CA1290267C - Proteine anti-inflammatoire inhibitrice de la phospholipase humaine - Google Patents

Proteine anti-inflammatoire inhibitrice de la phospholipase humaine

Info

Publication number
CA1290267C
CA1290267C CA000506584A CA506584A CA1290267C CA 1290267 C CA1290267 C CA 1290267C CA 000506584 A CA000506584 A CA 000506584A CA 506584 A CA506584 A CA 506584A CA 1290267 C CA1290267 C CA 1290267C
Authority
CA
Canada
Prior art keywords
pip
hpip
fragment
active
ptrp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000506584A
Other languages
English (en)
Inventor
Lorin K. Johnson
John P. Longenecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotechnology Research Partners Ltd
Original Assignee
Biotechnology Research Partners Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnology Research Partners Ltd filed Critical Biotechnology Research Partners Ltd
Application granted granted Critical
Publication of CA1290267C publication Critical patent/CA1290267C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
CA000506584A 1985-04-15 1986-04-14 Proteine anti-inflammatoire inhibitrice de la phospholipase humaine Expired - Lifetime CA1290267C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72304685A 1985-04-15 1985-04-15
US723,046 1985-04-15

Publications (1)

Publication Number Publication Date
CA1290267C true CA1290267C (fr) 1991-10-08

Family

ID=24904592

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000506584A Expired - Lifetime CA1290267C (fr) 1985-04-15 1986-04-14 Proteine anti-inflammatoire inhibitrice de la phospholipase humaine

Country Status (6)

Country Link
EP (1) EP0218696A4 (fr)
JP (2) JP2757987B2 (fr)
AU (1) AU5770786A (fr)
CA (1) CA1290267C (fr)
ES (1) ES8800691A1 (fr)
WO (1) WO1986006100A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0787789B2 (ja) * 1985-01-10 1995-09-27 バイオジェン インコーポレイテッド リポコルチンをコードするｄｎａ分子および形質転換宿主
US4874743A (en) * 1985-01-10 1989-10-17 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human phospholipase inhibitor-like polypeptides
US5081019A (en) * 1985-01-10 1992-01-14 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing lipocortin-like polypeptides
US4950646A (en) * 1985-01-10 1990-08-21 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human lipocortin-like polypeptides
US4879224A (en) * 1985-01-10 1989-11-07 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human phospholipase inhibitor polypeptides
JPS6256429A (ja) * 1985-09-04 1987-03-12 Teijin Ltd フオスフオリパ−ゼａ↓２阻害活性を有する蛋白
PT87083B (pt) * 1987-03-28 1992-07-31 Boehringer Ingelheim Int Processo para a preparacao de uma proteina anticoagulante vascular, de adn que codifica para esta proteina e de composicoes farmaceuticas que a contem
JPH06799B2 (ja) * 1987-04-02 1994-01-05 帝人株式会社 起炎性フオスフオリパ−ゼａ▲下２▼阻害活性を有する蛋白
DE68923107T2 (de) * 1988-02-26 1996-01-18 Biogen Inc DNA-Sequenzen, rekombinante DNA-Moleküle und Verfahren zur Herstellung von Lipocortin III, IV, V, und VI.
US5891664A (en) * 1989-04-07 1999-04-06 Cancerforskningsfondet Af 1989 Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)
ATE197067T1 (de) * 1989-04-07 2000-11-15 Cancerforskningsfonden Af 1989 Plasminogen-aktivator-rezeptor vom urokinasetyp
US5519120A (en) * 1989-04-07 1996-05-21 Cancerforskningsfondet Af 1989 Urokinase-type plasminogen activator receptor antibodies
US5344764A (en) * 1989-08-03 1994-09-06 Teijin Limited Protein inhibitors of phospholipase A2 purified from inflammatory sites and production process
EP0436737A4 (en) * 1989-08-03 1992-10-28 Teijin Limited Phospholipase a 2? inhibiting protein originating in inflamed region, production thereof, and gene therefor
DE69029269T2 (de) * 1989-08-29 1997-05-28 The Regents Of The University Of California, Berkeley, Calif. Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze
US6248715B1 (en) 1993-06-01 2001-06-19 Chiron Corporation Method of treating a urokinase-type plasminogen activator-mediated disorder
DE69432608T2 (de) 1993-06-01 2004-02-26 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Expression von inhibitoren vom plasminogenaktivator vom urokinasetyp
EP0970106B1 (fr) * 1997-03-20 2004-09-15 Fondazione Centro San Raffaele Del Monte Tabor PEPTIDES IMITANT L'uPAR

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0787789B2 (ja) * 1985-01-10 1995-09-27 バイオジェン インコーポレイテッド リポコルチンをコードするｄｎａ分子および形質転換宿主
JPS6256429A (ja) * 1985-09-04 1987-03-12 Teijin Ltd フオスフオリパ−ゼａ↓２阻害活性を有する蛋白

Also Published As

Publication number Publication date
WO1986006100A1 (fr) 1986-10-23
ES553961A0 (es) 1987-11-16
JP2637709B2 (ja) 1997-08-06
JPS63500561A (ja) 1988-03-03
JPH08187087A (ja) 1996-07-23
EP0218696A1 (fr) 1987-04-22
JP2757987B2 (ja) 1998-05-25
AU5770786A (en) 1986-11-05
EP0218696A4 (fr) 1989-08-16
ES8800691A1 (es) 1987-11-16

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