BRPI9912726A - derivado de amida, composição farmacêutica, e, uso de um derivado de amida. - Google Patents
derivado de amida, composição farmacêutica, e, uso de um derivado de amida.Info
- Publication number
- BRPI9912726A BRPI9912726A BRPI9912726A BRPI9912726A BRPI9912726A BR PI9912726 A BRPI9912726 A BR PI9912726A BR PI9912726 A BRPI9912726 A BR PI9912726A BR PI9912726 A BRPI9912726 A BR PI9912726A BR PI9912726 A BRPI9912726 A BR PI9912726A
- Authority
- BR
- Brazil
- Prior art keywords
- alkoxy
- alkyl
- amide derivative
- heterocyclyl
- heteroaryl
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"derivado de amida, processo para a preparação de um derivado de amida, composição farmacêutica, e, uso de um derivado de amida" a invenção refere-se a derivados de amida da fórmula (i) em que r³ é (1-6c)alquila ou halogênio; q é arila ou heteroarila que porta opcionalmente 1, 2, 3 ou 4 substituintes selecionados dentre hidróxi, halogênio, trifluorometila, ciano, (1-6c)alquila, (1-6c)alcóxi, halogênio-1-6c)alquila, hidróxi-1-6c)alquila, di-[(1-6c)alquil]amino, hidróxi-(2-6c)alcóxi, (1-6c)alcóxi-(2-6c)alcóxi, di[(1-6c)alquil]amino-(2-6c)alcóxi, amino-(2-6c)alquilamino, <mu>n<mv>-(1-6c)alquil-(1-6c)alquilamino-(2-6c)alquilamino, arila, aril-(1-6c)alcóxi, heterarila, heteroaril-(1-6c)alcóxi, heterociclila, heterociclil-(1-6c)alquila, heterociclilóxi e heterociclil-(1-6c)alcóxi; p é 0-2 e r² é um substituinte, como hidróxi ou halogênio; q é 0-4; e r^ 4^ inclui arila opcionalmente substituído, cicloalquila, heteroarila e heterociclila; ou seus sais farmaceuticamente aceitáveis ou ésteres cliváveis in vivo; a processos para sua preparação, a composições farmacêuticas contendo os mesmos e a seu uso no tratamento de doenças ou quadros clínicos mediados por citoquinas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9816837.0A GB9816837D0 (en) | 1998-08-04 | 1998-08-04 | Amide derivatives |
PCT/GB1999/002494 WO2000007980A1 (en) | 1998-08-04 | 1999-07-29 | Amide derivatives which are useful as cytokine inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI9912726A true BRPI9912726A (pt) | 2001-05-02 |
BRPI9912726B1 BRPI9912726B1 (pt) | 2011-05-31 |
BRPI9912726B8 BRPI9912726B8 (pt) | 2021-07-06 |
Family
ID=10836592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9912726 BRPI9912726B8 (pt) | 1998-08-04 | 1999-07-29 | derivado de amida, composição farmacêutica, e, uso de um derivado de amida. |
Country Status (25)
Country | Link |
---|---|
US (1) | US6821965B1 (pt) |
EP (1) | EP1102743B1 (pt) |
JP (1) | JP4502509B2 (pt) |
KR (1) | KR100628285B1 (pt) |
CN (1) | CN1243724C (pt) |
AT (1) | ATE221047T1 (pt) |
AU (1) | AU756292B2 (pt) |
BR (1) | BRPI9912726B8 (pt) |
CA (1) | CA2337770C (pt) |
CZ (1) | CZ301971B6 (pt) |
DE (1) | DE69902277T2 (pt) |
DK (1) | DK1102743T3 (pt) |
ES (1) | ES2178895T3 (pt) |
GB (1) | GB9816837D0 (pt) |
HK (1) | HK1037608A1 (pt) |
HU (1) | HU230343B1 (pt) |
IL (2) | IL141184A0 (pt) |
NO (1) | NO321017B1 (pt) |
NZ (1) | NZ509162A (pt) |
PL (1) | PL195722B1 (pt) |
PT (1) | PT1102743E (pt) |
RU (1) | RU2220951C2 (pt) |
SK (1) | SK286446B6 (pt) |
WO (1) | WO2000007980A1 (pt) |
ZA (1) | ZA200100617B (pt) |
Families Citing this family (76)
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PL195600B1 (pl) | 1998-05-15 | 2007-10-31 | Astrazeneca Ab | Pochodne benzamidowe, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku do leczenia stanów medycznych powstających za pośrednictwem cytokin |
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-
1998
- 1998-08-04 GB GBGB9816837.0A patent/GB9816837D0/en not_active Ceased
-
1999
- 1999-07-29 DK DK99936814T patent/DK1102743T3/da active
- 1999-07-29 AT AT99936814T patent/ATE221047T1/de active
- 1999-07-29 ES ES99936814T patent/ES2178895T3/es not_active Expired - Lifetime
- 1999-07-29 WO PCT/GB1999/002494 patent/WO2000007980A1/en active IP Right Grant
- 1999-07-29 PT PT99936814T patent/PT1102743E/pt unknown
- 1999-07-29 RU RU2001105984/04A patent/RU2220951C2/ru active
- 1999-07-29 SK SK172-2001A patent/SK286446B6/sk not_active IP Right Cessation
- 1999-07-29 CZ CZ20010384A patent/CZ301971B6/cs not_active IP Right Cessation
- 1999-07-29 KR KR1020017001485A patent/KR100628285B1/ko not_active IP Right Cessation
- 1999-07-29 NZ NZ509162A patent/NZ509162A/en not_active IP Right Cessation
- 1999-07-29 CA CA002337770A patent/CA2337770C/en not_active Expired - Lifetime
- 1999-07-29 BR BRPI9912726 patent/BRPI9912726B8/pt unknown
- 1999-07-29 CN CNB998117544A patent/CN1243724C/zh not_active Expired - Lifetime
- 1999-07-29 AU AU51791/99A patent/AU756292B2/en not_active Expired
- 1999-07-29 US US09/762,106 patent/US6821965B1/en not_active Expired - Lifetime
- 1999-07-29 JP JP2000563615A patent/JP4502509B2/ja not_active Expired - Lifetime
- 1999-07-29 PL PL99345809A patent/PL195722B1/pl unknown
- 1999-07-29 HU HU0103366A patent/HU230343B1/hu unknown
- 1999-07-29 EP EP99936814A patent/EP1102743B1/en not_active Expired - Lifetime
- 1999-07-29 DE DE69902277T patent/DE69902277T2/de not_active Expired - Lifetime
- 1999-07-29 IL IL14118499A patent/IL141184A0/xx unknown
-
2001
- 2001-01-22 ZA ZA200100617A patent/ZA200100617B/en unknown
- 2001-01-30 IL IL141184A patent/IL141184A/en not_active IP Right Cessation
- 2001-01-31 NO NO20010533A patent/NO321017B1/no not_active IP Right Cessation
- 2001-11-29 HK HK01108406A patent/HK1037608A1/xx not_active IP Right Cessation
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