CA1167845A - Imidazo¬1,2-a|pyridines, processes for their preparation and pharmaceutical compositions containing them - Google Patents

Imidazo¬1,2-a|pyridines, processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
CA1167845A
CA1167845A CA000368901A CA368901A CA1167845A CA 1167845 A CA1167845 A CA 1167845A CA 000368901 A CA000368901 A CA 000368901A CA 368901 A CA368901 A CA 368901A CA 1167845 A CA1167845 A CA 1167845A
Authority
CA
Canada
Prior art keywords
group
compound
hydrogen
formula
loweralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000368901A
Other languages
English (en)
French (fr)
Inventor
Chester Puchalski
James A. Bristol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of CA1167845A publication Critical patent/CA1167845A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000368901A 1980-01-23 1981-01-20 Imidazo¬1,2-a|pyridines, processes for their preparation and pharmaceutical compositions containing them Expired CA1167845A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11447380A 1980-01-23 1980-01-23
US114,473 1987-10-28

Publications (1)

Publication Number Publication Date
CA1167845A true CA1167845A (en) 1984-05-22

Family

ID=22355431

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000368901A Expired CA1167845A (en) 1980-01-23 1981-01-20 Imidazo¬1,2-a|pyridines, processes for their preparation and pharmaceutical compositions containing them

Country Status (21)

Country Link
EP (1) EP0033094B1 (Direct)
JP (1) JPS56113782A (Direct)
KR (1) KR850000240B1 (Direct)
AU (1) AU540840B2 (Direct)
CA (1) CA1167845A (Direct)
DE (1) DE3166531D1 (Direct)
DK (1) DK25081A (Direct)
FI (1) FI810147L (Direct)
GR (1) GR72960B (Direct)
HK (1) HK94187A (Direct)
HU (1) HU185857B (Direct)
IE (1) IE50682B1 (Direct)
IL (1) IL61939A (Direct)
MA (1) MA19048A1 (Direct)
MY (1) MY8700760A (Direct)
NO (1) NO157781C (Direct)
NZ (1) NZ196071A (Direct)
OA (1) OA06727A (Direct)
PT (1) PT72370B (Direct)
SG (1) SG70887G (Direct)
ZA (1) ZA81219B (Direct)

Families Citing this family (52)

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US4460584A (en) * 1981-03-13 1984-07-17 Imperial Chemical Industries Plc Nitrogen heterocycles
US4463005A (en) * 1981-03-18 1984-07-31 Imperial Chemical Industries Plc Bicyclic guanidines
EP0068378B1 (en) * 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
JPS61218589A (ja) * 1985-03-26 1986-09-29 Eisai Co Ltd ５―（６―イミダゾ〔１，２―ａ〕ピリジニル）ピリジン誘導体
GB8530878D0 (en) * 1985-12-16 1986-01-29 Fujisawa Pharmaceutical Co Imidazopyridine compounds
US4725601A (en) * 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
GB8514080D0 (en) * 1985-06-04 1985-07-10 Fujisawa Pharmaceutical Co Imidazopyridine compounds
EP0228006A1 (en) * 1985-12-16 1987-07-08 Fujisawa Pharmaceutical Co., Ltd. Imidazopyridine compounds and processes for preparation thereof
FR2593818B1 (fr) * 1986-02-05 1988-04-29 Synthelabo Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique
ATE62687T1 (de) * 1986-01-22 1991-05-15 Synthelabo Acylaminomethylimidazo(1,2-a>pyrimidinderivate, ihre herstellung und therapeutische verwendung.
US4831041A (en) * 1986-11-26 1989-05-16 Fujisawa Pharmaceutical Co., Ltd. Imidazopyridine compounds and processes for preparation thereof
IL86269A0 (en) * 1987-05-08 1988-11-15 Byk Gulden Lomberg Chem Fab Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ATE145907T1 (de) * 1987-07-16 1996-12-15 Byk Gulden Lomberg Chem Fab Imidazo(1,2-a>pyridine
GB8722488D0 (en) * 1987-09-24 1987-10-28 Fujisawa Pharmaceutical Co Imidazopyridine compound
AT390438B (de) * 1987-10-08 1990-05-10 Yamanouchi Pharma Co Ltd Neue imidazo(1,2-a)pyridinderivate und deren herstellung und diese enthaltende pharmazeutische zubereitungen
EP0368158A1 (de) * 1988-11-07 1990-05-16 Byk Gulden Lomberg Chemische Fabrik GmbH Neue Imidazopyridine
KR910011852A (ko) * 1989-12-04 1991-08-07 폴 디. 매튜카이티스 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물
US5716964A (en) * 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
IE904346A1 (en) * 1989-12-04 1991-06-05 Searle & Co IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
US5464843A (en) * 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury
US5574042A (en) * 1992-11-02 1996-11-12 Fujisawa Pharmaceutical Co., Ltd Imidazo [1,2-a] pyridines and their pharmaceutical use
IL108520A (en) * 1993-02-15 1997-09-30 Byk Gulden Lomberg Chem Fab 2, 3, 8-TRISUBSTITUTED IMIDAZO £1, 2-a| PYRIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5824687A (en) * 1993-04-22 1998-10-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyridinium salts and their use for the control of helicobacter bacteria
UA48122C2 (uk) * 1993-10-11 2002-08-15 Бік Гульден Ломберг Хеміше Фабрік Гмбх АЛКОКСІАЛКІЛКАРБАМАТИ ІМІДАЗО[1,2-а]ПІРИДИНІВ, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ЛІКАРСЬКИЙ ЗАСІБ НА ЇХ ОСНОВІ
MX9700624A (es) * 1994-07-28 1997-12-31 Byk Gulden Lomberg Chem Fab Azolidinonas de imidazopiridina.
WO1996005199A1 (de) * 1994-08-12 1996-02-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Imidazopyridinsalz
WO1996033195A1 (en) * 1995-04-21 1996-10-24 Shinnippon Pharmaceutical Inc. FUSED IMIDAZO[1,2-a]PYRIDINES
ATE294802T1 (de) * 1996-01-26 2005-05-15 Altana Pharma Ag 3-alkylimidazopyridine
WO1997027193A1 (de) * 1996-01-26 1997-07-31 Byk Gulden Lomberg Chemische Fabrik Gmbh Halogenimidazopyridine
DE19602855A1 (de) * 1996-01-26 1997-07-31 Byk Gulden Lomberg Chem Fab Neue 3-Methylimidazopyridine
SE9700661D0 (sv) * 1997-02-25 1997-02-25 Astra Ab New compounds
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
SE9802794D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
SE9802793D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
DE10001037C1 (de) 2000-01-13 2001-12-13 Byk Gulden Lomberg Chem Fab Verfahren und Zwischenprodukte zur Herstellung von Imidazopyridinen
CA2311483A1 (en) 2000-06-12 2001-12-12 Gregory N Beatch IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF
SE0003186D0 (sv) * 2000-09-07 2000-09-07 Astrazeneca Ab New process
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
EP1370261A2 (en) * 2001-03-08 2003-12-17 AstraZeneca AB New use
SE0102808D0 (sv) * 2001-08-22 2001-08-22 Astrazeneca Ab New compounds
DE10145457A1 (de) 2001-09-14 2003-04-03 Basf Ag Substituierte Imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-one, Verfahren zu ihrer Herstellung, sowie deren Verwendung zur Herstellung von Imidazo[1,2,-a]pyridinen
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
EP1534278A4 (en) 2002-08-01 2006-09-06 Nitromed Inc NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD
SE0301904D0 (sv) 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound II with therapeutic effect
WO2005026164A1 (en) * 2003-09-18 2005-03-24 Altana Pharma Ag Pharmacologically active imidazo[4,5-c]pyridines
EP1682133A1 (en) 2003-11-03 2006-07-26 AstraZeneca AB Imidazo 1,2-a pyridine derivatives for the treatment of silent gastro-esophageal reflux
FI20086158A0 (fi) 2008-12-03 2008-12-03 Mikael Dahlstroem Imidatsopyridiinijohdannaiset
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
KR101777971B1 (ko) * 2016-07-05 2017-09-12 제일약품주식회사 이미다조[1,2-a]피리딘 유도체, 이의 제조방법 및 이의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4096264A (en) * 1975-12-09 1978-06-20 Merck & Co., Inc. Certain substituted imidazo [1,2-a] pyridines
US4105767A (en) * 1977-03-28 1978-08-08 Merck & Co., Inc. Imidazo [1,2-a] pyridines substituted with a thienyl, thiazolyl, or thiadiazolyl group

Also Published As

Publication number Publication date
SG70887G (en) 1988-03-04
NO157781C (no) 1988-05-25
DE3166531D1 (en) 1984-11-15
MY8700760A (en) 1987-12-31
IL61939A0 (en) 1981-02-27
KR850000240B1 (ko) 1985-03-12
AU540840B2 (en) 1984-12-06
FI810147A7 (fi) 1981-07-24
MA19048A1 (fr) 1981-10-01
DK25081A (da) 1981-07-24
ZA81219B (en) 1982-01-27
AU6633781A (en) 1981-07-30
GR72960B (Direct) 1984-01-19
OA06727A (fr) 1982-06-30
HK94187A (en) 1987-12-18
IE810108L (en) 1981-07-23
PT72370B (en) 1982-07-23
PT72370A (en) 1981-02-01
KR830005212A (ko) 1983-08-03
JPS56113782A (en) 1981-09-07
NO810198L (no) 1981-07-24
EP0033094A1 (en) 1981-08-05
NZ196071A (en) 1984-05-31
IL61939A (en) 1986-01-31
IE50682B1 (en) 1986-06-11
NO157781B (no) 1988-02-08
FI810147L (fi) 1981-07-24
EP0033094B1 (en) 1984-10-10
HU185857B (en) 1985-04-28

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Legal Events

Date Code Title Description
MKEX Expiry