BRPI0407501A - glicolipìdeos e método sintético dos mesmos bem como seus intermediários sintéticos, e método sintético dos mesmos - Google Patents

glicolipìdeos e método sintético dos mesmos bem como seus intermediários sintéticos, e método sintético dos mesmos

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Publication number
BRPI0407501A
BRPI0407501A BRPI0407501-3A BRPI0407501A BRPI0407501A BR PI0407501 A BRPI0407501 A BR PI0407501A BR PI0407501 A BRPI0407501 A BR PI0407501A BR PI0407501 A BRPI0407501 A BR PI0407501A
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BR
Brazil
Prior art keywords
substituted
unsubstituted
group
synthetic
synthetic method
Prior art date
Application number
BRPI0407501-3A
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English (en)
Inventor
Hirokazu Annoura
Kenji Murata
Takashi Yamamura
Original Assignee
Daiichi Suntory Pharma Co Ltd
Japan President Nat Ct Neurology & Psychiatry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Suntory Pharma Co Ltd, Japan President Nat Ct Neurology & Psychiatry filed Critical Daiichi Suntory Pharma Co Ltd
Publication of BRPI0407501A publication Critical patent/BRPI0407501A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)

Abstract

"GLICOLIPìDEOS E MéTODO SINTéTICO DOS MESMOS BEM COMO SEUS INTERMEDIáRIOS SINTéTICOS, E MéTODO SINTéTICO DOS MESMOS". Novos derivados glicolipídicos, onde o substituinte da parte da base de esfingosina é um grupamento alquil de cadeia de carbono curta, um grupamento cicloalquil substituído ou não substituído, um grupamento aril substituído ou não substituído ou um grupamento aralquil substituído ou não substituído e métodos sintéticos eficientes para produção em massa realizável dos mesmos e intermediários úteis para a síntese destes compostos. São sintetizados quimicamente glicolipídeos tendo a fórmula (I): onde R¬ 3¬ indica um grupamento alquil linear C~ 1~ a C~ 7~ substituído ou não substituído, um grupamento cicloalquil substituído ou não substituído, um grupamento aril substituído ou não substituído, ou um grupamento aralquil substituído ou não substituído e R¬ 3¬ indica um grupamento alquil C~ 1~ a C~ 35~ substituído ou não substituído, um grupamento aril substituído ou não substituído ou um grupamento aralquil substituído ou não substituído.
BRPI0407501-3A 2003-02-14 2004-02-13 glicolipìdeos e método sintético dos mesmos bem como seus intermediários sintéticos, e método sintético dos mesmos BRPI0407501A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003037397 2003-02-14
PCT/JP2004/001566 WO2004072091A1 (ja) 2003-02-14 2004-02-13 糖脂質誘導体及びその製造法並びにそれらの合成中間体及びその製造法

Publications (1)

Publication Number Publication Date
BRPI0407501A true BRPI0407501A (pt) 2006-02-14

Family

ID=32866358

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407501-3A BRPI0407501A (pt) 2003-02-14 2004-02-13 glicolipìdeos e método sintético dos mesmos bem como seus intermediários sintéticos, e método sintético dos mesmos

Country Status (12)

Country Link
US (2) US7732583B2 (pt)
EP (2) EP2343306B1 (pt)
JP (2) JP4742220B2 (pt)
KR (1) KR20050105215A (pt)
CN (2) CN101165047B (pt)
AU (1) AU2004210784A1 (pt)
BR (1) BRPI0407501A (pt)
CA (1) CA2515396A1 (pt)
ES (2) ES2450043T3 (pt)
HU (1) HUE037560T2 (pt)
NO (1) NO20054032L (pt)
WO (1) WO2004072091A1 (pt)

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CA2591232C (en) * 2004-12-28 2014-10-21 The Rockefeller University Glycolipids and analogues thereof as antigens for nk t cells
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WO2008047174A1 (en) 2006-10-18 2008-04-24 Centre National De La Recherche Scientifique Alpha-galactosylceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them
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JP6328571B2 (ja) 2012-03-05 2018-05-23 ランダ コーポレイション リミテッド 剥離層の処理
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ES2835225T3 (es) 2012-03-05 2021-06-22 Landa Corp Ltd Construcciones de película de tinta
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GB201401173D0 (en) 2013-09-11 2014-03-12 Landa Corp Ltd Ink formulations and film constructions thereof
GB2536489B (en) 2015-03-20 2018-08-29 Landa Corporation Ltd Indirect printing system
GB2537813A (en) 2015-04-14 2016-11-02 Landa Corp Ltd Apparatus for threading an intermediate transfer member of a printing system
GB201609463D0 (en) 2016-05-30 2016-07-13 Landa Labs 2012 Ltd Method of manufacturing a multi-layer article
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Also Published As

Publication number Publication date
CA2515396A1 (en) 2004-08-26
KR20050105215A (ko) 2005-11-03
ES2676345T3 (es) 2018-07-18
CN101165047B (zh) 2010-10-20
WO2004072091B1 (ja) 2004-11-11
EP1619199B1 (en) 2013-12-18
US20060074235A1 (en) 2006-04-06
HUE037560T2 (hu) 2018-09-28
CN100537585C (zh) 2009-09-09
JP4742220B2 (ja) 2011-08-10
AU2004210784A1 (en) 2004-08-26
EP1619199A4 (en) 2009-12-16
US7732583B2 (en) 2010-06-08
CN101165047A (zh) 2008-04-23
EP1619199A1 (en) 2006-01-25
CN1768072A (zh) 2006-05-03
NO20054032D0 (no) 2005-08-30
US8034908B2 (en) 2011-10-11
JP5246448B2 (ja) 2013-07-24
JP2011063593A (ja) 2011-03-31
ES2450043T3 (es) 2014-03-21
WO2004072091A1 (ja) 2004-08-26
NO20054032L (no) 2005-11-01
US20100210828A1 (en) 2010-08-19
EP2343306A1 (en) 2011-07-13
JPWO2004072091A1 (ja) 2006-06-01
EP2343306B1 (en) 2018-04-04

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.

B15K Others concerning applications: alteration of classification

Ipc: C07D 317/28 (2006.01), C07C 247/04 (2006.01), C07H