CA2653054A1 - Methods and systems for increasing production of equilibrium reactions - Google Patents
Methods and systems for increasing production of equilibrium reactions Download PDFInfo
- Publication number
- CA2653054A1 CA2653054A1 CA002653054A CA2653054A CA2653054A1 CA 2653054 A1 CA2653054 A1 CA 2653054A1 CA 002653054 A CA002653054 A CA 002653054A CA 2653054 A CA2653054 A CA 2653054A CA 2653054 A1 CA2653054 A1 CA 2653054A1
- Authority
- CA
- Canada
- Prior art keywords
- monatin
- reaction
- tryptophan
- pathway
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 claims abstract description 354
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- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 108010025593 phenylalanine (histidine) aminotransferase Proteins 0.000 description 1
- 108010078226 phenylalanine oxidase Proteins 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
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- 229920002492 poly(sulfone) Polymers 0.000 description 1
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- 229920000642 polymer Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108010004914 prolylarginine Proteins 0.000 description 1
- 108010029020 prolylglycine Proteins 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000007420 reactivation Effects 0.000 description 1
- 238000006268 reductive amination reaction Methods 0.000 description 1
- 238000001448 refractive index detection Methods 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000010517 secondary reaction Methods 0.000 description 1
- 238000001877 single-ion monitoring Methods 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229940047047 sodium arsenate Drugs 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80310506P | 2006-05-24 | 2006-05-24 | |
| US60/803,105 | 2006-05-24 | ||
| PCT/US2007/069513 WO2007140195A2 (en) | 2006-05-24 | 2007-05-23 | Methods and systems for increasing production of equilibrium reactions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2653054A1 true CA2653054A1 (en) | 2007-12-06 |
Family
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Family Applications (1)
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|---|---|---|---|
| CA002653054A Abandoned CA2653054A1 (en) | 2006-05-24 | 2007-05-23 | Methods and systems for increasing production of equilibrium reactions |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7888081B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2038405A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2009538145A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101490249A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007267618B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0711972A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2653054A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007140195A2 (cg-RX-API-DMAC7.html) |
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| US7297800B2 (en) | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
| US7572607B2 (en) * | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US8372989B2 (en) * | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| CA2714881C (en) | 2002-08-26 | 2012-10-23 | Ajinomoto Co., Inc. | Novel aldolase and production process of substituted .alpha.-keto acids |
| KR100723826B1 (ko) | 2002-12-09 | 2007-06-04 | 아지노모토 가부시키가이샤 | 변이형 ｄ－아미노트랜스퍼라제 및 이를 사용하는 광학활성글루탐산 유도체의 제조방법 |
| US7556660B2 (en) * | 2003-06-11 | 2009-07-07 | James Kevin Shurtleff | Apparatus and system for promoting a substantially complete reaction of an anhydrous hydride reactant |
| WO2005014839A2 (en) * | 2003-08-01 | 2005-02-17 | Cargill, Incorporated | Monatin tabletop sweetener compositions and methods of making same |
| DE602004006141T2 (de) * | 2003-08-14 | 2007-12-27 | Cargill, Inc., Wayzata | Monatinhaltige kaugummizusammensetzungen und verfahren zu ihrer herstellung |
| JP2007503214A (ja) * | 2003-08-25 | 2007-02-22 | カーギル，インコーポレイティド | モナチンを含む飲料組成物及びその製造方法 |
| US8206955B2 (en) * | 2003-10-21 | 2012-06-26 | Cargill, Incorporated | Production of monatin and monatin precursors |
| US8158389B2 (en) * | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| CN101223444B (zh) * | 2005-04-20 | 2013-04-24 | 嘉吉有限公司 | 在体内分泌莫纳甜的方法 |
| US7582455B2 (en) * | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US8076108B2 (en) * | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US20080020260A1 (en) * | 2005-11-12 | 2008-01-24 | Brydon Chris A | Apparatus, system, and method for manifolded integration of a humidification chamber for input gas for a proton exchange membrane fuel cell |
| WO2007103389A2 (en) * | 2006-03-07 | 2007-09-13 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
| US20090198072A1 (en) * | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
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| US7651542B2 (en) | 2006-07-27 | 2010-01-26 | Thulite, Inc | System for generating hydrogen from a chemical hydride |
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| US20090025293A1 (en) * | 2007-07-25 | 2009-01-29 | John Patton | Apparatus, system, and method for processing hydrogen gas |
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| US8003361B2 (en) * | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8367847B2 (en) * | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| DK2238242T5 (en) * | 2008-01-03 | 2015-08-03 | Basf Enzymes Llc | -Transferases and oxidoreductases, nucleic acids encoding FOR THEM, AND PROCESSES FOR THE STILL LING AND USE THEREOF |
| WO2009088482A1 (en) | 2008-01-03 | 2009-07-16 | Cargill, Incorporated | Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using |
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| WO2011082353A1 (en) * | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | Separation and purification of monatin |
| WO2012166406A1 (en) * | 2011-05-31 | 2012-12-06 | Cargill, Incorporated | Increasing product yield and/or throughput by supersaturation of substrate |
| EP2909327A1 (en) * | 2012-10-18 | 2015-08-26 | Sandoz AG | A process for preparing indoline derivatives |
| MX2016016335A (es) | 2014-06-13 | 2017-07-20 | Proslide Technology Inc | Atraccion acuatica. |
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| BRPI0609876A2 (pt) | 2005-04-26 | 2010-05-11 | Cargill Inc | método para produzir estereoisÈmeros de monatina ou sal desta, composição compreendendo um precursor de r-monatina e enzimas d-aminotransferase e racemase |
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| WO2007103389A2 (en) | 2006-03-07 | 2007-09-13 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
-
2007
- 2007-05-23 AU AU2007267618A patent/AU2007267618B2/en not_active Expired - Fee Related
- 2007-05-23 BR BRPI0711972-0A patent/BRPI0711972A2/pt not_active Application Discontinuation
- 2007-05-23 CN CNA200780027087XA patent/CN101490249A/zh active Pending
- 2007-05-23 WO PCT/US2007/069513 patent/WO2007140195A2/en not_active Ceased
- 2007-05-23 EP EP07784058A patent/EP2038405A4/en not_active Withdrawn
- 2007-05-23 CA CA002653054A patent/CA2653054A1/en not_active Abandoned
- 2007-05-23 US US11/752,492 patent/US7888081B2/en not_active Expired - Fee Related
- 2007-05-23 JP JP2009512277A patent/JP2009538145A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009538145A (ja) | 2009-11-05 |
| AU2007267618A1 (en) | 2007-12-06 |
| EP2038405A4 (en) | 2009-10-21 |
| EP2038405A2 (en) | 2009-03-25 |
| AU2007267618B2 (en) | 2013-07-18 |
| BRPI0711972A2 (pt) | 2012-01-10 |
| WO2007140195A3 (en) | 2008-10-16 |
| US7888081B2 (en) | 2011-02-15 |
| WO2007140195A2 (en) | 2007-12-06 |
| US20080015361A1 (en) | 2008-01-17 |
| CN101490249A (zh) | 2009-07-22 |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20150325 |