BRPI0911442A2 - conjugados potentes e ligantes hidrofílicos - Google Patents

conjugados potentes e ligantes hidrofílicos

Info

Publication number
BRPI0911442A2
BRPI0911442A2 BRPI0911442-4A BRPI0911442A BRPI0911442A2 BR PI0911442 A2 BRPI0911442 A2 BR PI0911442A2 BR PI0911442 A BRPI0911442 A BR PI0911442A BR PI0911442 A2 BRPI0911442 A2 BR PI0911442A2
Authority
BR
Brazil
Prior art keywords
hydrophilic binders
conjugates
binders
cell
potent
Prior art date
Application number
BRPI0911442-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Singh Rajeeva
Kovtun Yelena
D. Wilhelm Sharon
V. J. Chari Ravi
Original Assignee
Immunogen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen, Inc. filed Critical Immunogen, Inc.
Publication of BRPI0911442A2 publication Critical patent/BRPI0911442A2/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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