DK1601646T3 - 2-substituerede vitamin D-analoger og terapeutiske anvendelser deraf - Google Patents

2-substituerede vitamin D-analoger og terapeutiske anvendelser deraf

Info

Publication number
DK1601646T3
DK1601646T3 DK04718886.7T DK04718886T DK1601646T3 DK 1601646 T3 DK1601646 T3 DK 1601646T3 DK 04718886 T DK04718886 T DK 04718886T DK 1601646 T3 DK1601646 T3 DK 1601646T3
Authority
DK
Denmark
Prior art keywords
analogues
vitamin
therapeutic uses
substituted vitamin
alkyl
Prior art date
Application number
DK04718886.7T
Other languages
English (en)
Inventor
Roger Bouillon
Annemieke Verstuyf
Maurits Vandewalle
Clercq Pierre De
Original Assignee
Leuven K U Res & Dev
Univ Gent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leuven K U Res & Dev, Univ Gent filed Critical Leuven K U Res & Dev
Application granted granted Critical
Publication of DK1601646T3 publication Critical patent/DK1601646T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04718886.7T 2003-03-10 2004-03-10 2-substituerede vitamin D-analoger og terapeutiske anvendelser deraf DK1601646T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0305332.9A GB0305332D0 (en) 2003-03-10 2003-03-10 Biological evaluation of novel vitamin D analogues
PCT/BE2004/000037 WO2004080922A2 (en) 2003-03-10 2004-03-10 Substituted vitamin d analogues and their therapeutic uses

Publications (1)

Publication Number Publication Date
DK1601646T3 true DK1601646T3 (da) 2011-10-03

Family

ID=9954381

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04718886.7T DK1601646T3 (da) 2003-03-10 2004-03-10 2-substituerede vitamin D-analoger og terapeutiske anvendelser deraf

Country Status (14)

Country Link
US (1) US20060189576A1 (da)
EP (1) EP1601646B1 (da)
JP (1) JP2006519788A (da)
AT (1) ATE517864T1 (da)
AU (1) AU2004220477B8 (da)
CA (1) CA2518531A1 (da)
CY (1) CY1111843T1 (da)
DK (1) DK1601646T3 (da)
ES (1) ES2368064T3 (da)
GB (1) GB0305332D0 (da)
PL (1) PL1601646T3 (da)
PT (1) PT1601646E (da)
SI (1) SI1601646T1 (da)
WO (1) WO2004080922A2 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ555282A (en) 2004-11-22 2010-12-24 Wisconsin Alumni Res Found 17,20(z)-dehydro vitamin D analogs and their uses
JP2008520689A (ja) 2004-11-22 2008-06-19 ウィスコンシン・アルムニ・リサーチ・ファウンデーション １９，２６，２７−トリノル−（２０Ｓ）−１α−ヒドロキシビタミンＤ３の２α−メチルおよび２β−メチル類似体およびそれらの使用
US7241751B2 (en) * 2004-11-22 2007-07-10 Wisconsin Alumi Research Foundation 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and its uses
WO2006060885A1 (en) * 2004-12-07 2006-06-15 K.U.Leuven Research & Development 7-(2-cyclohexylidene-ethylidene)-spiro[5.5]undecanes useful for making pharmaceutical compositions
WO2006119309A2 (en) 2005-05-03 2006-11-09 Wisconsin Alumni Research Foundation 19,26,27-TRINOR-1α,25-DIHYDROXYVITAMIN D3 COMPOUNDS
US7803789B2 (en) 2006-02-02 2010-09-28 Wisconsin Alumni Research Foundation Vitamin D analog—RAK, methods and uses thereof
US7528122B2 (en) 2006-02-02 2009-05-05 Wisconsin Alumni Research Foundation Vitamin D analog—NEL, methods and uses thereof
EP2021320A2 (en) 2006-04-06 2009-02-11 Wisconsin Alumni Research Foundation 2-substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin d analogs and uses thereof
AU2007349772A1 (en) 2006-04-06 2008-10-23 Wisconsin Alumni Research Foundation 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin D3 and uses thereof
JP2010505739A (ja) 2006-04-06 2010-02-25 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１α，２５−ジヒドロキシ−１９，２１−ジノルビタミンＤ３類縁体およびその使用
MX2009003241A (es) 2006-09-28 2009-05-05 Wisconsin Alumni Res Found Analogos de 2-metilen-(20r,25s)-19,27-dinor-(22e)-vitamina d.
UA105792C2 (uk) * 2009-05-20 2014-06-25 Ібріженікс Са Нове терапевтичне застосування інекальцитолу
EP2490695B1 (en) * 2009-10-21 2013-11-20 Wisconsin Alumni Research Foundation Method of preventing type 1 diabetes
EP2407152A1 (en) 2010-07-15 2012-01-18 Hybrigenics S.A. Formulations of 14-epi-analogues of vitamin D
AU2011278352B2 (en) 2010-07-15 2016-07-21 Hybrigenics Sa Formulations of 14 - epi -analogues of vitamin D
US20120015913A1 (en) * 2010-07-15 2012-01-19 Delansorne Remi Formulations of 14-EPI-Analogues of Vitamin D
WO2012118154A1 (ja) * 2011-03-02 2012-09-07 学校法人日本大学 パーシャルアゴニスト活性を持つ新規ビタミンd受容体モジュレーター
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
EP3220961B1 (en) 2014-10-22 2023-07-05 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
CN104326922B (zh) * 2014-11-03 2016-08-17 成都百裕制药股份有限公司 替格瑞洛中间体(1r,2s)-2-(2,3-二氟苯基)环丙胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ATE251133T1 (de) * 1993-07-09 2003-10-15 Theramex Neue strukturelle vitamin d derivate
US5936105A (en) * 1997-06-13 1999-08-10 Tetrionics, Inc. 14-EPI-19-nor-vitamin D compounds and methods
US6806262B2 (en) * 2000-05-31 2004-10-19 Wisconsin Alumni Research Foundation 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds

Also Published As

Publication number Publication date
GB0305332D0 (en) 2003-04-09
WO2004080922A3 (en) 2004-12-09
EP1601646B1 (en) 2011-07-27
AU2004220477B8 (en) 2010-10-14
AU2004220477B2 (en) 2010-05-06
SI1601646T1 (sl) 2011-11-30
AU2004220477A1 (en) 2004-09-23
ATE517864T1 (de) 2011-08-15
EP1601646A2 (en) 2005-12-07
WO2004080922A2 (en) 2004-09-23
CY1111843T1 (el) 2015-10-07
PL1601646T3 (pl) 2011-12-30
PT1601646E (pt) 2011-09-16
CA2518531A1 (en) 2004-09-23
JP2006519788A (ja) 2006-08-31
ES2368064T3 (es) 2011-11-14
US20060189576A1 (en) 2006-08-24

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