CA2656278C - Compositions and methods for treating rotator cuff injuries - Google Patents
Compositions and methods for treating rotator cuff injuries Download PDFInfo
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- CA2656278C CA2656278C CA2656278A CA2656278A CA2656278C CA 2656278 C CA2656278 C CA 2656278C CA 2656278 A CA2656278 A CA 2656278A CA 2656278 A CA2656278 A CA 2656278A CA 2656278 C CA2656278 C CA 2656278C
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- A61L2430/00—Materials or treatment for tissue regeneration
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Landscapes
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| PCT/US2007/015345 WO2008005427A2 (en) | 2006-06-30 | 2007-07-02 | Pdgf-biomatrix compositions and methods for treating rotator cuff injuries |
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| CA2656278A1 CA2656278A1 (en) | 2008-01-10 |
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Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| WO2007061889A2 (en) | 2005-11-17 | 2007-05-31 | Biomimetic Therapeutics, Inc. | Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix |
| EP1991282B1 (en) * | 2006-02-09 | 2013-06-19 | BioMimetic Therapeutics, LLC | Compositions and methods for treating bone |
| CA2656278C (en) | 2006-06-30 | 2016-02-09 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating rotator cuff injuries |
| US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| US8444758B2 (en) | 2006-10-19 | 2013-05-21 | Eastman Chemical Company | Low voc additives for extending the wet edge and open time of aqueous coatings |
| US8106008B2 (en) | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| WO2008103690A2 (en) * | 2007-02-20 | 2008-08-28 | Biomimetic Therapeutics, Inc. | Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw using pdgf and a bone matrix |
| EP2124831B1 (en) | 2007-03-15 | 2016-07-06 | Ortho-Space Ltd. | Prosthetic devices |
| ES2422259T3 (es) * | 2008-02-07 | 2013-09-10 | Biomimetic Therapeutics Inc | Composiciones para la osteogénesis por distracción |
| CN102098984B (zh) | 2008-05-14 | 2017-06-23 | 史密夫和内修有限公司 | 关节镜下二头肌腱固定术修复装置 |
| KR20110067035A (ko) * | 2008-09-09 | 2011-06-20 | 바이오미메틱 세라퓨틱스, 인크. | 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법 |
| EP2385807A2 (en) | 2008-12-09 | 2011-11-16 | Smith & Nephew, Inc. | Tissue repair assembly |
| US8858606B2 (en) | 2008-12-09 | 2014-10-14 | Smith & Nephew, Inc. | Tissue repair assembly |
| WO2010081029A1 (en) | 2009-01-08 | 2010-07-15 | Rotation Medical, Inc. | Implantable tendon protection systems and related kits and methods |
| US20100211174A1 (en) * | 2009-02-19 | 2010-08-19 | Tyco Healthcare Group Lp | Method For Repairing A Rotator Cuff |
| AU2010221089A1 (en) * | 2009-03-05 | 2011-09-15 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects |
| US9179910B2 (en) | 2009-03-20 | 2015-11-10 | Rotation Medical, Inc. | Medical device delivery system and method |
| US8231653B2 (en) * | 2009-03-31 | 2012-07-31 | Arthrex, Inc. | Method of forming knotless double row construct with graft or patch fixed under repair site |
| US12471975B2 (en) | 2009-06-04 | 2025-11-18 | Rotation Medical, Inc. | Methods and apparatus for deploying sheet-like materials |
| JP5718912B2 (ja) | 2009-06-04 | 2015-05-13 | ローテーション メディカル インコーポレイテッドRotation Medical,Inc. | 移植物搬送システム及び搬送システムを準備する方法 |
| JP5662427B2 (ja) | 2009-06-04 | 2015-01-28 | ローテーション メディカル インコーポレイテッドRotation Medical,Inc. | 目的の組織にシート状材料を固定するための装置 |
| US20120282235A1 (en) * | 2009-09-25 | 2012-11-08 | Ohashi Kevin L | Implantable patch and surgical kit for preparation thereof |
| US8690960B2 (en) * | 2009-11-24 | 2014-04-08 | Covidien Lp | Reinforced tissue patch |
| CN107080834A (zh) * | 2010-02-22 | 2017-08-22 | 生物模拟治疗有限责任公司 | 用于治疗腱病的血小板衍生生长因子组合物和方法 |
| US9198750B2 (en) | 2010-03-11 | 2015-12-01 | Rotation Medical, Inc. | Tendon repair implant and method of arthroscopic implantation |
| WO2012105224A1 (ja) * | 2011-01-31 | 2012-08-09 | オリンパス株式会社 | ワクチン・アジュバント |
| CA2825918C (en) | 2011-02-15 | 2018-08-07 | Rotation Medical, Inc. | Methods and apparatus for delivering and positioning sheet-like materials |
| WO2012145059A1 (en) | 2011-02-15 | 2012-10-26 | Rotation Medical, Inc. | Methods and apparatus for fixing sheet-like materials to a target tissue |
| US9289307B2 (en) | 2011-10-18 | 2016-03-22 | Ortho-Space Ltd. | Prosthetic devices and methods for using same |
| WO2013062994A1 (en) | 2011-10-25 | 2013-05-02 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating full thickness burn injuries |
| US20130108683A1 (en) * | 2011-10-25 | 2013-05-02 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating partial and full thickness wounds and injuries |
| US9107661B2 (en) | 2011-12-19 | 2015-08-18 | Rotation Medical, Inc. | Fasteners and fastener delivery devices for affixing sheet-like materials to bone or tissue |
| WO2013096224A1 (en) | 2011-12-19 | 2013-06-27 | Rotation Medical, Inc. | Fasteners for affixing sheet -like materials to bone or tissue |
| AU2012355433B2 (en) | 2011-12-19 | 2016-10-20 | Rotation Medical, Inc. | Apparatus and method for forming pilot holes in bone and delivering fasteners therein for retaining an implant |
| US9370356B2 (en) | 2011-12-19 | 2016-06-21 | Rotation Medical, Inc. | Fasteners and fastener delivery devices for affixing sheet-like materials to bone or tissue |
| EP2797532B1 (en) | 2011-12-29 | 2016-04-06 | Rotation Medical, Inc. | Apparatus for delivering and positioning sheet-like materials in surgery |
| WO2013101641A2 (en) | 2011-12-29 | 2013-07-04 | Rotation Medical, Inc. | Anatomical location markers and methods of use in positioning sheet-like materials during surgery |
| WO2013101640A1 (en) | 2011-12-29 | 2013-07-04 | Rotation Medical, Inc. | Guidewire having a distal fixation member for delivering and positioning sheet-like materials in surgery |
| US9345577B2 (en) * | 2013-03-14 | 2016-05-24 | Microaire Surgical Instruments Llc | Balloon implant device |
| CA2945821C (en) | 2014-05-09 | 2018-09-04 | Rotation Medical, Inc. | Medical implant delivery system for sheet-like implant |
| EP3166624B1 (en) | 2014-07-09 | 2020-06-03 | Mayo Foundation for Medical Education and Research | Treating rotator cuff conditions |
| MX2017004520A (es) * | 2014-10-14 | 2018-03-15 | Lynch Samuel | Composiciones para tratar heridas. |
| EP3215025B1 (en) | 2014-11-04 | 2020-12-23 | Rotation Medical, Inc. | Medical implant delivery system |
| US10675019B2 (en) | 2014-11-04 | 2020-06-09 | Rotation Medical, Inc. | Medical implant delivery system and related methods |
| EP4275620A3 (en) | 2014-11-04 | 2024-01-17 | Rotation Medical, Inc. | Medical implant delivery system |
| WO2016175967A1 (en) * | 2015-04-30 | 2016-11-03 | Encore Medical, L.P. | Soft tissue repair using a porous coating implant |
| US10898228B2 (en) | 2015-05-06 | 2021-01-26 | Rotation Medical, Inc. | Medical implant delivery system and related methods |
| WO2016205186A1 (en) | 2015-06-15 | 2016-12-22 | Rotation Medical, Inc. | Tendon repair implant and method of implantation |
| WO2017011762A1 (en) | 2015-07-16 | 2017-01-19 | Mayo Foundation For Medical Education And Research | Treating rotator cuff conditions |
| WO2017046647A1 (en) | 2015-09-18 | 2017-03-23 | Ortho-Space Ltd. | Intramedullary fixated subacromial spacers |
| US10172703B2 (en) | 2015-10-01 | 2019-01-08 | Arthrex, Inc. | Joint kinematic reconstruction techniques |
| US10813742B2 (en) | 2015-10-01 | 2020-10-27 | Arthrex, Inc. | Joint kinematic reconstruction techniques |
| AU2016344019B2 (en) | 2015-10-30 | 2021-07-15 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Suture sleeve patch and methods of delivery within an existing arthroscopic workflow |
| EP3370698B1 (en) | 2015-11-03 | 2022-01-26 | Zoetis Services LLC | Sol-gel polymer composites and uses thereof |
| CA3008670A1 (en) | 2015-12-31 | 2017-07-06 | Rotation Medical, Inc. | Fastener delivery system and related methods |
| US10314689B2 (en) | 2015-12-31 | 2019-06-11 | Rotation Medical, Inc. | Medical implant delivery system and related methods |
| US11484401B2 (en) | 2016-02-01 | 2022-11-01 | Medos International Sarl | Tissue augmentation scaffolds for use in soft tissue fixation repair |
| US20170273680A1 (en) | 2016-02-01 | 2017-09-28 | DePuy Synthes Products, Inc. | Tissue augmentation tacks for use with soft tissue fixation repair systems and methods |
| US11357495B2 (en) | 2016-02-01 | 2022-06-14 | Medos International Sarl | Tissue augmentation scaffolds for use with soft tissue fixation repair systems and methods |
| US9861410B2 (en) | 2016-05-06 | 2018-01-09 | Medos International Sarl | Methods, devices, and systems for blood flow |
| US10568733B2 (en) | 2017-01-24 | 2020-02-25 | Arthrex, Inc. | Anterior cable region superior capsule reconstructions |
| US11045981B2 (en) | 2017-01-30 | 2021-06-29 | Ortho-Space Ltd. | Processing machine and methods for processing dip-molded articles |
| WO2018144858A1 (en) * | 2017-02-02 | 2018-08-09 | Nanofiber Solutions, Inc. | Methods of improving bone-soft tissue healing using electrospun fibers |
| WO2019033082A1 (en) * | 2017-08-11 | 2019-02-14 | Theracell, Inc. | DEMINERALIZED BONE FIBER COMPOSITION FOR INCREASED FASTENING |
| USD904615S1 (en) * | 2017-10-31 | 2020-12-08 | Sicage Llc | Bone screw |
| EP3720385B1 (en) | 2017-12-07 | 2023-09-27 | Rotation Medical, Inc. | Medical implant delivery system |
| US20200179573A1 (en) * | 2018-12-06 | 2020-06-11 | National Cheng Kung University | Biodegradable metal alloy for anchoring detached tissue to hard tissue, method of making the same, and process for using the same |
| CN113677395A (zh) | 2019-02-13 | 2021-11-19 | 帕萨尔美德他克有限公司 | 用于骨科治疗的植入式电磁场产生器 |
| CN111068116B (zh) * | 2019-12-28 | 2022-03-22 | 河北柯瑞生物医药有限公司 | 一种注射用软骨修复温敏凝胶及其制备方法 |
| US11559330B2 (en) | 2020-02-11 | 2023-01-24 | Embody, Inc. | Surgical cannula with removable pressure seal |
| EP4103106B1 (en) | 2020-02-11 | 2026-03-11 | Embody, Inc. | Implant delivery device |
| AU2021220864B2 (en) | 2020-02-11 | 2024-03-07 | Embody, Inc. | Surgical anchoring device, deployment device, and method of use |
| US11957566B2 (en) * | 2020-02-14 | 2024-04-16 | B/G Ortho Innovations, LLC | Implants and methods for shoulder joint reconstruction |
| CN111346262B (zh) * | 2020-03-17 | 2022-02-01 | 四川大学 | 一种用于促进腱骨愈合的可注射钙磷陶瓷及其制备方法与应用 |
| US12310928B2 (en) | 2020-11-16 | 2025-05-27 | University Of Utah Research Foundation | Enthesis healing |
| CN113633821A (zh) * | 2021-08-18 | 2021-11-12 | 上海交通大学医学院附属第九人民医院 | 一种温敏型可注射型胶原/壳聚糖/掺锌生物玻璃纳米颗粒水凝胶材料及其制备方法 |
| CA3238654A1 (en) * | 2021-11-16 | 2023-05-25 | Mayo Foundation For Medical Education And Research | Methods and compositions for repair of tendon-bone interface |
| US20240261086A1 (en) * | 2023-02-07 | 2024-08-08 | Cannuflow, Inc. | Biological Patch and Fixation Device for Tendon Repair |
| CN121398834A (zh) * | 2023-06-23 | 2026-01-23 | 塞缪尔·E·林奇 | 用于皮肤修复、恢复活性和舒适的方法和组合物 |
Family Cites Families (264)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3943072A (en) | 1971-12-15 | 1976-03-09 | United Kingdom Atomic Energy Authority | Separation of molecules |
| USRE33161E (en) | 1982-04-29 | 1990-02-06 | American Dental Association Health Foundation | Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements |
| NL8402158A (nl) | 1983-07-09 | 1985-02-01 | Sumitomo Cement Co | Poreus keramisch materiaal en werkwijze voor de bereiding daarvan. |
| US4837285A (en) * | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
| US4889919A (en) | 1986-08-13 | 1989-12-26 | Zymogenetics, Inc. | Biologically active PDGF derived A-chain homodimers |
| US5187263A (en) | 1984-10-12 | 1993-02-16 | Zymogenetics, Inc. | Expression of biologically active PDGE analogs in eucaryotic cells |
| US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US5165938A (en) | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
| US5629191A (en) | 1985-01-03 | 1997-05-13 | Integra Lifesciences Corporation | Method of making a porous matrix particle |
| US5045633A (en) | 1985-02-25 | 1991-09-03 | Zymogenetics, Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US5516896A (en) | 1985-02-25 | 1996-05-14 | Zymogenetics, Inc. | Biologically active B-chain homodimers |
| US5106748A (en) | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
| US5108922A (en) | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
| US5187076A (en) | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
| ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
| US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| CA1322714C (en) | 1986-11-14 | 1993-10-05 | Harry N. Antoniades | Wound healing and bone regeneration |
| US5019559A (en) | 1986-11-14 | 1991-05-28 | President And Fellows Of Harvard College | Wound healing using PDGF and IGF-II |
| US5124316A (en) | 1986-11-14 | 1992-06-23 | President And Fellows Of Harvard College | Method for periodontal regeneration |
| DE3785758T2 (de) | 1986-11-14 | 1993-08-05 | Harvard College | Wundheilung und knochenregeneration. |
| US5219759A (en) | 1987-04-22 | 1993-06-15 | Chiron Corporation | Recombinant DNA encoding PDGF A-chain polypeptide and expression vectors |
| US5457093A (en) * | 1987-09-18 | 1995-10-10 | Ethicon, Inc. | Gel formulations containing growth factors |
| US4874746A (en) | 1987-12-22 | 1989-10-17 | Institute Of Molecular Biology, Inc. | Wound headling composition of TGF-alpha and PDGF |
| US5759815A (en) | 1988-02-11 | 1998-06-02 | Creative Biomolecules, Inc. | Production of platelet derived growth factor (PDGF) an muteins thereof |
| US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
| US4975526A (en) | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
| US5962028A (en) | 1988-04-20 | 1999-10-05 | Norian Corporation | Carbonated hydroxyapatite compositions and uses |
| US5129905A (en) | 1988-04-20 | 1992-07-14 | Norian Corporation | Methods for in situ prepared calcium phosphate minerals |
| US5053212A (en) | 1988-04-20 | 1991-10-01 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
| US4904259A (en) | 1988-04-29 | 1990-02-27 | Samuel Itay | Compositions and methods for repair of cartilage and bone |
| US5110604A (en) * | 1988-06-30 | 1992-05-05 | Collagen Corporation | Processes for producing collagen matrixes and methods of using same |
| US5219576A (en) | 1988-06-30 | 1993-06-15 | Collagen Corporation | Collagen wound healing matrices and process for their production |
| US5034375A (en) | 1988-08-10 | 1991-07-23 | Institute Of Molecular Biology, Inc. | Process of wound healing using PDGF and EGF |
| US5035887A (en) | 1989-09-07 | 1991-07-30 | Institute Of Moelcular Biology, Inc. | Wound healing composition of IL-1 and PDGF or IGF-1 |
| US5599558A (en) | 1989-09-15 | 1997-02-04 | Curative Technologies, Inc. | Selecting amounts of platelet releasate for efficacious treatment of tissue |
| US5112354A (en) | 1989-11-16 | 1992-05-12 | Northwestern University | Bone allograft material and method |
| US5011910A (en) | 1989-12-28 | 1991-04-30 | Washington University | Reagent and method for determining activity of retroviral protease |
| US5071655A (en) | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
| JP3159216B2 (ja) * | 1990-02-01 | 2001-04-23 | ユニバーシティ オブ サウス フロリダ | 白血球由来の成長因子 |
| TW199858B (enExample) | 1990-03-30 | 1993-02-11 | Fujirebio Kk | |
| ATE156363T1 (de) | 1990-04-10 | 1997-08-15 | Inst Molecular Biology Inc | Wundheilung |
| DE69132823T2 (de) | 1990-05-16 | 2002-07-18 | Genetics Institute, Inc. | Knochen- und knorpel-bildung hervorrufende proteine |
| EP0564502B1 (en) | 1990-11-27 | 2002-01-30 | The American National Red Cross | Tissue sealant and growth factor containing compositions that promote accelerated wound healing |
| US5853746A (en) | 1991-01-31 | 1998-12-29 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier |
| US5149691A (en) | 1991-03-12 | 1992-09-22 | Creative Biomolecules, Inc. | Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone |
| JPH06500802A (ja) * | 1991-06-14 | 1994-01-27 | アムジエン・インコーポレーテツド | コラーゲンフィルムによるタンパクのドラッグ・デリバリー |
| KR100255415B1 (ko) | 1991-06-25 | 2000-05-01 | 브루스 엠. 에이센 | 비엠피-9 조성물 |
| US5837258A (en) | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
| US5270300A (en) | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
| DE69233022T2 (de) | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| AU3062392A (en) | 1991-11-04 | 1993-06-07 | Novo Nordisk A/S | Pdgf gel formulation |
| HU218845B (hu) | 1992-02-12 | 2000-12-28 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh. | Új növekedési/differenciáló faktorokat kódoló DNS-szekvenciák, e faktorokat tartalmazó gyógyszerkészítmények, DNS-molekulák, gazdaszervezetek, antitestek, diagnosztikai eljárások |
| WO1993020859A1 (en) | 1992-04-20 | 1993-10-28 | Board Of Regents Of The University Of Washington | Sustained release compositions for delivery of growth factors |
| IL106278A0 (en) | 1992-07-13 | 1993-11-15 | Sumitomo Metal Ind | Bone formation-inducing protein |
| DK0662146T3 (da) | 1992-09-03 | 2000-11-13 | Univ California | Dorsalvævpåvirkende faktor og præparat |
| EP0690871A4 (en) | 1993-01-12 | 1999-10-20 | Univ Johns Hopkins Med | GROWTH DIFFERENTIATION FACTOR-5 |
| CA2153653C (en) | 1993-01-12 | 2010-12-07 | Se-Jin Lee | Growth differentiation factor-9 |
| EP1475440A3 (en) | 1993-01-12 | 2004-11-17 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-3 |
| ES2201076T3 (es) | 1993-03-19 | 2004-03-16 | The Johns Hopkins University School Of Medicine | Factor-8 de diferenciacion del crecimiento. |
| CN1104257C (zh) | 1993-03-29 | 2003-04-02 | 津莫吉尼蒂克斯公司 | 含pdgf和维生素d的刺激成骨细胞生长的组合物 |
| DK0698094T3 (da) | 1993-05-12 | 2004-05-03 | Inst Genetics Llc | BMP-11-sammensætninger |
| DE69433742T2 (de) | 1993-05-12 | 2005-07-07 | Genetics Institute, LLC, Cambridge | Bmp-10 zusammensetzungen |
| AU7205894A (en) | 1993-06-08 | 1995-01-03 | Neogenix, Inc. | Purified natural and synthetic compounds for the treatment of osteoarthritis |
| EP0717633A4 (en) | 1993-07-09 | 1998-05-20 | Univ Johns Hopkins Med | GROWTH DIFFERENTIATION FACTOR-7 |
| CA2165776A1 (en) | 1993-07-09 | 1995-01-19 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-6 |
| US5531794A (en) | 1993-09-13 | 1996-07-02 | Asahi Kogaku Kogyo Kabushiki Kaisha | Ceramic device providing an environment for the promotion and formation of new bone |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| CA2171546A1 (en) | 1993-10-08 | 1995-04-20 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-10 |
| US5518680A (en) | 1993-10-18 | 1996-05-21 | Massachusetts Institute Of Technology | Tissue regeneration matrices by solid free form fabrication techniques |
| DE69434651T2 (de) | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| JP3362267B2 (ja) | 1993-12-29 | 2003-01-07 | 日本特殊陶業株式会社 | 生体インプラント材料及びその製造方法 |
| AU704178B2 (en) | 1993-12-30 | 1999-04-15 | Imperial Cancer Research Technology Ltd | Vertebrate embryonic pattern-inducing hedgehog-like proteins |
| US5460962A (en) | 1994-01-04 | 1995-10-24 | Organogenesis Inc. | Peracetic acid sterilization of collagen or collagenous tissue |
| JPH07250688A (ja) | 1994-01-28 | 1995-10-03 | Sagami Chem Res Center | TGF−βスーパーファミリー蛋白質をコードするヒト新規cDNA |
| WO1995020967A1 (en) | 1994-02-04 | 1995-08-10 | Cell Therapeutics, Inc. | Composition for wound healing, neuron growth and vascularization |
| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| AU1999995A (en) | 1994-04-08 | 1995-11-10 | Atrix Laboratories, Inc. | An adjunctive polymer system for use with medical device |
| AU2297395A (en) | 1994-04-20 | 1995-11-16 | Institute Of Molecular Biology, Inc. | Administration of platelet-derived growth factor and bone seeking drugs for osteoporosis and bone regeneration |
| US7963997B2 (en) | 2002-07-19 | 2011-06-21 | Kensey Nash Corporation | Device for regeneration of articular cartilage and other tissue |
| WO1996001845A1 (en) | 1994-07-08 | 1996-01-25 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-11 |
| CA2195246A1 (en) | 1994-07-13 | 1996-02-01 | Se-Jin Lee | Growth differentiation factor-12 |
| US6180606B1 (en) | 1994-09-28 | 2001-01-30 | Gensci Orthobiologics, Inc. | Compositions with enhanced osteogenic potential, methods for making the same and uses thereof |
| US5651766A (en) | 1995-06-07 | 1997-07-29 | Transfusion Technologies Corporation | Blood collection and separation system |
| AU4137596A (en) | 1994-10-31 | 1996-05-23 | Sepracor, Inc. | Method for the treatment of periodontal disease and a pharmaceutical composition useful in said method |
| US6281332B1 (en) | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
| US5635372A (en) | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
| US6541037B1 (en) | 1995-05-19 | 2003-04-01 | Etex Corporation | Delivery vehicle |
| US6287341B1 (en) | 1995-05-19 | 2001-09-11 | Etex Corporation | Orthopedic and dental ceramic implants |
| US6027742A (en) | 1995-05-19 | 2000-02-22 | Etex Corporation | Bioresorbable ceramic composites |
| US5676976A (en) | 1995-05-19 | 1997-10-14 | Etex Corporation | Synthesis of reactive amorphous calcium phosphates |
| ES2293137T3 (es) | 1995-10-11 | 2008-03-16 | Novartis Vaccines And Diagnostics, Inc. | Combinacion de pdgf, kgf,igf e igfbp para curacion de heridas. |
| US5783217A (en) | 1995-11-07 | 1998-07-21 | Etex Corporation | Low temperature calcium phosphate apatite and a method of its manufacture |
| US5747273A (en) | 1996-05-07 | 1998-05-05 | Diagnostic Systems Laboratories, Inc. | Immunoassay of total insulin-like growth factor binding protein-1 |
| AU2759397A (en) | 1996-05-28 | 1998-01-05 | 1218122 Ontario Inc. | Resorbable implant biomaterial made of condensed calcium phosphate particles |
| FR2749756B1 (fr) | 1996-06-14 | 1998-09-11 | Bioland | Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre |
| US5965403A (en) | 1996-09-18 | 1999-10-12 | Genetics Institute, Inc. | Nucleic acids encoding bone morphogenic protein-16 (BMP-16) |
| CA2268156C (en) | 1996-10-16 | 2007-05-29 | Etex Corporation | Bioceramic compositions |
| US6037519A (en) | 1997-10-20 | 2000-03-14 | Sdgi Holdings, Inc. | Ceramic fusion implants and compositions |
| DE19646782C2 (de) | 1996-11-13 | 2000-05-25 | Merck Patent Gmbh | Bioresorbierbare Polymerisationsprodukte aus strahlungshärtbaren Bindemittelsystemen |
| WO1998026080A1 (en) | 1996-12-13 | 1998-06-18 | Chiron Corporation | Method for expression of heterologous proteins in yeast |
| US5866165A (en) | 1997-01-15 | 1999-02-02 | Orquest, Inc. | Collagen-polysaccharide matrix for bone and cartilage repair |
| FR2758988B1 (fr) | 1997-02-05 | 2000-01-21 | S H Ind | Procede d'elaboration de substituts osseux synthetiques d'architecture poreuse parfaitement maitrisee |
| EP1350525A3 (en) | 1997-02-07 | 2003-12-10 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods thereof |
| DE69823955T2 (de) | 1997-03-04 | 2005-06-16 | Technology Finance Corp. (Pty.) Ltd., Sandton | Als knochenimplantat geeignetes erzeugnis |
| US20020098222A1 (en) | 1997-03-13 | 2002-07-25 | John F. Wironen | Bone paste |
| US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
| US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
| JP3334558B2 (ja) * | 1997-04-23 | 2002-10-15 | 富士レビオ株式会社 | 酵素免疫測定方法及び試験片 |
| US20030032586A1 (en) | 1997-05-15 | 2003-02-13 | David C. Rueger | Compositions for morphogen-induced osteogenesis |
| GB2325934A (en) | 1997-06-03 | 1998-12-09 | Polybiomed Ltd | Treating metal surfaces to enhance bio-compatibility and/or physical characteristics |
| US6063624A (en) | 1997-06-09 | 2000-05-16 | Baxter International Inc. | Platelet suspensions and methods for resuspending platelets |
| EP0896825B1 (en) | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
| US6136029A (en) | 1997-10-01 | 2000-10-24 | Phillips-Origen Ceramic Technology, Llc | Bone substitute materials |
| US6090998A (en) | 1997-10-27 | 2000-07-18 | University Of Florida | Segmentally demineralized bone implant |
| WO1999030726A1 (en) | 1997-12-15 | 1999-06-24 | Page Roy C | Improved method for attaching dental and orthopedic implants, ligaments, and tendons to bone |
| US20020018796A1 (en) | 1998-01-28 | 2002-02-14 | John F. Wironen | Thermally sterilized bone paste |
| JP2000004875A (ja) | 1998-06-23 | 2000-01-11 | Teijin Ltd | 増殖因子の産生誘導方法 |
| SE514908C2 (sv) | 1998-07-13 | 2001-05-14 | Gs Dev Ab | Medel för benrekonstruktion |
| PT1100488E (pt) | 1998-07-28 | 2003-09-30 | Synthes Ag | Utilizacao de compostos de creatina para tratamento das celulas e tecidos do osso ou cartilagem |
| US20030114936A1 (en) | 1998-10-12 | 2003-06-19 | Therics, Inc. | Complex three-dimensional composite scaffold resistant to delimination |
| US6224635B1 (en) | 1998-11-06 | 2001-05-01 | Hospital For Joint Diseases | Implantation of surgical implants with calcium sulfate |
| US6663870B2 (en) * | 1998-12-07 | 2003-12-16 | Zymogenetics, Inc. | Methods for promoting growth of bone using zvegf3 |
| US6231528B1 (en) | 1999-01-15 | 2001-05-15 | Jonathan J. Kaufman | Ultrasonic and growth factor bone-therapy: apparatus and method |
| EP1025871A1 (en) | 1999-01-28 | 2000-08-09 | F. Hoffmann-La Roche Ag | Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair |
| ES2209820T3 (es) | 1999-02-04 | 2004-07-01 | Sdgi Holdings, Inc. | Composiciones esponjosas osteogenicas altamente mineralizadas, y usos de las mismas. |
| US6294187B1 (en) | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
| US7615373B2 (en) | 1999-02-25 | 2009-11-10 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
| KR20010043639A (ko) | 1999-03-15 | 2001-05-25 | 키이스 디 | 혈소판 수거 시스템 |
| US6296602B1 (en) | 1999-03-17 | 2001-10-02 | Transfusion Technologies Corporation | Method for collecting platelets and other blood components from whole blood |
| ES2199815T3 (es) | 1999-03-19 | 2004-03-01 | The Regents Of The University Of Michigan | Mineralizacion y desarrollo celular supeerficial sobre biomateriales. |
| JP4892133B2 (ja) | 1999-04-12 | 2012-03-07 | ハーベスト・テクノロジーズ・コーポレイション | 血小板富有血漿及び/又は血小板濃縮物を製造する方法 |
| SE515227C2 (sv) | 1999-04-28 | 2001-07-02 | Bruce Medical Ab | Kropp för åstadkommande av in- och tillväxt av benvävnad och/ eller bindväv och sätt för framställning av kroppen |
| US6468543B1 (en) * | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
| US6710025B1 (en) * | 1999-05-26 | 2004-03-23 | The Brigham And Women's Hospital, Inc. | Treatment of damaged tissue using agents that modulate the activity of alpha-smooth muscle actin |
| AU5444800A (en) | 1999-05-27 | 2000-12-18 | Research Foundation Of State University Of New York, The | LTiGTin vitroLT/iGT cell culture device including cartilage and methods of usingthe same |
| DE19926083A1 (de) | 1999-06-08 | 2000-12-14 | Universitaetsklinikum Freiburg | Biologisches Gelenkkonstrukt |
| US20040059416A1 (en) * | 1999-06-22 | 2004-03-25 | Murray Martha M. | Biologic replacement for fibrin clot |
| US6964685B2 (en) * | 1999-06-22 | 2005-11-15 | The Brigham And Women's Hospital, Inc. | Biologic replacement for fibrin clot |
| US6429013B1 (en) | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
| DE19940717A1 (de) | 1999-08-26 | 2001-03-01 | Gerontocare Gmbh | Resorblerbares Knochenersatz- und Knochenaufbaumaterial |
| US6280191B1 (en) * | 1999-09-03 | 2001-08-28 | Christopher B. Gordon | Distractor suitable for permanent implantation into bone |
| WO2001032197A2 (en) | 1999-11-02 | 2001-05-10 | Eli Lilly And Company | Methods of using lp8, a pdgf-related protein, to treat musculoskeletal disorders |
| US6451059B1 (en) | 1999-11-12 | 2002-09-17 | Ethicon, Inc. | Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds |
| AU1622801A (en) | 1999-11-18 | 2001-05-30 | Regents Of The University Of Michigan, The | Sustained drug delivery from structural matrices |
| US7887551B2 (en) | 1999-12-02 | 2011-02-15 | Smith & Nephew, Inc. | Soft tissue attachment and repair |
| WO2001041822A1 (en) | 1999-12-09 | 2001-06-14 | Biosyntech Canada Inc. | Mineral-polymer hybrid composition |
| US6479418B2 (en) | 1999-12-16 | 2002-11-12 | Isotis N.V. | Porous ceramic body |
| US20030103960A1 (en) | 1999-12-22 | 2003-06-05 | Pierre Philippart | Sealant and bone generating product |
| CA2396016A1 (en) | 1999-12-29 | 2001-07-05 | Andy Bernhardt | System for reconstituting pastes and methods of using same |
| AU4234901A (en) | 2000-01-28 | 2001-08-07 | Dot Dunnschicht Und Oberflache | Inorganic resorbable bone substitute material and production method |
| WO2001057083A1 (en) | 2000-02-04 | 2001-08-09 | Zymogenetics, Inc. | Methods for promoting growth of bone, ligament, and cartilage using zvegf4 |
| JP2001217440A (ja) * | 2000-02-04 | 2001-08-10 | Kanegafuchi Chem Ind Co Ltd | ハイブリッド型薄膜光電変換装置とそれに用いられる透光性積層体 |
| AU2001241594A1 (en) | 2000-02-18 | 2001-08-27 | Regeneration Technologies, Inc. | Implantable tissues infused with growth factors and other additives |
| IT1316769B1 (it) | 2000-02-18 | 2003-05-12 | Getters Spa | Pannello evacuato per isolamento termico con ridotta conduzione dicalore ai bordi |
| US7022506B2 (en) | 2000-02-23 | 2006-04-04 | The Trustees Of The University Of Pennsylvania | Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the human knee |
| CA2401421A1 (en) | 2000-03-03 | 2001-09-13 | Smith & Nephew, Inc. | Shaped particle and composition for bone deficiency and method of making the particle |
| US20030055511A1 (en) | 2000-03-03 | 2003-03-20 | Schryver Jeffrey E. | Shaped particle comprised of bone material and method of making the particle |
| ES2272452T3 (es) * | 2000-03-09 | 2007-05-01 | Zimmer Orthobiologics, Inc. | Producto de anclaje biologico de tejido conectivo al hueso. |
| AU784377B2 (en) | 2000-03-14 | 2006-03-23 | Arthur V. Sampaio | Compositions and methods for affecting osteogenesis |
| US20020006437A1 (en) | 2000-05-01 | 2002-01-17 | Grooms Jamie M. | Non-migration tissue capsule |
| US20020022885A1 (en) | 2000-05-19 | 2002-02-21 | Takahiro Ochi | Biomaterial |
| AU2001262605A1 (en) | 2000-05-19 | 2001-11-26 | Europrint Holdings Limited | Method and system for implementing a game |
| US7081240B1 (en) | 2000-06-28 | 2006-07-25 | Zimmer Orthobiologics, Inc. | Protein mixtures for wound healing |
| CN1471412B8 (zh) | 2000-06-29 | 2016-06-15 | 生物合成技术加拿大公司 | 用于修复和再生软骨和其它组织的组合物以及该组合物的用途 |
| DK177997B1 (da) | 2000-07-19 | 2015-02-23 | Ed Geistlich Söhne Ag Für Chemische Ind | Knoglemateriale og collagenkombination til opheling af beskadigede led |
| US6877735B2 (en) * | 2000-07-19 | 2005-04-12 | F&F Limited | Paper sheet managing device and recording system |
| US6739112B1 (en) | 2000-08-21 | 2004-05-25 | Nu Vasive, Inc. | Bone allograft packaging system |
| GB0020610D0 (en) | 2000-08-21 | 2000-10-11 | Dytech Corp Ltd | Uses of porous carriers |
| US6585730B1 (en) | 2000-08-30 | 2003-07-01 | Opus Medical, Inc. | Method and apparatus for attaching connective tissues to bone using a knotless suture anchoring device |
| US6773723B1 (en) * | 2000-08-30 | 2004-08-10 | Depuy Acromed, Inc. | Collagen/polysaccharide bilayer matrix |
| JP2004512145A (ja) | 2000-10-31 | 2004-04-22 | デピュイ・アクロメッド・インコーポレイテッド | 骨および軟骨の修復用の鉱物質化したコラーゲン−多糖類型基質 |
| US20020127265A1 (en) * | 2000-12-21 | 2002-09-12 | Bowman Steven M. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
| CA2365376C (en) * | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
| US7192604B2 (en) | 2000-12-22 | 2007-03-20 | Ethicon, Inc. | Implantable biodegradable devices for musculoskeletal repair or regeneration |
| JP2004533276A (ja) | 2001-01-25 | 2004-11-04 | リジェネレーション テクノロジーズ インク. | 注射可能な多孔性骨グラフト材料 |
| US7005135B2 (en) | 2001-01-30 | 2006-02-28 | Ethicon Inc. | Glass scaffolds with controlled resorption rates and methods for making same |
| US20020169122A1 (en) | 2001-02-23 | 2002-11-14 | Wyeth | Chondrogenic potential of human bone marrow-derived CD105+ cells by BMP |
| US6743232B2 (en) | 2001-02-26 | 2004-06-01 | David W. Overaker | Tissue scaffold anchor for cartilage repair |
| US6575986B2 (en) | 2001-02-26 | 2003-06-10 | Ethicon, Inc. | Scaffold fixation device for use in articular cartilage repair |
| US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
| US20030049328A1 (en) | 2001-03-02 | 2003-03-13 | Dalal Paresh S. | Porous beta-tricalcium phosphate granules and methods for producing same |
| WO2002102783A1 (en) | 2001-06-19 | 2002-12-27 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US20030109537A1 (en) | 2001-07-09 | 2003-06-12 | Turner Russell T. | Methods and materials for treating bone conditions |
| AU2002316694B2 (en) * | 2001-07-16 | 2007-09-06 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
| CA2460026C (en) | 2001-09-24 | 2011-06-28 | Millenium Biologix Inc. | Porous ceramic composite bone grafts |
| DE60224822T2 (de) * | 2001-10-19 | 2009-01-22 | Zymogenetics, Inc., Seattle | Dimerisierter wachstumsfaktor sowie materialien und verfahren zu seiner herstellung |
| US6649072B2 (en) | 2001-11-16 | 2003-11-18 | Robert Brandt | Method for producing autologous platelet-rich plasma |
| AU2002365969A1 (en) | 2001-11-20 | 2003-06-10 | Scott Bruder | Flowable osteogenic and chondrogenic compositions |
| US7045105B2 (en) | 2001-12-21 | 2006-05-16 | Lagow Richard J | Calcium phosphate bone replacement materials and methods of use thereof |
| US20030180344A1 (en) | 2002-02-05 | 2003-09-25 | Cambridge Scientific, Inc. | Bioresorbable osteoconductive compositions for bone regeneration |
| AU2003210996A1 (en) | 2002-02-11 | 2003-09-04 | Zymogenetics, Inc. | Materials and methods for preparing dimeric growth factors |
| US7879107B2 (en) | 2002-02-20 | 2011-02-01 | The Cleveland Clinic Foundation | Composition and method for inducing bone growth and healing |
| DK175356B1 (da) | 2002-02-28 | 2004-09-06 | Coloplast As | Stomiindretning |
| JP3739715B2 (ja) | 2002-03-19 | 2006-01-25 | オリンパス株式会社 | 人工骨および組織工学用担体 |
| KR100460685B1 (ko) | 2002-04-10 | 2004-12-09 | 재단법인서울대학교산학협력재단 | 인산칼슘계 화합물을 이용한 인공 골 충진재 및 그 제조방법 |
| AU2003228587A1 (en) * | 2002-04-18 | 2003-11-03 | University Of Florida | Biomimetic organic/inorganic composites, processes for their production, and methods of use |
| CA2485090A1 (en) * | 2002-05-02 | 2003-12-24 | Osteoscreen, Inc. | Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates (no-bisphosphonate) |
| US20040033949A1 (en) | 2002-05-06 | 2004-02-19 | Genentech, Inc. | Use of VEGF for treating bone defects |
| US7368125B2 (en) | 2002-06-05 | 2008-05-06 | Ethicon, Inc. | Amphiphilic polymers for medical applications |
| US7041309B2 (en) | 2002-06-13 | 2006-05-09 | Neuropro Technologies, Inc. | Spinal fusion using an HMG-CoA reductase inhibitor |
| CA2432583A1 (en) | 2002-06-20 | 2003-12-20 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Method of preparing alpha- and beta-tricalcium phosphate powders |
| US20040002770A1 (en) | 2002-06-28 | 2004-01-01 | King Richard S. | Polymer-bioceramic composite for orthopaedic applications and method of manufacture thereof |
| ES2242916T3 (es) | 2002-07-11 | 2005-11-16 | Biomet Deutschland Gmbh | Metodos de preparacion de segmentos y granulos de fosfato de calcio poroso mediante procesamiento con gelatina. |
| US7744651B2 (en) | 2002-09-18 | 2010-06-29 | Warsaw Orthopedic, Inc | Compositions and methods for treating intervertebral discs with collagen-based materials |
| EP1563846B1 (en) | 2002-10-10 | 2012-08-29 | Ono Pharmaceutical Co., Ltd. | Endogenous repair factor production promoters |
| US20040078090A1 (en) | 2002-10-18 | 2004-04-22 | Francois Binette | Biocompatible scaffolds with tissue fragments |
| US7824701B2 (en) * | 2002-10-18 | 2010-11-02 | Ethicon, Inc. | Biocompatible scaffold for ligament or tendon repair |
| AU2003203316B2 (en) | 2003-02-13 | 2007-01-11 | Synthes Gmbh | Injectable bone-replacement mixture |
| US20040230309A1 (en) | 2003-02-14 | 2004-11-18 | Depuy Spine, Inc. | In-situ formed intervertebral fusion device and method |
| WO2004078069A2 (en) | 2003-03-05 | 2004-09-16 | Therics, Inc. | Process for manufacturing biomedical articles by infiltrating biocompatible metal alloys in porous matrices |
| US20040193270A1 (en) | 2003-03-31 | 2004-09-30 | Depuyacromed, Inc. | Implantable bone graft |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| KR20060031808A (ko) | 2003-06-11 | 2006-04-13 | 오스테오테크, 인코포레이티드 | 뼈 임플란트 및 그의 제조 방법 |
| US6974862B2 (en) | 2003-06-20 | 2005-12-13 | Kensey Nash Corporation | High density fibrous polymers suitable for implant |
| ATE396669T1 (de) | 2003-06-24 | 2008-06-15 | Robert Mathys Foundation Dr H | Prothesenvorrichtung zur wiederherstellung von knorpel |
| DE10328892A1 (de) | 2003-06-26 | 2005-05-12 | Curasan Ag | Knochenaufbaumittel und Herstellungsverfahren |
| ES2564044T3 (es) | 2003-06-27 | 2016-03-17 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido del cordón umbilical y métodos de preparación y uso de las mismas |
| FI20031120A0 (fi) | 2003-07-31 | 2003-07-31 | Bci Bioabsorbable Concepts Ltd | Monifunktionaalinen implanttilaite |
| US7163920B2 (en) | 2003-09-30 | 2007-01-16 | Ethicon, Inc. | Peptide with osteogenic activity |
| CU23352A1 (es) | 2003-10-16 | 2009-03-16 | Centro Nacional De Investigaciones Cientificas | Biomateriales compuestos para implantes óseos |
| NZ547140A (en) * | 2003-10-22 | 2009-09-25 | Encelle Inc | Bioactive hydrogel compositions in dehydrated form for regenerating connective tissue |
| US20050098915A1 (en) * | 2003-11-07 | 2005-05-12 | Smith & Nephew Inc. | Manufacture of bone graft substitutes |
| WO2005065079A2 (en) | 2003-11-10 | 2005-07-21 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
| MXPA06005358A (es) | 2003-11-14 | 2006-07-10 | Univ Pennsylvania | Metodo y aparato para el tratamiento de la osteoartritis, enfermedades de los cartilagos, defectos y lesiones en la cadena humana. |
| DE10355559A1 (de) | 2003-11-21 | 2005-06-23 | Orthogen Ag | Transskin |
| EP1537839A1 (en) | 2003-12-02 | 2005-06-08 | Dr. h. c. Robert Mathys Foundation | Prosthetic device for cartilage repair |
| WO2005072656A1 (en) | 2004-01-27 | 2005-08-11 | Osteotech, Inc. | Stabilized bone graft |
| US7189263B2 (en) * | 2004-02-03 | 2007-03-13 | Vita Special Purpose Corporation | Biocompatible bone graft material |
| US11395865B2 (en) | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
| US7671012B2 (en) | 2004-02-10 | 2010-03-02 | Biosurface Engineering Technologies, Inc. | Formulations and methods for delivery of growth factor analogs |
| US7928059B2 (en) | 2004-02-24 | 2011-04-19 | Wisconsin Alumni Research Foundation | Use of neuropeptides for traumatic cartilage injury |
| KR101013999B1 (ko) | 2004-03-19 | 2011-02-14 | 재단법인서울대학교산학협력재단 | 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트 |
| US20070190101A1 (en) | 2004-03-31 | 2007-08-16 | Chunlin Yang | Flowable bone grafts |
| WO2006031388A2 (en) | 2004-08-20 | 2006-03-23 | Hyperbranch Medical Technology, Inc. | Dentritic polymers, crosslinked gels, and their uses in orthopedic applications |
| CN101084025A (zh) | 2004-09-14 | 2007-12-05 | 新加坡科技研究局 | 多孔生物材料-填充物复合物及其制造方法 |
| CN101060821A (zh) | 2004-09-21 | 2007-10-24 | 麻省理工学院 | 梯度支架及其制备方法 |
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| US7250550B2 (en) | 2004-10-22 | 2007-07-31 | Wright Medical Technology, Inc. | Synthetic bone substitute material |
| WO2006050493A2 (en) | 2004-11-03 | 2006-05-11 | The Regents Of The University Of Michigan | Biodegradable implant for intertransverse process fusion |
| WO2007008250A2 (en) | 2004-12-07 | 2007-01-18 | Gelwell Biotech Corporation | Biomaterials for guided tissue regeneration and target drug delivery |
| US20060151383A1 (en) | 2005-01-12 | 2006-07-13 | Aaf-Mcquay Inc. | Pleated corrugated media and method of making |
| US7621963B2 (en) | 2005-04-13 | 2009-11-24 | Ebi, Llc | Composite bone graft material |
| US8268344B2 (en) * | 2005-04-27 | 2012-09-18 | The Regents Of The University Of Michigan | Particle-containing complex porous materials |
| EP1909810B2 (en) | 2005-06-07 | 2017-08-23 | The Regents of the University of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of graft rejection and promotion of graft survival |
| US20060287676A1 (en) * | 2005-06-15 | 2006-12-21 | Rita Prajapati | Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use |
| WO2007061889A2 (en) | 2005-11-17 | 2007-05-31 | Biomimetic Therapeutics, Inc. | Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix |
| US7749555B2 (en) | 2006-01-25 | 2010-07-06 | Medtronic, Inc | Modification of chemical forces of bone constructs |
| WO2007090102A2 (en) | 2006-01-27 | 2007-08-09 | The Regents Of The University Of California | Biomimetic scaffolds |
| US20070178159A1 (en) | 2006-01-30 | 2007-08-02 | Alza Corporation | In-Situ Forming Porous Scaffold |
| EP1991282B1 (en) * | 2006-02-09 | 2013-06-19 | BioMimetic Therapeutics, LLC | Compositions and methods for treating bone |
| US7833270B2 (en) | 2006-05-05 | 2010-11-16 | Warsaw Orthopedic, Inc | Implant depots to deliver growth factors to treat osteoporotic bone |
| WO2007133451A1 (en) | 2006-05-08 | 2007-11-22 | Nuvasive, Inc. | Cancellous bone treated with collegenase and essentially free of blood cells |
| US9161967B2 (en) * | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| CA2656278C (en) | 2006-06-30 | 2016-02-09 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating rotator cuff injuries |
| US8106008B2 (en) * | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| WO2008086486A1 (en) | 2007-01-10 | 2008-07-17 | The Regents Of The University Of Michigan | Porous objects having immobilized encapsulated biomolecules |
| WO2008103690A2 (en) | 2007-02-20 | 2008-08-28 | Biomimetic Therapeutics, Inc. | Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw using pdgf and a bone matrix |
| CN101820895A (zh) | 2007-06-04 | 2010-09-01 | 生物模拟治疗公司 | 用于治疗脊柱的组合物和方法 |
| CA2690457C (en) | 2007-06-15 | 2018-02-20 | Osteotech, Inc. | Bone matrix compositions and methods |
| WO2009042514A1 (en) | 2007-09-25 | 2009-04-02 | Integra Lifesciences Corporation | Flowable wound matrix and its preparation and use |
| KR20110067035A (ko) | 2008-09-09 | 2011-06-20 | 바이오미메틱 세라퓨틱스, 인크. | 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법 |
| BRPI0923015A2 (pt) | 2008-12-19 | 2015-12-15 | Biomimetic Therapeutics Inc | enxertos ósseos com atividade de protease reduzida e métodos de seleção e uso |
| AU2010221089A1 (en) * | 2009-03-05 | 2011-09-15 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects |
| MX2017004520A (es) | 2014-10-14 | 2018-03-15 | Lynch Samuel | Composiciones para tratar heridas. |
-
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- 2007-07-02 AU AU2007269712A patent/AU2007269712B2/en not_active Ceased
- 2007-07-02 WO PCT/US2007/015345 patent/WO2008005427A2/en not_active Ceased
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- 2007-07-02 JP JP2009518331A patent/JP5484047B2/ja not_active Expired - Fee Related
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|---|---|
| US20180360914A1 (en) | 2018-12-20 |
| WO2008005427A2 (en) | 2008-01-10 |
| US9642891B2 (en) | 2017-05-09 |
| WO2008005427A3 (en) | 2008-08-07 |
| US20180360915A1 (en) | 2018-12-20 |
| EP2049145B1 (en) | 2018-03-14 |
| CA2656278A1 (en) | 2008-01-10 |
| EP2049145A2 (en) | 2009-04-22 |
| US10456450B2 (en) | 2019-10-29 |
| US20220160835A1 (en) | 2022-05-26 |
| AU2007269712A1 (en) | 2008-01-10 |
| EP3381463A1 (en) | 2018-10-03 |
| AU2007269712B2 (en) | 2013-02-07 |
| JP5484047B2 (ja) | 2014-05-07 |
| ES2664229T3 (es) | 2018-04-18 |
| US20170202920A1 (en) | 2017-07-20 |
| JP2009542681A (ja) | 2009-12-03 |
| US20080027470A1 (en) | 2008-01-31 |
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