CA2032513A1 - Derives de substitution d'isoxazolidines et d'isoxazolines comme intermediaires pour la delmopinol et preparation de la delmopinol utilisant ces intermediaires - Google Patents

Derives de substitution d'isoxazolidines et d'isoxazolines comme intermediaires pour la delmopinol et preparation de la delmopinol utilisant ces intermediaires

Info

Publication number
CA2032513A1
CA2032513A1 CA2032513A CA2032513A CA2032513A1 CA 2032513 A1 CA2032513 A1 CA 2032513A1 CA 2032513 A CA2032513 A CA 2032513A CA 2032513 A CA2032513 A CA 2032513A CA 2032513 A1 CA2032513 A1 CA 2032513A1
Authority
CA
Canada
Prior art keywords
delmopinol
intermediates
isoxazolines
preparation
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2032513A
Other languages
English (en)
Other versions
CA2032513C (fr
Inventor
Sven Hernestam
Bernt Thelin
Elisabeth Seifert
Arne Nilsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosurface Pharma AB
Original Assignee
Sven Hernestam
Bernt Thelin
Elisabeth Seifert
Arne Nilsson
Aktiebolaget Leo
Pharmacia Biosystems Aktiebolag
Kabi Pharmacia Aktiebolag
Pharmacia Aktiebolag
Pharmacia & Upjohn Aktiebolag
Biosurface Pharma Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE8901838A external-priority patent/SE8901838D0/xx
Priority claimed from SE8901837A external-priority patent/SE8901837D0/xx
Application filed by Sven Hernestam, Bernt Thelin, Elisabeth Seifert, Arne Nilsson, Aktiebolaget Leo, Pharmacia Biosystems Aktiebolag, Kabi Pharmacia Aktiebolag, Pharmacia Aktiebolag, Pharmacia & Upjohn Aktiebolag, Biosurface Pharma Ab filed Critical Sven Hernestam
Priority to CA002187114A priority Critical patent/CA2187114C/fr
Publication of CA2032513A1 publication Critical patent/CA2032513A1/fr
Application granted granted Critical
Publication of CA2032513C publication Critical patent/CA2032513C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Luminescent Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA002032513A 1989-05-24 1990-05-14 Derives de substitution d'isoxazolidines et d'isoxazolines comme intermediaires pour la delmopinol et preparation de la delmopinol utilisant ces intermediaires Expired - Lifetime CA2032513C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002187114A CA2187114C (fr) 1989-05-24 1990-05-14 Procede de preparation de delpominol en utilisant des derives de subsitution d'isoxazolidines et d'isoxazolines

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE8901838A SE8901838D0 (sv) 1989-05-24 1989-05-24 New process and intermediates
SE8901837-8 1989-05-24
SE8901837A SE8901837D0 (sv) 1989-05-24 1989-05-24 Substituted isoxazolidines and isoxazolines
SE8901838-6 1989-05-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002187114A Division CA2187114C (fr) 1989-05-24 1990-05-14 Procede de preparation de delpominol en utilisant des derives de subsitution d'isoxazolidines et d'isoxazolines

Publications (2)

Publication Number Publication Date
CA2032513A1 true CA2032513A1 (fr) 1990-11-25
CA2032513C CA2032513C (fr) 1996-12-17

Family

ID=26660511

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002032513A Expired - Lifetime CA2032513C (fr) 1989-05-24 1990-05-14 Derives de substitution d'isoxazolidines et d'isoxazolines comme intermediaires pour la delmopinol et preparation de la delmopinol utilisant ces intermediaires
CA002187114A Expired - Lifetime CA2187114C (fr) 1989-05-24 1990-05-14 Procede de preparation de delpominol en utilisant des derives de subsitution d'isoxazolidines et d'isoxazolines

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002187114A Expired - Lifetime CA2187114C (fr) 1989-05-24 1990-05-14 Procede de preparation de delpominol en utilisant des derives de subsitution d'isoxazolidines et d'isoxazolines

Country Status (26)

Country Link
US (1) US5155220A (fr)
EP (1) EP0426826B1 (fr)
JP (1) JP3042876B2 (fr)
KR (1) KR0176248B1 (fr)
CN (1) CN1039325C (fr)
AT (1) ATE104968T1 (fr)
AU (1) AU631648B2 (fr)
CA (2) CA2032513C (fr)
DD (1) DD300104A5 (fr)
DE (1) DE69008486T2 (fr)
DK (1) DK0426826T3 (fr)
ES (1) ES2053195T3 (fr)
FI (1) FI97057C (fr)
GE (1) GEP19971047B (fr)
GR (1) GR1001407B (fr)
HU (1) HU205118B (fr)
IE (1) IE65640B1 (fr)
IL (1) IL94427A (fr)
LV (1) LV10276B (fr)
MD (1) MD423C2 (fr)
NO (2) NO179870C (fr)
NZ (1) NZ233730A (fr)
PH (1) PH31619A (fr)
PT (1) PT94131B (fr)
RU (1) RU2042670C1 (fr)
WO (1) WO1990014342A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147632A (en) * 1990-10-31 1992-09-15 Warner-Lambert Company Anti-plaque compositions comprising a combination of morpholinoamino alcohol and chelating agent
GB9226857D0 (en) * 1992-12-23 1993-02-17 Boyd Edward A Pharmaceutical compositions
US5552757A (en) * 1994-05-27 1996-09-03 Littelfuse, Inc. Surface-mounted fuse device
US6878004B2 (en) * 2002-03-04 2005-04-12 Littelfuse, Inc. Multi-element fuse array
ES2278321T3 (es) 2003-06-12 2007-08-01 Btg International Limited Hidroxilamina ciclica como compuestos psicoactivos.
DE112004002301T5 (de) * 2003-11-26 2006-09-28 Littelfuse, Inc., Des Plaines Elektrische Schutzeinrichtung für ein Fahrzeug und System, das diese einsetzt
GB0523435D0 (en) * 2005-11-17 2005-12-28 Sinclair Pharmaceuticals Ltd Process
EP3184150B1 (fr) 2005-11-22 2019-06-19 Maelor Laboratories Limited Traitement des infections de poche sous-gingivale
GB0602424D0 (en) * 2006-02-07 2006-03-22 Sinclair Pharmaceuticals Ltd Compounds
GB0604018D0 (en) 2006-02-28 2006-04-05 Sinclair Pharmaceuticals Ltd Method
GB0615814D0 (en) 2006-08-09 2006-09-20 Sinclair Pharmaceuticals Ltd Medicament
GB201105162D0 (en) 2011-03-28 2011-05-11 Lane Jonathan Improved deodorant formulations
IT201600130642A1 (it) 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione di 2(3 alchilmorfolino)-etan-1-olo
IT201600130538A1 (it) 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione del delmopinolo
IT201600130729A1 (it) 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione degli intermedi del delmopinolo
IT201700076821A1 (it) 2017-08-24 2019-02-24 Lundbeck Pharmaceuticals Italy S P A Nuovo sale del delmopinolo
WO2021155350A1 (fr) * 2020-01-31 2021-08-05 You First Services, Inc. Procédés de fabrication de delmopinol et de sels de celui-ci

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE439011B (sv) * 1980-03-21 1985-05-28 Ferrosan Ab Morfolinoforeningar, kompositioner innehallande dessa och anvendning derav
JPS59164762A (ja) * 1983-03-09 1984-09-17 Univ Osaka 第２アミンからニトロンを合成する方法

Also Published As

Publication number Publication date
FI910148A0 (fi) 1991-01-11
IL94427A0 (en) 1991-03-10
ES2053195T3 (es) 1994-07-16
HUT57215A (en) 1991-11-28
JPH04500219A (ja) 1992-01-16
IL94427A (en) 1994-07-31
NO910131D0 (no) 1991-01-11
NO911873D0 (no) 1991-05-14
FI97057C (fi) 1996-10-10
JP3042876B2 (ja) 2000-05-22
EP0426826A1 (fr) 1991-05-15
CA2032513C (fr) 1996-12-17
EP0426826B1 (fr) 1994-04-27
NO910131L (no) 1991-01-11
NO180120C (no) 1997-02-19
GR900100397A (en) 1991-10-10
AU5675890A (en) 1990-12-18
HU205118B (en) 1992-03-30
LV10276B (en) 1995-08-20
NO179870C (no) 1997-01-02
RU2042670C1 (ru) 1995-08-27
US5155220A (en) 1992-10-13
IE65640B1 (en) 1995-11-15
KR0176248B1 (en) 1999-03-20
DE69008486T2 (de) 1994-09-15
GR1001407B (el) 1993-11-30
ATE104968T1 (de) 1994-05-15
FI97057B (fi) 1996-06-28
NZ233730A (en) 1992-09-25
PT94131A (pt) 1991-01-08
GEP19971047B (en) 1997-11-26
NO180120B (no) 1996-11-11
AU631648B2 (en) 1992-12-03
DK0426826T3 (da) 1994-07-04
MD423C2 (ro) 1996-09-30
CN1039325C (zh) 1998-07-29
DD300104A5 (de) 1992-05-21
NO179870B (no) 1996-09-23
CA2187114C (fr) 2002-03-19
LV10276A (lv) 1994-10-20
HU905108D0 (en) 1991-07-29
NO911873L (no) 1991-01-11
WO1990014342A1 (fr) 1990-11-29
CA2187114A1 (fr) 1990-11-25
CN1048218A (zh) 1991-01-02
PH31619A (en) 1999-01-12
DE69008486D1 (de) 1994-06-01
KR920701181A (ko) 1992-08-11
IE901748L (en) 1990-11-24
PT94131B (pt) 1997-01-31

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