BRPI0518958A2 - mÉtodo para produzir l-biopterina - Google Patents

mÉtodo para produzir l-biopterina

Info

Publication number
BRPI0518958A2
BRPI0518958A2 BRPI0518958-6A BRPI0518958A BRPI0518958A2 BR PI0518958 A2 BRPI0518958 A2 BR PI0518958A2 BR PI0518958 A BRPI0518958 A BR PI0518958A BR PI0518958 A2 BRPI0518958 A2 BR PI0518958A2
Authority
BR
Brazil
Prior art keywords
producing
biopterin
formula
represented
phenylhydrazones
Prior art date
Application number
BRPI0518958-6A
Other languages
English (en)
Inventor
Shinnosuke Tazawa
Original Assignee
Shiratori Pharm
Asubio Phama Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiratori Pharm, Asubio Phama Co Ltd filed Critical Shiratori Pharm
Publication of BRPI0518958A2 publication Critical patent/BRPI0518958A2/pt
Publication of BRPI0518958B1 publication Critical patent/BRPI0518958B1/pt
Publication of BRPI0518958B8 publication Critical patent/BRPI0518958B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Abstract

MÉTODO PARA PRODUZIR L-BIOPTERINA. Para fornecer um método para produção de L- biopterina em uma ampla escala industrial empregando-se um reagente que seja econômico e fácil de manipular, sem requerer um uso de qualquer equipamento ou usina particular. Um método por produzir um derivado de biopterina representado pela fórmula (6) onde R¹ e R², que são iguais ou diferentes de ou outro, cada representa um átomo de hidrogênio, um grupo de alquila, ou um grupo de arila, compreendendo: reagir um composto pertencendo a fenilidrazonas de triacetóxi-5- deóxi-L-arabinose representado pela fórmula (4) : onde R¹ e R² são como definido acima, 6-hidróxi-2,4,5- triaminopirimidina (5) sob influência catalítica de um ácido Lewis em um solvente aquoso.
BRPI0518958A 2004-12-27 2005-12-22 método para produzir um derivado de biopterina, 1;2'-0- diacetil-l-biopterina e l-biopterina BRPI0518958B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004375618 2004-12-27
PCT/JP2005/024195 WO2006070902A1 (en) 2004-12-27 2005-12-22 Method for producing l-biopterin

Publications (3)

Publication Number Publication Date
BRPI0518958A2 true BRPI0518958A2 (pt) 2008-12-16
BRPI0518958B1 BRPI0518958B1 (pt) 2019-01-22
BRPI0518958B8 BRPI0518958B8 (pt) 2021-05-25

Family

ID=36001125

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518958A BRPI0518958B8 (pt) 2004-12-27 2005-12-22 método para produzir um derivado de biopterina, 1;2'-0- diacetil-l-biopterina e l-biopterina

Country Status (14)

Country Link
US (1) US7361759B2 (pt)
EP (1) EP1831223B1 (pt)
JP (1) JP5153334B2 (pt)
KR (1) KR101342086B1 (pt)
CN (1) CN101087791B (pt)
AU (1) AU2005320525B2 (pt)
BR (1) BRPI0518958B8 (pt)
CA (1) CA2594320C (pt)
DK (1) DK1831223T3 (pt)
ES (1) ES2413480T3 (pt)
MX (1) MX2007007921A (pt)
PL (1) PL1831223T3 (pt)
PT (1) PT1831223E (pt)
WO (1) WO2006070902A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009067695A (ja) * 2007-09-11 2009-04-02 Kaneka Corp ビオプテリンの結晶多形、及びそれらの製造方法
WO2009088979A1 (en) * 2008-01-07 2009-07-16 Biomarin Pharmaceutical Inc. Method of synthesizing tetrahydrobiopterin
US20110218339A1 (en) * 2010-03-08 2011-09-08 Kaneka Corporation Crystalline polymorph of biopterin and production method thereof
CN102443006B (zh) 2010-10-13 2016-02-24 因华生技制药股份有限公司 (6r)-四氢生物喋呤盐酸盐的制备方法
CN102633799B (zh) 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
CN102627644B (zh) 2012-04-10 2014-04-16 凯莱英医药集团（天津）股份有限公司 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
CN107353314A (zh) * 2016-05-10 2017-11-17 江苏福锌雨医药科技有限公司 一种5-脱氧-l-阿拉伯糖的合成方法
CN109776540B (zh) * 2017-11-15 2021-07-06 北京启慧生物医药有限公司 一种盐酸沙丙蝶呤的制备方法
CN114380871B (zh) * 2022-01-27 2024-03-01 重庆迈德凯医药有限公司 一种5-脱氧-l-阿拉伯糖苯腙的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH500999A (de) 1967-04-07 1970-12-31 Ciba Geigy Ag Verfahren zur Herstellung von Pterinderivaten
JPS5883691A (ja) 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法
JPS59112987A (ja) 1982-12-20 1984-06-29 Kanegafuchi Chem Ind Co Ltd １′，２′―ジアシル―（６ｒ，ｓ）―５，６，７，８―テトラヒドロ―ｌ―ビオプテリンおよびその製法
JPS59186896A (ja) * 1983-04-04 1984-10-23 長谷川　正昭 気球への吊上物引上げ法
JPS59186986A (ja) * 1984-03-17 1984-10-23 Kanegafuchi Chem Ind Co Ltd １′，２′−ジアシル−ｌ−ビオプテリンの製造法
JPS617287A (ja) 1984-06-21 1986-01-13 Kanegafuchi Chem Ind Co Ltd ５‐デオキシ‐ｌ‐アラビノースの製造法
JP2567639B2 (ja) 1987-11-30 1996-12-25 株式会社ビタミン研究所 プテリジン誘導体
JP2567637B2 (ja) 1987-11-30 1996-12-25 株式会社ビタミン研究所 ジヒドロプテリジン誘導体
JP2674707B2 (ja) 1988-06-22 1997-11-12 株式会社ビタミン研究所 Ｌ‐ビオプテリンの製法
JP2567638B2 (ja) 1987-11-30 1996-12-25 株式会社ビタミン研究所 テトラヒドロプテリジン誘導体
JP2611790B2 (ja) 1987-11-30 1997-05-21 株式会社ビタミン研究所 テトラヒドロフラニルピリミジン誘導体
JP2575781B2 (ja) 1988-02-29 1997-01-29 日清製粉株式会社 ２，３−ジアシルオキシ−４−ヒドロキシ−トペンタナールおよびその製造方法
JPH0231720A (ja) 1988-07-22 1990-02-01 Mitsubishi Electric Corp 自動製パン器
JPH0255434A (ja) 1988-08-20 1990-02-23 Fujitsu Ltd コードジェネレータ
JP2843592B2 (ja) 1989-02-28 1999-01-06 日清製粉株式会社 Ｌ−リボース誘導体
JPH0332553A (ja) 1989-06-29 1991-02-13 Omron Corp 工具折損検出装置
JP2001302665A (ja) 2000-04-19 2001-10-31 Shiratori Pharmaceutical Co Ltd Ｌ−ビオプテリン又はｄ−ネオプテリンの製造法

Also Published As

Publication number Publication date
MX2007007921A (es) 2007-08-14
CA2594320A1 (en) 2006-07-06
AU2005320525A1 (en) 2006-07-06
WO2006070902A1 (en) 2006-07-06
US20060142573A1 (en) 2006-06-29
DK1831223T3 (da) 2013-06-10
US7361759B2 (en) 2008-04-22
EP1831223B1 (en) 2013-05-29
CA2594320C (en) 2013-08-13
AU2005320525B2 (en) 2011-06-16
PL1831223T3 (pl) 2013-10-31
JP2008525312A (ja) 2008-07-17
KR101342086B1 (ko) 2013-12-18
ES2413480T3 (es) 2013-07-16
BRPI0518958B1 (pt) 2019-01-22
BRPI0518958B8 (pt) 2021-05-25
CN101087791A (zh) 2007-12-12
EP1831223A1 (en) 2007-09-12
JP5153334B2 (ja) 2013-02-27
KR20070089957A (ko) 2007-09-04
CN101087791B (zh) 2010-08-25
PT1831223E (pt) 2013-07-09

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: SHIRATORI PHARMACEUTICAL CO., LTD. (JP) , DAIICHI

Free format text: TRANFERIDO POR INCORPORACAO DE: ASUBIO PHAMA CO., LTD.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/01/2019, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/12/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF