ES8105145A1 - Un procedimiento para la preparacion de una composicion de liberacion controlada de un compuesto biologicamente activo para su administracion a un animal - Google Patents

Un procedimiento para la preparacion de una composicion de liberacion controlada de un compuesto biologicamente activo para su administracion a un animal

Info

Publication number
ES8105145A1
ES8105145A1 ES491307A ES491307A ES8105145A1 ES 8105145 A1 ES8105145 A1 ES 8105145A1 ES 491307 A ES491307 A ES 491307A ES 491307 A ES491307 A ES 491307A ES 8105145 A1 ES8105145 A1 ES 8105145A1
Authority
ES
Spain
Prior art keywords
hydroxyalkyl
drug carrier
starch
starch drug
active compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491307A
Other languages
English (en)
Other versions
ES491307A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Hospital Supply Corp
Original Assignee
American Hospital Supply Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Hospital Supply Corp filed Critical American Hospital Supply Corp
Publication of ES491307A0 publication Critical patent/ES491307A0/es
Publication of ES8105145A1 publication Critical patent/ES8105145A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
    • C08B11/14—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals with nitrogen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
    • C08B15/06—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur containing nitrogen, e.g. carbamates

Abstract

PROCEDIMIENTO DE OBTENCION DE UNA COMPOSICION CONTROLADA DE UN COMPUESTO BIOLOGICAMENTE ACTIVO. CONSISTE EN HACER REACCIONAR EL COMPONENTE BIOLOGICO ACTIVO CON EL POLIMERO PARA FORMAR UN ENLACE ENTRE AMBOS; DICHO ENLACE ES UN ENLACE LABIL QUE ES SOMETIDO A INCISION <<IN VITRO>>. EL COMPUESTO BIOLOGICAMENTE ACTIVO MANTIENE SU ACTIVIDAD BIOLOGICA <<IN VIVO>> MIENTRAS ESTA UNIDO AL HIDROXIALQUIL-ALMIDON A TRAVES DE UN DERIVADO. EL HIDROXIETIL-ALMIDON PRESENTA UN GRADO DE SUSTITUCION DE 0,1 A 1, SIENDO SU PESO MOLECULAR DE 10.000 A 2.000.000, APROXIMADAMENTE. EL COMPUESTO BIOLOGICAMENTE ACTIVO ES HIERRO. LA COMPOSICION CONTIENE ADEMAS ACIDO CITRICO.
ES491307A 1979-05-10 1980-05-08 Un procedimiento para la preparacion de una composicion de liberacion controlada de un compuesto biologicamente activo para su administracion a un animal Expired ES8105145A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3798179A 1979-05-10 1979-05-10

Publications (2)

Publication Number Publication Date
ES491307A0 ES491307A0 (es) 1981-05-16
ES8105145A1 true ES8105145A1 (es) 1981-05-16

Family

ID=21897414

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491307A Expired ES8105145A1 (es) 1979-05-10 1980-05-08 Un procedimiento para la preparacion de una composicion de liberacion controlada de un compuesto biologicamente activo para su administracion a un animal

Country Status (10)

Country Link
EP (2) EP0019403B1 (es)
JP (1) JPH0140812B2 (es)
KR (1) KR840001798B1 (es)
AT (1) ATE12892T1 (es)
CA (1) CA1158159A (es)
DE (1) DE3070546D1 (es)
DK (1) DK155078C (es)
ES (1) ES8105145A1 (es)
NZ (1) NZ193618A (es)
WO (1) WO1980002374A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
DE3421954C1 (de) * 1984-06-13 1985-10-24 Pfrimmer & Co Pharmazeutische Werke Erlangen Gmbh, 8520 Erlangen Diätetisches Nährmittel, enthaltend Hydroxyethylstärke
DK110188D0 (da) * 1988-03-02 1988-03-02 Claus Selch Larsen High molecular weight prodrug derivatives of antiinflammatory drugs
US5830884A (en) * 1995-01-18 1998-11-03 National Starch And Chemical Investment Holding Corporation Pharmaceutical products containing thermally-inhibited starches
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
EP1400533A1 (en) * 2002-09-11 2004-03-24 Fresenius Kabi Deutschland GmbH HASylated polypeptides, especially HASylated erythropoietin
WO2004024776A1 (en) * 2002-09-11 2004-03-25 Fresenius Kabi Deutschland Gmbh Method of producing hydroxyalkyl starch derivatives
AU2003273413A1 (en) 2002-10-08 2004-05-04 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
DE10256558A1 (de) * 2002-12-04 2004-09-16 Supramol Parenteral Colloids Gmbh Ester von Polysaccharid Aldonsäuren, Verfahren zu ihrer Herstellung und Verwendung zur Kopplung an pharmazeutische Wirkstoffe
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
WO2005092928A1 (en) 2004-03-11 2005-10-06 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
EP2070950A1 (en) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation
GB0811743D0 (en) 2008-06-26 2008-07-30 Hemosol Biopharma Inc Composition

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1167794B (de) * 1953-09-03 1964-04-16 Corn Products Company Eine Ges Verfahren zum Einbetten wasserunloeslicher Vitamine und anderer bei der Aufbewahrung sich verschlechternder oder verdampfender Stoffe in eine Umhuellung
US3523938A (en) 1967-12-13 1970-08-11 American Hospital Supply Corp Starch plasma expanders and process of preparation
US3908004A (en) * 1970-05-20 1975-09-23 C L Basingstoke Limited Process for making injectable iron compositions for treating iron-deficiency anemia
US3928581A (en) * 1972-09-13 1975-12-23 Astra Laekemedel Ab Certain polymer-iron complexes for treatment of iron deficiency
DE2500076C3 (de) * 1975-01-02 1982-11-18 SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld Verfahren zur Gewinnung von intravenös-verträglichen Gammaglobulinen
US4026986A (en) * 1975-05-22 1977-05-31 The Dow Chemical Company Capsule shell
US4180567A (en) * 1977-09-02 1979-12-25 Pharmachem Corporation Iron preparations and methods of making and administering the same
DE2829037A1 (de) * 1978-07-01 1980-01-10 Fresenius Chem Pharm Ind Wasserloesliche, keimtoetende mittel enthaltende mund- und rachenpflegemittel
DE2838736A1 (de) * 1978-09-06 1980-03-20 Theodor Prof Dr Eckert Verwendung von hydroxyaethylstaerke als pudergrundlage
JPS6348545A (ja) * 1986-08-18 1988-03-01 Nippon Zeon Co Ltd 感光性フレキソ版用エラストマ−組成物

Also Published As

Publication number Publication date
WO1980002374A1 (en) 1980-11-13
EP0019403B1 (en) 1985-07-31
KR840001798B1 (ko) 1984-10-20
ES491307A0 (es) 1981-05-16
CA1158159A (en) 1983-12-06
NZ193618A (en) 1984-07-06
KR830002510A (ko) 1983-05-30
JPH0140812B2 (es) 1989-08-31
EP0028641B1 (en) 1985-04-24
ATE12892T1 (de) 1985-05-15
DE3070546D1 (de) 1985-06-05
EP0028641A1 (en) 1981-05-20
DK4481A (da) 1981-01-07
DK155078C (da) 1989-07-10
EP0019403A3 (en) 1981-10-07
EP0019403A2 (en) 1980-11-26
EP0028641A4 (en) 1981-09-01
JPS56500495A (es) 1981-04-16
DK155078B (da) 1989-02-06

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203