BRPI0710131B1 - Mutantes isolados de glicose desidrogenase solúvel dependente de pirrolquinolina quinona e método de detecção, determinação ou medição de glicose usando os mesmos - Google Patents
Mutantes isolados de glicose desidrogenase solúvel dependente de pirrolquinolina quinona e método de detecção, determinação ou medição de glicose usando os mesmos Download PDFInfo
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- BRPI0710131B1 BRPI0710131B1 BRPI0710131-7A BRPI0710131A BRPI0710131B1 BR PI0710131 B1 BRPI0710131 B1 BR PI0710131B1 BR PI0710131 A BRPI0710131 A BR PI0710131A BR PI0710131 B1 BRPI0710131 B1 BR PI0710131B1
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- gdh
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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| BRPI0710131A2 BRPI0710131A2 (pt) | 2011-08-02 |
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| US20130092536A1 (en) | 2010-07-23 | 2013-04-18 | Roche Diagnostics Operations, Inc. | Zwitterion buffer containing compositions and uses in electroanalytical methods |
| JP6194251B2 (ja) | 2010-12-20 | 2017-09-06 | レツク・フアーマシユーテイカルズ・デー・デー | 医薬品有効成分およびこれの中間体の酵素的合成 |
| EP2465936A1 (en) | 2010-12-20 | 2012-06-20 | LEK Pharmaceuticals d.d. | Enzymatic synthesis of statins and intermediates thereof |
| EP2656058A1 (en) | 2010-12-22 | 2013-10-30 | Roche Diagnostics GmbH | Systems and methods to compensate for sources of error during electrochemical testing |
| CN102559624B (zh) * | 2012-03-05 | 2013-10-16 | 浙江德清汇宁生物科技有限公司 | 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法 |
| JP6111323B2 (ja) | 2012-04-19 | 2017-04-05 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 血液中の検体濃度を測定する方法および装置 |
| EP2811299A1 (en) | 2013-06-07 | 2014-12-10 | Roche Diagniostics GmbH | Test element for detecting at least one analyte in a body fluid |
| EP3353310B1 (en) | 2015-09-25 | 2020-04-29 | H. Hoffnabb-La Roche Ag | Process for producing thioesters employing a sortase a |
| JP6998863B2 (ja) | 2015-09-25 | 2022-02-04 | エフ．ホフマン－ラ ロシュ アーゲー | 深共融溶媒におけるソルターゼａを利用したアミド基転移 |
| CN105331591B (zh) * | 2015-10-29 | 2020-02-28 | 英科隆生物技术（杭州）有限公司 | PQQ-sGDH突变体、聚核苷酸及葡萄糖检测装置 |
| CN105331590B (zh) * | 2015-10-29 | 2020-02-28 | 英科隆生物技术（杭州）有限公司 | 葡萄糖特异性改善的可溶性吡咯喹啉醌依赖性葡萄糖脱氢酶突变体、聚核苷酸及其应用 |
| WO2017109003A1 (en) | 2015-12-21 | 2017-06-29 | F. Hoffmann-La Roche Ag | Mutant 3-hydroxybutyrate dehydrogenase from alcaligenes faecalis as well as methods and uses involving the same |
| WO2017137491A1 (en) | 2016-02-09 | 2017-08-17 | Roche Diabetes Care Gmbh | Mutant 3-hydroxybutyrate dehydrogenase from rhodobacter sphaeroides as well as methods and uses involving the same |
| JP2019529935A (ja) | 2016-10-05 | 2019-10-17 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 多検体診断用試験エレメントのための検出試薬および電極配置、ならびにそれらを使用する方法 |
| CN115820608B (zh) * | 2022-08-31 | 2024-06-04 | 中国海洋大学 | λ-卡拉胶酶突变体OUC-CglA-DPQQ及其应用 |
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| DE3716957A1 (de) | 1987-05-20 | 1988-12-01 | Boehringer Mannheim Gmbh | Expressionsvektor zur regulierbaren expression von fremdgenen in prokaryonten |
| DE4311464A1 (de) | 1993-04-08 | 1994-10-13 | Boehringer Mannheim Gmbh | Verfahren zur kolorimetrischen Bestimmung eines Analyten mit einer PQQ-abhängigen Dehydrogenase |
| DE19639169A1 (de) | 1996-09-24 | 1998-04-02 | Boehringer Mannheim Gmbh | Redoxaktive Verbindungen und deren Anwendung |
| JPH10243786A (ja) | 1997-03-03 | 1998-09-14 | Koji Hayade | 改変型グルコース脱水素酵素 |
| US5997817A (en) | 1997-12-05 | 1999-12-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
| JPH11243949A (ja) | 1998-03-03 | 1999-09-14 | Toyobo Co Ltd | Ｐｑｑを補欠分子族とするグルコースデヒドロゲナーゼおよびその製造方法 |
| BR0008370A (pt) * | 1999-02-19 | 2001-11-06 | Merck Patent Gmbh | Proteìnas de fusão de glicose deshidrogenase e uso das mesmas em sistemas de expressão |
| JP2000350588A (ja) * | 1999-04-08 | 2000-12-19 | Koji Hayade | グルコース脱水素酵素 |
| TWI224136B (en) | 1999-04-30 | 2004-11-21 | Koji Sode | Glucose dehydrogenase |
| AU1596602A (en) * | 2000-10-27 | 2002-05-06 | Peter Kratzsch | Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase |
| JP2004344145A (ja) * | 2002-05-27 | 2004-12-09 | Toyobo Co Ltd | 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体 |
| JP2004173538A (ja) | 2002-11-25 | 2004-06-24 | Amano Enzyme Inc | ピロロキノリンキノン依存性グルコース脱水素酵素 |
| JP4842938B2 (ja) * | 2004-07-20 | 2011-12-21 | エフ．ホフマン−ラ ロシュ アーゲー | アミノ酸挿入を含む遺伝子操作されたピロロキノリンキノン依存性グルコースデヒドロゲナーゼ |
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| HK1131633A1 (zh) | 2010-01-29 |
| HUE032804T2 (en) | 2017-11-28 |
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| PT2010649T (pt) | 2017-05-03 |
| JP5683809B2 (ja) | 2015-03-11 |
| KR20080106349A (ko) | 2008-12-04 |
| MX2008013001A (es) | 2008-10-17 |
| EP3246402B1 (en) | 2020-05-20 |
| US20090148874A1 (en) | 2009-06-11 |
| AU2007237478A1 (en) | 2007-10-25 |
| CA2649135A1 (en) | 2007-10-25 |
| US7732179B2 (en) | 2010-06-08 |
| PT3246402T (pt) | 2020-07-14 |
| EP2010649A1 (en) | 2009-01-07 |
| EP3246402A1 (en) | 2017-11-22 |
| CA2649135C (en) | 2013-11-19 |
| PL2010649T3 (pl) | 2017-08-31 |
| BRPI0710131A2 (pt) | 2011-08-02 |
| HUE049911T2 (hu) | 2020-11-30 |
| JP6185617B2 (ja) | 2017-08-23 |
| WO2007118647A1 (en) | 2007-10-25 |
| JP2009533033A (ja) | 2009-09-17 |
| EP2010649B1 (en) | 2017-03-08 |
| CN101421396B (zh) | 2016-01-20 |
| PL3246402T3 (pl) | 2020-10-19 |
| AU2007237478B2 (en) | 2011-05-19 |
| JP2013198497A (ja) | 2013-10-03 |
| ES2624805T3 (es) | 2017-07-17 |
| KR101168623B1 (ko) | 2012-08-03 |
| JP5937547B2 (ja) | 2016-06-22 |
| CN101421396A (zh) | 2009-04-29 |
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