BRPI0407501A - glicolipìdeos e método sintético dos mesmos bem como seus intermediários sintéticos, e método sintético dos mesmos - Google Patents
glicolipìdeos e método sintético dos mesmos bem como seus intermediários sintéticos, e método sintético dos mesmosInfo
- Publication number
- BRPI0407501A BRPI0407501A BRPI0407501-3A BRPI0407501A BRPI0407501A BR PI0407501 A BRPI0407501 A BR PI0407501A BR PI0407501 A BRPI0407501 A BR PI0407501A BR PI0407501 A BRPI0407501 A BR PI0407501A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- unsubstituted
- group
- synthetic
- synthetic method
- Prior art date
Links
- 238000010189 synthetic method Methods 0.000 title abstract 5
- 229930186217 Glycolipid Natural products 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 abstract 1
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical class O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyridine Compounds (AREA)
Abstract
"GLICOLIPìDEOS E MéTODO SINTéTICO DOS MESMOS BEM COMO SEUS INTERMEDIáRIOS SINTéTICOS, E MéTODO SINTéTICO DOS MESMOS". Novos derivados glicolipídicos, onde o substituinte da parte da base de esfingosina é um grupamento alquil de cadeia de carbono curta, um grupamento cicloalquil substituído ou não substituído, um grupamento aril substituído ou não substituído ou um grupamento aralquil substituído ou não substituído e métodos sintéticos eficientes para produção em massa realizável dos mesmos e intermediários úteis para a síntese destes compostos. São sintetizados quimicamente glicolipídeos tendo a fórmula (I): onde R¬ 3¬ indica um grupamento alquil linear C~ 1~ a C~ 7~ substituído ou não substituído, um grupamento cicloalquil substituído ou não substituído, um grupamento aril substituído ou não substituído, ou um grupamento aralquil substituído ou não substituído e R¬ 3¬ indica um grupamento alquil C~ 1~ a C~ 35~ substituído ou não substituído, um grupamento aril substituído ou não substituído ou um grupamento aralquil substituído ou não substituído.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003037397 | 2003-02-14 | ||
| PCT/JP2004/001566 WO2004072091A1 (ja) | 2003-02-14 | 2004-02-13 | 糖脂質誘導体及びその製造法並びにそれらの合成中間体及びその製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0407501A true BRPI0407501A (pt) | 2006-02-14 |
Family
ID=32866358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0407501-3A BRPI0407501A (pt) | 2003-02-14 | 2004-02-13 | glicolipìdeos e método sintético dos mesmos bem como seus intermediários sintéticos, e método sintético dos mesmos |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7732583B2 (pt) |
| EP (2) | EP1619199B1 (pt) |
| JP (2) | JP4742220B2 (pt) |
| KR (1) | KR20050105215A (pt) |
| CN (2) | CN100537585C (pt) |
| AU (1) | AU2004210784A1 (pt) |
| BR (1) | BRPI0407501A (pt) |
| CA (1) | CA2515396A1 (pt) |
| ES (2) | ES2450043T3 (pt) |
| HU (1) | HUE037560T2 (pt) |
| NO (1) | NO20054032L (pt) |
| WO (1) | WO2004072091A1 (pt) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
| US7772380B2 (en) * | 2004-08-27 | 2010-08-10 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
| US7923013B2 (en) * | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
| WO2006071848A2 (en) * | 2004-12-28 | 2006-07-06 | The Rockefeller University | Glycolipids and analogues thereof as antigens for nk t cells |
| BRPI0612732A2 (pt) * | 2005-07-01 | 2011-08-16 | Japan As Represented By The President Of Nat Ct Of Neurology And Psychiatry | derivado de glicolipìdeo e uso do mesmo |
| WO2008047174A1 (en) * | 2006-10-18 | 2008-04-24 | Centre National De La Recherche Scientifique | Alpha-galactosylceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them |
| WO2008103392A2 (en) * | 2007-02-21 | 2008-08-28 | Vaccinex, Inc. | Modulation of nkt cell activity with antigen-loaded cdid molecules |
| KR20110137290A (ko) * | 2009-01-08 | 2011-12-22 | 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 | 세포벽 결합 세라미드 유사 당지질을 갖는 박테리아 백신 및 이의 용도 |
| CN101775051B (zh) * | 2010-01-07 | 2013-03-27 | 北京大学 | 一种区域选择性脱除糖o-苄基保护基的方法 |
| US10632740B2 (en) | 2010-04-23 | 2020-04-28 | Landa Corporation Ltd. | Digital printing process |
| JP6437312B2 (ja) | 2012-03-05 | 2018-12-12 | ランダ コーポレイション リミテッド | デジタル印刷プロセス |
| US9643403B2 (en) | 2012-03-05 | 2017-05-09 | Landa Corporation Ltd. | Printing system |
| CN104245340B (zh) | 2012-03-05 | 2016-11-23 | 兰达公司 | 释放层的处理 |
| US9498946B2 (en) | 2012-03-05 | 2016-11-22 | Landa Corporation Ltd. | Apparatus and method for control or monitoring of a printing system |
| US9902147B2 (en) | 2012-03-05 | 2018-02-27 | Landa Corporation Ltd. | Digital printing system |
| US10434761B2 (en) | 2012-03-05 | 2019-10-08 | Landa Corporation Ltd. | Digital printing process |
| JP6185938B2 (ja) | 2012-03-05 | 2017-08-23 | ランダ コーポレイション リミテッド | インクフィルム構築物 |
| US9353273B2 (en) | 2012-03-05 | 2016-05-31 | Landa Corporation Ltd. | Ink film constructions |
| US10190012B2 (en) | 2012-03-05 | 2019-01-29 | Landa Corporation Ltd. | Treatment of release layer and inkjet ink formulations |
| US10642198B2 (en) | 2012-03-05 | 2020-05-05 | Landa Corporation Ltd. | Intermediate transfer members for use with indirect printing systems and protonatable intermediate transfer members for use with indirect printing systems |
| US9517618B2 (en) | 2012-03-15 | 2016-12-13 | Landa Corporation Ltd. | Endless flexible belt for a printing system |
| EP2953957B1 (en) | 2013-02-08 | 2019-04-10 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
| US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
| EP3044010B1 (en) | 2013-09-11 | 2019-11-06 | Landa Corporation Ltd. | Release layer treatment formulations |
| GB201401173D0 (en) | 2013-09-11 | 2014-03-12 | Landa Corp Ltd | Ink formulations and film constructions thereof |
| GB2536489B (en) | 2015-03-20 | 2018-08-29 | Landa Corporation Ltd | Indirect printing system |
| GB2537813A (en) | 2015-04-14 | 2016-11-02 | Landa Corp Ltd | Apparatus for threading an intermediate transfer member of a printing system |
| GB201609463D0 (en) | 2016-05-30 | 2016-07-13 | Landa Labs 2012 Ltd | Method of manufacturing a multi-layer article |
| DE112017002714T5 (de) | 2016-05-30 | 2019-02-28 | Landa Corporation Ltd. | Digitales Druckverfahren |
| US10926532B2 (en) | 2017-10-19 | 2021-02-23 | Landa Corporation Ltd. | Endless flexible belt for a printing system |
| JP7225230B2 (ja) | 2017-11-19 | 2023-02-20 | ランダ コーポレイション リミテッド | デジタル印刷システム |
| WO2019102297A1 (en) | 2017-11-27 | 2019-05-31 | Landa Corporation Ltd. | Digital printing system |
| US11707943B2 (en) | 2017-12-06 | 2023-07-25 | Landa Corporation Ltd. | Method and apparatus for digital printing |
| US11679615B2 (en) | 2017-12-07 | 2023-06-20 | Landa Corporation Ltd. | Digital printing process and method |
| CN117885446A (zh) | 2018-06-26 | 2024-04-16 | 兰达公司 | 数字印刷系统的中间传输构件 |
| US10994528B1 (en) | 2018-08-02 | 2021-05-04 | Landa Corporation Ltd. | Digital printing system with flexible intermediate transfer member |
| US12001902B2 (en) | 2018-08-13 | 2024-06-04 | Landa Corporation Ltd. | Correcting distortions in digital printing by implanting dummy pixels in a digital image |
| JP7246496B2 (ja) | 2018-10-08 | 2023-03-27 | ランダ コーポレイション リミテッド | 印刷システムおよび方法に関する摩擦低減手段 |
| US11787170B2 (en) | 2018-12-24 | 2023-10-17 | Landa Corporation Ltd. | Digital printing system |
| EP3946953A4 (en) | 2019-03-31 | 2022-12-14 | Landa Corporation Ltd. | SYSTEMS AND METHODS FOR PREVENTING OR MINIMIZING PRINT DEFECTS IN PRINTING PROCESSES |
| EP4066064B1 (en) | 2019-11-25 | 2025-06-04 | Landa Corporation Ltd. | System for drying ink in digital printing using infrared radiation absorbed by particles embedded inside itm |
| US11321028B2 (en) | 2019-12-11 | 2022-05-03 | Landa Corporation Ltd. | Correcting registration errors in digital printing |
| US12011920B2 (en) | 2019-12-29 | 2024-06-18 | Landa Corporation Ltd. | Printing method and system |
| WO2022102557A1 (ja) * | 2020-11-12 | 2022-05-19 | 国立研究開発法人理化学研究所 | 擬似糖脂質誘導体並びにその合成中間体、製造方法及び用途 |
| US12430453B2 (en) | 2021-02-02 | 2025-09-30 | Landa Corporation Ltd. | Mitigating distortions in printed images |
| EP4301374A4 (en) | 2021-03-01 | 2025-09-10 | Deciduous Therapeutics Inc | COMPOUNDS FOR ACTIVATING INVARIANT NATURAL KILLER T CELLS AND METHODS OF USE IN ELIMINATING INFLAMMATORY SENESCENT CELLS |
| WO2025033387A1 (ja) * | 2023-08-07 | 2025-02-13 | Ｅａファーマ株式会社 | 糖脂質誘導体の製造法及びそれらの合成中間体並びにその結晶体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6072960A (ja) * | 1983-09-30 | 1985-04-25 | Sumitomo Chem Co Ltd | モノアゾ化合物およびそれを用いて染色または捺染する方法 |
| US5936076A (en) * | 1991-08-29 | 1999-08-10 | Kirin Beer Kabushiki Kaisha | αgalactosylceramide derivatives |
| JPH0559081A (ja) * | 1991-08-29 | 1993-03-09 | Kirin Brewery Co Ltd | 新規スフインゴ糖脂質、その製造法および使用 |
| AU683026B2 (en) | 1992-10-22 | 1997-10-30 | Kirin Pharma Kabushiki Kaisha | Novel shingoglycolipid and use thereof |
| JP2002226377A (ja) | 1996-10-14 | 2002-08-14 | Kirin Brewery Co Ltd | 配糖体含有末梢血幹細胞増加剤 |
| CN1222293C (zh) | 1997-04-10 | 2005-10-12 | 麒麟麦酒株式会社 | 含有α－糖基神经酰胺的NKT细胞活化剂 |
| HU229345B1 (en) * | 2001-08-16 | 2013-11-28 | Japan Government | Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient |
-
2004
- 2004-02-13 BR BRPI0407501-3A patent/BRPI0407501A/pt not_active IP Right Cessation
- 2004-02-13 AU AU2004210784A patent/AU2004210784A1/en not_active Abandoned
- 2004-02-13 ES ES04710993.9T patent/ES2450043T3/es not_active Expired - Lifetime
- 2004-02-13 EP EP04710993.9A patent/EP1619199B1/en not_active Expired - Lifetime
- 2004-02-13 CN CNB200480004216XA patent/CN100537585C/zh not_active Expired - Lifetime
- 2004-02-13 JP JP2005505007A patent/JP4742220B2/ja not_active Expired - Lifetime
- 2004-02-13 EP EP11160814.7A patent/EP2343306B1/en not_active Expired - Lifetime
- 2004-02-13 KR KR1020057014984A patent/KR20050105215A/ko not_active Ceased
- 2004-02-13 CA CA002515396A patent/CA2515396A1/en not_active Abandoned
- 2004-02-13 CN CN2007101544258A patent/CN101165047B/zh not_active Expired - Lifetime
- 2004-02-13 US US10/545,421 patent/US7732583B2/en not_active Expired - Lifetime
- 2004-02-13 HU HUE11160814A patent/HUE037560T2/hu unknown
- 2004-02-13 ES ES11160814.7T patent/ES2676345T3/es not_active Expired - Lifetime
- 2004-02-13 WO PCT/JP2004/001566 patent/WO2004072091A1/ja not_active Ceased
-
2005
- 2005-08-30 NO NO20054032A patent/NO20054032L/no not_active Application Discontinuation
-
2010
- 2010-04-15 US US12/760,793 patent/US8034908B2/en not_active Expired - Fee Related
- 2010-10-12 JP JP2010229896A patent/JP5246448B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5246448B2 (ja) | 2013-07-24 |
| EP1619199A1 (en) | 2006-01-25 |
| EP2343306B1 (en) | 2018-04-04 |
| US20100210828A1 (en) | 2010-08-19 |
| ES2450043T3 (es) | 2014-03-21 |
| CN1768072A (zh) | 2006-05-03 |
| ES2676345T3 (es) | 2018-07-18 |
| AU2004210784A1 (en) | 2004-08-26 |
| US8034908B2 (en) | 2011-10-11 |
| CN100537585C (zh) | 2009-09-09 |
| CN101165047B (zh) | 2010-10-20 |
| JPWO2004072091A1 (ja) | 2006-06-01 |
| EP1619199B1 (en) | 2013-12-18 |
| WO2004072091A1 (ja) | 2004-08-26 |
| US7732583B2 (en) | 2010-06-08 |
| JP4742220B2 (ja) | 2011-08-10 |
| KR20050105215A (ko) | 2005-11-03 |
| US20060074235A1 (en) | 2006-04-06 |
| HUE037560T2 (hu) | 2018-09-28 |
| NO20054032L (no) | 2005-11-01 |
| EP1619199A4 (en) | 2009-12-16 |
| JP2011063593A (ja) | 2011-03-31 |
| NO20054032D0 (no) | 2005-08-30 |
| EP2343306A1 (en) | 2011-07-13 |
| WO2004072091B1 (ja) | 2004-11-11 |
| CA2515396A1 (en) | 2004-08-26 |
| CN101165047A (zh) | 2008-04-23 |
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