BRPI0710131B1 - Mutantes isolados de glicose desidrogenase solúvel dependente de pirrolquinolina quinona e método de detecção, determinação ou medição de glicose usando os mesmos - Google Patents
Mutantes isolados de glicose desidrogenase solúvel dependente de pirrolquinolina quinona e método de detecção, determinação ou medição de glicose usando os mesmos Download PDFInfo
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- BRPI0710131B1 BRPI0710131B1 BRPI0710131-7A BRPI0710131A BRPI0710131B1 BR PI0710131 B1 BRPI0710131 B1 BR PI0710131B1 BR PI0710131 A BRPI0710131 A BR PI0710131A BR PI0710131 B1 BRPI0710131 B1 BR PI0710131B1
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- gdh
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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| PCT/EP2007/003207 WO2007118647A1 (en) | 2006-04-13 | 2007-04-11 | Improved mutants of pyrroloquinoline quinone dependent soluble glucose dehydrogenase |
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| BRPI0710131A2 BRPI0710131A2 (pt) | 2011-08-02 |
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| JP5753720B2 (ja) * | 2010-04-22 | 2015-07-22 | アークレイ株式会社 | バイオセンサ |
| WO2012010308A1 (en) | 2010-07-23 | 2012-01-26 | Roche Diagnostics Gmbh | Zwitterion buffer containing compositions and uses in electroanalytical devices and methods |
| EP2655650B1 (en) | 2010-12-20 | 2017-12-20 | LEK Pharmaceuticals d.d. | Enzymatic synthesis of active pharmaceutical ingredient and intermediates thereof |
| EP2465936A1 (en) | 2010-12-20 | 2012-06-20 | LEK Pharmaceuticals d.d. | Enzymatic synthesis of statins and intermediates thereof |
| EP2656058A1 (en) | 2010-12-22 | 2013-10-30 | Roche Diagnostics GmbH | Systems and methods to compensate for sources of error during electrochemical testing |
| CN102559624B (zh) * | 2012-03-05 | 2013-10-16 | 浙江德清汇宁生物科技有限公司 | 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法 |
| EP2839267B1 (de) | 2012-04-19 | 2019-12-04 | F.Hoffmann-La Roche Ag | Verfahren und vorrichtung zur bestimmung einer analytkonzentration in blut |
| EP2811299A1 (en) | 2013-06-07 | 2014-12-10 | Roche Diagniostics GmbH | Test element for detecting at least one analyte in a body fluid |
| EP3353310B1 (en) | 2015-09-25 | 2020-04-29 | H. Hoffnabb-La Roche Ag | Process for producing thioesters employing a sortase a |
| WO2017050872A1 (en) | 2015-09-25 | 2017-03-30 | F. Hoffmann-La Roche Ag | Transamidation employing sortase a in deep eutectic solvents |
| CN111073866B (zh) | 2015-10-29 | 2024-03-19 | 英科隆生物技术（杭州）有限公司 | PQQ-sGDH突变体、聚核苷酸及其在葡萄糖检测中的应用 |
| CN105331590B (zh) * | 2015-10-29 | 2020-02-28 | 英科隆生物技术（杭州）有限公司 | 葡萄糖特异性改善的可溶性吡咯喹啉醌依赖性葡萄糖脱氢酶突变体、聚核苷酸及其应用 |
| WO2017109003A1 (en) | 2015-12-21 | 2017-06-29 | F. Hoffmann-La Roche Ag | Mutant 3-hydroxybutyrate dehydrogenase from alcaligenes faecalis as well as methods and uses involving the same |
| ES2782199T3 (es) | 2016-02-09 | 2020-09-11 | Hoffmann La Roche | 3-Hidroxibutirato deshidrogenasa mutante de Rhodobacter sphaeroides, así como procedimientos y usos que implican la misma |
| PL3523639T3 (pl) | 2016-10-05 | 2025-03-17 | F. Hoffmann-La Roche Ag | Odczynniki wykrywające i układy elektrod do elementów diagnostycznych testów wieloanalitowych oraz sposoby ich zastosowania |
| CN115820608B (zh) * | 2022-08-31 | 2024-06-04 | 中国海洋大学 | λ-卡拉胶酶突变体OUC-CglA-DPQQ及其应用 |
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| DE3716957A1 (de) | 1987-05-20 | 1988-12-01 | Boehringer Mannheim Gmbh | Expressionsvektor zur regulierbaren expression von fremdgenen in prokaryonten |
| DE4311464A1 (de) | 1993-04-08 | 1994-10-13 | Boehringer Mannheim Gmbh | Verfahren zur kolorimetrischen Bestimmung eines Analyten mit einer PQQ-abhängigen Dehydrogenase |
| DE19639169A1 (de) | 1996-09-24 | 1998-04-02 | Boehringer Mannheim Gmbh | Redoxaktive Verbindungen und deren Anwendung |
| JPH10243786A (ja) | 1997-03-03 | 1998-09-14 | Koji Hayade | 改変型グルコース脱水素酵素 |
| US5997817A (en) | 1997-12-05 | 1999-12-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
| JPH11243949A (ja) | 1998-03-03 | 1999-09-14 | Toyobo Co Ltd | Ｐｑｑを補欠分子族とするグルコースデヒドロゲナーゼおよびその製造方法 |
| WO2000049039A2 (de) * | 1999-02-19 | 2000-08-24 | Merck Patent Gmbh | Glucose-dehydrogenase-fusionsproteine und ihre verwendung in expressionssystemen |
| JP2000350588A (ja) * | 1999-04-08 | 2000-12-19 | Koji Hayade | グルコース脱水素酵素 |
| TWI224136B (en) | 1999-04-30 | 2004-11-21 | Koji Sode | Glucose dehydrogenase |
| WO2002034919A1 (en) * | 2000-10-27 | 2002-05-02 | Roche Diagnostics Gmbh | Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase |
| JP2004344145A (ja) * | 2002-05-27 | 2004-12-09 | Toyobo Co Ltd | 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体 |
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| WO2006008132A1 (en) | 2004-07-20 | 2006-01-26 | Roche Diagnostics Gmbh | Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an amino acid insertion |
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| KR101168623B1 (ko) | 2012-08-03 |
| ES2807530T3 (es) | 2021-02-23 |
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| EP3246402A1 (en) | 2017-11-22 |
| WO2007118647A1 (en) | 2007-10-25 |
| CA2649135A1 (en) | 2007-10-25 |
| JP5683809B2 (ja) | 2015-03-11 |
| JP6185617B2 (ja) | 2017-08-23 |
| PL2010649T3 (pl) | 2017-08-31 |
| HK1131633A1 (zh) | 2010-01-29 |
| BRPI0710131A2 (pt) | 2011-08-02 |
| ES2624805T3 (es) | 2017-07-17 |
| US7732179B2 (en) | 2010-06-08 |
| JP2013198497A (ja) | 2013-10-03 |
| CN101421396B (zh) | 2016-01-20 |
| PT2010649T (pt) | 2017-05-03 |
| AU2007237478B2 (en) | 2011-05-19 |
| KR20080106349A (ko) | 2008-12-04 |
| CN101421396A (zh) | 2009-04-29 |
| EP3246402B1 (en) | 2020-05-20 |
| CA2649135C (en) | 2013-11-19 |
| JP2009533033A (ja) | 2009-09-17 |
| AU2007237478A1 (en) | 2007-10-25 |
| EP2010649B1 (en) | 2017-03-08 |
| PT3246402T (pt) | 2020-07-14 |
| MX2008013001A (es) | 2008-10-17 |
| HUE049911T2 (hu) | 2020-11-30 |
| PL3246402T3 (pl) | 2020-10-19 |
| JP5937547B2 (ja) | 2016-06-22 |
| JP2016119904A (ja) | 2016-07-07 |
| EP2010649A1 (en) | 2009-01-07 |
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