BRPI9506596B8 - composto l-nucleosídeo. - Google Patents

composto l-nucleosídeo.

Info

Publication number
BRPI9506596B8
BRPI9506596B8 BRPI9506596A BR9506596A BRPI9506596B8 BR PI9506596 B8 BRPI9506596 B8 BR PI9506596B8 BR PI9506596 A BRPI9506596 A BR PI9506596A BR 9506596 A BR9506596 A BR 9506596A BR PI9506596 B8 BRPI9506596 B8 BR PI9506596B8
Authority
BR
Brazil
Prior art keywords
fluoro
beta
arabinofuranosyl
ebv
deoxy
Prior art date
Application number
BRPI9506596A
Other languages
English (en)
Other versions
BR9506596A (pt
BR9506596B1 (pt
Inventor
Balakrishna S Pai
Chung K Chu
Gang-Qing Yao
Yung-Chi Cheng
Original Assignee
Univ Georgia
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22695792&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI9506596(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Georgia, Univ Yale filed Critical Univ Georgia
Publication of BR9506596A publication Critical patent/BR9506596A/pt
Publication of BR9506596B1 publication Critical patent/BR9506596B1/pt
Publication of BRPI9506596B8 publication Critical patent/BRPI9506596B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

patente de invenção de "composto lnucleosídeo e processo para tratamento de ser humano infectado com hbv ou ebv". é proporcionado um processo para tratamento de um hospedeiro, e, em particular, um ser humano, infectado com hbv ou ebv, que inclui administrar uma quantidade, adequada para tratamento de hbv ou ebv, de um l-nucleosídeo de fórmula (i), em que r é uma base purina ou pirimidina. em uma configuração preferida, o composto ativo é 2-flúor-5-metil-ß-l-arabinofuranosiluridina (também chamado de l-fmau). esse composto é um potente agente antiviral contra hbv e ebv e apresenta abaixo atoxicidade. outros exemplos específicos de compostos ativos incluem n~ 1~-(2'-flúor-ß-l- arabinofuranosil)-5-etiluracil, n~ 1~- (2'-de-oxi-2'-flúor-ß-arabinofuranosil)-5- iodocitosina e n~ 1~-(2'-deoxi-2'-flúor-ß-l-arabinofuranosil)-5 -iodouracil.
BRPI9506596A 1994-01-28 1995-01-30 composto l-nucleosídeo. BRPI9506596B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/189,070 US5587362A (en) 1994-01-28 1994-01-28 L-nucleosides
PCT/US1995/001253 WO1995020595A1 (en) 1994-01-28 1995-01-30 L-nucleosides for the treatment of hepatitis b-virus and epstein-bar virus

Publications (3)

Publication Number Publication Date
BR9506596A BR9506596A (pt) 1997-09-09
BR9506596B1 BR9506596B1 (pt) 2010-10-05
BRPI9506596B8 true BRPI9506596B8 (pt) 2016-05-24

Family

ID=22695792

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9506596A BRPI9506596B8 (pt) 1994-01-28 1995-01-30 composto l-nucleosídeo.

Country Status (23)

Country Link
US (3) US5587362A (pt)
EP (2) EP1283211B1 (pt)
JP (1) JP3899440B2 (pt)
KR (1) KR100321209B1 (pt)
CN (1) CN1043769C (pt)
AT (2) ATE236186T1 (pt)
AU (1) AU710262B2 (pt)
BG (1) BG62571B1 (pt)
BR (1) BRPI9506596B8 (pt)
CA (1) CA2182273C (pt)
CZ (1) CZ292574B6 (pt)
DE (2) DE69535047T2 (pt)
DK (2) DK1283211T3 (pt)
ES (2) ES2266402T3 (pt)
FI (4) FI117475B (pt)
HK (1) HK1014716A1 (pt)
HU (1) HU228135B1 (pt)
NO (1) NO306408B1 (pt)
NZ (2) NZ281058A (pt)
PT (2) PT1283211E (pt)
RO (1) RO116623B1 (pt)
SK (1) SK285191B6 (pt)
WO (1) WO1995020595A1 (pt)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069252A (en) * 1990-02-01 2000-05-30 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
AU722214B2 (en) 1995-06-07 2000-07-27 Centre National De La Recherche Scientifique (Cnrs) Nucleosides with anti-hepatitis B virus activity
US6025335A (en) * 1995-09-21 2000-02-15 Lipitek International, Inc. L-Nucleoside Dimer Compounds and therapeutic uses
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
US6509320B1 (en) * 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
IL129126A0 (en) * 1996-10-16 2000-02-17 Icn Pharmaceuticals Monocyclic l-nucleosides analogs and uses thereof
EP1072607A3 (en) * 1996-10-16 2001-09-12 ICN Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses therof
EP1302474A1 (en) * 1996-10-16 2003-04-16 Ribapharm, Inc. Monocyclic L-nucleosides, analogs and uses thereof
ATE271063T1 (de) * 1996-10-16 2004-07-15 Icn Pharmaceuticals Purin-l-nukleoside, deren analoga und verwendungen
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
GB9716567D0 (en) * 1997-08-05 1997-10-08 Pfizer Process
US6090602A (en) * 1998-02-18 2000-07-18 Promelas Research Corporation Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent
BR9908270A (pt) 1998-02-25 2004-06-29 Univ Emory 2-fluoro-nucleosìdeos, composições farmacêuticas e seus usos
KR100449618B1 (ko) * 1998-03-27 2004-11-16 부광약품 주식회사 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법
JP2003525017A (ja) * 1998-04-20 2003-08-26 リボザイム・ファーマシューティカルズ・インコーポレーテッド 遺伝子発現を調節しうる新規な化学組成を有する核酸分子
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
ES2579903T3 (es) 1998-08-10 2016-08-17 Centre National De La Recherche Scientifique (Cnrs) Beta-L-2'-desoxi-nucleósidos para el tratamiento de la hepatitis B
EP1382343B1 (en) 1998-11-02 2010-02-17 Gilead Sciences, Inc. Combination therapy to treat hepatitis B virus
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
US6653318B1 (en) 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
US6583149B1 (en) 1999-09-24 2003-06-24 Biochem Pharma Inc. Method for the treatment or prevention of viral infection using nucleoside analogues
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
EP1284720B1 (en) * 2000-03-29 2006-09-13 Georgetown University L-fmau for the treatment of hepatitis delta viral infection
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
NZ547204A (en) 2000-05-26 2008-01-31 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
WO2002006296A1 (fr) * 2000-07-19 2002-01-24 Mitsui Chemicals, Inc. Procedes de preparation de derives de compose d'acide nucleique 2,2'-anhydro
CN1646141B (zh) 2000-10-18 2014-06-25 吉利德制药有限责任公司 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物
AU2002335489B2 (en) * 2001-03-01 2008-06-05 Abbott Laboratories Polymorphic and other crystalline forms of cis-FTC
CN1330660C (zh) * 2001-03-30 2007-08-08 三角药品公司 2＇－卤代－β－L－阿拉伯呋喃糖基核苷的制备方法
GB0112617D0 (en) 2001-05-23 2001-07-18 Hoffmann La Roche Antiviral nucleoside derivatives
EP1478322A4 (en) 2001-06-22 2007-08-08 Pharmasset Ltd Beta 2'-OR 3'-HALONUCLEOSIDE
KR100487992B1 (ko) * 2001-10-25 2005-05-09 부광약품 주식회사 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체
AU2002360697B2 (en) * 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
SE521676C2 (sv) * 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
AU2003248748A1 (en) 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
PT1572095E (pt) * 2002-09-13 2015-10-13 Novartis Ag Β-l-2'-desoxinucleósidos para tratamento de estirpes resistentes de vhb
KR20050088079A (ko) 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이
CA2509687C (en) 2002-12-12 2012-08-14 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
BRPI0408561A (pt) * 2003-03-20 2006-03-21 Microbiol Quimica Farmaceutica métodos para manufatura de 2'-desoxi-59-l-nucleosìeos
CA2734052A1 (en) 2003-05-30 2005-01-13 Pharmasset, Inc. Modified fluorinated nucleoside analogues
CA2577526A1 (en) * 2004-08-23 2006-03-02 Joseph Armstrong Martin Antiviral 4'-azido-nucleosides
JP2006265156A (ja) * 2005-03-23 2006-10-05 Ajinomoto Co Inc ２−デオキシ−ｌ−リボフラノシルクロリド化合物の製造方法
CN103735560A (zh) * 2005-06-07 2014-04-23 耶鲁大学 使用克来夫定和替比夫定治疗癌症和其它病症或疾病状态的方法
US7951788B2 (en) 2005-12-02 2011-05-31 Yale University Method of treating cancer and other conditions or disease states using L-cytosine nucleoside analogs
US8076303B2 (en) 2005-12-13 2011-12-13 Spring Bank Pharmaceuticals, Inc. Nucleotide and oligonucleotide prodrugs
JP5254033B2 (ja) 2005-12-23 2013-08-07 イデニク プハルマセウティカルス，インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
US8895531B2 (en) * 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
AP2009004812A0 (en) * 2006-10-10 2009-04-30 Medivir Ab HCV nucleoside inhibitor
WO2008069303A1 (ja) 2006-12-08 2008-06-12 Api Corporation フラノース誘導体の製造方法
CN101801390B (zh) * 2007-09-10 2012-11-14 雅玛山酱油株式会社 针对爱泼斯坦-巴尔病毒相关疾病的药剂
US20090274686A1 (en) * 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives
EA039123B1 (ru) * 2014-12-15 2021-12-08 Эмори Юниверсити Фосфорамидаты для лечения вируса гепатита в
CA2969372C (en) * 2014-12-15 2023-05-16 Emory University Phosphoramidates for the treatment of hepatitis b virus
CA3029315A1 (en) 2016-06-24 2017-12-28 Emory University Phosphoramidates for the treatment of hepatitis b virus
CN109467583A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种克拉夫定的绿色合成工艺

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3116268A (en) * 1955-12-21 1963-12-31 Du Pont Polyphosphonamide polymers and copolymers
US3116266A (en) * 1960-06-17 1963-12-31 Minnesota Mining & Mfg Scorch resistant, thermally curable polymeric compositions, and their curing
US3553192A (en) * 1968-07-15 1971-01-05 Robugen Gmbh Substituted (2'-deoxyribosyl) uracil compounds, compositions containing same and process of making and using same
US4000137A (en) * 1975-06-10 1976-12-28 American Home Products Corporation Antitumor derivatives of periodate-oxidized nucleosides
JPS5668674A (en) * 1979-11-08 1981-06-09 Shionogi & Co Ltd 5-fluorouracil derivative
US4666892A (en) * 1984-03-06 1987-05-19 Sloan-Kettering Memorial Cancer Center Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
EP0206497B1 (en) * 1985-05-15 1994-07-20 The Wellcome Foundation Limited Therapeutic nucleosides and their preparation
US4879277A (en) * 1985-08-26 1989-11-07 The United States Of America As Represented By The Department Of Health And Human Services Antiviral compositions and methods
JPS62501712A (ja) * 1985-08-26 1987-07-09 アメリカ合衆国 ２′、３′―ジデオキシイノシン、２′，３′―ジデオキシグアノシンまたは２′，３′―ジデオキシアデノシンを含有する抗ｈｔｌｖ―３／ｌａｖ剤
DK167377B1 (da) * 1985-09-17 1993-10-25 Wellcome Found 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion
IN164556B (pt) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US5446029A (en) * 1986-07-04 1995-08-29 Medivir Ab Anti-retroviral activity of 2',3'-dideoxy-3'-fluoronucleosides
GB8617861D0 (en) * 1986-07-22 1986-08-28 Ciba Geigy Ag Flame retardant compositions
US4963533A (en) * 1986-10-24 1990-10-16 Stichting Rega Vzw (Rega) Therapeutic application of dideoxycytidinene
US5215971A (en) * 1986-12-19 1993-06-01 Medivir Ab Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
EP0285884A3 (en) * 1987-03-20 1990-07-04 Bristol-Myers Squibb Company process to produce 2', 3'-dideoxynucleosides
NZ223990A (en) * 1987-03-24 1990-08-28 Nycomed As Acylated 2',3'-dideoxynucleosides and pharmaceutical compositions
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
IL87646A (en) * 1987-09-03 1994-07-31 Sloan Kettering Inst Cancer Preparation for the treatment of hepatitis virus containing 1 -) 2 '- Deoxy - 2' - Fluoro - Beta - B - D - Arabino - Furanozil (- 5 - Orcil
US5246924A (en) * 1987-09-03 1993-09-21 Sloan-Kettering Institute For Cancer Research Method for treating hepatitis B virus infections using 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil
US5466806A (en) * 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5270315A (en) * 1988-04-11 1993-12-14 Biochem Pharma Inc. 4-(purinyl bases)-substituted-1,3-dioxlanes
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
SE8802687D0 (sv) * 1988-07-20 1988-07-20 Astra Ab Nucleoside derivatives
EP0375329B1 (en) * 1988-12-19 1995-05-31 The Wellcome Foundation Limited Antiviral pyrimidine and purine compounds, process for their preparation and pharmaceutical compositions containing them
UA45942A (uk) * 1989-02-08 2002-05-15 Біокем Фарма, Інк. 1,3-оксатіолан, його похідні, спосіб (варіанти) його одержання та фармацевтична композиція
HU226137B1 (en) * 1989-02-08 2008-05-28 Shire Canada Inc Process for preparing substituted 1,3-oxathiolanes with antiviral properties
NZ233197A (en) * 1989-04-13 1991-11-26 Richard Thomas Walker Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions
US5059690A (en) * 1990-03-01 1991-10-22 E. R. Squibb & Sons, Inc. Purinyl tetrahydrofurans
US5071983A (en) * 1989-10-06 1991-12-10 Burroughs Wellcome Co. Therapeutic nucleosides
IE904378A1 (en) * 1989-12-20 1991-07-03 Abbott Lab Analogs of oxetanyl purines and pyrimidines
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5527782A (en) * 1990-03-13 1996-06-18 Acic (Canada) Inc. 5-halo-2,3'-O-cyclocytidines
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US5248776A (en) * 1990-12-05 1993-09-28 University Of Georgia Research Foundation, Inc. Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides
AU9125991A (en) * 1990-12-05 1992-07-08 University Of Georgia Research Foundation, Inc., The Enantiomerically pure beta -l-(-)-1,3-oxathiolane nucleosides
US5179104A (en) * 1990-12-05 1993-01-12 University Of Georgia Research Foundation, Inc. Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
NZ250842A (en) * 1991-02-22 1996-03-26 Univ Emory Resolution of a racemic mixture of nucleoside enantiomers such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (ftc)
SK279542B6 (sk) * 1991-03-06 1998-12-02 The Wellcome Foundation Limited U
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
WO1992018517A1 (en) * 1991-04-17 1992-10-29 Yale University Method of treating or preventing hepatitis b virus
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
ZA923640B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
CA2109702A1 (en) * 1991-05-23 1992-11-26 Jesse K. Wong Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
GB9111902D0 (en) * 1991-06-03 1991-07-24 Glaxo Group Ltd Chemical compounds
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US5432165A (en) * 1992-04-06 1995-07-11 Oclassen Pharmaceuticals, Inc. Methods for the treatment of infection caused by Hepatitis B virus (HBV)
FR2698325B1 (fr) * 1992-11-20 1995-01-13 Renault Dispositif de commande de débrayage à l'arrêt de transmission automatique.
GB9226927D0 (en) * 1992-12-24 1993-02-17 Iaf Biochem Int Dideoxy nucleoside analogues
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
US5439893A (en) * 1993-05-26 1995-08-08 University Of Montana Methods for the treatment and prevention of diarrhea
FR2709754B1 (fr) * 1993-09-10 1995-12-01 Centre Nat Rech Scient Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale.
WO1995007086A1 (en) * 1993-09-10 1995-03-16 Emory University Nucleosides with anti-hepatitis b virus activity
WO1995018137A1 (en) * 1993-12-30 1995-07-06 Genta Incorporated Improved process for the purification of oligomers
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides

Also Published As

Publication number Publication date
EP0748330B1 (en) 2003-04-02
JP3899440B2 (ja) 2007-03-28
DE69535047T2 (de) 2006-12-07
FI20051033A (fi) 2005-10-13
EP1283211A3 (en) 2003-02-19
CN1143966A (zh) 1997-02-26
FI117475B (fi) 2006-10-31
SK92696A3 (en) 1997-08-06
CA2182273C (en) 2006-07-11
PT1283211E (pt) 2006-09-29
DE69530192D1 (de) 2003-05-08
BR9506596A (pt) 1997-09-09
HU228135B1 (en) 2012-12-28
US5565438A (en) 1996-10-15
DK1283211T3 (da) 2006-10-09
BG100792A (bg) 1997-03-31
KR100321209B1 (ko) 2002-10-04
NZ281058A (en) 1998-06-26
EP0748330A4 (en) 1997-03-19
FI962986A (fi) 1996-07-26
WO1995020595A1 (en) 1995-08-03
ES2194902T3 (es) 2003-12-01
DK0748330T3 (da) 2003-07-28
US5587362A (en) 1996-12-24
FI121846B (fi) 2011-05-13
NZ330137A (en) 2000-08-25
HUT75514A (en) 1997-05-28
FI20070005A (fi) 2007-01-03
AU1737695A (en) 1995-08-15
SK285191B6 (sk) 2006-08-03
EP1283211A2 (en) 2003-02-12
PT748330E (pt) 2003-08-29
RO116623B1 (ro) 2001-04-30
DE69530192T2 (de) 2004-01-08
FI118954B (fi) 2008-05-30
FI119416B (fi) 2008-11-14
CA2182273A1 (en) 1995-08-03
EP0748330A1 (en) 1996-12-18
HK1014716A1 (en) 1999-09-30
BG62571B1 (bg) 2000-02-29
CZ211496A3 (cs) 1998-09-16
ATE236186T1 (de) 2003-04-15
ES2266402T3 (es) 2007-03-01
NO306408B1 (no) 1999-11-01
CZ292574B6 (cs) 2003-10-15
NO963138L (no) 1996-09-26
HU9601774D0 (en) 1996-09-30
US5567688A (en) 1996-10-22
DE69535047D1 (de) 2006-07-20
BR9506596B1 (pt) 2010-10-05
FI962986A0 (fi) 1996-07-26
FI20080432A (fi) 2008-07-08
CN1043769C (zh) 1999-06-23
AU710262B2 (en) 1999-09-16
NO963138D0 (no) 1996-07-26
JPH09508394A (ja) 1997-08-26
EP1283211B1 (en) 2006-06-07
ATE328889T1 (de) 2006-06-15

Similar Documents

Publication Publication Date Title
BR9506596B1 (pt) composto l-nucleosìdeo.
ATE165004T1 (de) Ematiomerenreine beta-d-dioxolane nucleoside mit selektiver antihepatitis b-virus wirkung
FI20001231A (fi) 2-Deoksi-2,3-didehydro-N-asetyylineuramiinihapon johdannaisia ja niiden analogeja ja niiden käyttö antiviraalisina aineina
DE69334348D1 (de) Enantiomerisch reine Beta-D-Dioxolan-Nukleoside
IL99755A0 (en) Hydroxymethyl(methylenecyclopentyl)purines and pyrimidines and pharmaceutical compositions containing the same
NZ230919A (en) 5'-substituted, 3'-azido-2',3'-dideoxynucleosides and pharmaceutical compositions thereof
FR2591890B1 (fr) Composition a usage therapeutique comprenant des composes organo-silicies
MX9603029A (es) Nucleosidos-l para el tratamiento del virus-b de hepatitis y el virus de epstein-barr.
DE68901443D1 (de) Derivate von nukleosiden.
JPS6426594A (en) Nucleotides and antitumor agent
JPS5673022A (en) Antiviral agent

Legal Events

Date Code Title Description
FA11 Dismissal: dismissal - article 38, par. 2 of industrial property law
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
FBOS Technical and formal requirements: other requirements
HKFN Application deemed withdrawn (deleted)
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
HJEG Technical examination (opinion): technical examination (opinion) related to article 229 of industrial property law
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 05/10/2010, OBSERVADAS AS CONDICOES LEGAIS.

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI-52400.061590/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132375-39.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE STATE OF QUEENSLAND THROUGH ITS DEPARTMENTE OF PRIMARY INDUSTRIES, THE STATE OF NEW SOUTH WALES THROUGH ITS DEPARTMENT OF AGRICULTURE, THE

B19A Notification of judicial decision: notification of judicial decision

Free format text: INPI-52400.061590/2013 SECAO JUDICIARIA DO RIO DE JANEIRO 09A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132375-39.2013.4.02.5101 AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL INPI REU: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION E OUTROS E DECISAO: VISTOS E RELATADOS OS PRESENTES AUTOS EM QUE SAO PARTES AS ACIMA INDICADAS, ACORDAM OS MEMBROS DA SEGUNDA TURMA ESPECIALIZADA DO TRIBUNAL REGIONAL FEDERAL DA 2A REGIAO, POR MAIORIA, DAR PROVIMENTO A REMESSA NECESSARIA, NOS TERMOS DO VOTO DO DESEMBARGADOR ANDRE FONTES, QUE FICA FAZENDO PARTE INTEGRANTE DESTE JULGADO. REFORMAR PARCIALMENTE A SENTENCA DE MODO A JULGAR PROCEDENTE, NOS TERMOS DO ARTIGO 269, I, DO CODI

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REFERENTE A RPI 2074 DE 05/10/2010, QUANTO AO PRAZO DE VALIDADE, CONFORME DETERMINACAO JUDICIAL DA 9A VARA FEDERAL DO RIO DE JANEIRO - PROCESSO NO 0132375-39.2013.4.02.5101 - INPI- 52400.061590/2013.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 30/01/2015, CFE. DESP. 16.3 DA RPI 2368, DE 24/05/2016