CN101801390B - 针对爱泼斯坦-巴尔病毒相关疾病的药剂 - Google Patents
针对爱泼斯坦-巴尔病毒相关疾病的药剂 Download PDFInfo
- Publication number
- CN101801390B CN101801390B CN2008801062690A CN200880106269A CN101801390B CN 101801390 B CN101801390 B CN 101801390B CN 2008801062690 A CN2008801062690 A CN 2008801062690A CN 200880106269 A CN200880106269 A CN 200880106269A CN 101801390 B CN101801390 B CN 101801390B
- Authority
- CN
- China
- Prior art keywords
- epstein
- barr virus
- cell
- medicament
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 27
- 201000010099 disease Diseases 0.000 title claims abstract description 19
- 241000701044 Human gammaherpesvirus 4 Species 0.000 title claims description 38
- 238000000034 method Methods 0.000 title description 28
- 238000012216 screening Methods 0.000 title description 17
- 239000003814 drug Substances 0.000 claims abstract description 57
- 241000700605 Viruses Species 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 5
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Natural products O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims description 10
- 229940035893 uracil Drugs 0.000 claims description 9
- 230000002265 prevention Effects 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 230000001684 chronic effect Effects 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 230000001154 acute effect Effects 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 25
- 239000013612 plasmid Substances 0.000 abstract description 22
- 230000003013 cytotoxicity Effects 0.000 abstract description 4
- 231100000135 cytotoxicity Toxicity 0.000 abstract description 4
- 101000800463 Homo sapiens Transketolase Proteins 0.000 abstract 2
- JKQGUWCMZVJBEK-LQBCMXCNSA-N 1-[(2r,3r,4s,5r)-3-fluoro-3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@@](F)(O)[C@H](O)[C@@H](CO)S1 JKQGUWCMZVJBEK-LQBCMXCNSA-N 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 55
- 102000006601 Thymidine Kinase Human genes 0.000 description 25
- 108020004440 Thymidine kinase Proteins 0.000 description 25
- 108090000623 proteins and genes Proteins 0.000 description 25
- 101150003725 TK gene Proteins 0.000 description 13
- 206010015108 Epstein-Barr virus infection Diseases 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 8
- 229960002963 ganciclovir Drugs 0.000 description 8
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 8
- 108020004414 DNA Proteins 0.000 description 7
- 231100000331 toxic Toxicity 0.000 description 7
- 230000002588 toxic effect Effects 0.000 description 7
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 208000037581 Persistent Infection Diseases 0.000 description 5
- 230000037396 body weight Effects 0.000 description 5
- 230000007541 cellular toxicity Effects 0.000 description 5
- 210000002751 lymph Anatomy 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 239000012453 solvate Substances 0.000 description 5
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 5
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 230000008676 import Effects 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 230000026731 phosphorylation Effects 0.000 description 4
- 238000006366 phosphorylation reaction Methods 0.000 description 4
- 239000013600 plasmid vector Substances 0.000 description 4
- 210000001541 thymus gland Anatomy 0.000 description 4
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 4
- 229960002555 zidovudine Drugs 0.000 description 4
- 230000000840 anti-viral effect Effects 0.000 description 3
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 3
- 231100000433 cytotoxic Toxicity 0.000 description 3
- 230000001472 cytotoxic effect Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000000581 natural killer T-cell Anatomy 0.000 description 3
- 229940113082 thymine Drugs 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- -1 2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl Chemical group 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- ODZBBRURCPAEIQ-DJLDLDEBSA-N Brivudine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C=CBr)=C1 ODZBBRURCPAEIQ-DJLDLDEBSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 2
- 229930193140 Neomycin Natural products 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 229960004150 aciclovir Drugs 0.000 description 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 239000008365 aqueous carrier Substances 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 235000019445 benzyl alcohol Nutrition 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 229940104302 cytosine Drugs 0.000 description 2
- 206010017758 gastric cancer Diseases 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 238000001638 lipofection Methods 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 2
- 229960004927 neomycin Drugs 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 201000008968 osteosarcoma Diseases 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 201000011549 stomach cancer Diseases 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- GBBJCSTXCAQSSJ-JVZYCSMKSA-N 1-[(2r,3s,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@@H](F)[C@H](O)[C@@H](CO)O1 GBBJCSTXCAQSSJ-JVZYCSMKSA-N 0.000 description 1
- GCQYYIHYQMVWLT-BDNRQGISSA-N 5-(2-bromoethenyl)-1-[(2r,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C=CBr)=C1 GCQYYIHYQMVWLT-BDNRQGISSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 102000009097 Phosphorylases Human genes 0.000 description 1
- 108010073135 Phosphorylases Proteins 0.000 description 1
- 101710132082 Pyrimidine/purine nucleoside phosphorylase Proteins 0.000 description 1
- GCQYYIHYQMVWLT-HQNLTJAPSA-N Sorivudine Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(\C=C\Br)=C1 GCQYYIHYQMVWLT-HQNLTJAPSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 102000013537 Thymidine Phosphorylase Human genes 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003005 anticarcinogenic agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000006189 buccal tablet Substances 0.000 description 1
- 229940046011 buccal tablet Drugs 0.000 description 1
- 239000012830 cancer therapeutic Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000013613 expression plasmid Substances 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- RQFLGKYCYMMRMC-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O RQFLGKYCYMMRMC-UHFFFAOYSA-N 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/03—Herpetoviridae, e.g. pseudorabies virus
- G01N2333/05—Epstein-Barr virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (3)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-233552 | 2007-09-10 | ||
JP2007233552 | 2007-09-10 | ||
PCT/JP2008/066175 WO2009034945A1 (ja) | 2007-09-10 | 2008-09-08 | エプスタイン・バールウイルス関連疾患に対する薬剤およびそのスクリーニング法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101801390A CN101801390A (zh) | 2010-08-11 |
CN101801390B true CN101801390B (zh) | 2012-11-14 |
Family
ID=40451953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801062690A Active CN101801390B (zh) | 2007-09-10 | 2008-09-08 | 针对爱泼斯坦-巴尔病毒相关疾病的药剂 |
Country Status (6)
Country | Link |
---|---|
US (2) | US20100330563A1 (zh) |
EP (1) | EP2189161B1 (zh) |
JP (1) | JP5326173B2 (zh) |
CN (1) | CN101801390B (zh) |
CA (1) | CA2698645A1 (zh) |
WO (1) | WO2009034945A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6719369B2 (ja) * | 2016-05-13 | 2020-07-08 | 富士フイルム株式会社 | 2’−フルオロ−5−メチル−4’−チオアラビノウリジンの製造方法及びその一部の工程を含む方法 |
TWI773520B (zh) * | 2021-09-07 | 2022-08-01 | 博訊生物科技股份有限公司 | 用於藥物篩檢的細胞和藥劑分注裝置及其方法 |
US11761974B2 (en) | 2021-11-01 | 2023-09-19 | Drsignal Biotechnology Co., Ltd. | Cell and medicament dispensing device for drug screening and method thereof |
WO2023182460A1 (ja) * | 2022-03-24 | 2023-09-28 | 学校法人 聖マリアンナ医科大学 | 慢性活動性Epstein-Barrウイルス感染症(CAEBV)の検出方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ234534A (en) * | 1989-07-17 | 1994-12-22 | Univ Birmingham | Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor |
IE74701B1 (en) | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
JPH1087687A (ja) | 1996-04-09 | 1998-04-07 | Yamasa Shoyu Co Ltd | 5−置換−1−(2−デオキシ−2−フルオロ−4−チオ−β−D−アラビノフラノシル)ウラシル |
EP1569658A4 (en) * | 2001-12-20 | 2007-05-30 | Pharmassett Ltd | TREATMENT OF EPSTEIN-BARR VIRUS, INFECTION WITH KAPOSI-ASSOCIATED SARCOMA HERPESVIRUS AND ABNORMAL CELL PROLIFERATION |
JP4729836B2 (ja) * | 2003-03-28 | 2011-07-20 | Tdk株式会社 | 磁気記憶セルおよび磁気メモリデバイスならびに磁気メモリデバイスの製造方法 |
-
2008
- 2008-09-08 CA CA2698645A patent/CA2698645A1/en not_active Abandoned
- 2008-09-08 US US12/677,116 patent/US20100330563A1/en not_active Abandoned
- 2008-09-08 JP JP2009532175A patent/JP5326173B2/ja active Active
- 2008-09-08 CN CN2008801062690A patent/CN101801390B/zh active Active
- 2008-09-08 WO PCT/JP2008/066175 patent/WO2009034945A1/ja active Application Filing
- 2008-09-08 EP EP08830964A patent/EP2189161B1/en not_active Not-in-force
-
2012
- 2012-04-16 US US13/447,727 patent/US20120225837A1/en not_active Abandoned
Non-Patent Citations (3)
Title |
---|
Gang-Qing Yao,et al.Inhibition of Epstein-Barr Virus Replication by a Novel L-Nucleoside, 2’-Fluoro-5-methyl-β-L-arabinofuranosyluracil.《Biochemical Pharmacology》.1996,第51卷第941-947页. * |
Haruhiko Machida,et al..Anti-herpesvirus activity profile of 4’-thioarabinofuranosyl purine and uracil nucleosides and activity of 1-β-D-2’-fluoro-4’-thioarabinofuranosyl guanine and 2,6-diaminopurine against clinical isolates of human cytomegalovirus.《Antiviral Research》.1998,第39卷第129–137页. * |
HaruhikoMachida et al..Anti-herpesvirus activity profile of 4’-thioarabinofuranosyl purine and uracil nucleosides and activity of 1-β-D-2’-fluoro-4’-thioarabinofuranosyl guanine and 2 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2009034945A1 (ja) | 2010-12-24 |
CA2698645A1 (en) | 2009-03-19 |
EP2189161B1 (en) | 2012-08-08 |
CN101801390A (zh) | 2010-08-11 |
US20100330563A1 (en) | 2010-12-30 |
US20120225837A1 (en) | 2012-09-06 |
WO2009034945A1 (ja) | 2009-03-19 |
JP5326173B2 (ja) | 2013-10-30 |
EP2189161A4 (en) | 2011-11-09 |
EP2189161A1 (en) | 2010-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Chen et al. | Cytokine receptor signaling is required for the survival of ALK− anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations | |
JP2023144131A (ja) | ガンマデルタt細胞の活性化のための方法および組成物 | |
CN101060844B (zh) | 包含嘧啶的nnrti和rt抑制剂的组合 | |
JP2017505623A5 (zh) | ||
CN101801390B (zh) | 针对爱泼斯坦-巴尔病毒相关疾病的药剂 | |
Rabaan et al. | Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies | |
Heidari et al. | Transcriptomic analysis of host immune response in the skin of chickens infected with Marek's disease virus | |
Laphanuwat et al. | Senescent T cells: Beneficial and detrimental roles | |
Luo et al. | Adenovirus-mediated double suicide gene selectively kills gastric cancer cells | |
Ni et al. | Antitumor efficacy of CRISPR/Cas9–engineered ICP6 mutant herpes simplex viruses in a mouse xenograft model for lung adenocarcinoma | |
US20120195911A1 (en) | Method of treatment of cancer patients | |
Xu et al. | Very virulent plus strains of MDV induce an acute form of transient paralysis in both susceptible and resistant chicken lines | |
WO2017064558A1 (ja) | 新規免疫賦活化剤 | |
WO2013056510A1 (zh) | 脱氧核苷与核苷组合在制备肿瘤药物中的应用 | |
Shaw et al. | Ganciclovir and penciclovir, but not acyclovir, induce apoptosis in herpes simplex virus thymidine kinasetransformed baby hamster kidney cells | |
Machida et al. | Anti-herpesvirus activity profile of 4′-thioarabinofuranosyl purine and uracil nucleosides and activity of 1-β-d-2′-fluoro-4′-thioarabinofuranosyl guanine and 2, 6-diaminopurine against clinical isolates of human cytomegalovirus | |
CN112399858A (zh) | 医学用途 | |
QAMAR et al. | An Investigation On The Antiviral Activity, Pharmacokinetic Properties, And Therapeutic Efficiency Of Hiv Infection Treatment: A Review | |
Davis et al. | Temperature elevation synergises with and enhances the type-I IFN-mediated restriction of MPXV | |
CN113413465B (zh) | 岩藻糖基化抑制剂在抗癌导致炎症中的应用 | |
CN117751188A (zh) | 用于预防性和治疗性治疗的含有g-四链体的寡核苷酸 | |
Sissolak et al. | AIDS defining lymphomas in the era of highly active antiretroviral therapy (HAART)–an African perspective | |
Igorevna et al. | UDC 61 ROLE OF VIRUS VECTORS IN THE PROCESSES OF TRANSFER OF GENETIC MATERIAL | |
KR20130097585A (ko) | 암치료 보조용 조성물 | |
Kenney et al. | The Molecular Basis of Lytic Induction Therapy in Relation to Gamma herpesvirus (KSHV, EBV)-Associated, AIDS-Related Tumors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: UNIV KYOTO Effective date: 20130930 Owner name: EIICHI KODAMA Free format text: FORMER OWNER: YAMASA CORP. Effective date: 20130930 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20130930 Address after: Japan Kyoto Sakyo District shogoin Sichuan haramachi of Kyoto University National University in 53 virus Patentee after: Kodama Eiichi Address before: Chiba County, Japan Patentee before: Yamasa Corp. Patentee before: University of Kyoto |