CA1163995A - Anti-tumor quinazoline compounds - Google Patents

Anti-tumor quinazoline compounds

Info

Publication number
CA1163995A
CA1163995A CA000395526A CA395526A CA1163995A CA 1163995 A CA1163995 A CA 1163995A CA 000395526 A CA000395526 A CA 000395526A CA 395526 A CA395526 A CA 395526A CA 1163995 A CA1163995 A CA 1163995A
Authority
CA
Canada
Prior art keywords
formula
methyl
compound
methoxy
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000395526A
Other languages
English (en)
French (fr)
Inventor
William E. Kreighbaum
William T. Comer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of CA1163995A publication Critical patent/CA1163995A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA000395526A 1981-03-06 1982-02-04 Anti-tumor quinazoline compounds Expired CA1163995A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US241,317 1981-03-06
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (1)

Publication Number Publication Date
CA1163995A true CA1163995A (en) 1984-03-20

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000395526A Expired CA1163995A (en) 1981-03-06 1982-02-04 Anti-tumor quinazoline compounds

Country Status (31)

Country Link
US (1) US4343940A (Direct)
JP (1) JPS57158780A (Direct)
KR (1) KR880001852B1 (Direct)
AR (1) AR231138A1 (Direct)
AT (1) AT380476B (Direct)
AU (1) AU556099B2 (Direct)
BE (1) BE891936A (Direct)
CA (1) CA1163995A (Direct)
CH (1) CH647776A5 (Direct)
CY (1) CY1371A (Direct)
DE (1) DE3203770C2 (Direct)
DK (1) DK159442C (Direct)
ES (1) ES8304095A1 (Direct)
FI (1) FI71559C (Direct)
FR (1) FR2501207B1 (Direct)
GB (1) GB2094295B (Direct)
GR (1) GR75903B (Direct)
HK (1) HK4588A (Direct)
HU (1) HU189997B (Direct)
IE (1) IE52385B1 (Direct)
IL (1) IL64875A0 (Direct)
IT (1) IT1154272B (Direct)
KE (1) KE3715A (Direct)
LU (1) LU83903A1 (Direct)
NL (1) NL8200473A (Direct)
NZ (1) NZ199576A (Direct)
PH (1) PH18529A (Direct)
PT (1) PT74394B (Direct)
SE (1) SE461732B (Direct)
SG (1) SG30787G (Direct)
YU (1) YU42031B (Direct)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US6645969B1 (en) * 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
ATE188377T1 (de) * 1993-06-29 2000-01-15 Takeda Chemical Industries Ltd Chinoline oder chinazolin-derivate und deren verwendung zur herstellung eines medikaments für die behandlung von osteoporose
CZ288955B6 (cs) * 1994-02-23 2001-10-17 Pfizer Inc. Substituované chinazolinové deriváty, jejich pouľití a farmaceutické prostředky na jejich bázi
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (Direct) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
AU5343096A (en) * 1995-04-27 1996-11-18 Zeneca Limited Quinazoline derivatives
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
JPH11507052A (ja) * 1995-06-07 1999-06-22 スージェン・インコーポレーテッド キナゾリンおよび医薬組成物
US6143764A (en) * 1995-11-07 2000-11-07 Kirin Beer Kabushiki Kaisha Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
DE69720965T2 (de) 1996-02-13 2004-02-05 Astrazeneca Ab Chinazolinderivate und deren verwendung als vegf hemmer
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
PT885198E (pt) 1996-03-05 2002-06-28 Astrazeneca Ab Derivados de 4-anilinoquinazolina
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
EP0948604B1 (en) * 1996-12-11 2004-07-21 Sugen, Inc. Screening methods for compounds binding to the Pyk2 polypeptide
US6818440B2 (en) 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US6388063B1 (en) 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
US6495353B1 (en) 1998-01-21 2002-12-17 Sugen, Inc. Human orthologues of wart
DE69926742T2 (de) * 1998-04-14 2006-06-14 Sugen Inc Ste20-verwandte proteinkinasen
WO1999061428A1 (en) 1998-05-28 1999-12-02 Parker Hughes Institute Quinazolines for treating brain tumor
US6800649B1 (en) 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
ATE292121T1 (de) 1998-08-21 2005-04-15 Parker Hughes Inst Chinazolinderivate
US6861442B1 (en) * 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) * 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
EP1222273A2 (en) * 1999-10-22 2002-07-17 PHARMACIA & UPJOHN COMPANY Drosophila g protein coupled receptors, nucleic acids, and methods related to the same
UA72946C2 (uk) * 1999-11-05 2005-05-16 Астразенека Аб Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf)
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
EP1237909A2 (en) * 1999-11-16 2002-09-11 PHARMACIA & UPJOHN COMPANY Human g protein-coupled receptors
US20030003451A1 (en) * 2000-02-23 2003-01-02 Gabriel Vogeli Novel G protein-coupled receptors
DE60121931T2 (de) * 2000-04-07 2007-03-01 Astrazeneca Ab Chinazolinverbindungen
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
IL166528A0 (en) 2002-08-02 2006-01-15 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
NZ546645A (en) * 2003-10-23 2010-02-26 Ab Science 2-Aminoaryloxazole compounds as tyrosine kinase inhibitors
RU2445308C2 (ru) 2005-04-04 2012-03-20 Аб Сьянс Замещенные производные оксазола и их применение в качестве ингибиторов тирозинкиназы
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
AU2007303846B2 (en) 2006-10-04 2011-03-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists
US8338433B2 (en) * 2006-11-22 2012-12-25 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetoplastid agents
SG177225A1 (en) * 2006-12-01 2012-01-30 Agency Science Tech & Res Cancer-related protein kinases
SG10201601711SA (en) 2011-03-04 2016-04-28 Newgen Therapeutics Inc Alkyne Substituted Quinazoline Compound And Methods Of Use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
AU438472B2 (en) * 1970-12-23 1973-08-09 Sumitomo Chemical Company, Limited Quinazolinone derivatives anda process for production thereof
JPS6011032B2 (ja) 1975-12-16 1985-03-22 大鵬薬品工業株式会社 ２―置換―５―フルオルピリミジン―４―オン誘導体の製造法
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions

Also Published As

Publication number Publication date
IT1154272B (it) 1987-01-21
IL64875A0 (en) 1982-03-31
HK4588A (en) 1988-01-29
GB2094295A (en) 1982-09-15
DE3203770C2 (de) 1993-11-04
IT8247713A1 (it) 1983-08-03
FR2501207A1 (fr) 1982-09-10
BE891936A (fr) 1982-07-28
FI71559C (fi) 1987-01-19
FI71559B (fi) 1986-10-10
ES509434A0 (es) 1983-02-16
YU42031B (en) 1988-04-30
DK159442C (da) 1991-03-18
DE3203770A1 (de) 1982-11-11
CY1371A (en) 1987-08-07
NL8200473A (nl) 1982-10-01
ES8304095A1 (es) 1983-02-16
SE461732B (sv) 1990-03-19
SE8200526L (sv) 1982-09-07
YU25682A (en) 1985-03-20
JPS57158780A (en) 1982-09-30
ATA39582A (de) 1985-10-15
SG30787G (en) 1988-09-16
US4343940A (en) 1982-08-10
AU556099B2 (en) 1986-10-23
IT8247713A0 (it) 1982-02-03
DK159442B (da) 1990-10-15
AU7998182A (en) 1982-09-09
AR231138A1 (es) 1984-09-28
HU189997B (en) 1986-08-28
GB2094295B (en) 1984-09-12
IE52385B1 (en) 1987-10-14
KR830009050A (ko) 1983-12-17
NZ199576A (en) 1986-05-09
LU83903A1 (fr) 1982-09-13
PH18529A (en) 1985-08-02
AT380476B (de) 1986-05-26
JPH0337552B2 (Direct) 1991-06-05
FI820399L (fi) 1982-09-07
IE820163L (en) 1982-09-06
FR2501207B1 (fr) 1985-12-06
PT74394B (en) 1984-10-22
KR880001852B1 (ko) 1988-09-22
PT74394A (en) 1982-03-01
KE3715A (en) 1987-04-16
GR75903B (Direct) 1984-08-02
CH647776A5 (de) 1985-02-15
DK50482A (da) 1982-09-07

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