BRPI0720664A2 - Derivados de mononitrato de isossorbida para o tratamento de hipertensão ocular. - Google Patents
Derivados de mononitrato de isossorbida para o tratamento de hipertensão ocular. Download PDFInfo
- Publication number
- BRPI0720664A2 BRPI0720664A2 BRPI0720664-0A BRPI0720664A BRPI0720664A2 BR PI0720664 A2 BRPI0720664 A2 BR PI0720664A2 BR PI0720664 A BRPI0720664 A BR PI0720664A BR PI0720664 A2 BRPI0720664 A2 BR PI0720664A2
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- mononitrate
- cycloalkyl
- alkyl
- compound
- Prior art date
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical compound C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229940072358 xylocaine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06380338A EP1941876A1 (en) | 2006-12-28 | 2006-12-28 | Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension |
| EP06380338.1 | 2006-12-28 | ||
| PCT/EP2007/064570 WO2008080939A1 (en) | 2006-12-28 | 2007-12-27 | Isosorbide mononitrate derivatives for the treatment of ocular hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0720664A2 true BRPI0720664A2 (pt) | 2014-01-14 |
Family
ID=38043051
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0720664-0A BRPI0720664A2 (pt) | 2006-12-28 | 2007-12-27 | Derivados de mononitrato de isossorbida para o tratamento de hipertensão ocular. |
| BRPI0720663-1A BRPI0720663A2 (pt) | 2006-12-28 | 2007-12-27 | Derivados de mononitrato de isossorbida para o tratamento de transtornos intestinais |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0720663-1A BRPI0720663A2 (pt) | 2006-12-28 | 2007-12-27 | Derivados de mononitrato de isossorbida para o tratamento de transtornos intestinais |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20080161389A1 (enExample) |
| EP (3) | EP1941876A1 (enExample) |
| JP (2) | JP2010514733A (enExample) |
| KR (2) | KR20090112673A (enExample) |
| CN (2) | CN101600425A (enExample) |
| AR (1) | AR064543A1 (enExample) |
| AT (2) | ATE484279T1 (enExample) |
| AU (2) | AU2007341289B2 (enExample) |
| BR (2) | BRPI0720664A2 (enExample) |
| CA (2) | CA2674144A1 (enExample) |
| CL (2) | CL2007003836A1 (enExample) |
| DE (2) | DE602007009877D1 (enExample) |
| ES (3) | ES2324130B1 (enExample) |
| IL (2) | IL198912A0 (enExample) |
| MX (2) | MX2009007038A (enExample) |
| NO (2) | NO20092763L (enExample) |
| PL (2) | PL2124930T3 (enExample) |
| RU (2) | RU2009128970A (enExample) |
| UY (1) | UY30847A1 (enExample) |
| WO (2) | WO2008080939A1 (enExample) |
| ZA (2) | ZA200903566B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2149577B1 (en) * | 2008-07-22 | 2011-04-27 | Lacer, S.A. | New stereospecific method for the preparation of dioxa-bicyclooctane compounds |
| EP2149576A1 (en) * | 2008-07-22 | 2010-02-03 | Lacer, S.A. | Isosorbide Nitrates having vasodilating activity |
| EP2177216A1 (en) * | 2008-10-13 | 2010-04-21 | Lacer, S.A. | Use of dianhydrohexite mononitrate derivatives as healing agents |
| WO2010055138A1 (en) * | 2008-11-14 | 2010-05-20 | Lacer, S.A. | New stereospecific method for the preparation of dioxa-bicyclooctane compounds |
| EP2199294A1 (en) * | 2008-12-19 | 2010-06-23 | Lacer, S.A. | New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds |
| ES2587191T3 (es) * | 2009-12-23 | 2016-10-21 | Arca Biopharma, Inc. | Métodos y composiciones para enfermedades y afecciones cardiovasculares |
| CA2902009A1 (en) * | 2013-03-05 | 2014-09-12 | Archer Daniels Midland Company | Isohexide monotriflates and process for synthesis thereof |
| WO2018224419A1 (en) | 2017-06-06 | 2018-12-13 | Nicox S.A. | Nitric oxide donating isomannide derivatives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2739689C2 (de) * | 1977-09-02 | 1986-10-16 | Euratom | Thermische Wärmepumpe |
| JPS60149521A (ja) * | 1984-01-18 | 1985-08-07 | Eisai Co Ltd | 高眼圧・緑内障治療・予防用点眼剤 |
| US5573758A (en) * | 1995-04-28 | 1996-11-12 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers |
| US5925342A (en) * | 1996-11-13 | 1999-07-20 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers |
| GB9720797D0 (en) * | 1997-09-30 | 1997-12-03 | Rhodes John | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
| ES2142773B1 (es) * | 1998-10-07 | 2001-01-01 | Lacer Sa | Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida. |
| WO2002060449A2 (de) * | 2001-01-31 | 2002-08-08 | Merck Patent Gmbh | Pharmazeutische formulierung enthaltend pyrazolo[4,3-d]pyrimidine und nitrate oder thienopyrimidine und nitrate |
| US20060264353A1 (en) * | 2002-03-21 | 2006-11-23 | Maxey Kirk M | Prostaglandin f2alpha analogs and their use in combination with antimicrobial proteins for the treatment of glaucoma and intraocular hypertension |
| JP2007504807A (ja) * | 2003-09-08 | 2007-03-08 | ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 培養培地にプロスタグランジン又はプロスタグランジン類似物を補足することによってインビトロ胚発生を高めるための方法及び組成 |
| ES2258365B1 (es) * | 2003-10-03 | 2007-12-01 | Lacer, S.A. | Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos. |
-
2006
- 2006-12-28 EP EP06380338A patent/EP1941876A1/en not_active Withdrawn
-
2007
- 2007-01-23 ES ES200700181A patent/ES2324130B1/es not_active Expired - Fee Related
- 2007-03-01 US US11/680,691 patent/US20080161389A1/en not_active Abandoned
- 2007-12-27 UY UY30847A patent/UY30847A1/es not_active Application Discontinuation
- 2007-12-27 KR KR1020097015821A patent/KR20090112673A/ko not_active Withdrawn
- 2007-12-27 WO PCT/EP2007/064570 patent/WO2008080939A1/en not_active Ceased
- 2007-12-27 DE DE602007009877T patent/DE602007009877D1/de active Active
- 2007-12-27 ZA ZA200903566A patent/ZA200903566B/xx unknown
- 2007-12-27 WO PCT/EP2007/064591 patent/WO2008080955A1/en not_active Ceased
- 2007-12-27 CL CL200703836A patent/CL2007003836A1/es unknown
- 2007-12-27 AU AU2007341289A patent/AU2007341289B2/en not_active Ceased
- 2007-12-27 JP JP2009543471A patent/JP2010514733A/ja active Pending
- 2007-12-27 AR ARP070105911A patent/AR064543A1/es unknown
- 2007-12-27 KR KR1020097015820A patent/KR20100100584A/ko not_active Withdrawn
- 2007-12-27 BR BRPI0720664-0A patent/BRPI0720664A2/pt not_active IP Right Cessation
- 2007-12-27 CA CA002674144A patent/CA2674144A1/en not_active Abandoned
- 2007-12-27 JP JP2009543474A patent/JP2010514734A/ja active Pending
- 2007-12-27 CN CNA2007800441623A patent/CN101600425A/zh active Pending
- 2007-12-27 MX MX2009007038A patent/MX2009007038A/es active IP Right Grant
- 2007-12-27 BR BRPI0720663-1A patent/BRPI0720663A2/pt not_active IP Right Cessation
- 2007-12-27 EP EP07858167A patent/EP2114398B1/en active Active
- 2007-12-27 PL PL07858187T patent/PL2124930T3/pl unknown
- 2007-12-27 AU AU2007341218A patent/AU2007341218B2/en not_active Ceased
- 2007-12-27 CN CN2007800443012A patent/CN101600426B/zh not_active Expired - Fee Related
- 2007-12-27 AT AT07858187T patent/ATE484279T1/de not_active IP Right Cessation
- 2007-12-27 CL CL200703837A patent/CL2007003837A1/es unknown
- 2007-12-27 DE DE602007007523T patent/DE602007007523D1/de active Active
- 2007-12-27 EP EP07858187A patent/EP2124930B1/en active Active
- 2007-12-27 ZA ZA200903567A patent/ZA200903567B/xx unknown
- 2007-12-27 ES ES07858187T patent/ES2354317T3/es active Active
- 2007-12-27 MX MX2009007040A patent/MX2009007040A/es active IP Right Grant
- 2007-12-27 ES ES07858167T patent/ES2348314T3/es active Active
- 2007-12-27 RU RU2009128970/15A patent/RU2009128970A/ru not_active Application Discontinuation
- 2007-12-27 CA CA002674550A patent/CA2674550A1/en not_active Abandoned
- 2007-12-27 RU RU2009128968/15A patent/RU2009128968A/ru not_active Application Discontinuation
- 2007-12-27 PL PL07858167T patent/PL2114398T3/pl unknown
- 2007-12-27 AT AT07858167T patent/ATE472324T1/de not_active IP Right Cessation
-
2009
- 2009-05-24 IL IL198912A patent/IL198912A0/en unknown
- 2009-05-25 IL IL198941A patent/IL198941A0/en unknown
- 2009-07-27 NO NO20092763A patent/NO20092763L/no not_active Application Discontinuation
- 2009-07-27 NO NO20092764A patent/NO20092764L/no not_active Application Discontinuation
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2277 DE 26/08/2014. |