CA1082170A - Procede de preparation de nouveau derives halogenes de la serie du 16 .alpha.-methyl pregnane - Google Patents

Procede de preparation de nouveau derives halogenes de la serie du 16 .alpha.-methyl pregnane

Info

Publication number
CA1082170A
CA1082170A CA272,894A CA272894A CA1082170A CA 1082170 A CA1082170 A CA 1082170A CA 272894 A CA272894 A CA 272894A CA 1082170 A CA1082170 A CA 1082170A
Authority
CA
Canada
Prior art keywords
formula
products
product
radical
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA272,894A
Other languages
English (en)
French (fr)
Inventor
Germain Costerousse
Jean G. Teutsch
Roger Deraedt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of CA1082170A publication Critical patent/CA1082170A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA272,894A 1976-03-02 1977-03-01 Procede de preparation de nouveau derives halogenes de la serie du 16 .alpha.-methyl pregnane Expired CA1082170A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7605854 1976-03-02
FR7605854A FR2342738A1 (fr) 1976-03-02 1976-03-02 Nouveaux derives halogenes de la serie du 16a-methyl pregnane

Publications (1)

Publication Number Publication Date
CA1082170A true CA1082170A (fr) 1980-07-22

Family

ID=9169832

Family Applications (1)

Application Number Title Priority Date Filing Date
CA272,894A Expired CA1082170A (fr) 1976-03-02 1977-03-01 Procede de preparation de nouveau derives halogenes de la serie du 16 .alpha.-methyl pregnane

Country Status (16)

Country Link
JP (1) JPS52106855A (ja)
AT (1) AT355237B (ja)
AU (1) AU509948B2 (ja)
BE (1) BE851944A (ja)
CA (1) CA1082170A (ja)
CH (1) CH619969A5 (ja)
DE (1) DE2709078C2 (ja)
DK (1) DK156401C (ja)
FR (1) FR2342738A1 (ja)
GB (1) GB1530975A (ja)
IE (1) IE44866B1 (ja)
LU (1) LU76867A1 (ja)
NL (1) NL7702166A (ja)
PT (1) PT66261B (ja)
SE (1) SE7702250L (ja)
ZA (1) ZA771078B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462443A1 (fr) * 1979-07-26 1981-02-13 Roussel Uclaf Nouveau derive halogene de la serie du 16a-methyl pregnane, son procede de preparation et son application comme medicament
FR2533928A1 (fr) * 1982-10-05 1984-04-06 Roussel Uclaf Nouveaux derives dichlores de la serie du 16a-methyl pregnane, leur procede de preparation et leur application comme medicaments
DE4433374A1 (de) * 1994-09-20 1996-03-21 Hoechst Ag 17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928301A (en) * 1958-06-20 1963-06-12 Scherico Ltd 9, 11-dihalogeno steroids
US3049554A (en) * 1959-06-01 1962-08-14 Schering Corp 9, 11-dihalogeno-3, 20-diketopregnanes and processes for their manufacture

Also Published As

Publication number Publication date
FR2342738B1 (ja) 1979-10-12
NL7702166A (nl) 1977-09-06
DK156401C (da) 1990-01-08
IE44866L (en) 1977-09-02
DK156401B (da) 1989-08-14
DE2709078C2 (de) 1986-09-11
CH619969A5 (en) 1980-10-31
SE7702250L (sv) 1977-09-03
JPS6150960B2 (ja) 1986-11-06
PT66261A (fr) 1977-04-01
PT66261B (fr) 1979-01-17
FR2342738A1 (fr) 1977-09-30
AU2280877A (en) 1978-09-07
DK88277A (da) 1977-09-03
BE851944A (fr) 1977-09-01
IE44866B1 (en) 1982-04-21
AT355237B (de) 1980-02-25
AU509948B2 (en) 1980-06-05
ATA136577A (de) 1979-07-15
DE2709078A1 (de) 1977-09-08
ZA771078B (en) 1978-04-26
JPS52106855A (en) 1977-09-07
GB1530975A (en) 1978-11-01
LU76867A1 (ja) 1977-09-26

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Legal Events

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