试剂或试剂盒中的应用
CN115901901A (zh) * 2022-01-15 2023-04-04 山东师范大学 TiO2-MoO3纳米阵列及基于其的miR-145-3p早检传感芯片及其应用
CN114388121B (zh) * 2022-03-25 2022-06-03 北京盛坤康如医疗器械有限责任公司 心脏标志物poct系统及医疗器材
EP4533484A4 (en) * 2022-06-03 2026-06-03 Found Medicine Inc METHODS AND SYSTEMS FOR CLASSIFYING DISEASE ENTITIES BY MIXTURE MODELING
CN114990229B (zh) * 2022-06-20 2023-01-03 广东医科大学附属医院 一种嗜碱性粒细胞活化相关的生物标志物及其应用
CN116334206B (zh) * 2022-11-09 2026-04-07 上海长征医院 miR-541在制备肝纤维化/肝硬化无创诊断及预后评估试剂盒中的应用
KR20250031367A (ko) * 2023-08-28 2025-03-07 고려대학교 산학협력단 동맥경화증 진단용 엑소좀 유래 바이오 마커
WO2025135469A1 (ko) * 2023-12-22 2025-06-26 서울대학교병원 대사질환 예측 또는 진단을 위한 마이크로 rna 바이오마커 및 이의 용도
CN117737262A (zh) * 2024-02-21 2024-03-22 山东第一医科大学(山东省医学科学院) 一种miRNA标志物在制备鉴别体液斑产品中的应用
CN120608147A (zh) * 2025-07-24 2025-09-09 重庆医科大学附属第二医院 一种用于检测miRNA标记物的试剂、试剂盒及应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6059724A (en) * 1997-02-14 2000-05-09 Biosignal, Inc. System for predicting future health
US7888497B2 (en) * 2003-08-13 2011-02-15 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
US7306562B1 (en) * 2004-04-23 2007-12-11 Medical Software, Llc Medical risk assessment method and program product
US7635563B2 (en) * 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
US20070099239A1 (en) * 2005-06-24 2007-05-03 Raymond Tabibiazar Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease
JP2010505427A (ja) * 2006-10-09 2010-02-25 ジュリアス−マキシミリアンズ−ユニベルシタット ワーズブルグ 心疾患の診断及び治療用マイクロＲＮＡ（ｍｉＲＮＡ）
SG177948A1 (en) * 2006-10-19 2012-02-28 Entelos Inc Method and apparatus for modeling atherosclerosis
WO2008080126A2 (en) * 2006-12-22 2008-07-03 Aviir, Inc. Two biomarkers for diagnosis and monitoring of atherosclerotic cardiovascular disease
US8768718B2 (en) * 2006-12-27 2014-07-01 Cardiac Pacemakers, Inc. Between-patient comparisons for risk stratification of future heart failure decompensation
US20090156906A1 (en) * 2007-06-25 2009-06-18 Liebman Michael N Patient-centric data model for research and clinical applications
BRPI0813527A2 (pt) * 2007-07-18 2014-12-30 Univ Colorado Expressão diferencial de micro-rnas em corações humanos que não falham versus que falham
US20110160285A1 (en) * 2008-03-13 2011-06-30 The Regents Of The University Of Colorado Identification of mirna profiles that are diagnostic of hypertrophic cardiomyopathy
SG177937A1 (en) * 2008-03-26 2012-02-28 Theranos Inc Methods and systems for assessing clinical outcomes
US8224665B2 (en) * 2008-06-26 2012-07-17 Archimedes, Inc. Estimating healthcare outcomes for individuals

Also Published As

Publication number Publication date
JP2013513387A (ja) 2013-04-22
WO2011072177A3 (en) 2011-07-28
WO2011072177A2 (en) 2011-06-16
US20110144914A1 (en) 2011-06-16
AU2010328019A2 (en) 2012-06-28
AU2010328019A1 (en) 2012-06-28
US20150376704A1 (en) 2015-12-31
CN102762743A (zh) 2012-10-31
EP2510116A2 (en) 2012-10-17

Similar Documents

Publication Publication Date Title
US20150376704A1 (en) Biomarker assay for diagnosis and classification of cardiovascular disease
US20220042102A1 (en) Mirna fingerprint in the diagnosis of lung cancer
US9528158B2 (en) miRNA fingerprint in the diagnosis of COPD
US9822416B2 (en) miRNA in the diagnosis of ovarian cancer
US20210130905A1 (en) Micro-rna biomarkers and methods of using same
WO2014169226A2 (en) Methods of diagnosing and treating chronic pain
US20160138106A1 (en) Circulating Non-coding RNA Profiles for Detection of Cardiac Transplant Rejection
EP2925884B1 (en) Compositions and methods for evaluating heart failure
US20150152499A1 (en) Diagnostic portfolio and its uses
Class et al. Patent application title: miRNA FINGERPRINT IN THE DIAGNOSIS OF PROSTATE CANCER Inventors: Andreas Keller (Puettlingen, DE) Andreas Keller (Puettlingen, DE) Eckart Meese (Huetschenhausen, DE) Eckart Meese (Huetschenhausen, DE) Anne Borries (Heidelberg, DE) Anne Borries (Heidelberg, DE) Markus Beier (Weinheim, DE) Markus Beier (Weinheim, DE) Assignees: Comprehensive Biomarker Center GmbH
HK1252674B (en) Mirna fingerprint in the diagnosis of lung cancer
Yan et al. MicroRNA Expression Profile in Patients Admitted to ICU as Novel and Reliable Approach for Diagnostic and Therapeutic Purposes

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20151209