CA2200871C - Aniline derivatives - Google Patents

Aniline derivatives Download PDF

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Publication number
CA2200871C
CA2200871C CA002200871A CA2200871A CA2200871C CA 2200871 C CA2200871 C CA 2200871C CA 002200871 A CA002200871 A CA 002200871A CA 2200871 A CA2200871 A CA 2200871A CA 2200871 C CA2200871 C CA 2200871C
Authority
CA
Canada
Prior art keywords
alkylamino
amino
formula
alkoxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002200871A
Other languages
English (en)
French (fr)
Other versions
CA2200871A1 (en
Inventor
Dearg Sutherland Brown
Jeffrey James Morris
Andrew Peter Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
AstraZeneca UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9422866A external-priority patent/GB9422866D0/en
Priority claimed from GBGB9507308.6A external-priority patent/GB9507308D0/en
Application filed by AstraZeneca UK Ltd filed Critical AstraZeneca UK Ltd
Publication of CA2200871A1 publication Critical patent/CA2200871A1/en
Application granted granted Critical
Publication of CA2200871C publication Critical patent/CA2200871C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002200871A 1994-11-12 1995-11-08 Aniline derivatives Expired - Fee Related CA2200871C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9422866A GB9422866D0 (en) 1994-11-12 1994-11-12 Aniline derivatives
GB9422866.5 1995-04-07
GB9507308.6 1995-04-07
GBGB9507308.6A GB9507308D0 (en) 1995-04-07 1995-04-07 Aniline derivatives
PCT/GB1995/002606 WO1996015118A1 (en) 1994-11-12 1995-11-08 Aniline derivatives

Publications (2)

Publication Number Publication Date
CA2200871A1 CA2200871A1 (en) 1996-05-23
CA2200871C true CA2200871C (en) 2008-08-19

Family

ID=26305974

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002200871A Expired - Fee Related CA2200871C (en) 1994-11-12 1995-11-08 Aniline derivatives

Country Status (16)

Country Link
US (1) US5821246A (en:Method)
EP (1) EP0790986B1 (en:Method)
JP (1) JP4011109B2 (en:Method)
AT (1) ATE175962T1 (en:Method)
AU (1) AU703328B2 (en:Method)
CA (1) CA2200871C (en:Method)
DE (1) DE69507505T2 (en:Method)
DK (1) DK0790986T3 (en:Method)
ES (1) ES2128092T3 (en:Method)
FI (1) FI119933B (en:Method)
IL (1) IL115959A (en:Method)
MX (1) MX9702956A (en:Method)
NO (1) NO307178B1 (en:Method)
NZ (1) NZ294917A (en:Method)
TW (1) TW321649B (en:Method)
WO (1) WO1996015118A1 (en:Method)

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DE69507505D1 (de) 1999-03-04
EP0790986A1 (en) 1997-08-27
DE69507505T2 (de) 1999-06-02
FI119933B (fi) 2009-05-15
US5821246A (en) 1998-10-13
AU703328B2 (en) 1999-03-25
CA2200871A1 (en) 1996-05-23
WO1996015118A1 (en) 1996-05-23
NO307178B1 (no) 2000-02-21
IL115959A (en) 2004-06-20
IL115959A0 (en) 1996-01-31
FI971970A0 (fi) 1997-05-07
ES2128092T3 (es) 1999-05-01
JPH10508616A (ja) 1998-08-25
NZ294917A (en) 1999-02-25
NO972152D0 (no) 1997-05-09
NO972152L (no) 1997-05-12
TW321649B (en:Method) 1997-12-01
ATE175962T1 (de) 1999-02-15
MX9702956A (es) 1997-06-28

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