CA2398887C - 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents - Google Patents

2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents Download PDF

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Publication number
CA2398887C
CA2398887C CA002398887A CA2398887A CA2398887C CA 2398887 C CA2398887 C CA 2398887C CA 002398887 A CA002398887 A CA 002398887A CA 2398887 A CA2398887 A CA 2398887A CA 2398887 C CA2398887 C CA 2398887C
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CA
Canada
Prior art keywords
4alkyl
amino
optionally substituted
heterocyclic group
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002398887A
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English (en)
French (fr)
Other versions
CA2398887A1 (en
Inventor
Elizabeth Janet Pease
Emma Jane Williams
Robert Hugh Bradbury
Stuart Eric Pearson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
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AstraZeneca AB
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9886703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2398887(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CA2398887A1 publication Critical patent/CA2398887A1/en
Application granted granted Critical
Publication of CA2398887C publication Critical patent/CA2398887C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
CA002398887A 2000-03-01 2001-02-26 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents Expired - Lifetime CA2398887C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0004887.6A GB0004887D0 (en) 2000-03-01 2000-03-01 Chemical compounds
GB0004887.6 2000-03-01
PCT/GB2001/000829 WO2001064656A1 (en) 2000-03-01 2001-02-26 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents

Publications (2)

Publication Number Publication Date
CA2398887A1 CA2398887A1 (en) 2001-09-07
CA2398887C true CA2398887C (en) 2008-12-16

Family

ID=9886703

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002398887A Expired - Lifetime CA2398887C (en) 2000-03-01 2001-02-26 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents

Country Status (25)

Country Link
US (2) US6838464B2 (cg-RX-API-DMAC7.html)
EP (1) EP1278735B1 (cg-RX-API-DMAC7.html)
JP (2) JP2003525279A (cg-RX-API-DMAC7.html)
KR (2) KR20020075463A (cg-RX-API-DMAC7.html)
CN (1) CN1220684C (cg-RX-API-DMAC7.html)
AT (1) ATE472537T1 (cg-RX-API-DMAC7.html)
AU (2) AU2001233979B2 (cg-RX-API-DMAC7.html)
BE (1) BE2021C507I2 (cg-RX-API-DMAC7.html)
BR (1) BR0108879A (cg-RX-API-DMAC7.html)
CA (1) CA2398887C (cg-RX-API-DMAC7.html)
CY (2) CY1111093T1 (cg-RX-API-DMAC7.html)
DE (1) DE60142469D1 (cg-RX-API-DMAC7.html)
DK (1) DK1278735T3 (cg-RX-API-DMAC7.html)
ES (1) ES2346288T3 (cg-RX-API-DMAC7.html)
FR (1) FR21C1010I2 (cg-RX-API-DMAC7.html)
GB (1) GB0004887D0 (cg-RX-API-DMAC7.html)
HK (1) HK1053111B (cg-RX-API-DMAC7.html)
IL (2) IL150920A0 (cg-RX-API-DMAC7.html)
LU (1) LUC00197I2 (cg-RX-API-DMAC7.html)
MX (1) MXPA02007581A (cg-RX-API-DMAC7.html)
NO (2) NO325443B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ520502A (cg-RX-API-DMAC7.html)
PT (1) PT1278735E (cg-RX-API-DMAC7.html)
WO (1) WO2001064656A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200206192B (cg-RX-API-DMAC7.html)

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