MX9603029A - Nucleosidos-l para el tratamiento del virus-b de hepatitis y el virus de epstein-barr. - Google Patents

Nucleosidos-l para el tratamiento del virus-b de hepatitis y el virus de epstein-barr.

Info

Publication number
MX9603029A
MX9603029A MX9603029A MX9603029A MX9603029A MX 9603029 A MX9603029 A MX 9603029A MX 9603029 A MX9603029 A MX 9603029A MX 9603029 A MX9603029 A MX 9603029A MX 9603029 A MX9603029 A MX 9603029A
Authority
MX
Mexico
Prior art keywords
virus
fluoro
beta
treatment
arabinofuranosyl
Prior art date
Application number
MX9603029A
Other languages
English (en)
Other versions
MXPA96003029A (es
Inventor
Chung K Chu
Yung-Chi Cheng
Balakrishna S Pai
Gang-Qing Yao
Original Assignee
Univ Georgia Res Found
Inc
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgia Res Found, Inc, Univ Yale filed Critical Univ Georgia Res Found
Priority claimed from PCT/US1995/001253 external-priority patent/WO1995020595A1/en
Publication of MXPA96003029A publication Critical patent/MXPA96003029A/es
Publication of MX9603029A publication Critical patent/MX9603029A/es

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se proporciona un método para el tratamiento de un huésped, y en particular, un humano, infectado con HEV o EBV, que incluye la administracion de una cantidad de tratamiento de HBV o EBV de un nucleosido.L de la formula (I) en donde R es una base de purina o pirimidina. En una modalidad preferida, el compuesto activo es 2'-fluoro-5-metilo- beta-L-arabinofuranosilurina (también referida como L-FMAU). Este compuesto es un agente antiviral potente contra el HBV y el EBV y exhibe baja citotoxicidad. Otros ejemplos específicos de compuestos activos incluyen N1-(2'-deoxi-2'-fluoro- beta-L-arabinofuranosilo)-5-et iluracilo, N1-(2'-deoxi-2'-fluoro- beta-L-arabinofuranosilo)-5-yo docitosina, y N1-(2'-deoxi-2'-fluoro- beta-L-arabinofuranosilo)-5-yo douracilo.
MX9603029A 1995-01-30 1995-01-30 Nucleosidos-l para el tratamiento del virus-b de hepatitis y el virus de epstein-barr. MX9603029A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08189070 1994-01-28
PCT/US1995/001253 WO1995020595A1 (en) 1994-01-28 1995-01-30 L-nucleosides for the treatment of hepatitis b-virus and epstein-bar virus

Publications (2)

Publication Number Publication Date
MXPA96003029A MXPA96003029A (es) 1998-01-01
MX9603029A true MX9603029A (es) 1998-01-31

Family

ID=39164855

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603029A MX9603029A (es) 1995-01-30 1995-01-30 Nucleosidos-l para el tratamiento del virus-b de hepatitis y el virus de epstein-barr.

Country Status (1)

Country Link
MX (1) MX9603029A (es)

Similar Documents

Publication Publication Date Title
CA2182273A1 (en) L-nucleosides for the treatment of hepatitis b-virus and epstein-bar virus
CA2268703A1 (en) Enantiomerically pure .beta.-d-dioxolane nucleosides with selective anti-hepatitis b virus activity
CA2163520A1 (en) L-2',3'-dideoxy nucleoside analogs as anti-hepatitis b (hbv) and anti-hiv agents
HU210717A9 (en) Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents
CA2063417A1 (en) Antiviral composition
DK615788D0 (da) Nucleosidforbindelser til anvendelse mod virale infektioner
MX9603029A (es) Nucleosidos-l para el tratamiento del virus-b de hepatitis y el virus de epstein-barr.
JPS6426594A (en) Nucleotides and antitumor agent
RU96117323A (ru) L-нуклеозиды для лечения заболеваний, вызванных вирусом гепатита b и вирусом эпштейна - барра
JPS6422894A (en) Nulceosides