BRPI0719280A2 - Composto, composição farmacêutica, métodos para modular a atividade de um receptor de p2x7 in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor de p2x7 em um paciente, para inibir a morte de células do gânglio retinal em um paciente, para determinar a presença ou ausência de receptor de p2x7 em uma amostra, preparação farmacêutica acondicionada, método para tratar ou prevenir cirrose em um paciente, e, uso de um composto. - Google Patents
Composto, composição farmacêutica, métodos para modular a atividade de um receptor de p2x7 in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor de p2x7 em um paciente, para inibir a morte de células do gânglio retinal em um paciente, para determinar a presença ou ausência de receptor de p2x7 em uma amostra, preparação farmacêutica acondicionada, método para tratar ou prevenir cirrose em um paciente, e, uso de um composto. Download PDFInfo
- Publication number
- BRPI0719280A2 BRPI0719280A2 BRPI0719280-0A BRPI0719280A BRPI0719280A2 BR PI0719280 A2 BRPI0719280 A2 BR PI0719280A2 BR PI0719280 A BRPI0719280 A BR PI0719280A BR PI0719280 A2 BRPI0719280 A2 BR PI0719280A2
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- amino
- mono
- formula
- membered
- Prior art date
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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| EA016076B1 (ru) * | 2006-07-06 | 2012-01-30 | Глэксо Груп Лимитед | Замещенные n-фенилметил-5-оксопролин-2-амиды в качестве антагонистов р2х7-рецептора и способы их применения |
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| CN102464631B (zh) * | 2010-11-08 | 2016-08-10 | 中国科学院上海药物研究所 | 哌嗪取代的1,3-二取代脲类化合物及哌嗪取代的酰胺类化合物及其制备方法和用途 |
| KR101995088B1 (ko) | 2011-07-22 | 2019-07-02 | 이도르시아 파마슈티컬스 리미티드 | Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체 |
| NZ628910A (en) | 2012-01-20 | 2016-02-26 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
| PL2931717T3 (pl) * | 2012-12-12 | 2017-05-31 | Actelion Pharmaceuticals Ltd. | Pochodne indolokarboksyamidu jako antagoniści receptora p2x7 |
| US9556117B2 (en) | 2012-12-18 | 2017-01-31 | Actelion Pharmaceuticals Ltd. | Indole carboxamide derivatives as P2X7 receptor antagonists |
| KR102222220B1 (ko) | 2013-01-22 | 2021-03-03 | 이도르시아 파마슈티컬스 리미티드 | Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체 |
| WO2014115078A1 (en) | 2013-01-22 | 2014-07-31 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
| HRP20191860T1 (hr) | 2013-03-13 | 2019-12-27 | Forma Therapeutics, Inc. | Derivati 2-hidroksi-1-{4-[(4-fenilfenil)karbonil]piperazin-1-il}etan-1-ona i srodni spojevi kao inhibitori sintaze masnih kiselina (fasn) za liječenje raka |
| EP3287443B1 (en) | 2015-04-24 | 2021-10-27 | Shionogi & Co., Ltd | 6-membered heterocyclic derivative and pharmaceutical composition comprising same |
| CN108290894A (zh) | 2015-07-01 | 2018-07-17 | 西北大学 | 被取代的4-甲基-吡咯并[1,2-a]嘧啶-8-甲酰胺类化合物及其调节葡糖脑苷脂酶活性的用途 |
| WO2017030938A1 (en) * | 2015-08-14 | 2017-02-23 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| WO2018074390A1 (ja) * | 2016-10-17 | 2018-04-26 | 塩野義製薬株式会社 | 二環性含窒素複素環誘導体およびそれらを含有する医薬組成物 |
| SG11202002032SA (en) | 2017-09-22 | 2020-04-29 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| CA3076476A1 (en) | 2017-10-18 | 2019-04-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
| BR112020008851A2 (pt) | 2017-11-06 | 2020-10-20 | Jubilant Prodel LLC | composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas |
| PL3704120T3 (pl) | 2017-11-24 | 2024-09-16 | Jubilant Episcribe Llc | Związki heterocykliczne jako inhibitory prmt5 |
| JP7461104B2 (ja) * | 2017-11-29 | 2024-04-03 | 中外製薬株式会社 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体を含有する医薬組成物 |
| SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
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| WO2020092395A1 (en) | 2018-10-29 | 2020-05-07 | Forma Therapeutics, Inc. | SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE |
| JP7637630B2 (ja) | 2019-03-19 | 2025-02-28 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物 |
| PH12022553222A1 (en) | 2020-05-29 | 2024-02-12 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic heterocyclic compounds |
| AR127495A1 (es) | 2021-11-01 | 2024-01-31 | Boehringer Ingelheim Vetmedica Gmbh | Compuestos de pirrolopiridazina como antihelmínticos |
| CN119241538A (zh) * | 2024-09-30 | 2025-01-03 | 陕西科技大学 | 一类三唑并吡啶结构的化合物、合成方法及其应用 |
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-
2007
- 2007-11-27 CA CA002670636A patent/CA2670636A1/en not_active Abandoned
- 2007-11-27 CN CN200780049692A patent/CN101621931A/zh active Pending
- 2007-11-27 ZA ZA200904477A patent/ZA200904477B/xx unknown
- 2007-11-27 NZ NZ577814A patent/NZ577814A/en not_active IP Right Cessation
- 2007-11-27 EP EP07862234.7A patent/EP2096923B1/en active Active
- 2007-11-27 BR BRPI0719280-0A patent/BRPI0719280A2/pt not_active IP Right Cessation
- 2007-11-27 EP EP13150025.8A patent/EP2591675A1/en not_active Withdrawn
- 2007-11-27 EA EA200970516A patent/EA018036B1/ru not_active IP Right Cessation
- 2007-11-27 JP JP2009538419A patent/JP2010510987A/ja active Pending
- 2007-11-27 KR KR1020097013490A patent/KR20090094336A/ko not_active Ceased
- 2007-11-27 WO PCT/US2007/024396 patent/WO2008066789A2/en not_active Ceased
- 2007-11-27 EA EA201300152A patent/EA201300152A1/ru unknown
- 2007-11-27 AU AU2007325780A patent/AU2007325780B9/en not_active Ceased
- 2007-11-27 MX MX2009005478A patent/MX2009005478A/es active IP Right Grant
- 2007-11-27 US US12/516,480 patent/US8431593B2/en not_active Expired - Fee Related
- 2007-11-27 MY MYPI20092150 patent/MY150731A/en unknown
- 2007-11-27 UA UAA200906538A patent/UA99448C2/ru unknown
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2009
- 2009-05-19 IL IL198827A patent/IL198827A0/en unknown
- 2009-06-26 CO CO09066902A patent/CO6190582A2/es active IP Right Grant
- 2009-06-26 NO NO20092444A patent/NO20092444L/no not_active Application Discontinuation
-
2013
- 2013-01-29 US US13/812,960 patent/US20130172549A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL198827A0 (en) | 2010-02-17 |
| ZA200904477B (en) | 2010-09-29 |
| EP2096923B1 (en) | 2014-01-22 |
| NZ577814A (en) | 2012-03-30 |
| EP2096923A4 (en) | 2011-01-12 |
| UA99448C2 (en) | 2012-08-27 |
| AU2007325780B9 (en) | 2013-09-12 |
| WO2008066789A3 (en) | 2008-08-21 |
| US20130172549A1 (en) | 2013-07-04 |
| EA200970516A1 (ru) | 2009-12-30 |
| JP2010510987A (ja) | 2010-04-08 |
| KR20090094336A (ko) | 2009-09-04 |
| AU2007325780A1 (en) | 2008-06-05 |
| MY150731A (en) | 2014-02-28 |
| EA201300152A1 (ru) | 2013-07-30 |
| US8431593B2 (en) | 2013-04-30 |
| CO6190582A2 (es) | 2010-08-19 |
| EA018036B1 (ru) | 2013-05-30 |
| EP2096923A2 (en) | 2009-09-09 |
| AU2007325780B2 (en) | 2013-05-02 |
| WO2008066789A2 (en) | 2008-06-05 |
| NO20092444L (no) | 2009-08-27 |
| CN101621931A (zh) | 2010-01-06 |
| US20100216763A1 (en) | 2010-08-26 |
| EP2591675A1 (en) | 2013-05-15 |
| CA2670636A1 (en) | 2008-06-05 |
| MX2009005478A (es) | 2009-08-12 |
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