KR20000020729A - 에리트로포이에틴과 인간 혈청알부민의 포합체 - Google Patents
에리트로포이에틴과 인간 혈청알부민의 포합체 Download PDFInfo
- Publication number
- KR20000020729A KR20000020729A KR1019980039459A KR19980039459A KR20000020729A KR 20000020729 A KR20000020729 A KR 20000020729A KR 1019980039459 A KR1019980039459 A KR 1019980039459A KR 19980039459 A KR19980039459 A KR 19980039459A KR 20000020729 A KR20000020729 A KR 20000020729A
- Authority
- KR
- South Korea
- Prior art keywords
- epo
- conjugate
- hsa
- erythropoietin
- serum albumin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
포합체 | t1/2(시간) |
EPO-HSA | 13.8 |
EPO-DEX70K | 4.81 |
EPO-DEX40K | 1.54 |
EPO-DEX12K | 1.24 |
천연형 EPO | 3.3 |
Claims (3)
- 에리트로포이에틴과 인간 혈청알부민의 몰비가 1:1∼1:10인 에리트로포이에틴과 인간 혈청알부민의 포합체를 유효성분으로 함유하는 에리트로포이에틴의 지속성 제제.
- 제 1 항에 있어서, 피하 또는 정맥주사제로 제형화되는 에리트로포이에틴의 지속성 제제.
- 완충액에 용해시킨 에리트로포이에틴에 산화된 인간 혈청알부민을 1:1∼1:10의 몰비로 가하여 포합반응시키고, 반응액에 환원제를 가하여 포합반응을 종료시키고, 투석 및 겔 여과에 의하여 생성된 포합체를 분리하여 에리트로포이에틴과 인간 혈청알부민의 포합체를 제조하는 방법.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019980039459A KR100534622B1 (ko) | 1998-09-23 | 1998-09-23 | 에리트로포이에틴과 인간 혈청알부민의 포합체 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019980039459A KR100534622B1 (ko) | 1998-09-23 | 1998-09-23 | 에리트로포이에틴과 인간 혈청알부민의 포합체 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20000020729A true KR20000020729A (ko) | 2000-04-15 |
KR100534622B1 KR100534622B1 (ko) | 2006-06-16 |
Family
ID=19551636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019980039459A KR100534622B1 (ko) | 1998-09-23 | 1998-09-23 | 에리트로포이에틴과 인간 혈청알부민의 포합체 |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR100534622B1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008157824A2 (en) * | 2007-06-21 | 2008-12-24 | Conjuchem Biotechnologies Inc. | Thrombopoietin peptide conjugates |
-
1998
- 1998-09-23 KR KR1019980039459A patent/KR100534622B1/ko not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008157824A2 (en) * | 2007-06-21 | 2008-12-24 | Conjuchem Biotechnologies Inc. | Thrombopoietin peptide conjugates |
WO2008157824A3 (en) * | 2007-06-21 | 2009-12-30 | Conjuchem Biotechnologies Inc. | Thrombopoietin peptide conjugates |
Also Published As
Publication number | Publication date |
---|---|
KR100534622B1 (ko) | 2006-06-16 |
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