CA2719507C - Oxymethylene aryl compounds and uses thereof - Google Patents
Oxymethylene aryl compounds and uses thereof Download PDFInfo
- Publication number
- CA2719507C CA2719507C CA2719507A CA2719507A CA2719507C CA 2719507 C CA2719507 C CA 2719507C CA 2719507 A CA2719507 A CA 2719507A CA 2719507 A CA2719507 A CA 2719507A CA 2719507 C CA2719507 C CA 2719507C
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- substituted
- group
- dpp
- thiazol
- inhibitor
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- SCGQNJHAAYUQOO-UHFFFAOYSA-N tert-butyl 4-carbamothioylpiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(C(N)=S)CC1 SCGQNJHAAYUQOO-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- CWXPZXBSDSIRCS-UHFFFAOYSA-N tert-butyl piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCNCC1 CWXPZXBSDSIRCS-UHFFFAOYSA-N 0.000 description 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
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- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
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| US4119608P | 2008-03-31 | 2008-03-31 | |
| US61/041,196 | 2008-03-31 | ||
| PCT/US2009/038847 WO2009123992A1 (en) | 2008-03-31 | 2009-03-30 | Oxymethylene aryl compounds and uses thereof |
Publications (2)
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| CA2719507A1 CA2719507A1 (en) | 2009-10-08 |
| CA2719507C true CA2719507C (en) | 2018-03-27 |
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| CA2719507A Expired - Fee Related CA2719507C (en) | 2008-03-31 | 2009-03-30 | Oxymethylene aryl compounds and uses thereof |
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| AU (1) | AU2009231906A1 (enExample) |
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| TW (1) | TW201002705A (enExample) |
| WO (1) | WO2009123992A1 (enExample) |
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| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DOP2006000008A (es) * | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| SG174054A1 (en) | 2006-05-04 | 2011-09-29 | Boehringer Ingelheim Int | Polymorphs |
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| AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
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2009
- 2009-03-30 PL PL09727673T patent/PL2280704T3/pl unknown
- 2009-03-30 KR KR1020107022940A patent/KR20100134659A/ko not_active Withdrawn
- 2009-03-30 US US12/414,639 patent/US20090270404A1/en not_active Abandoned
- 2009-03-30 CA CA2719507A patent/CA2719507C/en not_active Expired - Fee Related
- 2009-03-30 DK DK09727673.7T patent/DK2280704T3/en active
- 2009-03-30 CL CL2009000782A patent/CL2009000782A1/es unknown
- 2009-03-30 CN CN200980110894.7A patent/CN102026636B/zh not_active Expired - Fee Related
- 2009-03-30 ES ES09727673.7T patent/ES2543358T3/es active Active
- 2009-03-30 WO PCT/US2009/038847 patent/WO2009123992A1/en not_active Ceased
- 2009-03-30 MX MX2010010562A patent/MX2010010562A/es not_active Application Discontinuation
- 2009-03-30 TW TW098110577A patent/TW201002705A/zh unknown
- 2009-03-30 AU AU2009231906A patent/AU2009231906A1/en not_active Abandoned
- 2009-03-30 EP EP20090727673 patent/EP2280704B1/en not_active Not-in-force
- 2009-03-30 JP JP2011502137A patent/JP5711655B2/ja not_active Expired - Fee Related
- 2009-03-30 BR BRPI0909469A patent/BRPI0909469A2/pt not_active Application Discontinuation
- 2009-03-31 AR ARP090101153A patent/AR072352A1/es unknown
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2010
- 2010-09-17 ZA ZA2010/06687A patent/ZA201006687B/en unknown
- 2010-09-19 IL IL208230A patent/IL208230A0/en unknown
- 2010-10-28 SM SM201000118T patent/SMP201000118B/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2280704T3 (pl) | 2015-10-30 |
| KR20100134659A (ko) | 2010-12-23 |
| IL208230A0 (en) | 2010-12-30 |
| US20090270404A1 (en) | 2009-10-29 |
| JP2011516428A (ja) | 2011-05-26 |
| WO2009123992A1 (en) | 2009-10-08 |
| AU2009231906A1 (en) | 2009-10-08 |
| TW201002705A (en) | 2010-01-16 |
| BRPI0909469A2 (pt) | 2015-12-29 |
| CA2719507A1 (en) | 2009-10-08 |
| MX2010010562A (es) | 2010-12-07 |
| AR072352A1 (es) | 2010-08-25 |
| SMAP201000118A (it) | 2011-01-19 |
| CN102026636A (zh) | 2011-04-20 |
| DK2280704T3 (en) | 2015-06-29 |
| CN102026636B (zh) | 2014-07-16 |
| EP2280704A1 (en) | 2011-02-09 |
| CL2009000782A1 (es) | 2010-04-30 |
| ES2543358T3 (es) | 2015-08-18 |
| HK1153946A1 (en) | 2012-04-20 |
| EP2280704B1 (en) | 2015-05-13 |
| JP5711655B2 (ja) | 2015-05-07 |
| SMP201000118B (it) | 2011-09-09 |
| ZA201006687B (en) | 2011-12-28 |
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