CY1111843T1 - 2-υποκατεστημενα αναλογα βιταμινης d και θεραπευτικες χρησεις αυτων - Google Patents

2-υποκατεστημενα αναλογα βιταμινης d και θεραπευτικες χρησεις αυτων

Info

Publication number
CY1111843T1
CY1111843T1 CY20111100873T CY111100873T CY1111843T1 CY 1111843 T1 CY1111843 T1 CY 1111843T1 CY 20111100873 T CY20111100873 T CY 20111100873T CY 111100873 T CY111100873 T CY 111100873T CY 1111843 T1 CY1111843 T1 CY 1111843T1
Authority
CY
Cyprus
Prior art keywords
analogues
vitamin
therapeutic uses
substituted vitamin
alkyl
Prior art date
Application number
CY20111100873T
Other languages
English (en)
Inventor
Roger Bouillon
Annemieke Verstuyf
Maurits Vandewalle
Clercq Pierre De
Original Assignee
K.U. Leuven Research And Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by K.U. Leuven Research And Development filed Critical K.U. Leuven Research And Development
Publication of CY1111843T1 publication Critical patent/CY1111843T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση αφορά ανάλογα βιταμίνης D δηλαδή 14-επι-2-αλκυλ-19-νορ βιταμίνης D παράγωγα. Επίσης περιγράφεται γενική μέθοδος για τη σύνθεση και οι βιολογικές δραστικότητες. Ο γενικός τύπος είναι: (I) όπου το R (α ή β προσανατολισμένο) αντιπροσωπεύει αλκύλ υποκατάστατη και το Χ τμήμα μιας τυπικής πλευρικής αλύσου βιταμίνης D ή ενός των καθιερωμένων αναλόγων αυτής.
CY20111100873T 2003-03-10 2011-09-13 2-υποκατεστημενα αναλογα βιταμινης d και θεραπευτικες χρησεις αυτων CY1111843T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0305332.9A GB0305332D0 (en) 2003-03-10 2003-03-10 Biological evaluation of novel vitamin D analogues
EP04718886A EP1601646B1 (en) 2003-03-10 2004-03-10 2-substituted vitamin d analogues and their therapeutic uses

Publications (1)

Publication Number Publication Date
CY1111843T1 true CY1111843T1 (el) 2015-10-07

Family

ID=9954381

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100873T CY1111843T1 (el) 2003-03-10 2011-09-13 2-υποκατεστημενα αναλογα βιταμινης d και θεραπευτικες χρησεις αυτων

Country Status (14)

Country Link
US (1) US20060189576A1 (el)
EP (1) EP1601646B1 (el)
JP (1) JP2006519788A (el)
AT (1) ATE517864T1 (el)
AU (1) AU2004220477B8 (el)
CA (1) CA2518531A1 (el)
CY (1) CY1111843T1 (el)
DK (1) DK1601646T3 (el)
ES (1) ES2368064T3 (el)
GB (1) GB0305332D0 (el)
PL (1) PL1601646T3 (el)
PT (1) PT1601646E (el)
SI (1) SI1601646T1 (el)
WO (1) WO2004080922A2 (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE469127T1 (de) 2004-11-22 2010-06-15 Wisconsin Alumni Res Found 17,20(z)-dehydro-vitamin-d-analoge und deren verwendungen
US7241751B2 (en) 2004-11-22 2007-07-10 Wisconsin Alumi Research Foundation 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and its uses
EP1824818A2 (en) 2004-11-22 2007-08-29 Wisconsin Alumni Research Foundation 2ALFA-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1ALFA-HYDROXYVITAMIN D3 AND THEIR USES
WO2006060885A1 (en) * 2004-12-07 2006-06-15 K.U.Leuven Research & Development 7-(2-cyclohexylidene-ethylidene)-spiro[5.5]undecanes useful for making pharmaceutical compositions
CA2605727A1 (en) * 2005-05-03 2006-11-09 Wisconsin Alumni Research Foundation 19,26,27-trinor-1.alpha.,25-dihydroxyvitamin d3 compounds
US7803789B2 (en) 2006-02-02 2010-09-28 Wisconsin Alumni Research Foundation Vitamin D analog—RAK, methods and uses thereof
US7528122B2 (en) 2006-02-02 2009-05-05 Wisconsin Alumni Research Foundation Vitamin D analog—NEL, methods and uses thereof
US8404666B2 (en) 2006-04-06 2013-03-26 Wisconsin Alumni Research Foundation 2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
WO2008125901A2 (en) 2006-04-06 2008-10-23 Wisconsin Alumni Research Foundation 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof
US7648973B2 (en) 2006-04-06 2010-01-19 Wisconsin Alumni Research Foundation 2-methylene-1α,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof
US7741314B2 (en) 2006-09-28 2010-06-22 Wisconsin Alumni Research Foundation 2-Methylene-(20R,25S)-19,27-Dinor-(22E)-Vitamin D Analogs
ATE505194T1 (de) * 2009-05-20 2011-04-15 Hybrigenics Sa Neue therapeutische verwendungen von inecalcitol
AU2010310654B2 (en) * 2009-10-21 2015-05-14 Wisconsin Alumni Research Foundation Method of preventing Type 1 diabetes
US20120015913A1 (en) * 2010-07-15 2012-01-19 Delansorne Remi Formulations of 14-EPI-Analogues of Vitamin D
EP2407152A1 (en) 2010-07-15 2012-01-18 Hybrigenics S.A. Formulations of 14-epi-analogues of vitamin D
AU2011278352B2 (en) 2010-07-15 2016-07-21 Hybrigenics Sa Formulations of 14 - epi -analogues of vitamin D
EP2682386B1 (en) * 2011-03-02 2016-08-17 Nihon University Novel vitamin d receptor modulator with partial agonist activity
JP6946182B2 (ja) 2014-10-22 2021-10-06 エクステンド バイオサイエンシズ インコーポレーテッドＥｘｔｅｎｄ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ 治療用ビタミンｄコンジュゲート
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
CN104326922B (zh) * 2014-11-03 2016-08-17 成都百裕制药股份有限公司 替格瑞洛中间体(1r,2s)-2-(2,3-二氟苯基)环丙胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
EP0972762B1 (en) * 1993-07-09 2003-10-01 Laboratoire Theramex Novel structural analogues of vitamin D
US5936105A (en) * 1997-06-13 1999-08-10 Tetrionics, Inc. 14-EPI-19-nor-vitamin D compounds and methods
DK1286962T3 (da) * 2000-05-31 2008-10-06 Wisconsin Alumni Res Found 2-Ethyl og 2-ethyliden-19-nor-vitamin D-forbindelser

Also Published As

Publication number Publication date
GB0305332D0 (en) 2003-04-09
EP1601646B1 (en) 2011-07-27
CA2518531A1 (en) 2004-09-23
US20060189576A1 (en) 2006-08-24
AU2004220477B2 (en) 2010-05-06
DK1601646T3 (da) 2011-10-03
AU2004220477B8 (en) 2010-10-14
PL1601646T3 (pl) 2011-12-30
ES2368064T3 (es) 2011-11-14
EP1601646A2 (en) 2005-12-07
SI1601646T1 (sl) 2011-11-30
ATE517864T1 (de) 2011-08-15
PT1601646E (pt) 2011-09-16
WO2004080922A3 (en) 2004-12-09
WO2004080922A2 (en) 2004-09-23
AU2004220477A1 (en) 2004-09-23
JP2006519788A (ja) 2006-08-31

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