CA1158159A - Hydroxyalkyl starch drug carrier - Google Patents

Hydroxyalkyl starch drug carrier

Info

Publication number
CA1158159A
CA1158159A CA000351586A CA351586A CA1158159A CA 1158159 A CA1158159 A CA 1158159A CA 000351586 A CA000351586 A CA 000351586A CA 351586 A CA351586 A CA 351586A CA 1158159 A CA1158159 A CA 1158159A
Authority
CA
Canada
Prior art keywords
active compound
composition
biologically active
animal
controlled release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000351586A
Other languages
English (en)
French (fr)
Inventor
Jon M. Brake
Kenneth L. Berger
Fred H. Deindoerfer
Charles S. Bankert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Hospital Supply Corp
Original Assignee
American Hospital Supply Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Hospital Supply Corp filed Critical American Hospital Supply Corp
Application granted granted Critical
Publication of CA1158159A publication Critical patent/CA1158159A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
    • C08B11/14—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals with nitrogen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
    • C08B15/06—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur containing nitrogen, e.g. carbamates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA000351586A 1979-05-10 1980-05-09 Hydroxyalkyl starch drug carrier Expired CA1158159A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3798179A 1979-05-10 1979-05-10
US037,981 1979-05-10

Publications (1)

Publication Number Publication Date
CA1158159A true CA1158159A (en) 1983-12-06

Family

ID=21897414

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000351586A Expired CA1158159A (en) 1979-05-10 1980-05-09 Hydroxyalkyl starch drug carrier

Country Status (10)

Country Link
EP (2) EP0019403B1 (da)
JP (1) JPH0140812B2 (da)
KR (1) KR840001798B1 (da)
AT (1) ATE12892T1 (da)
CA (1) CA1158159A (da)
DE (1) DE3070546D1 (da)
DK (1) DK155078C (da)
ES (1) ES8105145A1 (da)
NZ (1) NZ193618A (da)
WO (1) WO1980002374A1 (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009155705A1 (en) 2008-06-26 2009-12-30 Therapure Biopharma Inc. Polysaccharide-protein conjugates reversibly coupled via imine bonds

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
DE3421954C1 (de) * 1984-06-13 1985-10-24 Pfrimmer & Co Pharmazeutische Werke Erlangen Gmbh, 8520 Erlangen Diätetisches Nährmittel, enthaltend Hydroxyethylstärke
DK110188D0 (da) * 1988-03-02 1988-03-02 Claus Selch Larsen High molecular weight prodrug derivatives of antiinflammatory drugs
US5830884A (en) * 1995-01-18 1998-11-03 National Starch And Chemical Investment Holding Corporation Pharmaceutical products containing thermally-inhibited starches
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
DE10209822A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
KR101045401B1 (ko) * 2002-09-11 2011-06-30 프레제니우스 카비 도이치란트 게엠베하 하이드록시알킬 전분 유도체
EP1400533A1 (en) * 2002-09-11 2004-03-24 Fresenius Kabi Deutschland GmbH HASylated polypeptides, especially HASylated erythropoietin
ES2314238T3 (es) 2002-10-08 2009-03-16 Fresenius Kabi Deutschland Gmbh Conjugados de oligosacaridos farmaceuticamente activos.
DE10256558A1 (de) * 2002-12-04 2004-09-16 Supramol Parenteral Colloids Gmbh Ester von Polysaccharid Aldonsäuren, Verfahren zu ihrer Herstellung und Verwendung zur Kopplung an pharmazeutische Wirkstoffe
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
DE202005021885U1 (de) 2004-03-11 2011-03-03 Fresenius Kabi Deutschland Gmbh Hydroxyalkylstärke-Protein-Konjugate, durch reduktive Aminierung hergestellt
EP2070950A1 (en) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1167794B (de) * 1953-09-03 1964-04-16 Corn Products Company Eine Ges Verfahren zum Einbetten wasserunloeslicher Vitamine und anderer bei der Aufbewahrung sich verschlechternder oder verdampfender Stoffe in eine Umhuellung
US3523938A (en) 1967-12-13 1970-08-11 American Hospital Supply Corp Starch plasma expanders and process of preparation
US3908004A (en) * 1970-05-20 1975-09-23 C L Basingstoke Limited Process for making injectable iron compositions for treating iron-deficiency anemia
US3928581A (en) * 1972-09-13 1975-12-23 Astra Laekemedel Ab Certain polymer-iron complexes for treatment of iron deficiency
DE2500076C3 (de) * 1975-01-02 1982-11-18 SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld Verfahren zur Gewinnung von intravenös-verträglichen Gammaglobulinen
US4026986A (en) * 1975-05-22 1977-05-31 The Dow Chemical Company Capsule shell
US4180567A (en) * 1977-09-02 1979-12-25 Pharmachem Corporation Iron preparations and methods of making and administering the same
DE2829037A1 (de) * 1978-07-01 1980-01-10 Fresenius Chem Pharm Ind Wasserloesliche, keimtoetende mittel enthaltende mund- und rachenpflegemittel
DE2838736A1 (de) * 1978-09-06 1980-03-20 Theodor Prof Dr Eckert Verwendung von hydroxyaethylstaerke als pudergrundlage
JPS6348545A (ja) * 1986-08-18 1988-03-01 Nippon Zeon Co Ltd 感光性フレキソ版用エラストマ−組成物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009155705A1 (en) 2008-06-26 2009-12-30 Therapure Biopharma Inc. Polysaccharide-protein conjugates reversibly coupled via imine bonds
US8840877B2 (en) 2008-06-26 2014-09-23 Therapure Biopharma Inc. Polysaccharide-protein conjugates reversibly coupled via imine bonds

Also Published As

Publication number Publication date
EP0019403B1 (en) 1985-07-31
KR840001798B1 (ko) 1984-10-20
ES491307A0 (es) 1981-05-16
DE3070546D1 (de) 1985-06-05
EP0028641A1 (en) 1981-05-20
KR830002510A (ko) 1983-05-30
WO1980002374A1 (en) 1980-11-13
EP0019403A3 (en) 1981-10-07
EP0028641A4 (en) 1981-09-01
EP0028641B1 (en) 1985-04-24
NZ193618A (en) 1984-07-06
JPH0140812B2 (da) 1989-08-31
ES8105145A1 (es) 1981-05-16
ATE12892T1 (de) 1985-05-15
EP0019403A2 (en) 1980-11-26
DK4481A (da) 1981-01-07
DK155078C (da) 1989-07-10
JPS56500495A (da) 1981-04-16
DK155078B (da) 1989-02-06

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