ES2032009T3 - Procedimiento para preparar complejos estables de interferon. - Google Patents

Procedimiento para preparar complejos estables de interferon.

Info

Publication number
ES2032009T3
ES2032009T3 ES198888301500T ES88301500T ES2032009T3 ES 2032009 T3 ES2032009 T3 ES 2032009T3 ES 198888301500 T ES198888301500 T ES 198888301500T ES 88301500 T ES88301500 T ES 88301500T ES 2032009 T3 ES2032009 T3 ES 2032009T3
Authority
ES
Spain
Prior art keywords
procedure
stable complexes
interferon
prepare
prepare interferon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888301500T
Other languages
English (en)
Inventor
Zachary Yim
Imtiaz A. Chaudry
Michael A. Zupon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2032009T3 publication Critical patent/ES2032009T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPLEJO INSOLUBLE DE CINCPROTAMINA Y ALFA-INTERFERON, UTIL COMO FORMA DE DOSIFICACION INYECTABLE, DE LIBERACION RETARDADA, PARA DMINISTRAR ALFA-INTERFERON.
ES198888301500T 1987-02-24 1988-02-23 Procedimiento para preparar complejos estables de interferon. Expired - Lifetime ES2032009T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/018,243 US4853218A (en) 1987-02-24 1987-02-24 Zinc-protamine-alpha interferon complex

Publications (1)

Publication Number Publication Date
ES2032009T3 true ES2032009T3 (es) 1993-01-01

Family

ID=21786960

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888301500T Expired - Lifetime ES2032009T3 (es) 1987-02-24 1988-02-23 Procedimiento para preparar complejos estables de interferon.

Country Status (23)

Country Link
US (1) US4853218A (es)
EP (2) EP0375678A1 (es)
JP (1) JPH0611712B2 (es)
KR (1) KR940001372B1 (es)
AT (1) ATE76580T1 (es)
AU (1) AU608584B2 (es)
CA (1) CA1316105C (es)
DE (1) DE3871407D1 (es)
DK (1) DK167048B1 (es)
ES (1) ES2032009T3 (es)
FI (1) FI93309C (es)
GR (1) GR3005358T3 (es)
HU (1) HU201881B (es)
IE (1) IE61340B1 (es)
IL (1) IL85523A (es)
MX (1) MX9203328A (es)
MY (1) MY103212A (es)
NO (1) NO173279C (es)
NZ (1) NZ223598A (es)
OA (1) OA09737A (es)
PT (1) PT86810B (es)
WO (1) WO1988006456A1 (es)
ZA (1) ZA881258B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA873743B (en) * 1986-05-27 1987-11-25 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
US5028422A (en) * 1986-05-27 1991-07-02 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
ES2054815T3 (es) * 1987-09-08 1994-08-16 Takeda Chemical Industries Ltd Citoquinas insolubilizadas en agua.
DE69125035T2 (de) * 1990-06-04 1997-07-10 Schering Corp Verfahren zur herstellung von interferon-alpha-2 kristallen
US5912015A (en) * 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
ATE195652T1 (de) * 1992-12-02 2000-09-15 Alkermes Inc Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung
US5441734A (en) * 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals
US6087324A (en) 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
AU706180B2 (en) * 1994-07-25 1999-06-10 Alkermes Controlled Therapeutics, Inc. Controlled release of metal cation-stabilized interferon
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
JP3837769B2 (ja) * 1995-06-12 2006-10-25 大塚製薬株式会社 抗ウイルス剤
CA2230494A1 (en) * 1995-08-31 1997-03-06 Alkermes Controlled Therapeutics Inc. Composition for sustained release of an agent
ATE203157T1 (de) * 1996-12-20 2001-08-15 Alza Corp Injizierbare depotgelzubereitung und herstellungsverfahren
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
ATE507816T1 (de) * 2001-11-14 2011-05-15 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
ES2329346T3 (es) * 2001-11-14 2009-11-25 Durect Corporation Composicion de deposito inyectable.
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
CA2467239A1 (en) * 2001-11-14 2003-05-22 Alza Corporation Catheter injectable depot compositions and uses thereof
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
AR039729A1 (es) 2002-06-25 2005-03-09 Alza Corp Formulaciones de deposito de corta duracion
MXPA05001244A (es) 2002-07-31 2005-06-08 Alza Corp Composiciones de deposito de polimero multimodal inyectable y usos de las mismas.
ES2319400T3 (es) * 2002-07-31 2009-05-07 Durect Corporation Composiciones deposito inyectables y empleo de las mismas.
MXPA05004927A (es) * 2002-11-06 2005-09-08 Alza Corp Formulaciones de deposito de liberacion controlada.
NZ571243A (en) * 2002-12-31 2010-04-30 Altus Pharmaceuticals Inc Complexes of protein crystals and ionic polymers comprising human growth hormone and protamine
WO2004060310A2 (en) * 2002-12-31 2004-07-22 Altus Pharmaceuticals Inc. Human growth hormone crystals and methods for preparing them
EP1643968A1 (en) * 2003-05-30 2006-04-12 ALZA Corporation Implantable elastomeric depot compositions, uses thereof and method of manufacturing
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
US20050106214A1 (en) * 2003-11-14 2005-05-19 Guohua Chen Excipients in drug delivery vehicles
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
EP1976551A4 (en) * 2005-12-23 2009-12-30 Altus Pharmaceuticals Inc COMPOSITIONS COMPRISING COMPLEX PROTEIN CRYSTALS BY POLYCATIONS AND PROCESSING METHOD THEREOF
US7753078B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick with an integral pressure sensor and an outlet port
US7753077B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick for electrically operating valves
JP4889782B2 (ja) * 2008-12-24 2012-03-07 株式会社マルハニチロ食品 プロタミン及び／またはその塩と酸性高分子化合物とを含む生理活性複合体及びその用途
CN105753965A (zh) * 2009-01-28 2016-07-13 斯马特塞尔斯公司 用于受控药物递送的基于缀合物的系统
CN103384528B (zh) * 2010-11-24 2016-04-13 杜雷科特公司 生物可降解的药物递送组合物
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
BR112022013784A2 (pt) 2020-01-13 2022-10-11 Durect Corp Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1282504A (fr) * 1954-06-03 1962-01-27 Novo Terapeutisk Labor As Procédé de production de suspensions stables d'insuline zinc-protamine
US3912807A (en) * 1974-04-18 1975-10-14 American Home Prod Treatment of diabetes using somatostatin and insulin
IN150740B (es) * 1978-11-24 1982-12-04 Hoffmann La Roche
IE54096B1 (en) * 1980-01-08 1989-06-21 Biogen Nv Dn sequences, recombinant dna molecules and processes for producing human interferon - like polypeptides
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
EP0082481B2 (en) * 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
US4605555A (en) * 1984-09-20 1986-08-12 Sun Star Kabushiki Kaisha Composition and method for treating keratosic disorder of skin and mucosa

Also Published As

Publication number Publication date
FI93309B (fi) 1994-12-15
KR890700359A (ko) 1989-04-24
IL85523A (en) 1992-11-15
FI93309C (fi) 1995-03-27
FI893929A (fi) 1989-08-22
DK582188D0 (da) 1988-10-19
OA09737A (en) 1993-11-30
HUT51902A (en) 1990-06-28
US4853218A (en) 1989-08-01
IL85523A0 (en) 1988-08-31
IE880480L (en) 1988-08-24
NO173279C (no) 1993-11-24
WO1988006456A1 (en) 1988-09-07
DK167048B1 (da) 1993-08-23
MY103212A (en) 1993-05-29
DK582188A (da) 1988-10-19
AU608584B2 (en) 1991-04-11
PT86810A (pt) 1988-03-01
KR940001372B1 (ko) 1994-02-21
NZ223598A (en) 1989-12-21
IE61340B1 (en) 1994-11-02
FI893929A0 (fi) 1989-08-22
HU201881B (en) 1991-01-28
AU1394688A (en) 1988-09-26
EP0375678A1 (en) 1990-07-04
NO884596D0 (no) 1988-10-14
PT86810B (pt) 1992-05-29
ATE76580T1 (de) 1992-06-15
JPH0611712B2 (ja) 1994-02-16
CA1316105C (en) 1993-04-13
EP0281299B1 (en) 1992-05-27
NO884596L (no) 1988-10-14
NO173279B (no) 1993-08-16
MX9203328A (es) 1992-07-01
DE3871407D1 (de) 1992-07-02
GR3005358T3 (es) 1993-05-24
JPH03500286A (ja) 1991-01-24
ZA881258B (en) 1988-08-23
EP0281299A1 (en) 1988-09-07

Similar Documents

Publication Publication Date Title
ES2032009T3 (es) Procedimiento para preparar complejos estables de interferon.
DE3875425T2 (de) Vasokinetisch wirkende polyungesaettigte saeuren und sie enthaltende pharmazeutische oder kosmetische zubereitungen.
MX9204861A (es) Analogos de polipeptidos que tienen actividad liberadora de la hormona de crecimiento.
DE3772521D1 (de) Insulinzubereitung fuer nicht-parenterale verabreichung.
ES2069582T3 (es) Nucleosidos terapeuticos.
PT87753A (pt) Process for the preparation of a pharmaceutical composition forthe promotion of healing of meniscal tissue having an angiogenic factor as activ ingredient
ES2002083A6 (es) Un metodo para preparar derivados de piroglutamida
DK328088A (da) Farmaceutisk komposition til behandling af tumorer
ATE59550T1 (de) Chlorpheniramine therapie.
DE3751602D1 (de) Subkutane Verabreichung des humanen Choriongonadotropins.
ATE22531T1 (de) Pharmazeutische zusammenstellung fuer induktion von cytoprotektion.
DE68900693D1 (de) Pharmazeutische praeparate zur transdermalen applikation von heparin.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 281299

Country of ref document: ES