BRPI9904104B1 - processo para produção de sacarídeos empregando uma enzima de formação de sacarídeo não redutor e uma enzima de liberação de trealose - Google Patents

processo para produção de sacarídeos empregando uma enzima de formação de sacarídeo não redutor e uma enzima de liberação de trealose Download PDF

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Publication number
BRPI9904104B1
BRPI9904104B1 BRPI9904104A BR9904104A BRPI9904104B1 BR PI9904104 B1 BRPI9904104 B1 BR PI9904104B1 BR PI9904104 A BRPI9904104 A BR PI9904104A BR 9904104 A BR9904104 A BR 9904104A BR PI9904104 B1 BRPI9904104 B1 BR PI9904104B1
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BR
Brazil
Prior art keywords
enzyme
trehalose
dna
reducing
reducing saccharide
Prior art date
Application number
BRPI9904104A
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English (en)
Portuguese (pt)
Other versions
BR9904104A (pt
Inventor
Kazuhiko Maruta
Michio Kubota
Shigeharu Fukuda
Takuo Yamamoto
Toshio Miyake
Original Assignee
Hayashibara Co
Hayashibara Biochem Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hayashibara Co, Hayashibara Biochem Lab filed Critical Hayashibara Co
Publication of BR9904104A publication Critical patent/BR9904104A/pt
Publication of BRPI9904104B1 publication Critical patent/BRPI9904104B1/pt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/14Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/18Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01001Alpha-amylase (3.2.1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01002Beta-amylase (3.2.1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01003Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0102Alpha-glucosidase (3.2.1.20)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
BRPI9904104A 1998-09-11 1999-09-13 processo para produção de sacarídeos empregando uma enzima de formação de sacarídeo não redutor e uma enzima de liberação de trealose BRPI9904104B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25839498 1998-09-11
JP35225298 1998-12-11
JP01693199A JP3958884B2 (ja) 1998-09-11 1999-01-26 非還元性糖質生成酵素及びトレハロース遊離酵素ならびに該酵素を用いる糖質の製造方法

Publications (2)

Publication Number Publication Date
BR9904104A BR9904104A (pt) 2000-10-17
BRPI9904104B1 true BRPI9904104B1 (pt) 2016-04-26

Family

ID=27281623

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9904104A BRPI9904104B1 (pt) 1998-09-11 1999-09-13 processo para produção de sacarídeos empregando uma enzima de formação de sacarídeo não redutor e uma enzima de liberação de trealose

Country Status (10)

Country Link
US (3) US7186535B1 (enExample)
EP (1) EP0990704B1 (enExample)
JP (1) JP3958884B2 (enExample)
KR (1) KR100729498B1 (enExample)
CN (2) CN1180081C (enExample)
AT (1) ATE417110T1 (enExample)
BR (1) BRPI9904104B1 (enExample)
DE (1) DE69940045D1 (enExample)
DK (1) DK0990704T3 (enExample)
ES (1) ES2318884T3 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4224302B2 (ja) * 2001-04-27 2009-02-12 株式会社林原生物化学研究所 イソマルトースの製造方法並びに用途
US7709230B2 (en) 2001-04-27 2010-05-04 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for producing isomaltose and uses thereof
JP4536002B2 (ja) 2002-12-19 2010-09-01 株式会社林原生物化学研究所 組成物における水分の変動を抑制する方法とその用途
WO2004071472A1 (ja) 2003-02-13 2004-08-26 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo α,α−トレハロースの糖質誘導体を含有することを特徴とする皮膚外用剤
JP4512036B2 (ja) 2003-02-13 2010-07-28 株式会社林原生物化学研究所 揮発性アルデヒド類の生成及び/又は脂肪酸類の分解を抑制する方法とその用途
JP2005013227A (ja) * 2003-06-06 2005-01-20 Hayashibara Biochem Lab Inc 加工品の品質保持方法
US20070099869A1 (en) * 2003-06-10 2007-05-03 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Association product of α-glycosyl α,α-trehalose with ionic metal compound
CN101232891A (zh) 2005-08-11 2008-07-30 株式会社林原生物化学研究所 胶原产生增强剂及其用途
CN101126101A (zh) * 2006-08-18 2008-02-20 Bapp酶工程有限公司 酒精酿造方法
MX336759B (es) 2010-11-02 2016-01-29 Abbott Lab Fortificante concentrado liquido estable para leche materna.
ES2674599T3 (es) * 2011-09-21 2018-07-02 Hayashibara Co., Ltd. Proceso para producir un polvo que contiene dihidrato de alfa,alfa-trehalosa cristalino
JP5993674B2 (ja) * 2012-09-12 2016-09-14 株式会社林原 α,α−トレハロース二含水結晶含有粉末の製造方法
CN103194434B (zh) * 2013-04-15 2014-08-13 山东天力药业有限公司 麦芽寡糖基海藻糖水解酶、酶基因、含该基因的重组表达载体及重组工程菌及酶的制备
CN103194432B (zh) * 2013-04-15 2014-08-20 山东天力药业有限公司 新型麦芽寡糖基海藻糖合成酶、酶基因、含该基因的重组表达载体及重组工程菌及酶的制备
CN107058201A (zh) * 2017-04-24 2017-08-18 江南大学 一种提高MTSase和MTHase产量的方法
EP4023289A4 (en) 2019-08-29 2023-06-14 National University Corporation Ehime University Method for producing cultured tissue, and preparation for external application

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5823799A (ja) 1981-08-03 1983-02-12 株式会社林原生物化学研究所 高純度マルト−スの製造方法
JPS5872598A (ja) 1981-10-26 1983-04-30 Hayashibara Biochem Lab Inc 高純度イソマルト−スの製造方法
DK594084A (da) 1984-12-12 1986-06-13 Novo Industri As Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning
DK160947C (da) 1986-04-17 1991-10-21 Novo Industri As Gen-udtrykkelsessystem
DK639689D0 (da) 1989-12-18 1989-12-18 Novo Nordisk As Indfoering af dna i celler
DE69332781T2 (de) 1992-12-28 2004-02-12 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Reinigung von Trehalose
KR960701209A (ko) 1993-02-19 1996-02-24 안네 제케르 전분분해효소(An Amylolytic Enzyme)
JP3559585B2 (ja) 1993-06-03 2004-09-02 株式会社林原生物化学研究所 トレハロース遊離酵素とその製造方法並びに用途
JP2780063B2 (ja) 1993-08-10 1998-07-23 ユニリーバー・ナームローゼ・ベンノートシャープ ライ麦粉
FI962288L (fi) 1993-12-01 1996-07-26 Novo Nordisk Biotech Inc Aspergillus ilmentämisjärjestelmä
DE69418594T2 (de) 1994-02-18 1999-09-16 Tapematic S.P.A., Monza Beschicktigungsanlage für Kassetten in einer automatischen Maschine für die Aufladung von Bändern in die Kassetten und damit durchgeführtes Verfahren zum Laden
US5871993A (en) * 1994-02-23 1999-02-16 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo DNA encoding enzyme, recombinant DNA and enzyme, transformant, and their preparations and uses
JP3557272B2 (ja) 1994-02-23 2004-08-25 株式会社林原生物化学研究所 組換え型酵素とその製造方法並びに用途
JP3559609B2 (ja) 1994-03-07 2004-09-02 株式会社林原生物化学研究所 組換え型酵素とその製造方法並びに用途
DE69532485T2 (de) * 1994-03-07 2004-11-04 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Trehalose-freisetzendes Enzym, dafür kodierende DNA, Herstellung und Verwendung
JP3557277B2 (ja) 1994-06-25 2004-08-25 株式会社林原生物化学研究所 耐熱性トレハロース遊離酵素とその製造方法並びに用途
JP3662972B2 (ja) 1994-06-27 2005-06-22 株式会社林原生物化学研究所 非還元性糖質とその製造方法並びに用途
JP3793590B2 (ja) 1994-06-27 2006-07-05 株式会社林原生物化学研究所 非還元性糖質とその製造方法並びに用途
EP1130101B1 (en) 1994-06-15 2008-10-15 Kirin Beer Kabushiki Kaisha Transferase and amylase, process for producing the enzymes, use thereof, and genes coding for the same
US5714368A (en) 1994-06-24 1998-02-03 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Thermostable non-reducing saccharide-forming enzyme its production and uses
JP3557287B2 (ja) 1994-06-24 2004-08-25 株式会社林原生物化学研究所 耐熱性非還元性糖質生成酵素とその製造方法並びに用途
JP4070250B2 (ja) 1994-06-27 2008-04-02 株式会社林原生物化学研究所 還元性を低減させた糖質とその製造方法並びに用途
IL114030A (en) 1994-06-27 2000-08-13 Hayashibara Biochem Lab Saccharide composition with a lesser reducibility its preparation and compositions containing it
EP0693558B1 (en) 1994-07-19 2002-12-04 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Trehalose and its production and use
JP3616166B2 (ja) 1994-07-19 2005-02-02 株式会社林原生物化学研究所 トレハロースとその製造方法並びに用途
JP3557288B2 (ja) 1994-07-21 2004-08-25 株式会社林原生物化学研究所 還元性澱粉糖から末端にトレハロース構造を有する非還元性糖質を生成する組換え型耐熱性酵素
JP3557289B2 (ja) 1994-07-21 2004-08-25 株式会社林原生物化学研究所 非還元性糖質からトレハロースを遊離する組換え型耐熱性酵素
JP3084609B2 (ja) 1995-04-12 2000-09-04 株式会社林原生物化学研究所 トレハロース含有シラップ
JP3624038B2 (ja) 1995-12-11 2005-02-23 株式会社林原生物化学研究所 糖衣固形物及びその製造方法
JPH09252719A (ja) 1996-03-21 1997-09-30 Kyokuto Internatl Corp カット野菜・カット果物の鮮度保持剤
JP3549366B2 (ja) 1996-06-20 2004-08-04 株式会社林原生物化学研究所 飲食物の塩から味及び/又は旨味増強方法
JP3806498B2 (ja) 1996-10-07 2006-08-09 株式会社林原生物化学研究所 トレハロース高含有シラップとその製造方法並びに用途
US5916881A (en) 1996-10-07 1999-06-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo High trehalose content syrup
JP4034846B2 (ja) 1996-12-10 2008-01-16 株式会社林原生物化学研究所 結晶性粉末糖質とその製造方法並びに用途
JPH11263795A (ja) 1997-03-04 1999-09-28 Hayashibara Biochem Lab Inc 活性酸素消去能低減抑制剤
EP0868916A3 (en) 1997-03-04 2004-09-15 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Reduction inhibitory agent for active-oxygen eliminating activity
JP4034862B2 (ja) 1997-06-02 2008-01-16 株式会社林原生物化学研究所 スクロースの後味改善方法とその用途
JPH1160590A (ja) 1997-08-22 1999-03-02 Yakult Honsha Co Ltd オリゴフコース誘導体又はオリゴラムノース誘導体及びその製造法
JPH1172763A (ja) 1997-08-29 1999-03-16 Ando Electric Co Ltd 音響光学変調器
JP3782874B2 (ja) 1997-09-05 2006-06-07 株式会社林原生物化学研究所 コーヒーホワイトナー
JP4098855B2 (ja) 1997-09-16 2008-06-11 株式会社林原生物化学研究所 経口摂取用固状成形物とその製造方法
JPH11158075A (ja) 1997-11-25 1999-06-15 Hayashibara Biochem Lab Inc 膵機能調節剤
JP3908868B2 (ja) 1997-12-26 2007-04-25 株式会社林原生物化学研究所 トリメチルアミン生成抑制方法とその用途

Also Published As

Publication number Publication date
BR9904104A (pt) 2000-10-17
CN1504567A (zh) 2004-06-16
EP0990704A2 (en) 2000-04-05
EP0990704A3 (en) 2000-04-26
CN1180081C (zh) 2004-12-15
KR20000023095A (ko) 2000-04-25
JP2000228980A (ja) 2000-08-22
CN1271203C (zh) 2006-08-23
US20070218529A1 (en) 2007-09-20
ES2318884T3 (es) 2009-05-01
US7186535B1 (en) 2007-03-06
KR100729498B1 (ko) 2007-06-15
EP0990704B1 (en) 2008-12-10
DK0990704T3 (da) 2009-02-09
US7575900B2 (en) 2009-08-18
CN1252442A (zh) 2000-05-10
JP3958884B2 (ja) 2007-08-15
DE69940045D1 (de) 2009-01-22
US20070281346A1 (en) 2007-12-06
ATE417110T1 (de) 2008-12-15
US7582463B2 (en) 2009-09-01

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