BRPI0719280A2 - Composto, composição farmacêutica, métodos para modular a atividade de um receptor de p2x7 in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor de p2x7 em um paciente, para inibir a morte de células do gânglio retinal em um paciente, para determinar a presença ou ausência de receptor de p2x7 em uma amostra, preparação farmacêutica acondicionada, método para tratar ou prevenir cirrose em um paciente, e, uso de um composto. - Google Patents
Composto, composição farmacêutica, métodos para modular a atividade de um receptor de p2x7 in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor de p2x7 em um paciente, para inibir a morte de células do gânglio retinal em um paciente, para determinar a presença ou ausência de receptor de p2x7 em uma amostra, preparação farmacêutica acondicionada, método para tratar ou prevenir cirrose em um paciente, e, uso de um composto. Download PDFInfo
- Publication number
- BRPI0719280A2 BRPI0719280A2 BRPI0719280-0A BRPI0719280A BRPI0719280A2 BR PI0719280 A2 BRPI0719280 A2 BR PI0719280A2 BR PI0719280 A BRPI0719280 A BR PI0719280A BR PI0719280 A2 BRPI0719280 A2 BR PI0719280A2
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- amino
- mono
- formula
- membered
- Prior art date
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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| MX2009010523A (es) * | 2007-04-10 | 2009-12-15 | Lundbeck & Co As H | Análogos de amidas heteroarílicas como antagonistas de p2x7. |
| WO2009140101A2 (en) * | 2008-05-12 | 2009-11-19 | Boehringer Ingelheim International Gmbh | Imidazopyridine compounds useful as mmp-13 inhibitors |
| WO2011082271A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted triazolo-pyrimidine compounds |
| CN102464631B (zh) * | 2010-11-08 | 2016-08-10 | 中国科学院上海药物研究所 | 哌嗪取代的1,3-二取代脲类化合物及哌嗪取代的酰胺类化合物及其制备方法和用途 |
| TW201309706A (zh) | 2011-07-22 | 2013-03-01 | Actelion Pharmaceuticals Ltd | 作為ｐ２ｘ７受體拮抗劑之雜環醯胺衍生物 |
| AU2013210682B2 (en) | 2012-01-20 | 2017-05-25 | Idorsia Pharmaceuticals Ltd | Heterocyclic amide derivatives as P2X7 receptor antagonists |
| EA029644B1 (ru) | 2012-12-12 | 2018-04-30 | Идорсиа Фармасьютиклз Лтд | Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов |
| CA2891499C (en) | 2012-12-18 | 2021-07-06 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
| JP6282017B2 (ja) | 2013-01-22 | 2018-02-21 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体 |
| ES2616114T3 (es) * | 2013-01-22 | 2017-06-09 | Actelion Pharmaceuticals Ltd. | Derivados de amida heterocíclica como antagonistas del receptor P2X7 |
| KR102194745B1 (ko) | 2013-03-13 | 2020-12-24 | 포르마 세라퓨틱스 인크. | Ｆａｓｎ 억제용 신규 화합물 및 조성물 |
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| AU2018372211B2 (en) | 2017-11-24 | 2023-02-02 | Jubilant Episcribe LLC, | Heterocyclic compounds as PRMT5 inhibitors |
| JP7461104B2 (ja) * | 2017-11-29 | 2024-04-03 | 中外製薬株式会社 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体を含有する医薬組成物 |
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| CN119241538A (zh) * | 2024-09-30 | 2025-01-03 | 陕西科技大学 | 一类三唑并吡啶结构的化合物、合成方法及其应用 |
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-
2007
- 2007-11-27 UA UAA200906538A patent/UA99448C2/ru unknown
- 2007-11-27 CN CN200780049692A patent/CN101621931A/zh active Pending
- 2007-11-27 EA EA201300152A patent/EA201300152A1/ru unknown
- 2007-11-27 NZ NZ577814A patent/NZ577814A/en not_active IP Right Cessation
- 2007-11-27 EA EA200970516A patent/EA018036B1/ru not_active IP Right Cessation
- 2007-11-27 EP EP13150025.8A patent/EP2591675A1/en not_active Withdrawn
- 2007-11-27 BR BRPI0719280-0A patent/BRPI0719280A2/pt not_active IP Right Cessation
- 2007-11-27 EP EP07862234.7A patent/EP2096923B1/en active Active
- 2007-11-27 ZA ZA200904477A patent/ZA200904477B/xx unknown
- 2007-11-27 AU AU2007325780A patent/AU2007325780B9/en not_active Ceased
- 2007-11-27 JP JP2009538419A patent/JP2010510987A/ja active Pending
- 2007-11-27 MY MYPI20092150 patent/MY150731A/en unknown
- 2007-11-27 MX MX2009005478A patent/MX2009005478A/es active IP Right Grant
- 2007-11-27 CA CA002670636A patent/CA2670636A1/en not_active Abandoned
- 2007-11-27 KR KR1020097013490A patent/KR20090094336A/ko not_active Ceased
- 2007-11-27 US US12/516,480 patent/US8431593B2/en not_active Expired - Fee Related
- 2007-11-27 WO PCT/US2007/024396 patent/WO2008066789A2/en not_active Ceased
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2009
- 2009-05-19 IL IL198827A patent/IL198827A0/en unknown
- 2009-06-26 CO CO09066902A patent/CO6190582A2/es active IP Right Grant
- 2009-06-26 NO NO20092444A patent/NO20092444L/no not_active Application Discontinuation
-
2013
- 2013-01-29 US US13/812,960 patent/US20130172549A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| AU2007325780A1 (en) | 2008-06-05 |
| MY150731A (en) | 2014-02-28 |
| WO2008066789A2 (en) | 2008-06-05 |
| US8431593B2 (en) | 2013-04-30 |
| CO6190582A2 (es) | 2010-08-19 |
| MX2009005478A (es) | 2009-08-12 |
| CN101621931A (zh) | 2010-01-06 |
| IL198827A0 (en) | 2010-02-17 |
| EP2591675A1 (en) | 2013-05-15 |
| AU2007325780B2 (en) | 2013-05-02 |
| EA201300152A1 (ru) | 2013-07-30 |
| NO20092444L (no) | 2009-08-27 |
| KR20090094336A (ko) | 2009-09-04 |
| EA200970516A1 (ru) | 2009-12-30 |
| EP2096923A4 (en) | 2011-01-12 |
| CA2670636A1 (en) | 2008-06-05 |
| EP2096923B1 (en) | 2014-01-22 |
| ZA200904477B (en) | 2010-09-29 |
| US20100216763A1 (en) | 2010-08-26 |
| EA018036B1 (ru) | 2013-05-30 |
| AU2007325780B9 (en) | 2013-09-12 |
| UA99448C2 (en) | 2012-08-27 |
| NZ577814A (en) | 2012-03-30 |
| WO2008066789A3 (en) | 2008-08-21 |
| EP2096923A2 (en) | 2009-09-09 |
| US20130172549A1 (en) | 2013-07-04 |
| JP2010510987A (ja) | 2010-04-08 |
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