HK1037608A1 - Amide derivatives which are useful as cytokine inhibitors - Google Patents

Amide derivatives which are useful as cytokine inhibitors

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Publication number
HK1037608A1
HK1037608A1 HK01108406A HK01108406A HK1037608A1 HK 1037608 A1 HK1037608 A1 HK 1037608A1 HK 01108406 A HK01108406 A HK 01108406A HK 01108406 A HK01108406 A HK 01108406A HK 1037608 A1 HK1037608 A1 HK 1037608A1
Authority
HK
Hong Kong
Prior art keywords
alkoxy
alkyl
halogeno
heterocyclyl
heteroaryl
Prior art date
Application number
HK01108406A
Inventor
Dearg Sutherland Brown
George Robert Brown
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1037608A1 publication Critical patent/HK1037608A1/en

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

The invention concerns amide derivatives of the Formula (I)wherein R<3 >is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluoromethyl, cyano, (1-6C)alkyl, (1-6C)alkoxy, halogeno(1-6C)alkyl, hydroxy-(1-6C)alkyl, di-[(1-6C)alklyl]amino-(1-6C)alkyl, hydroxy-(2-6C)alkoxy, (1-6)alkoxy-(2-6C)alkoxy, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, amino-2(2-6C)alkylamino, N-(1-6C)alkyl-(1-6C)alkylamino-(2-6C)alkylamino, aryl, aryl-(1-6C)alkoxy, heteroaryl, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyl-(1-6C)alkyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; p is 0-2 and R<2 >is a substituent such as hydroxy and halogeno; q is 0-4; and R<4 >includes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
HK01108406A 1998-08-04 2001-11-29 Amide derivatives which are useful as cytokine inhibitors HK1037608A1 (en)

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GBGB9816837.0A GB9816837D0 (en) 1998-08-04 1998-08-04 Amide derivatives
PCT/GB1999/002494 WO2000007980A1 (en) 1998-08-04 1999-07-29 Amide derivatives which are useful as cytokine inhibitors

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