CA1094071A - Trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido[4,3- b] indoles - Google Patents

Trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido[4,3- b] indoles

Info

Publication number
CA1094071A
CA1094071A CA303,710A CA303710A CA1094071A CA 1094071 A CA1094071 A CA 1094071A CA 303710 A CA303710 A CA 303710A CA 1094071 A CA1094071 A CA 1094071A
Authority
CA
Canada
Prior art keywords
fluoro
fluorophenyl
hexahydro
trans
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA303,710A
Other languages
English (en)
French (fr)
Inventor
Willard M. Welch, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of CA1094071A publication Critical patent/CA1094071A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA303,710A 1977-05-23 1978-05-19 Trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido[4,3- b] indoles Expired CA1094071A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79939277A 1977-05-23 1977-05-23
US799,392 1977-05-23

Publications (1)

Publication Number Publication Date
CA1094071A true CA1094071A (en) 1981-01-20

Family

ID=25175793

Family Applications (1)

Application Number Title Priority Date Filing Date
CA303,710A Expired CA1094071A (en) 1977-05-23 1978-05-19 Trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido[4,3- b] indoles

Country Status (31)

Country Link
JP (1) JPS53144600A (hu)
AR (2) AR217688A1 (hu)
AT (1) AT368995B (hu)
AU (1) AU499618B1 (hu)
BE (1) BE867249A (hu)
CA (1) CA1094071A (hu)
CH (1) CH634321A5 (hu)
CS (1) CS207612B2 (hu)
DD (4) DD145537A5 (hu)
DE (1) DE2822465C2 (hu)
DK (1) DK226678A (hu)
EG (1) EG13590A (hu)
FI (1) FI63402C (hu)
FR (1) FR2392023A1 (hu)
GB (1) GB1586655A (hu)
GR (1) GR69985B (hu)
HU (3) HU187782B (hu)
IE (1) IE46975B1 (hu)
IL (1) IL54755A (hu)
IT (1) IT1096307B (hu)
LU (1) LU79684A1 (hu)
NL (1) NL7804210A (hu)
NO (2) NO150204C (hu)
NZ (1) NZ187333A (hu)
PH (1) PH13756A (hu)
PL (5) PL117107B1 (hu)
PT (1) PT68058B (hu)
SE (2) SE441448B (hu)
SU (4) SU873883A3 (hu)
YU (4) YU91478A (hu)
ZA (1) ZA782918B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224329A (en) * 1979-01-23 1980-09-23 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
US4451655A (en) * 1982-05-17 1984-05-29 Pfizer Inc. Process for preparing carboline derivatives and compounds used in their preparation
RU2106864C1 (ru) * 1995-10-23 1998-03-20 Николай Серафимович Зефиров Средство для лечения болезни альцгеймера
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0101773D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
DE20204239U1 (de) 2002-03-16 2002-05-29 Funke Kunststoffe GmbH, 48324 Sendenhorst Universal-Rohrdichtung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205452A1 (es) * 1973-12-06 1976-05-07 Endo Lab Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles
JPS50126699A (hu) * 1974-03-20 1975-10-04
US4001263A (en) * 1974-04-01 1977-01-04 Pfizer Inc. 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines

Also Published As

Publication number Publication date
IL54755A0 (en) 1978-07-31
SU873883A3 (ru) 1981-10-15
YU40796B (en) 1986-06-30
IT7823673A0 (it) 1978-05-22
FI781612A (fi) 1978-11-24
DE2822465A1 (de) 1978-11-30
IL54755A (en) 1981-02-27
SU841589A3 (ru) 1981-06-23
SE448459B (sv) 1987-02-23
FI63402B (fi) 1983-02-28
ZA782918B (en) 1979-06-27
IE46975B1 (en) 1983-11-16
YU221782A (en) 1983-01-21
EG13590A (en) 1982-03-31
SE8305917L (sv) 1983-10-27
NO150204B (no) 1984-05-28
PL114547B1 (en) 1981-02-28
JPS53144600A (en) 1978-12-15
PL117107B1 (en) 1981-07-31
FR2392023A1 (fr) 1978-12-22
YU91478A (en) 1983-01-21
PT68058B (en) 1979-10-24
DD138321A5 (de) 1979-10-24
AR221721A1 (es) 1981-03-13
DK226678A (da) 1978-11-24
FR2392023B1 (hu) 1980-11-07
AU499618B1 (en) 1979-04-26
YU221682A (en) 1983-01-21
CH634321A5 (en) 1983-01-31
CS207612B2 (en) 1981-08-31
YU221882A (en) 1983-01-21
GR69985B (hu) 1982-07-22
NO151862C (no) 1985-06-19
PH13756A (en) 1980-09-17
HU188802B (en) 1986-05-28
AR217688A1 (es) 1980-04-15
GB1586655A (en) 1981-03-25
ATA369678A (de) 1982-04-15
IT1096307B (it) 1985-08-26
AT368995B (de) 1982-11-25
NZ187333A (en) 1984-05-31
DD145537A5 (de) 1980-12-17
SU818484A3 (ru) 1981-03-30
IE781013L (en) 1978-11-23
DE2822465C2 (de) 1986-08-28
DD145536A5 (de) 1980-12-17
FI63402C (fi) 1983-06-10
NO150204C (no) 1984-09-05
PL206903A1 (pl) 1979-10-22
SE7803625L (sv) 1978-11-24
JPS5711912B2 (hu) 1982-03-08
HU185009B (en) 1984-11-28
NO151862B (no) 1985-03-11
NO781770L (no) 1978-11-24
LU79684A1 (fr) 1979-12-06
SE441448B (sv) 1985-10-07
BE867249A (fr) 1978-11-20
NO831790L (no) 1978-11-24
PT68058A (en) 1978-06-01
PL114541B1 (en) 1981-02-28
SU843749A3 (ru) 1981-06-30
DD146186A5 (de) 1981-01-28
HU187782B (en) 1986-02-28
SE8305917D0 (sv) 1983-10-27
NL7804210A (nl) 1978-11-27
PL116944B1 (en) 1981-07-31

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Legal Events

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