PT1601646E - Análogos da vitamina d e suas utilizações terapêuticas - Google Patents

Análogos da vitamina d e suas utilizações terapêuticas Download PDF

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Publication number
PT1601646E
PT1601646E PT04718886T PT04718886T PT1601646E PT 1601646 E PT1601646 E PT 1601646E PT 04718886 T PT04718886 T PT 04718886T PT 04718886 T PT04718886 T PT 04718886T PT 1601646 E PT1601646 E PT 1601646E
Authority
PT
Portugal
Prior art keywords
analogues
vitamin
therapeutic uses
substituted vitamin
alkyl
Prior art date
Application number
PT04718886T
Other languages
English (en)
Inventor
Roger Bouillon
Maurits Vandewalle
Annemieke Verstuyf
Pierre De Clercq
Original Assignee
Leuven K U Res & Dev
Univ Gent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leuven K U Res & Dev, Univ Gent filed Critical Leuven K U Res & Dev
Publication of PT1601646E publication Critical patent/PT1601646E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT04718886T 2003-03-10 2004-03-10 Análogos da vitamina d e suas utilizações terapêuticas PT1601646E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0305332.9A GB0305332D0 (en) 2003-03-10 2003-03-10 Biological evaluation of novel vitamin D analogues

Publications (1)

Publication Number Publication Date
PT1601646E true PT1601646E (pt) 2011-09-16

Family

ID=9954381

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04718886T PT1601646E (pt) 2003-03-10 2004-03-10 Análogos da vitamina d e suas utilizações terapêuticas

Country Status (14)

Country Link
US (1) US20060189576A1 (pt)
EP (1) EP1601646B1 (pt)
JP (1) JP2006519788A (pt)
AT (1) ATE517864T1 (pt)
AU (1) AU2004220477B8 (pt)
CA (1) CA2518531A1 (pt)
CY (1) CY1111843T1 (pt)
DK (1) DK1601646T3 (pt)
ES (1) ES2368064T3 (pt)
GB (1) GB0305332D0 (pt)
PL (1) PL1601646T3 (pt)
PT (1) PT1601646E (pt)
SI (1) SI1601646T1 (pt)
WO (1) WO2004080922A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ555283A (en) * 2004-11-22 2010-12-24 Wisconsin Alumni Res Found 2alpha-methyl-19-nor-(20s)-1alpha-hydroxy-bishomopregnacalciferol and its uses
US7241752B2 (en) 2004-11-22 2007-07-10 Wisconsin Alumni Research Foundation 17,20(E)-dehydro vitamin D analogs and their uses
US7241749B2 (en) * 2004-11-22 2007-07-10 Wisconsin Alumni Research Foundation 2α-Methyl and 2β-methyl analogs of 19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and their uses
WO2006060885A1 (en) * 2004-12-07 2006-06-15 K.U.Leuven Research & Development 7-(2-cyclohexylidene-ethylidene)-spiro[5.5]undecanes useful for making pharmaceutical compositions
JP2008542201A (ja) 2005-05-03 2008-11-27 ウイスコンシン アラムニ リサーチ ファンデーション １９，２６，２７−トリノル−１α，２５−ジヒドロキシビタミンＤ３化合物
US7803789B2 (en) 2006-02-02 2010-09-28 Wisconsin Alumni Research Foundation Vitamin D analog—RAK, methods and uses thereof
US7528122B2 (en) 2006-02-02 2009-05-05 Wisconsin Alumni Research Foundation Vitamin D analog—NEL, methods and uses thereof
AU2007234717B2 (en) 2006-04-06 2012-04-19 Wisconsin Alumni Research Foundation 2-methylene-1alpha,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof
WO2008125901A2 (en) 2006-04-06 2008-10-23 Wisconsin Alumni Research Foundation 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof
AU2007298673A1 (en) 2006-04-06 2008-03-27 Wisconsin Alumni Research Foundation 2- substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
WO2008039754A1 (en) 2006-09-28 2008-04-03 Wisconsin Alumni Research Foundation 2-methylene-(20r,25s)-19,27-dinor-(22e)-vitamin d analogs
ES2363070T3 (es) * 2009-05-20 2011-07-19 Hybrigenics Nuevos usos terapéuticos de inecalcitol.
AU2010310654B2 (en) * 2009-10-21 2015-05-14 Wisconsin Alumni Research Foundation Method of preventing Type 1 diabetes
DK2407154T3 (da) 2010-07-15 2013-03-04 Hybrigenics Sa Formuleringer af 14-epi-analoger af D-vitamin
US20120015913A1 (en) * 2010-07-15 2012-01-19 Delansorne Remi Formulations of 14-EPI-Analogues of Vitamin D
EP2407152A1 (en) 2010-07-15 2012-01-18 Hybrigenics S.A. Formulations of 14-epi-analogues of vitamin D
WO2012118154A1 (ja) 2011-03-02 2012-09-07 学校法人日本大学 パーシャルアゴニスト活性を持つ新規ビタミンd受容体モジュレーター
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
US9616109B2 (en) 2014-10-22 2017-04-11 Extend Biosciences, Inc. Insulin vitamin D conjugates
CN104326922B (zh) * 2014-11-03 2016-08-17 成都百裕制药股份有限公司 替格瑞洛中间体(1r,2s)-2-(2,3-二氟苯基)环丙胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ATE251133T1 (de) * 1993-07-09 2003-10-15 Theramex Neue strukturelle vitamin d derivate
US5936105A (en) * 1997-06-13 1999-08-10 Tetrionics, Inc. 14-EPI-19-nor-vitamin D compounds and methods
US6806262B2 (en) * 2000-05-31 2004-10-19 Wisconsin Alumni Research Foundation 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds

Also Published As

Publication number Publication date
AU2004220477B8 (en) 2010-10-14
DK1601646T3 (da) 2011-10-03
GB0305332D0 (en) 2003-04-09
AU2004220477B2 (en) 2010-05-06
CA2518531A1 (en) 2004-09-23
US20060189576A1 (en) 2006-08-24
WO2004080922A3 (en) 2004-12-09
PL1601646T3 (pl) 2011-12-30
ATE517864T1 (de) 2011-08-15
CY1111843T1 (el) 2015-10-07
ES2368064T3 (es) 2011-11-14
EP1601646B1 (en) 2011-07-27
SI1601646T1 (sl) 2011-11-30
JP2006519788A (ja) 2006-08-31
WO2004080922A2 (en) 2004-09-23
EP1601646A2 (en) 2005-12-07
AU2004220477A1 (en) 2004-09-23

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