CA2760953C - Triptolide prodrugs - Google Patents
Triptolide prodrugs Download PDFInfo
- Publication number
- CA2760953C CA2760953C CA2760953A CA2760953A CA2760953C CA 2760953 C CA2760953 C CA 2760953C CA 2760953 A CA2760953 A CA 2760953A CA 2760953 A CA2760953 A CA 2760953A CA 2760953 C CA2760953 C CA 2760953C
- Authority
- CA
- Canada
- Prior art keywords
- cancer
- compound
- formula
- pharmaceutically acceptable
- triptolide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical compound O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 title description 103
- YKUJZZHGTWVWHA-UHFFFAOYSA-N triptolide Natural products COC12CC3OC3(C(C)C)C(O)C14OC4CC5C6=C(CCC25C)C(=O)OC6 YKUJZZHGTWVWHA-UHFFFAOYSA-N 0.000 title description 96
- 229940002612 prodrug Drugs 0.000 title description 48
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Classifications
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
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- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2964631A CA2964631A1 (en) | 2009-05-07 | 2010-05-07 | Triptolide prodrugs |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17624909P | 2009-05-07 | 2009-05-07 | |
| US61/176,249 | 2009-05-07 | ||
| PCT/US2010/034117 WO2010129918A1 (en) | 2009-05-07 | 2010-05-07 | Triptolide prodrugs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2964631A Division CA2964631A1 (en) | 2009-05-07 | 2010-05-07 | Triptolide prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2760953A1 CA2760953A1 (en) | 2010-11-11 |
| CA2760953C true CA2760953C (en) | 2017-05-30 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2760953A Active CA2760953C (en) | 2009-05-07 | 2010-05-07 | Triptolide prodrugs |
| CA2964631A Abandoned CA2964631A1 (en) | 2009-05-07 | 2010-05-07 | Triptolide prodrugs |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2964631A Abandoned CA2964631A1 (en) | 2009-05-07 | 2010-05-07 | Triptolide prodrugs |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8507552B2 (enExample) |
| EP (1) | EP2427467B1 (enExample) |
| JP (3) | JP6000122B2 (enExample) |
| KR (1) | KR101821823B1 (enExample) |
| CN (1) | CN102596977B (enExample) |
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| US9150600B2 (en) | 2009-05-07 | 2015-10-06 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| DK3510860T3 (da) | 2012-08-23 | 2021-10-18 | Senestech Inc | Nedsættelse af pattedyrs reproduktive kapacitet |
| WO2014047783A1 (zh) * | 2012-09-25 | 2014-04-03 | 鼎泓国际投资（香港）有限公司 | 含有雷公藤甲素及雷公藤甲素类衍生物和Bcl-2抑制剂的药物组合物及其应用 |
| WO2014167581A2 (en) * | 2013-04-01 | 2014-10-16 | Laurus Labs Private Limited | An improved process for the preparation of triptolide prodrugs |
| JP6931228B2 (ja) * | 2015-09-11 | 2021-09-01 | ワイズ・エー・シー株式会社 | 抗ｃｄ２６抗体と他の抗癌剤とを組み合わせた癌治療用組成物 |
| CN109942665B (zh) * | 2018-04-02 | 2021-04-06 | 欣凯医药化工中间体（上海）有限公司 | 雷公藤内酯醇衍生物及其制备方法和应用 |
| CN110551171B (zh) * | 2018-05-31 | 2021-07-27 | 欣凯医药化工中间体（上海）有限公司 | 一种雷公藤内酯醇衍生物的制备方法 |
| CN113056474A (zh) * | 2018-09-13 | 2021-06-29 | 米尼阿姆里塔治疗学有限责任公司 | 用于治疗纤维化、nash和nafld的方法中的雷公藤内酯及其前药 |
| WO2021221179A1 (ja) * | 2020-04-28 | 2021-11-04 | 国立大学法人高知大学 | ヒト膵癌オルガノイドを用いたマウスモデルの樹立 |
| US20230303618A1 (en) | 2020-08-21 | 2023-09-28 | Reyoung Corporation | Triptolide conjugates and uses thereof |
| CN115227829B (zh) * | 2022-02-22 | 2023-10-13 | 成都中医药大学 | 酸敏感性适配体雷公藤甲素偶联物及应用 |
| KR102821060B1 (ko) | 2023-03-09 | 2025-06-16 | 미네암리타 테라퓨틱스, 엘엘씨 | 위암의 치료를 위한 약물 조합 |
| KR20250154513A (ko) | 2023-03-09 | 2025-10-28 | 미네암리타 테라퓨틱스, 엘엘씨 | 췌장암 치료용 약물 조합 |
| WO2024187139A1 (en) | 2023-03-09 | 2024-09-12 | Minneamrita Therapeutics Llc | Drug combination for treatment of gastric cancer |
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| US5609991A (en) | 1995-02-10 | 1997-03-11 | Morton International, Inc. | Photoimageable composition having improved alkaline process resistance and tack-free surface for contact imaging |
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| US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| US6548537B1 (en) | 1998-09-02 | 2003-04-15 | Pharmagenesis, Inc. | Triptolide prodrugs having high aqueous solubility |
| DE69909633T2 (de) * | 1998-09-02 | 2004-05-13 | Pharmagenesis, Inc., Palo Alto | Gut wasserlösliche triptolid-prodrugs |
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| ATE554758T1 (de) | 2004-03-02 | 2012-05-15 | Pharmagenesis Inc | Triptolid-lacton-ring-derivate als immunmodulatoren und mittel gegen krebs |
| US20070244080A1 (en) | 2004-06-25 | 2007-10-18 | Pharmagenesis, Inc. | Method for Treatment of Inflammatory Disorders Using Triptolide Compounds |
| WO2007025031A2 (en) * | 2005-08-24 | 2007-03-01 | Cephalon, Inc. | Prodrugs of indanone and tetralone compounds |
| CN101049300A (zh) | 2006-04-04 | 2007-10-10 | 中国科学院上海药物研究所 | 包含雷公藤内酯醇衍生物的药物组合物、其剂型和应用 |
| CA2658793A1 (en) * | 2006-07-25 | 2008-02-07 | Daniel Dumas | Quinoline derivatives |
| EP2133355A4 (en) * | 2007-03-06 | 2011-12-28 | Eisai R&D Man Co Ltd | COMPOSITION WITH A CHLOROMETHYPHOSPHATE DERIVATIVE WITH INCREASED STABILITY AND METHOD FOR THE PRODUCTION THEREOF |
| FI20070574A0 (fi) * | 2007-07-30 | 2007-07-30 | Kuopion Yliopisto | Vesiliukoinen propofolin etylideenifosfaatti-aihiolääke |
| WO2009023201A1 (en) | 2007-08-16 | 2009-02-19 | Myelorx Llc | Rigid derivatives of triptolide as anticancer, immune suppressant, anti-fibrosis, and cns protectant agents |
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| EP2427467A1 (en) | 2012-03-14 |
| EP2427467B1 (en) | 2015-08-05 |
| PL2427467T3 (pl) | 2016-04-29 |
| EA201190293A1 (ru) | 2012-11-30 |
| CA2760953A1 (en) | 2010-11-11 |
| MY160392A (en) | 2017-03-15 |
| WO2010129918A1 (en) | 2010-11-11 |
| ES2552163T3 (es) | 2015-11-26 |
| WO2010129918A8 (en) | 2011-01-20 |
| JP2014185181A (ja) | 2014-10-02 |
| JP6000122B2 (ja) | 2016-09-28 |
| AU2010245669A1 (en) | 2011-12-01 |
| KR20120015339A (ko) | 2012-02-21 |
| JP2016065099A (ja) | 2016-04-28 |
| US8507552B2 (en) | 2013-08-13 |
| MX2011011776A (es) | 2012-08-03 |
| BRPI1014802B1 (pt) | 2020-09-24 |
| AU2010245669B2 (en) | 2015-11-26 |
| KR101821823B1 (ko) | 2018-01-24 |
| CN102596977A (zh) | 2012-07-18 |
| HK1168107A1 (en) | 2012-12-21 |
| DK2427467T3 (en) | 2015-11-09 |
| CA2964631A1 (en) | 2010-11-11 |
| CN102596977B (zh) | 2016-06-29 |
| SG175885A1 (en) | 2011-12-29 |
| JP2012526148A (ja) | 2012-10-25 |
| BRPI1014802B8 (pt) | 2021-05-25 |
| PT2427467E (pt) | 2015-11-19 |
| BRPI1014802A2 (pt) | 2016-04-05 |
| US20120238529A1 (en) | 2012-09-20 |
| EA021135B1 (ru) | 2015-04-30 |
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