CA1323366C - (1h-imidazol-1-ylmethyl) substituted benzimidazole derivatives - Google Patents

(1h-imidazol-1-ylmethyl) substituted benzimidazole derivatives

Info

Publication number
CA1323366C
CA1323366C CA000546763A CA546763A CA1323366C CA 1323366 C CA1323366 C CA 1323366C CA 000546763 A CA000546763 A CA 000546763A CA 546763 A CA546763 A CA 546763A CA 1323366 C CA1323366 C CA 1323366C
Authority
CA
Canada
Prior art keywords
6alkyl
substituted
formula
parts
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000546763A
Other languages
English (en)
French (fr)
Inventor
Alfons Herman Margaretha Raeymaekers
Eddy Jean Edgard Freyne
Gerard Charles Sanz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of CA1323366C publication Critical patent/CA1323366C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000546763A 1986-09-15 1987-09-14 (1h-imidazol-1-ylmethyl) substituted benzimidazole derivatives Expired - Lifetime CA1323366C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90790386A 1986-09-15 1986-09-15
US907,903 1986-09-15

Publications (1)

Publication Number Publication Date
CA1323366C true CA1323366C (en) 1993-10-19

Family

ID=25424835

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000546763A Expired - Lifetime CA1323366C (en) 1986-09-15 1987-09-14 (1h-imidazol-1-ylmethyl) substituted benzimidazole derivatives

Country Status (23)

Country Link
EP (1) EP0260744B1 (enEXAMPLES)
JP (1) JPS6485975A (enEXAMPLES)
KR (1) KR960014353B1 (enEXAMPLES)
CN (1) CN1020903C (enEXAMPLES)
AU (1) AU595064B2 (enEXAMPLES)
BG (1) BG61321B2 (enEXAMPLES)
CA (1) CA1323366C (enEXAMPLES)
CY (1) CY1803A (enEXAMPLES)
DE (1) DE3783107T2 (enEXAMPLES)
DK (1) DK174728B1 (enEXAMPLES)
ES (1) ES2053524T3 (enEXAMPLES)
FI (1) FI87781C (enEXAMPLES)
GR (1) GR3006841T3 (enEXAMPLES)
HK (1) HK123694A (enEXAMPLES)
HU (1) HU198039B (enEXAMPLES)
IE (1) IE60514B1 (enEXAMPLES)
IL (1) IL83892A (enEXAMPLES)
NO (1) NO167202C (enEXAMPLES)
NZ (1) NZ221729A (enEXAMPLES)
PH (1) PH25022A (enEXAMPLES)
PT (1) PT85692B (enEXAMPLES)
SU (1) SU1662350A3 (enEXAMPLES)
ZA (1) ZA876881B (enEXAMPLES)

Families Citing this family (58)

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CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
GB8827820D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
CA2002864C (en) * 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
FR2643903A1 (fr) * 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
PT95899A (pt) * 1989-11-17 1991-09-13 Glaxo Group Ltd Processo para a preparacao de derivados indole
US5021448A (en) * 1990-02-22 1991-06-04 Ciba-Geigy Corporation Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist
FR2663028B1 (fr) * 1990-06-08 1994-10-14 Roussel Uclaf Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5216003A (en) * 1992-01-02 1993-06-01 G. D. Searle & Co. Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
AU7275894A (en) * 1993-08-04 1995-02-28 Yamanouchi Pharmaceutical Co., Ltd. Imidazolylalkylamine derivative and pharmaceutical composition thereof
CN1131944A (zh) * 1993-09-30 1996-09-25 山之内制药株式会社 唑类衍生物和它的药物组合物
JPH09508915A (ja) * 1994-02-18 1997-09-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フェンノートシヤツプ 鏡像異性体的に純粋な(−)−リアロゾール
EP0745077A1 (en) * 1994-02-18 1996-12-04 Janssen Pharmaceutica N.V. Enantiomerically pure (+)-liarozole
GB9418443D0 (en) * 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
DK0800519T3 (da) * 1994-12-22 2004-03-01 Ligand Pharm Inc Steroidreceptormodulatorforbindelser og fremgangsmåder
US6696459B1 (en) 1994-12-22 2004-02-24 Ligand Pharmaceuticals Inc. Steroid receptor modulator compounds and methods
US5688810A (en) * 1994-12-22 1997-11-18 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
TW316902B (enEXAMPLES) * 1994-12-28 1997-10-01 Janssen Pharmaceutica Nv
PL322028A1 (en) * 1995-03-01 1998-01-05 Yamanouchi Pharma Co Ltd Derivatives of imidazoles and pharmaceutic composition containing them
US6288100B1 (en) * 1995-06-06 2001-09-11 American Home Products Corporation Benzimidazole derivatives
DE19535500A1 (de) * 1995-09-25 1997-03-27 Bayer Ag Verfahren zur Herstellung von 3-Chlor-3'-nitro-4'-methoxybenzophenon
ES2244979T3 (es) * 1995-12-28 2005-12-16 Fujisawa Pharmaceutical Co., Ltd. Derivados de benzimidazol.
KR100365312B1 (ko) 1996-06-27 2003-03-06 얀센 파마슈티카 엔.브이. N-[4-(헤테로아릴메틸)페닐]헤테로아릴아민
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
CN1104422C (zh) * 1996-11-25 2003-04-02 普罗克特和甘保尔公司 用作α-2肾上腺素能受体兴奋剂的胍基杂环化合物
US6420375B1 (en) 1997-02-21 2002-07-16 Takeda Chemical Industries, Ltd. Fused ring compounds, process for producing the same and use thereof
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
ES2224462T3 (es) * 1997-12-11 2005-03-01 Janssen Pharmaceutica N.V. Anilidas mimeticas del acido retinoico.
DE19831985A1 (de) 1998-07-16 2000-01-20 Bayer Ag Substituierte Benzimidazole, ihre Herstellung und ihre Verwendung als Mittel gegen parasitäre Protozoen
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
ATE256666T1 (de) * 1999-06-04 2004-01-15 Elan Pharma Int Ltd Zusammensetzungen und methoden zur verhinderung des zelltods
RU2268258C2 (ru) 2000-03-16 2006-01-20 Ф.Хоффманн-Ля Рош Аг Производные карбоновых кислот в качестве антагонистов ip
DE60119963T2 (de) 2000-11-17 2006-10-05 Takeda Pharmaceutical Co. Ltd. Imidazol derivate, ihre herstellung und ihre verwendung
WO2002040470A1 (fr) 2000-11-20 2002-05-23 Takeda Chemical Industries, Ltd. Derives de l'imidazole, leur procede de preparation et leur application
AU2002221080A1 (en) 2000-12-08 2002-06-18 Masami Kusaka Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparingthe same and use thereof
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
US6492517B1 (en) * 2001-07-19 2002-12-10 Air Products And Chemicals, Inc. Method for preparing halomethyl heterocyclic compounds
EP1452528B1 (en) * 2001-11-16 2008-08-13 Nippon Chemiphar Co., Ltd. Xanthine oxidase inhibitors
CA2504448C (en) * 2002-11-01 2012-06-19 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
EP1654221A2 (en) * 2003-06-10 2006-05-10 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
FR2860235A1 (fr) * 2003-09-29 2005-04-01 Yang Ji Chemical Company Ltd Utilisation d'un compose de formule (i) inhibiteur de l'aromatase a des fins therapeutiques et composes de formule (i) en tant que tels
WO2006076009A2 (en) 2004-04-23 2006-07-20 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
CA2582347C (en) * 2004-09-30 2014-09-23 Janssen Pharmaceutica N.V. Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
EP1805147B1 (en) * 2004-09-30 2014-08-13 Janssen Pharmaceutica NV Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
PL1984343T3 (pl) * 2006-01-24 2013-08-30 Janssen Pharmaceutica Nv 2-podstawione benzimidazole jako selektywne modulatory receptora androgenowego (SARM)
WO2007095124A2 (en) * 2006-02-10 2007-08-23 Transtech Pharma, Inc. Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
KR101307497B1 (ko) * 2006-04-19 2013-09-11 주식회사 동진쎄미켐 디이미다졸계 화합물 및 이를 이용한 유기발광소자
CN100496308C (zh) * 2006-06-02 2009-06-10 上海烟草(集团)公司 造纸法再造烟叶半逆流多级萃取工艺
EP1992228A1 (en) * 2007-05-14 2008-11-19 Bayer CropScience AG Insecticidal substituted thiourea derivatives
BRPI0811783A2 (pt) * 2007-05-23 2014-11-11 Allergan Inc Compostos de ((heteroarila bicíclica)imidazolil)metil-heteroarila como agonistas dos receptores adrenérgicos.
DE102009038950A1 (de) 2009-08-26 2011-03-03 Bayer Animal Health Gmbh Neue antiparasitäre Kombination von Wirkstoffen
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GR75101B (enEXAMPLES) * 1980-10-23 1984-07-13 Pfizer
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
EP0178413A1 (en) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles

Also Published As

Publication number Publication date
SU1662350A3 (ru) 1991-07-07
DE3783107T2 (de) 1993-04-22
NO873840D0 (no) 1987-09-14
NO873840L (no) 1988-03-16
HK123694A (en) 1994-11-18
DE3783107D1 (de) 1993-01-28
IE60514B1 (en) 1994-07-27
EP0260744A2 (en) 1988-03-23
HUT45051A (en) 1988-05-30
CY1803A (en) 1987-09-09
CN87106423A (zh) 1988-04-20
AU7838587A (en) 1988-04-14
IL83892A (en) 1991-11-21
PH25022A (en) 1991-01-28
FI87781B (fi) 1992-11-13
FI873977A7 (fi) 1988-03-16
DK174728B1 (da) 2003-10-06
HU198039B (en) 1989-07-28
JPS6485975A (en) 1989-03-30
PT85692A (en) 1987-10-01
BG61321B2 (bg) 1997-05-30
KR960014353B1 (ko) 1996-10-15
AU595064B2 (en) 1990-03-22
EP0260744A3 (en) 1989-01-18
FI87781C (fi) 1993-02-25
DK479487D0 (da) 1987-09-14
NO167202B (no) 1991-07-08
NO167202C (no) 1991-10-16
PT85692B (pt) 1990-06-29
ZA876881B (en) 1989-04-26
IE872487L (en) 1988-03-15
FI873977A0 (fi) 1987-09-14
CN1020903C (zh) 1993-05-26
JPH0587071B2 (enEXAMPLES) 1993-12-15
GR3006841T3 (enEXAMPLES) 1993-06-30
KR880003935A (ko) 1988-06-01
ES2053524T3 (es) 1994-08-01
IL83892A0 (en) 1988-02-29
NZ221729A (en) 1989-07-27
EP0260744B1 (en) 1992-12-16
DK479487A (da) 1988-03-16

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Effective date: 20101019