HRP20050382A2 - Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases - Google Patents
Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenasesInfo
- Publication number
- HRP20050382A2 HRP20050382A2 HR20050382A HRP20050382A HRP20050382A2 HR P20050382 A2 HRP20050382 A2 HR P20050382A2 HR 20050382 A HR20050382 A HR 20050382A HR P20050382 A HRP20050382 A HR P20050382A HR P20050382 A2 HRP20050382 A2 HR P20050382A2
- Authority
- HR
- Croatia
- Prior art keywords
- dicarboxamides
- collagenases
- selective inhibition
- novel pyrimidine
- pyrimidine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Pirimidin-4,6-dikarboksamidi formule (I)su prikladni za selektivnu inhibiciju kolagenaze (MMP 13). Pirimidin-4,6-dikarboksamidi se stoga mogu upotrijebiti za liječenje degenerativnih bolesti zglobova.Pyrimidine-4,6-dicarboxamides of formula (I) are suitable for the selective inhibition of collagenase (MMP 13). Pyrimidine-4,6-dicarboxamides can therefore be used to treat degenerative joint diseases.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10251019A DE10251019A1 (en) | 2002-11-02 | 2002-11-02 | New pyrimidine-4,6-dicarboxamide derivatives, are selective collagenase inhibitors useful e.g. for treating degenerative joint diseases, connective tissue disorders or cancer |
DE10254092A DE10254092A1 (en) | 2002-11-20 | 2002-11-20 | New pyrimidine-4,6-dicarboxamide derivatives, are selective collagenase inhibitors useful e.g. for treating degenerative joint diseases, connective tissue disorders or cancer |
PCT/EP2003/011515 WO2004041788A1 (en) | 2002-11-02 | 2003-10-18 | Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20050382A2 true HRP20050382A2 (en) | 2006-12-31 |
HRP20050382B1 HRP20050382B1 (en) | 2013-09-30 |
Family
ID=32313538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20050382AA HRP20050382B1 (en) | 2002-11-02 | 2005-04-29 | Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1560815B1 (en) |
JP (1) | JP4564359B2 (en) |
KR (1) | KR101050680B1 (en) |
AR (1) | AR043058A1 (en) |
AT (1) | ATE388941T1 (en) |
AU (1) | AU2003301847A1 (en) |
BR (1) | BR0315055A (en) |
CA (1) | CA2504153C (en) |
CO (1) | CO5700759A2 (en) |
DE (1) | DE50309381D1 (en) |
DK (1) | DK1560815T3 (en) |
ES (1) | ES2298621T3 (en) |
HK (1) | HK1083503A1 (en) |
HR (1) | HRP20050382B1 (en) |
MA (1) | MA27412A1 (en) |
MX (1) | MXPA05004365A (en) |
MY (1) | MY135375A (en) |
NO (1) | NO330345B1 (en) |
PE (1) | PE20040605A1 (en) |
PL (1) | PL375044A1 (en) |
PT (1) | PT1560815E (en) |
RS (1) | RS20050294A (en) |
RU (1) | RU2344129C2 (en) |
TW (1) | TWI316512B (en) |
WO (1) | WO2004041788A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060173183A1 (en) * | 2004-12-31 | 2006-08-03 | Alantos Pharmaceuticals, Inc., | Multicyclic bis-amide MMP inhibitors |
US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
WO2006128184A2 (en) * | 2005-05-20 | 2006-11-30 | Alantos-Pharmaceuticals, Inc. | Pyrimidine or triazine fused bicyclic metalloprotease inhibitors |
EP2069313A2 (en) * | 2006-06-29 | 2009-06-17 | Alantos Pharmaceuticals Holdings, Inc. | Metalloprotease inhibitors |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
TWI444379B (en) * | 2007-06-29 | 2014-07-11 | Sunesis Pharmaceuticals Inc | Compounds useful as raf kinase inhibitors |
AR068509A1 (en) * | 2007-09-19 | 2009-11-18 | Jerini Ag | BRADIQUININE B1 RECEIVER ANTAGOSNIST |
US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
CA3108488A1 (en) | 2010-04-22 | 2011-10-27 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
AR086113A1 (en) | 2011-04-30 | 2013-11-20 | Abbott Lab | ISOXAZOLINS AS THERAPEUTIC AGENTS |
IL266286B2 (en) | 2014-04-15 | 2023-11-01 | Vertex Pharma | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3931432A1 (en) * | 1989-09-21 | 1991-04-04 | Hoechst Ag | PYRIMIDIN-4,6-DICARBONSAEUREDIAMIDE, METHOD FOR THE PRODUCTION AND USE THEREOF AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS |
CA2433772C (en) * | 2001-02-14 | 2008-10-07 | Warner-Lambert Company Llc | Pyrimidine matrix metalloproteinase inhibitors |
DOP2002000332A (en) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | MATRIX METALOPROTEINAS PYRIDINE INHIBITORS |
DE10160357A1 (en) * | 2001-12-08 | 2003-06-18 | Aventis Pharma Gmbh | Use of pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides for the selective inhibition of collagenases |
-
2003
- 2003-10-18 EP EP03810401A patent/EP1560815B1/en not_active Expired - Lifetime
- 2003-10-18 WO PCT/EP2003/011515 patent/WO2004041788A1/en active IP Right Grant
- 2003-10-18 JP JP2004548752A patent/JP4564359B2/en not_active Expired - Fee Related
- 2003-10-18 ES ES03810401T patent/ES2298621T3/en not_active Expired - Lifetime
- 2003-10-18 AU AU2003301847A patent/AU2003301847A1/en not_active Abandoned
- 2003-10-18 KR KR1020057007598A patent/KR101050680B1/en not_active IP Right Cessation
- 2003-10-18 AT AT03810401T patent/ATE388941T1/en active
- 2003-10-18 PL PL03375044A patent/PL375044A1/en unknown
- 2003-10-18 DE DE50309381T patent/DE50309381D1/en not_active Expired - Lifetime
- 2003-10-18 MX MXPA05004365A patent/MXPA05004365A/en active IP Right Grant
- 2003-10-18 BR BR0315055-0A patent/BR0315055A/en not_active Application Discontinuation
- 2003-10-18 PT PT03810401T patent/PT1560815E/en unknown
- 2003-10-18 CA CA2504153A patent/CA2504153C/en not_active Expired - Fee Related
- 2003-10-18 DK DK03810401T patent/DK1560815T3/en active
- 2003-10-18 RU RU2005116847/04A patent/RU2344129C2/en not_active IP Right Cessation
- 2003-10-18 RS YUP-2005/0294A patent/RS20050294A/en unknown
- 2003-10-27 PE PE2003001085A patent/PE20040605A1/en not_active Application Discontinuation
- 2003-10-29 TW TW092129976A patent/TWI316512B/en not_active IP Right Cessation
- 2003-10-30 MY MYPI20034144A patent/MY135375A/en unknown
- 2003-10-30 AR ARP030103974A patent/AR043058A1/en not_active Application Discontinuation
-
2005
- 2005-04-29 CO CO05041024A patent/CO5700759A2/en not_active Application Discontinuation
- 2005-04-29 MA MA28244A patent/MA27412A1/en unknown
- 2005-04-29 HR HRP20050382AA patent/HRP20050382B1/en not_active IP Right Cessation
- 2005-05-31 NO NO20052628A patent/NO330345B1/en not_active IP Right Cessation
-
2006
- 2006-03-20 HK HK06103488A patent/HK1083503A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1083503A1 (en) | 2006-07-07 |
NO330345B1 (en) | 2011-03-28 |
TWI316512B (en) | 2009-11-01 |
BR0315055A (en) | 2005-08-16 |
ES2298621T3 (en) | 2008-05-16 |
KR20050067212A (en) | 2005-06-30 |
PE20040605A1 (en) | 2004-10-15 |
MXPA05004365A (en) | 2005-07-05 |
KR101050680B1 (en) | 2011-07-21 |
TW200418808A (en) | 2004-10-01 |
DE50309381D1 (en) | 2008-04-24 |
RU2344129C2 (en) | 2009-01-20 |
PL375044A1 (en) | 2005-11-14 |
RS20050294A (en) | 2007-11-15 |
PT1560815E (en) | 2008-04-07 |
CA2504153A1 (en) | 2004-05-21 |
AU2003301847A1 (en) | 2004-06-07 |
ATE388941T1 (en) | 2008-03-15 |
NO20052628L (en) | 2005-07-08 |
JP2006513158A (en) | 2006-04-20 |
NO20052628D0 (en) | 2005-05-31 |
MA27412A1 (en) | 2005-06-01 |
EP1560815A1 (en) | 2005-08-10 |
AR043058A1 (en) | 2005-07-13 |
HRP20050382B1 (en) | 2013-09-30 |
CA2504153C (en) | 2012-07-03 |
MY135375A (en) | 2008-04-30 |
EP1560815B1 (en) | 2008-03-12 |
WO2004041788A1 (en) | 2004-05-21 |
DK1560815T3 (en) | 2008-06-16 |
JP4564359B2 (en) | 2010-10-20 |
CO5700759A2 (en) | 2006-11-30 |
RU2005116847A (en) | 2006-01-20 |
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