CA2006718C - Antibacterial antiplaque, anticalculus oral composition - Google Patents
Antibacterial antiplaque, anticalculus oral composition Download PDFInfo
- Publication number
- CA2006718C CA2006718C CA002006718A CA2006718A CA2006718C CA 2006718 C CA2006718 C CA 2006718C CA 002006718 A CA002006718 A CA 002006718A CA 2006718 A CA2006718 A CA 2006718A CA 2006718 C CA2006718 C CA 2006718C
- Authority
- CA
- Canada
- Prior art keywords
- agent
- antibacterial
- oral composition
- enhancing
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 128
- 230000002272 anti-calculus Effects 0.000 title claims abstract description 48
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 31
- 230000002882 anti-plaque Effects 0.000 title claims abstract description 25
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 96
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 68
- 229920000388 Polyphosphate Polymers 0.000 claims abstract description 44
- 239000001205 polyphosphate Substances 0.000 claims abstract description 44
- 235000011176 polyphosphates Nutrition 0.000 claims abstract description 44
- 230000014759 maintenance of location Effects 0.000 claims abstract description 27
- 235000011180 diphosphates Nutrition 0.000 claims abstract description 15
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims abstract description 14
- 239000000551 dentifrice Substances 0.000 claims abstract description 10
- 239000002324 mouth wash Substances 0.000 claims abstract description 10
- 229940051866 mouthwash Drugs 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 55
- -1 alkali metal pyrophosphate Chemical class 0.000 claims description 45
- 150000003839 salts Chemical class 0.000 claims description 30
- 239000000463 material Substances 0.000 claims description 27
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 27
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 27
- 229920000642 polymer Polymers 0.000 claims description 26
- 229920005646 polycarboxylate Polymers 0.000 claims description 24
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 23
- 229910052700 potassium Inorganic materials 0.000 claims description 23
- 239000011591 potassium Substances 0.000 claims description 23
- 229910052783 alkali metal Inorganic materials 0.000 claims description 20
- 125000000129 anionic group Chemical group 0.000 claims description 20
- 229920001577 copolymer Polymers 0.000 claims description 20
- 230000002708 enhancing effect Effects 0.000 claims description 20
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 16
- 150000001340 alkali metals Chemical group 0.000 claims description 16
- 229910052708 sodium Inorganic materials 0.000 claims description 16
- 239000011734 sodium Substances 0.000 claims description 16
- 239000000178 monomer Substances 0.000 claims description 13
- 229940048084 pyrophosphate Drugs 0.000 claims description 13
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 12
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 12
- 125000000524 functional group Chemical group 0.000 claims description 12
- 238000005498 polishing Methods 0.000 claims description 12
- 150000002500 ions Chemical class 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 150000008064 anhydrides Chemical class 0.000 claims description 8
- 239000003906 humectant Substances 0.000 claims description 8
- 125000000962 organic group Chemical group 0.000 claims description 8
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000002091 cationic group Chemical group 0.000 claims description 7
- 159000000000 sodium salts Chemical class 0.000 claims description 7
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 6
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- 229960003742 phenol Drugs 0.000 claims description 6
- 150000002989 phenols Chemical class 0.000 claims description 6
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 6
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 6
- PGKQTZHDCHKDQK-UHFFFAOYSA-N 2-phenylethenylphosphonic acid Chemical compound OP(O)(=O)C=CC1=CC=CC=C1 PGKQTZHDCHKDQK-UHFFFAOYSA-N 0.000 claims description 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 5
- 125000004429 atom Chemical group 0.000 claims description 5
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 5
- 230000002378 acidificating effect Effects 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 150000003460 sulfonic acids Chemical class 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 3
- 239000005770 Eugenol Substances 0.000 claims description 3
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 3
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- 229920006318 anionic polymer Polymers 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 3
- 229960002217 eugenol Drugs 0.000 claims description 3
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical group COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 3
- 229960000790 thymol Drugs 0.000 claims description 3
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 claims description 2
- 239000003349 gelling agent Substances 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 238000000034 method Methods 0.000 claims 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 abstract description 10
- 229960003500 triclosan Drugs 0.000 abstract description 8
- 229910052751 metal Inorganic materials 0.000 abstract description 6
- 239000002184 metal Substances 0.000 abstract description 6
- 229940112822 chewing gum Drugs 0.000 abstract description 5
- 235000015218 chewing gum Nutrition 0.000 abstract description 5
- 239000007937 lozenge Substances 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 description 19
- 150000001875 compounds Chemical class 0.000 description 18
- 239000000606 toothpaste Substances 0.000 description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 12
- 229940034610 toothpaste Drugs 0.000 description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 11
- 210000003296 saliva Anatomy 0.000 description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 8
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 8
- 239000000499 gel Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000000600 sorbitol Substances 0.000 description 8
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- 229910052588 hydroxylapatite Inorganic materials 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 7
- 239000011775 sodium fluoride Substances 0.000 description 7
- 235000013024 sodium fluoride Nutrition 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
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- 239000000796 flavoring agent Substances 0.000 description 5
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- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
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- 125000005341 metaphosphate group Chemical group 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 3
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- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 2
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
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- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39860589A | 1989-08-25 | 1989-08-25 | |
| US398,605 | 1989-08-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2006718A1 CA2006718A1 (en) | 1991-02-25 |
| CA2006718C true CA2006718C (en) | 2000-11-14 |
Family
ID=23576018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002006718A Expired - Lifetime CA2006718C (en) | 1989-08-25 | 1989-12-27 | Antibacterial antiplaque, anticalculus oral composition |
Country Status (40)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE507731C2 (sv) * | 1988-12-29 | 1998-07-06 | Colgate Palmolive Co | Antibakteriell oral antiplaquekomposition |
| JP2690371B2 (ja) * | 1989-09-29 | 1997-12-10 | 株式会社クラレ | 歯科用組成物 |
| US5252313A (en) * | 1991-12-20 | 1993-10-12 | Colgate-Palmolive Company | Visually clear gel dentifrice |
| US5192533A (en) * | 1992-03-25 | 1993-03-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Nonirritating antitartar and antiplaque oral compositions |
| ES2092967B1 (es) * | 1995-06-01 | 1997-08-01 | Compania Anonima De Importacio | Composicion dentifrica en forma de comprimido. |
| SK284210B6 (en) * | 1996-02-08 | 2004-11-03 | Warner Lambert Co | Anticalculus dentifrice containing highly soluble pyrophosphate |
| WO1999032073A1 (en) | 1997-12-22 | 1999-07-01 | Ciba Specialty Chemicals Holding, Inc. | Use of polyanionic and polyanionically-derivatised natural polysaccharides for inhibiting alkaline phosphatase |
| AU5982199A (en) * | 1998-10-06 | 2000-04-26 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of 4,4'-dihalogen-o-hydroxydiphenyl compounds |
| RU2145209C1 (ru) * | 1999-06-24 | 2000-02-10 | Открытое акционерное общество косметическое объединение "Свобода" | Лечебно-профилактическая зубная паста |
| US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| RU2153322C1 (ru) * | 1999-12-22 | 2000-07-27 | Общество с ограниченной ответственностью Институт фармацевтических реактивов "Рефарм" | Зубная паста |
| EP1255526A1 (en) * | 2000-01-27 | 2002-11-13 | The Procter & Gamble Company | Improved low-cost dentifrice composition |
| US6315987B1 (en) * | 2000-05-10 | 2001-11-13 | Isp Investments Inc. | Polymeric delivery and release systems for oral care actives |
| AU2002308717A1 (en) * | 2001-05-15 | 2002-11-25 | The Procter And Gamble Company | Confectionery compositions |
| US6723305B2 (en) * | 2002-03-04 | 2004-04-20 | Colgate Palmolive Company | Anti-microbial breath freshening mouthrinse |
| FR2872430B1 (fr) * | 2004-06-30 | 2009-01-09 | Royal Canin S A Sa | Procede d'inhibition de l'effet probiotique des proteines alimentaires vis-a-vis de la microflore bacterienne buccale des carnivores domestiques |
| US8895084B2 (en) | 2004-12-23 | 2014-11-25 | Colgate-Palmolive Company | Oral care composition containing extract of unoxidized Camellia |
| BRPI0608631A2 (pt) * | 2005-03-18 | 2010-11-30 | Colgate Palmolive Co | composição oral antiplaca, pasta de dentes ou composição em gel, e, método para inibir crescimento bacteriano na cavidade oral de um animal |
| US20070041914A1 (en) * | 2005-08-17 | 2007-02-22 | Colgate-Palmolive Company | Inhibition of bacterial deposition on oral surfaces |
| MX2008013618A (es) | 2006-05-09 | 2008-10-30 | Colgate Palmolive Co | Regimen para el cuidado oral. |
| EP1891984A1 (en) * | 2006-08-24 | 2008-02-27 | Graftys | Macroporous and highly resorbable apatitic calcium-phosphate cement |
| US20090087461A1 (en) * | 2007-10-01 | 2009-04-02 | Thomas James Boyd | Anti-bacterial pyrocatechols and related methods |
| EP2249788B1 (en) * | 2008-02-08 | 2018-01-03 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| US9724278B2 (en) | 2008-06-13 | 2017-08-08 | Colgate-Palmolive Company | Oral compositions and uses thereof |
| SG189861A1 (en) | 2010-11-12 | 2013-06-28 | Colgate Palmolive Co | Oral care product and methods of use and manufacture thereof |
| RU2452477C1 (ru) * | 2011-01-12 | 2012-06-10 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) | Антибактериальная и антимикотическая композиция широкого спектра действия на основе солей фосфония и замещенного бензофуроксана |
| GB201121300D0 (en) | 2011-12-12 | 2012-01-25 | Glaxo Group Ltd | Novel composition |
| EP2790656B1 (en) * | 2011-12-15 | 2016-11-02 | Colgate-Palmolive Company | Aqueous oral care compositions |
| CN102512337B (zh) * | 2012-01-10 | 2013-04-24 | 广州薇美姿个人护理用品有限公司 | 一种益晚牙膏和一种益早益晚组合牙膏 |
| ES2684637T3 (es) | 2014-11-04 | 2018-10-03 | The Procter & Gamble Company | Composiciones para el cuidado bucal antisarro que proporcionan prevención de cristalización |
| EP3017807B1 (en) | 2014-11-04 | 2019-01-16 | The Procter and Gamble Company | Anti-tatar oral care compositions providing crystallisation prevention |
| CN105496797A (zh) * | 2015-12-14 | 2016-04-20 | 天津君润新材料科技有限公司 | 一种光固化防龋用氟化物涂膜 |
| CN110559211B (zh) * | 2019-10-10 | 2022-05-20 | 重庆登康口腔护理用品股份有限公司 | 一种抑菌防龋组合物及其制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138477A (en) * | 1976-05-28 | 1979-02-06 | Colgate Palmolive Company | Composition to control mouth odor |
| US4217343A (en) * | 1977-12-19 | 1980-08-12 | Colgate Palmolive Company | Magnesium polycarboxylate complexes as anticalculus agents |
| JPS5793904A (en) * | 1980-12-03 | 1982-06-11 | Lion Corp | Composition for oral cavity |
| US4342857A (en) * | 1980-12-31 | 1982-08-03 | Colgate-Palmolive Company | Antigingivitis composition comprising vinyl phosphonic acid/vinyl phosphonyl fluoride copolymer |
| PH22221A (en) * | 1982-06-22 | 1988-06-28 | Procter & Gamble | Oral compositions |
| JPS5988416A (ja) * | 1982-11-15 | 1984-05-22 | ジヨンソン・エンド・ジヨンソン・プロダクツ・インコ−ポレ−テツド | 口腔衛生組成物 |
| DE3445695A1 (de) * | 1983-12-28 | 1985-07-11 | Colgate-Palmolive Co., New York, N.Y. | Mittel zur oral-dentalen anwendung gegen plaque und gingivitis |
| US4816245A (en) * | 1983-12-28 | 1989-03-28 | Colgate-Palmolive Company | Antiplaque/antigingivitis method using certain polyphosphonic acids |
| US4806340A (en) * | 1985-09-13 | 1989-02-21 | Colgate-Palmolive Company | Anticalculus oral composition |
| US4627977A (en) * | 1985-09-13 | 1986-12-09 | Colgate-Palmolive Company | Anticalculus oral composition |
| US4770324A (en) * | 1985-12-13 | 1988-09-13 | Colgate-Palmolive Company | Dental cream package |
| DK111187D0 (da) * | 1986-03-05 | 1987-03-04 | Monsanto Co | Tandbehandlingsmiddel |
| DE3607480A1 (de) * | 1986-03-07 | 1987-09-10 | Blendax Werke Schneider Co | Zahnpasta |
| EP0249398A3 (en) * | 1986-06-09 | 1989-07-19 | The Procter & Gamble Company | Oral compositions |
| GB8615534D0 (en) * | 1986-06-25 | 1986-07-30 | Beecham Group Plc | Composition |
| GB2201593A (en) * | 1987-01-30 | 1988-09-07 | Procter & Gamble | Toothpaste compositions |
| IN168400B (enrdf_load_stackoverflow) * | 1987-01-30 | 1991-03-23 | Colgate Palmolive Co | |
| GB2204487A (en) * | 1987-05-13 | 1988-11-16 | Procter & Gamble | Oral compositions |
| EP0311412A3 (en) * | 1987-10-08 | 1989-05-17 | The Procter & Gamble Company | Anticalculus compositions |
| SE8904179L (sv) * | 1988-12-29 | 1990-06-30 | Colgate Palmolive Co | Foerpackade orala anti-plaquekompositioner |
| SE507731C2 (sv) * | 1988-12-29 | 1998-07-06 | Colgate Palmolive Co | Antibakteriell oral antiplaquekomposition |
-
1989
- 1989-12-12 SE SE8904181A patent/SE512333C2/sv unknown
- 1989-12-13 IL IL9269489A patent/IL92694A/en not_active IP Right Cessation
- 1989-12-13 AU AU46766/89A patent/AU640355B2/en not_active Expired
- 1989-12-18 ZM ZM50/89A patent/ZM5089A1/xx unknown
- 1989-12-21 GB GB8928953A patent/GB2235133B/en not_active Expired - Lifetime
- 1989-12-21 GR GR890100854A patent/GR1000860B/el not_active IP Right Cessation
- 1989-12-22 IT IT04869689A patent/IT1237484B/it active IP Right Grant
- 1989-12-22 DE DE3942644A patent/DE3942644B4/de not_active Expired - Lifetime
- 1989-12-25 DZ DZ890196A patent/DZ1381A1/fr active
- 1989-12-26 MA MA21973A patent/MA21711A1/fr unknown
- 1989-12-26 EG EG63789A patent/EG19386A/xx active
- 1989-12-27 MY MYPI89001863A patent/MY105878A/en unknown
- 1989-12-27 CA CA002006718A patent/CA2006718C/en not_active Expired - Lifetime
- 1989-12-27 CH CH4655/89A patent/CH680111A5/de not_active IP Right Cessation
- 1989-12-27 PT PT92733A patent/PT92733B/pt not_active IP Right Cessation
- 1989-12-28 KR KR1019890020631A patent/KR0156549B1/ko not_active Expired - Fee Related
- 1989-12-28 IE IE419689A patent/IE894196A1/en not_active IP Right Cessation
- 1989-12-28 CZ CS897509A patent/CZ283162B6/cs not_active IP Right Cessation
- 1989-12-28 FI FI896318A patent/FI97443C/fi not_active IP Right Cessation
- 1989-12-28 CN CN89109474A patent/CN1071110C/zh not_active Expired - Lifetime
- 1989-12-28 DK DK198906712A patent/DK175758B1/da not_active IP Right Cessation
- 1989-12-28 ES ES8904395A patent/ES2023295A6/es not_active Expired - Lifetime
- 1989-12-28 HU HU896807A patent/HU210575B/hu unknown
- 1989-12-28 ZA ZA899973A patent/ZA899973B/xx unknown
- 1989-12-28 RU SU894742780A patent/RU2066180C1/ru active
- 1989-12-28 FR FR8917374A patent/FR2651124B1/fr not_active Expired - Lifetime
- 1989-12-28 NO NO895311A patent/NO179161C/no unknown
- 1989-12-28 SK SK7509-89A patent/SK280834B6/sk not_active IP Right Cessation
- 1989-12-29 AT AT0296689A patent/AT400000B/de not_active IP Right Cessation
- 1989-12-29 PL PL89283116A patent/PL163551B1/pl unknown
- 1989-12-29 LU LU87651A patent/LU87651A1/fr unknown
- 1989-12-29 DD DD89336812A patent/DD291244A5/de unknown
- 1989-12-29 BR BR898906854A patent/BR8906854A/pt not_active Application Discontinuation
- 1989-12-29 NL NL8903185A patent/NL8903185A/nl active Search and Examination
- 1989-12-29 OA OA59718A patent/OA09254A/xx unknown
- 1989-12-29 TR TR00074/90A patent/TR28621A/xx unknown
- 1989-12-29 BE BE8901398A patent/BE1004240A4/fr not_active IP Right Cessation
-
1990
- 1990-01-04 JP JP2000214A patent/JP2506473B2/ja not_active Expired - Fee Related
- 1990-05-11 TW TW079103808A patent/TW215056B/zh active
-
1993
- 1993-03-18 GB GB9305553A patent/GB2263066B/en not_active Expired - Lifetime
- 1993-06-17 RU RU93029619A patent/RU2116781C1/ru active
- 1993-11-26 AU AU51999/93A patent/AU673014B2/en not_active Expired
-
1997
- 1997-05-29 HK HK70597A patent/HK70597A/xx not_active IP Right Cessation
- 1997-05-29 HK HK70697A patent/HK70697A/xx not_active IP Right Cessation
- 1997-10-13 SE SE9703714A patent/SE513702C2/sv unknown
- 1997-10-13 SE SE9703715A patent/SE523627C2/sv unknown
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