BRPI0920679A2 - Células construídas expressando múltiplos imunomoduladores e usos das mesmas - Google Patents

Células construídas expressando múltiplos imunomoduladores e usos das mesmas

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Publication number
BRPI0920679A2
BRPI0920679A2 BRPI0920679A BRPI0920679A BRPI0920679A2 BR PI0920679 A2 BRPI0920679 A2 BR PI0920679A2 BR PI0920679 A BRPI0920679 A BR PI0920679A BR PI0920679 A BRPI0920679 A BR PI0920679A BR PI0920679 A2 BRPI0920679 A2 BR PI0920679A2
Authority
BR
Brazil
Prior art keywords
immunomodulators
expressing multiple
cells constructed
constructed expressing
multiple immunomodulators
Prior art date
Application number
BRPI0920679A
Other languages
English (en)
Portuguese (pt)
Inventor
Petterson Beech Robert
d reed Thomas
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of BRPI0920679A2 publication Critical patent/BRPI0920679A2/pt

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BRPI0920679A 2008-10-08 2009-10-08 Células construídas expressando múltiplos imunomoduladores e usos das mesmas BRPI0920679A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10381008P 2008-10-08 2008-10-08
PCT/US2009/005510 WO2010042189A2 (en) 2008-10-08 2009-10-08 Engineered cells expressing multiple immunomodulators and uses thereof

Publications (1)

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BRPI0920679A2 true BRPI0920679A2 (pt) 2022-05-17

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US (4) US9492482B2 (cg-RX-API-DMAC7.html)
EP (1) EP2356219A4 (cg-RX-API-DMAC7.html)
JP (3) JP2012504959A (cg-RX-API-DMAC7.html)
KR (2) KR101361416B1 (cg-RX-API-DMAC7.html)
CN (1) CN102575227A (cg-RX-API-DMAC7.html)
AU (3) AU2009302804B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0920679A2 (cg-RX-API-DMAC7.html)
CA (1) CA2739902A1 (cg-RX-API-DMAC7.html)
IL (3) IL212184A (cg-RX-API-DMAC7.html)
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Families Citing this family (67)

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JP2010540534A (ja) 2007-09-28 2010-12-24 イントレキソン コーポレーション 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用
KR20130010121A (ko) * 2010-03-23 2013-01-25 인트렉손 코포레이션 치료적 단백질을 조건부로 발현하는 벡터，상기 벡터를 포함하는 숙주 세포 및 이의 용도
CA2828411A1 (en) * 2011-03-04 2012-09-13 Intrexon Corporation Vectors conditionally expressing protein
CN106187812A (zh) 2011-09-08 2016-12-07 英特瑞克斯顿股份有限公司 结晶状二酰基肼及其用途
WO2013040371A2 (en) * 2011-09-16 2013-03-21 Baylor College Of Medicine Targeting the tumor microenvironment using manipulated nkt cells
WO2013053775A1 (en) * 2011-10-11 2013-04-18 Universität Zürich Prorektorat Mnw Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy
US11951157B2 (en) 2011-10-11 2024-04-09 Universitat Zurich Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
CN102631671B (zh) * 2012-04-05 2014-11-26 倪国颖 提高疫苗诱导的细胞毒性t细胞反应的治疗性疫苗
CN105307725B (zh) * 2013-04-11 2020-06-16 布里格姆及妇女医院股份有限公司 治疗自身免疫疾病的方法和组合物
FI3461491T3 (fi) * 2013-04-18 2025-02-20 Tilt Biotherapeutics Oy Tehostettu adoptiivinen soluterapia
US12421502B2 (en) 2013-04-18 2025-09-23 Tilt Biotherapeutics Oy Enhanced adoptive cell therapy
AU2014352749A1 (en) * 2013-11-22 2016-06-09 Dnatrix, Inc. Adenovirus expressing immune cell stimulatory receptor agonist(s)
DK3597742T3 (da) * 2014-10-09 2022-10-03 Univ Yamaguchi Car-udtrykkende vektor og car-udtrykkende t-celler
MA41538A (fr) * 2014-10-17 2017-12-26 Baylor College Medicine Cellules immunitaires bipartites et tripartites de signalisation
CN107002070A (zh) * 2014-12-03 2017-08-01 阿内罗药物科学株式会社 共表达质粒
HUE067123T2 (hu) 2014-12-09 2024-10-28 Regeneron Pharma Humanizált differenciációs klaszter 274 génnel rendelkezõ nem humán állatok
AU2016211688A1 (en) * 2015-01-26 2017-08-10 Fate Therapeutics, Inc. Cells with increased immuno-regulatory properties and methods for their use and manufacture
JP6947647B2 (ja) * 2015-02-24 2021-10-13 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System 遺伝子改変ｔ細胞の選択方法
SG10201907164SA (en) 2015-04-22 2019-09-27 Curevac Ag Rna containing composition for treatment of tumor diseases
US20170020922A1 (en) * 2015-07-16 2017-01-26 Batu Biologics Inc. Gene editing for immunological destruction of neoplasia
WO2017062953A1 (en) 2015-10-10 2017-04-13 Intrexon Corporation Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12
RU2758489C2 (ru) 2015-11-11 2021-10-28 Пресиджен, Инк. Композиции и способы для экспрессии нескольких биологически активных полипептидов с одного вектора для лечения заболеваний сердца и других патологий
WO2017106795A1 (en) * 2015-12-18 2017-06-22 Oncosec Medical Incorporated Plasmid constructs for heterologous protein expression and methods of use
CN109415703B (zh) 2016-01-08 2024-08-30 雷普利穆内有限公司 经修饰的溶瘤病毒
KR102186180B1 (ko) * 2016-03-17 2020-12-03 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 면역 기능 제어 인자를 발현하는 면역 담당 세포 및 발현 벡터
EP3443001B1 (en) 2016-04-11 2025-04-30 Obsidian Therapeutics, Inc. REGULATED BIOCIRCUIT SYSTEMS
CN118652336A (zh) 2016-06-08 2024-09-17 普瑞赛格恩公司 Cd33特异性嵌合抗原受体
US12281339B2 (en) * 2016-07-05 2025-04-22 Polaris Group Combination cancer immunotherapies with arginine depletion agents
UY37343A (es) 2016-07-25 2018-02-28 Intrexon Corp Control del fenotipo en plantas
JP2018023343A (ja) * 2016-08-12 2018-02-15 国立大学法人山口大学 細胞培養用培地、及び細胞培養方法
GB201700350D0 (en) 2017-01-09 2017-02-22 Replimune Ltd Altered virus
WO2018132494A1 (en) * 2017-01-10 2018-07-19 Intrexon Corporation Modulating expression of polypeptides via new gene switch expression systems
RU2740713C1 (ru) 2017-02-28 2021-01-20 Генемедицине Ко., Лтд. Противораковая композиция, содержащая опухолеспецифический онколитический аденовирус и ингибитор контрольной точки иммунного ответа
AU2018251898A1 (en) 2017-04-13 2019-10-31 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
AU2018256436B2 (en) 2017-04-19 2024-12-05 Board Of Regents, The University Of Texas System Immune cells expressing engineered antigen receptors
WO2018226897A1 (en) 2017-06-07 2018-12-13 Intrexon Corporation Expression of novel cell tags
US20200123566A1 (en) * 2017-06-13 2020-04-23 Oncosec Medical Incorporated Multigene construct for immune-modulatory protein expression and methods of use
AU2019203918B2 (en) 2018-01-25 2020-04-30 I-Mab Biopharma Us Limited Anti-PD-L1 antibody and IL-7 fusions
WO2019151760A1 (ko) * 2018-02-02 2019-08-08 주식회사 에스엘백시젠 신규 다가 hpv 백신 조성물
EP3747459A4 (en) * 2018-02-02 2021-12-01 SL Vaxigen, Inc. NEW IMMUNOADJUVANT VACCINE
EP3755349A4 (en) 2018-02-21 2021-11-17 Board of Regents, The University of Texas System PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES
AU2019231652B2 (en) 2018-03-06 2025-05-22 Precigen, Inc. Hepatitis B vaccines and uses of the same
EP3762022A4 (en) 2018-03-06 2022-06-15 Precigen, Inc. HUMAN PAPILLOMAVIRUS VACCINES AND USES THEREOF
AU2019271819A1 (en) 2018-05-15 2021-01-14 Crage Medical Co., Limited Genetically engineered cell and application thereof
CA3103367A1 (en) * 2018-06-13 2019-12-19 The Council Of The Queensland Institute Of Medical Research Viral detection assay
AU2019291861A1 (en) * 2018-06-27 2021-01-07 Precigen, Inc. In vivo controlled combination therapy for treatment of cancer
EP3820488A4 (en) 2018-07-09 2022-07-13 The Regents Of The University Of California Gene targets for t-cell-based immunotherapy
JP2022512766A (ja) 2018-10-17 2022-02-07 センティ バイオサイエンシズ インコーポレイテッド 組み合わせがん免疫療法
US11419898B2 (en) 2018-10-17 2022-08-23 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
TWI850282B (zh) * 2018-11-27 2024-08-01 香港商弘年發展有限公司 用於治療癌症之質體建構體和使用方法
JP2022513639A (ja) * 2018-11-29 2022-02-09 ヴァイロジン バイオテック カナダ リミテッド 低神経毒性ｈｓｖベクター
WO2020131656A1 (en) * 2018-12-17 2020-06-25 Immune Design Corp. Pathogen-associated molecular pattern molecules and rna immunogenic compositions and methods of using the compositions for treating cancer
WO2020206056A1 (en) 2019-04-04 2020-10-08 Greenvenus Llc Peptides and methods of plant protection
CN110354260B (zh) * 2019-08-19 2020-06-26 启辰生生物科技(珠海)有限公司 免疫增强剂、药物组合物及其应用
CN110732021B (zh) * 2019-11-21 2020-08-25 北京启辰生生物科技有限公司 用于解除肿瘤免疫抑制的组合物及其应用
EP4061485A4 (en) * 2019-11-22 2023-12-20 Alaunos Therapeutics, Inc. METHOD FOR TREATING GLIOBLASTOMA
CN110904050B (zh) * 2019-12-16 2021-02-05 启辰生生物科技(珠海)有限公司 工程化抗原递呈细胞、免疫调节组合物及应用
CN113005090A (zh) * 2019-12-20 2021-06-22 上海细胞治疗集团有限公司 共表达趋化因子和共刺激分子的dc细胞及其应用
JP7543419B2 (ja) * 2020-02-18 2024-09-02 ヴァクディアグン バイオテクノロジー カンパニー リミテッド 組換えウイルスベクター、それを含む免疫組成物及び用途
AU2021236879A1 (en) * 2020-03-16 2022-11-10 Vrije Universiteit Brussel A mixture of mRNA to enhance the potency of dendritic cells
CN112029730A (zh) * 2020-05-20 2020-12-04 深圳市芥至和生物科技有限公司 一种基因修饰的间充质干细胞及其应用
JP7477120B2 (ja) * 2020-06-09 2024-05-01 サムスン ライフ パブリック ウェルフェア ファウンデーション Ｎｋ細胞の活性化及び増幅のために遺伝的に操作された細胞株、及びその用途
US12071633B2 (en) 2020-10-13 2024-08-27 Kriya Therapeutics, Inc. Viral vector constructs for delivery of nucleic acids encoding cytokines and uses thereof for treating cancer
CN116426483B (zh) * 2021-12-30 2024-02-23 南京紫珑生物科技有限公司 Cd258蛋白在免疫治疗中的应用
CN114426585B (zh) * 2022-02-15 2023-10-03 广东香雪干细胞再生医学科技有限公司 融合蛋白及其表达细胞株与应用
CN115433734B (zh) * 2022-06-01 2025-03-04 北京奇糖科技有限公司 核酸片段及其在制备肿瘤疫苗中的应用
CN119470910A (zh) * 2024-11-01 2025-02-18 安徽医科大学 一种IL-12p70蛋白在认知障碍疾病中的应用

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228458A1 (de) 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
ES2111289T5 (es) 1993-01-21 2005-07-16 President And Fellows Of Harvard College Metodos y kits de diagnostico que emplean promotores de estres en mamiferos para determinar la toxicidad de un compuesto.
US5698413A (en) 1993-05-05 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Method of evaluating chemotherapeutic agents in vivo
US20040265288A1 (en) 1995-03-08 2004-12-30 Gilman Michael Z. New applications of gene therapy technology
US5744304A (en) 1995-05-30 1998-04-28 Board Of Regents, The University Of Texas System Inflammation-induced expression of a recombinant gene
US6306649B1 (en) 1995-06-27 2001-10-23 Ariad Gene Therapeutics, Inc. Heterologous transcription factors
US5922685A (en) 1996-06-05 1999-07-13 Powderject Vaccines, Inc. IL-12 gene therapy of tumors
US20040086494A1 (en) 1996-10-07 2004-05-06 John Constance Mary Immune privileged cells for delivery of proteins and peptides
ATE371736T1 (de) 1996-10-29 2007-09-15 Baylor College Medicine Modifizierte steroid-hormon rezeptoren
US20040103448A1 (en) 1997-09-05 2004-05-27 Anders Bjorklund Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain
ATE243045T1 (de) 1997-11-20 2003-07-15 Vical Inc Behandlung von krebs durch verwendung von zytokin-exprimierender polynukleotiden und zusammensetzungen dafür
US6617171B2 (en) 1998-02-27 2003-09-09 The General Hospital Corporation Methods for diagnosing and treating autoimmune disease
US6866842B1 (en) 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
US7279565B2 (en) 1998-05-05 2007-10-09 Richard Voellmy Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress
CA2343355A1 (en) 1998-09-15 2000-03-23 University Of Pittsburgh Of The Commonwealth System Of Higher Education In situ injection of antigen-presenting cells with genetically enhanced cytokine expression
WO2000031286A1 (en) 1998-11-20 2000-06-02 Valentis, Inc. Adenoviral vector-mediated delivery of modified steroid hormone receptors and related products and methods
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6696272B1 (en) 1999-06-02 2004-02-24 Hsc Research & Development Limited Partnership Products and methods for gaucher disease therapy
CN1304578C (zh) 2000-03-22 2007-03-14 罗姆和哈斯公司 新的基于蜕皮激素受体的可诱导的基因表达系统
EP1326969B1 (en) * 2000-09-25 2009-04-15 Genetronics, Inc. Improved system for regulation of transgene expression
US20030180719A1 (en) 2001-04-13 2003-09-25 Thomas Herget Human cellular protein gastrointestinal glutathione peroxidase as target for medical intervention against hepatitis C virus infections
US20040235169A1 (en) 2001-04-20 2004-11-25 Evans Ronald M. Inducible expression of transfected genes
US20030221203A1 (en) 2001-10-03 2003-11-27 Agha-Mohammadi Siamak High efficiency regulatable gene expression system
ATE446106T1 (de) * 2001-11-29 2009-11-15 Dandrit Biotech As Pharmazeutische zusammensetzung zur auslösung einer immunantwort bei einem menschen oder einem tier
GB0216286D0 (en) 2002-07-15 2002-08-21 Univ Leeds Network
EP1556487A2 (de) 2002-10-14 2005-07-27 F. Hoffmann-La Roche Ag Transplantierbare zelle
EP2933334B1 (en) 2003-02-18 2019-09-18 Baylor College of Medicine Induced activation in dendritic cells
US7304162B2 (en) 2003-02-21 2007-12-04 Intrexon Corporation Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
EP1639108A2 (en) 2003-02-28 2006-03-29 McGILL UNIVERSITY Cell and enzyme compositions for modulating bile acids, cholesterol and triglycerides
US7456315B2 (en) * 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
JP2007525166A (ja) * 2003-03-28 2007-09-06 ザ・スクリップス・リサーチ・インスティテュート 樹状細胞に対する感染性が増大したアデノウイルス粒子と、肝細胞に対する感染性が低下した粒子
DK1651161T3 (da) 2003-08-07 2012-01-30 Healor Ltd Farmaceutiske præparater og fremgangsmåder til at fremme sårheling
WO2005033297A1 (en) 2003-09-19 2005-04-14 The Rockefeller University Compositions, methods and kits relating to reprogramming adult differentiated cells and production of embryonic stem cell-like cells
US20070053845A1 (en) 2004-03-02 2007-03-08 Shiladitya Sengupta Nanocell drug delivery system
US20050267027A1 (en) 2004-04-05 2005-12-01 Lounsbury Karen M Use of erythropoietin for treatment of cancer
US7704714B2 (en) 2004-07-26 2010-04-27 Agency For Science, Technology & Research Encapsulation of cells in biologic compatible scaffolds by coacervation of charged polymers
US20060067942A1 (en) 2004-09-24 2006-03-30 Salama Zoser B Pharmaceutical agent comprising amino acids, peptides, proteins and/or fractions and fragments thereof and the use of same in the prophylaxis and treatment of immune system deficiency in humans and animals
CA2608764A1 (en) 2005-05-19 2006-11-23 Schering Ag Treatment of disease using an improved regulated expression system
CN101501055B (zh) 2005-06-23 2016-05-11 贝勒医学院 负性免疫调节因子的调节和免疫疗法应用
US20070036770A1 (en) 2005-08-12 2007-02-15 Wagner Darrell O Biologic device for regulation of gene expression and method therefor
CA2626056A1 (en) 2005-11-18 2007-05-24 Ares Trading S.A. Interferon in influenza
WO2007078922A2 (en) 2005-12-30 2007-07-12 Neurotech Usa Inc. Micronized device for the delivery of biologically active molecules and methods of use thereof
US20080181874A1 (en) 2007-01-29 2008-07-31 Alexander Kharazi Cell composition and method for treating cancer
US20080241100A1 (en) 2007-03-27 2008-10-02 Stefan Strobl Pharmaceutical composition comprising a cytokine
US8076517B2 (en) * 2007-05-29 2011-12-13 Intrexon Corporation Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US20090017108A1 (en) 2007-07-11 2009-01-15 Alexander Yuzhakov Liposome compositions for treatment of hepatitis C
EP2185730A4 (en) 2007-08-23 2010-10-27 Intrexon Corp METHOD AND COMPOSITIONS FOR SICKNESS DIAGNOSIS
JP2010540534A (ja) 2007-09-28 2010-12-24 イントレキソン コーポレーション 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用
ES2636460T3 (es) 2007-10-08 2017-10-05 Intrexon Corporation Células dendríticas modificadas por ingeniería y usos para el tratamiento del cáncer
KR20130010121A (ko) 2010-03-23 2013-01-25 인트렉손 코포레이션 치료적 단백질을 조건부로 발현하는 벡터，상기 벡터를 포함하는 숙주 세포 및 이의 용도

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