CA1316105C - Stable interferon complexes - Google Patents

Stable interferon complexes

Info

Publication number
CA1316105C
CA1316105C CA000559620A CA559620A CA1316105C CA 1316105 C CA1316105 C CA 1316105C CA 000559620 A CA000559620 A CA 000559620A CA 559620 A CA559620 A CA 559620A CA 1316105 C CA1316105 C CA 1316105C
Authority
CA
Canada
Prior art keywords
protamine
zinc
alpha interferon
composition
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000559620A
Other languages
English (en)
French (fr)
Inventor
Zachary Yim
Michael A. Zupon
Imtiaz A. Chaudry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of CA1316105C publication Critical patent/CA1316105C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA000559620A 1987-02-24 1988-02-23 Stable interferon complexes Expired - Fee Related CA1316105C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/018,243 US4853218A (en) 1987-02-24 1987-02-24 Zinc-protamine-alpha interferon complex
US018,243 1987-02-24

Publications (1)

Publication Number Publication Date
CA1316105C true CA1316105C (en) 1993-04-13

Family

ID=21786960

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000559620A Expired - Fee Related CA1316105C (en) 1987-02-24 1988-02-23 Stable interferon complexes

Country Status (23)

Country Link
US (1) US4853218A (OSRAM)
EP (2) EP0281299B1 (OSRAM)
JP (1) JPH0611712B2 (OSRAM)
KR (1) KR940001372B1 (OSRAM)
AT (1) ATE76580T1 (OSRAM)
AU (1) AU608584B2 (OSRAM)
CA (1) CA1316105C (OSRAM)
DE (1) DE3871407D1 (OSRAM)
DK (1) DK167048B1 (OSRAM)
ES (1) ES2032009T3 (OSRAM)
FI (1) FI93309C (OSRAM)
GR (1) GR3005358T3 (OSRAM)
HU (1) HU201881B (OSRAM)
IE (1) IE61340B1 (OSRAM)
IL (1) IL85523A (OSRAM)
MX (1) MX9203328A (OSRAM)
MY (1) MY103212A (OSRAM)
NO (1) NO173279C (OSRAM)
NZ (1) NZ223598A (OSRAM)
OA (1) OA09737A (OSRAM)
PT (1) PT86810B (OSRAM)
WO (1) WO1988006456A1 (OSRAM)
ZA (1) ZA881258B (OSRAM)

Families Citing this family (43)

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US5028422A (en) * 1986-05-27 1991-07-02 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
AU601741B2 (en) * 1986-05-27 1990-09-20 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
ES2054815T3 (es) * 1987-09-08 1994-08-16 Takeda Chemical Industries Ltd Citoquinas insolubilizadas en agua.
MX9203319A (es) * 1990-06-04 1992-07-31 Schering Corp Metodo para la preparacion de cristales de alfa-2 interferona.
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
WO1994012158A1 (en) 1992-12-02 1994-06-09 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
US5441734A (en) * 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals
US6087324A (en) 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
AU706180B2 (en) * 1994-07-25 1999-06-10 Alkermes Controlled Therapeutics, Inc. Controlled release of metal cation-stabilized interferon
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
JP3837769B2 (ja) * 1995-06-12 2006-10-25 大塚製薬株式会社 抗ウイルス剤
JP2000507912A (ja) * 1995-08-31 2000-06-27 アルカームズ コントロールド セラピューティックス，インコーポレイテッド 作用剤の徐放性組成物
US6331311B1 (en) * 1996-12-20 2001-12-18 Alza Corporation Injectable depot gel composition and method of preparing the composition
US6465425B1 (en) * 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
CN100446809C (zh) * 2001-11-14 2008-12-31 阿尔扎有限公司 可注射的长效组合物
ATE502621T1 (de) * 2001-11-14 2011-04-15 Durect Corp Katheterinjizierbare depotzusammensetzungen und deren verwendung
ATE507816T1 (de) * 2001-11-14 2011-05-15 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
AR039729A1 (es) 2002-06-25 2005-03-09 Alza Corp Formulaciones de deposito de corta duracion
US8501215B2 (en) 2002-07-31 2013-08-06 Guohua Chen Injectable multimodal polymer depot compositions and uses thereof
NZ537955A (en) * 2002-07-31 2007-10-26 Alza Corp Injectable depot compositions and uses thereof
EP1581181B1 (en) * 2002-11-06 2008-12-24 ALZA Corporation Controlled release depot formulations
JP4686361B2 (ja) * 2002-12-31 2011-05-25 アルタス ファーマシューティカルズ インコーポレイテッド ヒト成長ホルモンの結晶およびその調製方法
BR0317896A (pt) * 2002-12-31 2005-12-06 Altus Pharmaceuticals Inc Complexos de cristais de proteìna e polìmeros iÈnicos
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
MXPA05013003A (es) * 2003-05-30 2006-03-17 Alza Corp Composiciones de deposito elastomerico implantables, usos de las mismas y metodo para elaboracion.
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
US20050106214A1 (en) * 2003-11-14 2005-05-19 Guohua Chen Excipients in drug delivery vehicles
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
EP1976551A4 (en) * 2005-12-23 2009-12-30 Altus Pharmaceuticals Inc COMPOSITIONS COMPRISING COMPLEX PROTEIN CRYSTALS BY POLYCATIONS AND PROCESSING METHOD THEREOF
US7753078B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick with an integral pressure sensor and an outlet port
US7753077B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick for electrically operating valves
JP4889782B2 (ja) * 2008-12-24 2012-03-07 株式会社マルハニチロ食品 プロタミン及び／またはその塩と酸性高分子化合物とを含む生理活性複合体及びその用途
BRPI1007457A2 (pt) * 2009-01-28 2015-08-25 Smartcells Inc Conjungado, formulação de liberação prolongada, e, sistema de distribuição de bomba.
KR20140015266A (ko) * 2010-11-24 2014-02-06 듀렉트 코퍼레이션 생분해성 약물 전달 조성물
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
CN116940358A (zh) 2021-01-12 2023-10-24 度勒科特公司 持续释放药物递送系统和有关的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1282504A (fr) * 1954-06-03 1962-01-27 Novo Terapeutisk Labor As Procédé de production de suspensions stables d'insuline zinc-protamine
US3912807A (en) * 1974-04-18 1975-10-14 American Home Prod Treatment of diabetes using somatostatin and insulin
IN150740B (OSRAM) * 1978-11-24 1982-12-04 Hoffmann La Roche
NO164037C (no) * 1980-01-08 1990-08-22 Biogen Inc Fremgangsmaate ved fremstilling av et polypeptid av interferon alfa (ifnalfa)-type.
ES8302778A1 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
EP0082481B2 (en) * 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
US4605555A (en) * 1984-09-20 1986-08-12 Sun Star Kabushiki Kaisha Composition and method for treating keratosic disorder of skin and mucosa

Also Published As

Publication number Publication date
KR940001372B1 (ko) 1994-02-21
IL85523A (en) 1992-11-15
IE880480L (en) 1988-08-24
NO884596D0 (no) 1988-10-14
EP0281299B1 (en) 1992-05-27
FI893929L (fi) 1989-08-22
AU1394688A (en) 1988-09-26
US4853218A (en) 1989-08-01
WO1988006456A1 (en) 1988-09-07
JPH03500286A (ja) 1991-01-24
EP0281299A1 (en) 1988-09-07
JPH0611712B2 (ja) 1994-02-16
ES2032009T3 (es) 1993-01-01
EP0375678A1 (en) 1990-07-04
DE3871407D1 (de) 1992-07-02
DK582188D0 (da) 1988-10-19
NO173279B (no) 1993-08-16
ATE76580T1 (de) 1992-06-15
MX9203328A (es) 1992-07-01
HUT51902A (en) 1990-06-28
DK167048B1 (da) 1993-08-23
NZ223598A (en) 1989-12-21
AU608584B2 (en) 1991-04-11
PT86810A (pt) 1988-03-01
DK582188A (da) 1988-10-19
OA09737A (en) 1993-11-30
KR890700359A (ko) 1989-04-24
HU201881B (en) 1991-01-28
MY103212A (en) 1993-05-29
FI93309C (fi) 1995-03-27
FI93309B (fi) 1994-12-15
PT86810B (pt) 1992-05-29
ZA881258B (en) 1988-08-23
IE61340B1 (en) 1994-11-02
FI893929A0 (fi) 1989-08-22
IL85523A0 (en) 1988-08-31
NO173279C (no) 1993-11-24
GR3005358T3 (OSRAM) 1993-05-24
NO884596L (no) 1988-10-14

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