BRPI0510567A - anticorpos - Google Patents

anticorpos

Info

Publication number
BRPI0510567A
BRPI0510567A BRPI0510567-6A BRPI0510567A BRPI0510567A BR PI0510567 A BRPI0510567 A BR PI0510567A BR PI0510567 A BRPI0510567 A BR PI0510567A BR PI0510567 A BRPI0510567 A BR PI0510567A
Authority
BR
Brazil
Prior art keywords
antibodies
nucleic acids
immunoglobulin chains
cell
modulating
Prior art date
Application number
BRPI0510567-6A
Other languages
English (en)
Inventor
Rong-Hwa Lin
Chung Nan Chang
Pei-Jiun Chen
Chiu-Chen Huang
Original Assignee
Abgenomics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35394680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0510567(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abgenomics Corp filed Critical Abgenomics Corp
Publication of BRPI0510567A publication Critical patent/BRPI0510567A/pt
Publication of BRPI0510567B1 publication Critical patent/BRPI0510567B1/pt
Publication of BRPI0510567B8 publication Critical patent/BRPI0510567B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Plant Pathology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

ANTICORPOS. Cadeias de imunoglobulina ou anticorpos tendo regiões determinantes de complementariedade de cadeia leve ou pesada de anticorpos que ligam ao Ligante 1 de Glicoproteína da P-selectina. São também revelados ácidos nucléicos que codificam as cadeias de imunoglobulina, vetores e células hospedeiras tendo os ácidos nucléicos, e métodos de induzir morte de uma célula T ativada e de modular uma resposta imune media da por célula T em um sujeito.
BRPI0510567A 2004-05-10 2005-05-10 anticorpos isolados, vetores, células hospedeiras e usos dos ditos anticorpos BRPI0510567B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56989204P 2004-05-10 2004-05-10
PCT/US2005/016357 WO2005110475A2 (en) 2004-05-10 2005-05-10 Antibodies

Publications (3)

Publication Number Publication Date
BRPI0510567A true BRPI0510567A (pt) 2007-11-20
BRPI0510567B1 BRPI0510567B1 (pt) 2018-11-13
BRPI0510567B8 BRPI0510567B8 (pt) 2021-05-25

Family

ID=35394680

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510567A BRPI0510567B8 (pt) 2004-05-10 2005-05-10 anticorpos isolados, vetores, células hospedeiras e usos dos ditos anticorpos

Country Status (28)

Country Link
US (8) US7604800B2 (pt)
EP (3) EP1765396B1 (pt)
JP (4) JP5623690B2 (pt)
KR (1) KR101256400B1 (pt)
CN (2) CN1984680B (pt)
AR (1) AR048781A1 (pt)
AU (1) AU2005244072C1 (pt)
BR (1) BRPI0510567B8 (pt)
CA (3) CA2812040C (pt)
DK (1) DK1765396T3 (pt)
EC (1) ECSP067056A (pt)
EG (1) EG26781A (pt)
ES (3) ES2598034T3 (pt)
HK (1) HK1102760A1 (pt)
IL (3) IL178838A (pt)
MX (1) MXPA06012986A (pt)
MY (1) MY148646A (pt)
NO (1) NO341844B1 (pt)
NZ (3) NZ590690A (pt)
PH (1) PH12015500247A1 (pt)
PL (1) PL1765396T3 (pt)
PT (1) PT1765396E (pt)
RU (1) RU2482131C2 (pt)
SG (2) SG187443A1 (pt)
TW (2) TWI448474B (pt)
UA (1) UA100356C2 (pt)
UY (1) UY28886A1 (pt)
WO (1) WO2005110475A2 (pt)

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MY148646A (en) 2004-05-10 2013-05-15 Abgenomics Cooperatief Ua Anti-psgl-1 antibodies
UA105493C2 (uk) * 2004-05-11 2014-05-26 Абдженомікс Коеператіеф У.А. Спосіб одержання антитіла для викликання смерті активованих т-клітин, спосіб визначення прийнятної сполуки для викликання смерті активованих т-клітин та фармацевтична композиція
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JP7211961B2 (ja) 2017-03-14 2023-01-24 ファイヴ プライム セラピューティクス インク 酸性ｐＨでＶＩＳＴＡに結合する抗体
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BR112021024242A2 (pt) * 2019-06-04 2022-04-26 Verseau Therapeutics Inc Composições e métodos anti-psgl-1 para modular fenótipos inflamatórios de células mieloides e usos dos mesmos
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MY148646A (en) 2004-05-10 2013-05-15 Abgenomics Cooperatief Ua Anti-psgl-1 antibodies
UA105493C2 (uk) 2004-05-11 2014-05-26 Абдженомікс Коеператіеф У.А. Спосіб одержання антитіла для викликання смерті активованих т-клітин, спосіб визначення прийнятної сполуки для викликання смерті активованих т-клітин та фармацевтична композиція
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Also Published As

Publication number Publication date
ES2602633T3 (es) 2017-02-21
RU2006143686A (ru) 2008-06-20
NO341844B1 (no) 2018-02-05
UY28886A1 (es) 2005-12-30
US20130102762A1 (en) 2013-04-25
UA100356C2 (ru) 2012-12-25
TW201313740A (zh) 2013-04-01
US20150183870A1 (en) 2015-07-02
EP2377889A2 (en) 2011-10-19
SG187443A1 (en) 2013-02-28
AU2005244072B2 (en) 2012-05-31
US8828397B2 (en) 2014-09-09
US20090198044A1 (en) 2009-08-06
CA2907141A1 (en) 2005-11-24
NO20065542L (no) 2007-01-31
KR101256400B1 (ko) 2013-04-26
PT1765396E (pt) 2014-02-25
CA2566305C (en) 2014-10-14
EP1765396A4 (en) 2008-07-02
EP2377889B1 (en) 2016-07-13
US8287871B2 (en) 2012-10-16
EP2377890B1 (en) 2016-08-10
CN1984680A (zh) 2007-06-20
JP2011200247A (ja) 2011-10-13
EP2377890A2 (en) 2011-10-19
TWI448474B (zh) 2014-08-11
NZ590690A (en) 2012-10-26
JP2014223084A (ja) 2014-12-04
IL228032A0 (en) 2013-09-30
CA2812040C (en) 2016-05-03
CA2812040A1 (en) 2005-11-24
US20130101587A1 (en) 2013-04-25
US8663641B2 (en) 2014-03-04
TWI402274B (zh) 2013-07-21
JP2007536933A (ja) 2007-12-20
MY148646A (en) 2013-05-15
JP2014094010A (ja) 2014-05-22
AR048781A1 (es) 2006-05-24
CA2907141C (en) 2016-05-31
EP2377890A3 (en) 2011-12-28
NZ578647A (en) 2012-04-27
BRPI0510567B8 (pt) 2021-05-25
WO2005110475A2 (en) 2005-11-24
CA2566305A1 (en) 2005-11-24
BRPI0510567B1 (pt) 2018-11-13
ECSP067056A (es) 2007-01-26
IL178838A (en) 2017-08-31
CN103980361B (zh) 2017-06-23
AU2005244072A1 (en) 2005-11-24
US9631019B2 (en) 2017-04-25
NZ551626A (en) 2010-03-26
US20090191204A1 (en) 2009-07-30
WO2005110475A3 (en) 2006-02-23
HK1102760A1 (en) 2007-12-07
US20050266003A1 (en) 2005-12-01
AU2005244072C1 (en) 2012-09-20
CN1984680B (zh) 2014-11-05
US20110172397A1 (en) 2011-07-14
IL178838A0 (en) 2007-03-08
MXPA06012986A (es) 2007-02-12
RU2482131C2 (ru) 2013-05-20
CN103980361A (zh) 2014-08-13
ES2448468T3 (es) 2014-03-14
US10030075B2 (en) 2018-07-24
IL228033A0 (en) 2013-09-30
EG26781A (en) 2014-09-07
PH12015500247A1 (en) 2015-12-14
US7604800B2 (en) 2009-10-20
EP2377889A3 (en) 2012-03-28
JP5623690B2 (ja) 2014-11-12
TW200536860A (en) 2005-11-16
EP1765396B1 (en) 2013-11-20
US20170190782A1 (en) 2017-07-06
DK1765396T3 (en) 2014-02-24
PL1765396T3 (pl) 2014-07-31
EP1765396A2 (en) 2007-03-28
KR20070020048A (ko) 2007-02-16
SG10201606541UA (en) 2016-09-29
US8361472B2 (en) 2013-01-29
ES2598034T3 (es) 2017-01-24

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