DE3166531D1 - Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them - Google Patents
Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- DE3166531D1 DE3166531D1 DE8181100247T DE3166531T DE3166531D1 DE 3166531 D1 DE3166531 D1 DE 3166531D1 DE 8181100247 T DE8181100247 T DE 8181100247T DE 3166531 T DE3166531 T DE 3166531T DE 3166531 D1 DE3166531 D1 DE 3166531D1
- Authority
- DE
- Germany
- Prior art keywords
- pyridines
- imidazo
- processes
- preparation
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11447380A | 1980-01-23 | 1980-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3166531D1 true DE3166531D1 (en) | 1984-11-15 |
Family
ID=22355431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8181100247T Expired DE3166531D1 (en) | 1980-01-23 | 1981-01-15 | Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0033094B1 (de) |
JP (1) | JPS56113782A (de) |
KR (1) | KR850000240B1 (de) |
AU (1) | AU540840B2 (de) |
CA (1) | CA1167845A (de) |
DE (1) | DE3166531D1 (de) |
DK (1) | DK25081A (de) |
FI (1) | FI810147L (de) |
GR (1) | GR72960B (de) |
HK (1) | HK94187A (de) |
HU (1) | HU185857B (de) |
IE (1) | IE50682B1 (de) |
IL (1) | IL61939A (de) |
MA (1) | MA19048A1 (de) |
MY (1) | MY8700760A (de) |
NO (1) | NO157781C (de) |
NZ (1) | NZ196071A (de) |
OA (1) | OA06727A (de) |
PT (1) | PT72370B (de) |
SG (1) | SG70887G (de) |
ZA (1) | ZA81219B (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4460584A (en) * | 1981-03-13 | 1984-07-17 | Imperial Chemical Industries Plc | Nitrogen heterocycles |
US4463005A (en) * | 1981-03-18 | 1984-07-31 | Imperial Chemical Industries Plc | Bicyclic guanidines |
DE3269604D1 (en) * | 1981-06-26 | 1986-04-10 | Schering Corp | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
JPS61218589A (ja) * | 1985-03-26 | 1986-09-29 | Eisai Co Ltd | 5―(6―イミダゾ〔1,2―a〕ピリジニル)ピリジン誘導体 |
GB8530878D0 (en) * | 1985-12-16 | 1986-01-29 | Fujisawa Pharmaceutical Co | Imidazopyridine compounds |
GB8514080D0 (en) * | 1985-06-04 | 1985-07-10 | Fujisawa Pharmaceutical Co | Imidazopyridine compounds |
US4725601A (en) * | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
EP0228006A1 (de) * | 1985-12-16 | 1987-07-08 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridinverbindungen und Verfahren zu ihrer Herstellung |
ES2032455T3 (es) * | 1986-01-22 | 1993-02-16 | Synthelabo | Procedimiento para preparar derivados de 3-acilaminometil-imidazo (-1,2-a)piridinas. |
FR2593818B1 (fr) * | 1986-02-05 | 1988-04-29 | Synthelabo | Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique |
US4831041A (en) * | 1986-11-26 | 1989-05-16 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine compounds and processes for preparation thereof |
IL86269A0 (en) * | 1987-05-08 | 1988-11-15 | Byk Gulden Lomberg Chem Fab | Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
CA1327796C (en) * | 1987-07-16 | 1994-03-15 | Jorg Senn-Bilfinger | Diazoles |
GB8722488D0 (en) * | 1987-09-24 | 1987-10-28 | Fujisawa Pharmaceutical Co | Imidazopyridine compound |
AT390438B (de) * | 1987-10-08 | 1990-05-10 | Yamanouchi Pharma Co Ltd | Neue imidazo(1,2-a)pyridinderivate und deren herstellung und diese enthaltende pharmazeutische zubereitungen |
EP0368158A1 (de) * | 1988-11-07 | 1990-05-16 | Byk Gulden Lomberg Chemische Fabrik GmbH | Neue Imidazopyridine |
US5716964A (en) * | 1989-12-04 | 1998-02-10 | G.D. Searle & Co. | Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury |
KR910011852A (ko) * | 1989-12-04 | 1991-08-07 | 폴 디. 매튜카이티스 | 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물 |
IE904346A1 (en) * | 1989-12-04 | 1991-06-05 | Searle & Co | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY |
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
US5464843A (en) * | 1992-06-23 | 1995-11-07 | G.D. Searle & Co. | Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury |
US5574042A (en) * | 1992-11-02 | 1996-11-12 | Fujisawa Pharmaceutical Co., Ltd | Imidazo [1,2-a] pyridines and their pharmaceutical use |
IL108520A (en) * | 1993-02-15 | 1997-09-30 | Byk Gulden Lomberg Chem Fab | 2, 3, 8-TRISUBSTITUTED IMIDAZO £1, 2-a| PYRIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US5824687A (en) * | 1993-04-22 | 1998-10-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyridinium salts and their use for the control of helicobacter bacteria |
UA48122C2 (uk) * | 1993-10-11 | 2002-08-15 | Бік Гульден Ломберг Хеміше Фабрік Гмбх | АЛКОКСІАЛКІЛКАРБАМАТИ ІМІДАЗО[1,2-а]ПІРИДИНІВ, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ЛІКАРСЬКИЙ ЗАСІБ НА ЇХ ОСНОВІ |
DE59510131D1 (de) * | 1994-07-28 | 2002-05-02 | Byk Gulden Lomberg Chem Fab | Imidazopyridin-azolidinone |
AU3343295A (en) * | 1994-08-12 | 1996-03-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Imidazopyridine salt |
CN1064360C (zh) * | 1995-04-21 | 2001-04-11 | 新日本药品株式会社 | 稠合咪唑并[1,2-a]吡啶类 |
WO1997027192A1 (de) * | 1996-01-26 | 1997-07-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | 3-methylimidazopyridine |
WO1997027193A1 (de) * | 1996-01-26 | 1997-07-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Halogenimidazopyridine |
DE19602855A1 (de) * | 1996-01-26 | 1997-07-31 | Byk Gulden Lomberg Chem Fab | Neue 3-Methylimidazopyridine |
SE9700661D0 (sv) * | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
SE9801526D0 (sv) * | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
SE9802793D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
DE10001037C1 (de) * | 2000-01-13 | 2001-12-13 | Byk Gulden Lomberg Chem Fab | Verfahren und Zwischenprodukte zur Herstellung von Imidazopyridinen |
CA2311483A1 (en) | 2000-06-12 | 2001-12-12 | Gregory N Beatch | IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF |
SE0003186D0 (sv) * | 2000-09-07 | 2000-09-07 | Astrazeneca Ab | New process |
UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
JP2004520422A (ja) * | 2001-03-08 | 2004-07-08 | アストラゼネカ・アクチエボラーグ | 新しい用途 |
SE0102808D0 (sv) * | 2001-08-22 | 2001-08-22 | Astrazeneca Ab | New compounds |
DE10145457A1 (de) | 2001-09-14 | 2003-04-03 | Basf Ag | Substituierte Imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-one, Verfahren zu ihrer Herstellung, sowie deren Verwendung zur Herstellung von Imidazo[1,2,-a]pyridinen |
MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
US7211590B2 (en) | 2002-08-01 | 2007-05-01 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
SE0301904D0 (sv) | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | Novel imidazopyridine compound II with therapeutic effect |
EP1670795A1 (de) * | 2003-09-18 | 2006-06-21 | ALTANA Pharma AG | Pharmakologisch wirksame imidazo[4,5-c]pyridine |
EP1974730A1 (de) | 2003-11-03 | 2008-10-01 | AstraZeneca AB | Imidazo[1,2-a]pyridin-Derivate zur Behandlung von Schlafstörungen durch stummen gastroösophagealen Reflux |
FI20086158A0 (fi) | 2008-12-03 | 2008-12-03 | Mikael Dahlstroem | Imidatsopyridiinijohdannaiset |
US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
KR101777971B1 (ko) * | 2016-07-05 | 2017-09-12 | 제일약품주식회사 | 이미다조[1,2-a]피리딘 유도체, 이의 제조방법 및 이의 용도 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4096264A (en) * | 1975-12-09 | 1978-06-20 | Merck & Co., Inc. | Certain substituted imidazo [1,2-a] pyridines |
US4105767A (en) * | 1977-03-28 | 1978-08-08 | Merck & Co., Inc. | Imidazo [1,2-a] pyridines substituted with a thienyl, thiazolyl, or thiadiazolyl group |
-
1981
- 1981-01-13 ZA ZA00810219A patent/ZA81219B/xx unknown
- 1981-01-15 EP EP81100247A patent/EP0033094B1/de not_active Expired
- 1981-01-15 DE DE8181100247T patent/DE3166531D1/de not_active Expired
- 1981-01-20 IL IL61939A patent/IL61939A/xx unknown
- 1981-01-20 CA CA000368901A patent/CA1167845A/en not_active Expired
- 1981-01-20 KR KR1019810000150A patent/KR850000240B1/ko active
- 1981-01-20 JP JP712181A patent/JPS56113782A/ja active Pending
- 1981-01-20 DK DK25081A patent/DK25081A/da not_active Application Discontinuation
- 1981-01-20 AU AU66337/81A patent/AU540840B2/en not_active Ceased
- 1981-01-20 OA OA57305A patent/OA06727A/xx unknown
- 1981-01-20 GR GR63921A patent/GR72960B/el unknown
- 1981-01-20 FI FI810147A patent/FI810147L/fi not_active Application Discontinuation
- 1981-01-20 PT PT72370A patent/PT72370B/pt unknown
- 1981-01-21 IE IE108/81A patent/IE50682B1/en unknown
- 1981-01-21 NO NO810198A patent/NO157781C/no unknown
- 1981-01-21 NZ NZ196071A patent/NZ196071A/en unknown
- 1981-01-22 HU HU81137A patent/HU185857B/hu unknown
- 1981-01-22 MA MA19249A patent/MA19048A1/fr unknown
-
1987
- 1987-08-27 SG SG708/87A patent/SG70887G/en unknown
- 1987-12-10 HK HK941/87A patent/HK94187A/xx unknown
- 1987-12-30 MY MY760/87A patent/MY8700760A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA1167845A (en) | 1984-05-22 |
OA06727A (fr) | 1982-06-30 |
IE810108L (en) | 1981-07-23 |
JPS56113782A (en) | 1981-09-07 |
HK94187A (en) | 1987-12-18 |
PT72370B (en) | 1982-07-23 |
PT72370A (en) | 1981-02-01 |
KR830005212A (ko) | 1983-08-03 |
NO157781C (no) | 1988-05-25 |
IL61939A0 (en) | 1981-02-27 |
EP0033094A1 (de) | 1981-08-05 |
HU185857B (en) | 1985-04-28 |
EP0033094B1 (de) | 1984-10-10 |
NO157781B (no) | 1988-02-08 |
DK25081A (da) | 1981-07-24 |
NZ196071A (en) | 1984-05-31 |
MY8700760A (en) | 1987-12-31 |
IE50682B1 (en) | 1986-06-11 |
NO810198L (no) | 1981-07-24 |
MA19048A1 (fr) | 1981-10-01 |
AU540840B2 (en) | 1984-12-06 |
GR72960B (de) | 1984-01-19 |
SG70887G (en) | 1988-03-04 |
ZA81219B (en) | 1982-01-27 |
AU6633781A (en) | 1981-07-30 |
IL61939A (en) | 1986-01-31 |
FI810147L (fi) | 1981-07-24 |
KR850000240B1 (ko) | 1985-03-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |