BRPI0506906A - composição farmacêutica sólida estável, processos para a estabilização de um sal, e para a preparação de um sal cristalino, e, sal cristalino - Google Patents

composição farmacêutica sólida estável, processos para a estabilização de um sal, e para a preparação de um sal cristalino, e, sal cristalino

Info

Publication number
BRPI0506906A
BRPI0506906A BRPI0506906-8A BRPI0506906A BRPI0506906A BR PI0506906 A BRPI0506906 A BR PI0506906A BR PI0506906 A BRPI0506906 A BR PI0506906A BR PI0506906 A BRPI0506906 A BR PI0506906A
Authority
BR
Brazil
Prior art keywords
salt
crystalline
pharmaceutical composition
crystalline salt
solid pharmaceutical
Prior art date
Application number
BRPI0506906-8A
Other languages
English (en)
Inventor
Karl Jansson
Tomas Fristedt
Hans Wonnman
Anders Bj Rk
Original Assignee
Active Biotech Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Biotech Ab filed Critical Active Biotech Ab
Publication of BRPI0506906A publication Critical patent/BRPI0506906A/pt
Publication of BRPI0506906B1 publication Critical patent/BRPI0506906B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSIçãO FARMACêUTICA SóLIDA ESTAVéL, PROCESSOS PARA A ESTABILIZAçãO DE UM SAL, E PARA A PREPARAçãO DE UM SAL CRISTALINO,E,SAL CRISTALINO Composição farmacêutica sólida estavel consistinto essencialmente de uma quantidade eficaz de um sal de fórmula(II) juntamente com um componente de reação alcalino mantendo o pH preferivelmente acima de 8, ou um sal com cátion de metal divalente; e pelo menos um excipiente farmacêutico; dito sal de fórmula (II) sendo essencialmente estável durante a armazenagem em temperatura ambiente por um período de pelo menos 3 anos. Um processo para estabilização do sal de fómula (II). Um sal cristalino de fómula (II) e um processo para a preparação de dito sal.
BRPI0506906-8A 2004-02-06 2005-02-04 Composição farmacêutica sólida estável contendo sal de um derivado de 3-quinolinacarboxamida, e processos para a estabilização de um sal, e para a preparação de um sal cristalino BRPI0506906B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0400235-8 2004-02-06
SE0400235A SE0400235D0 (sv) 2004-02-06 2004-02-06 New composition containing quinoline compounds
PCT/EP2005/050485 WO2005074899A2 (en) 2004-02-06 2005-02-04 New compositions containing quinoline compounds

Publications (2)

Publication Number Publication Date
BRPI0506906A true BRPI0506906A (pt) 2007-05-29
BRPI0506906B1 BRPI0506906B1 (pt) 2018-05-15

Family

ID=31885235

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506906-8A BRPI0506906B1 (pt) 2004-02-06 2005-02-04 Composição farmacêutica sólida estável contendo sal de um derivado de 3-quinolinacarboxamida, e processos para a estabilização de um sal, e para a preparação de um sal cristalino

Country Status (26)

Country Link
US (1) US7589208B2 (pt)
EP (1) EP1720531B1 (pt)
JP (1) JP4864724B2 (pt)
KR (3) KR101457463B1 (pt)
CN (1) CN1980669B (pt)
AP (1) AP2395A (pt)
AT (1) ATE505186T1 (pt)
AU (1) AU2005210174B2 (pt)
BR (1) BRPI0506906B1 (pt)
CA (1) CA2552463C (pt)
CY (1) CY1111697T1 (pt)
DE (1) DE602005027445D1 (pt)
DK (1) DK1720531T3 (pt)
ES (1) ES2364754T3 (pt)
HK (1) HK1105866A1 (pt)
IL (1) IL176255A (pt)
NO (1) NO337235B1 (pt)
NZ (1) NZ548469A (pt)
PL (1) PL1720531T3 (pt)
PT (1) PT1720531E (pt)
RU (1) RU2339622C2 (pt)
SE (1) SE0400235D0 (pt)
SI (1) SI1720531T1 (pt)
UA (1) UA90463C2 (pt)
WO (1) WO2005074899A2 (pt)
ZA (1) ZA200605619B (pt)

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KR101189557B1 (ko) 2012-10-12
JP4864724B2 (ja) 2012-02-01
IL176255A0 (en) 2006-10-05
AU2005210174A1 (en) 2005-08-18
CY1111697T1 (el) 2015-10-07
RU2339622C2 (ru) 2008-11-27
EP1720531B1 (en) 2011-04-13
KR20130012084A (ko) 2013-01-31
CA2552463C (en) 2013-05-14
NO20063931L (no) 2006-09-04
RU2006132070A (ru) 2008-03-20
PT1720531E (pt) 2011-06-27
WO2005074899A3 (en) 2007-04-19
ES2364754T3 (es) 2011-09-13
CN1980669B (zh) 2011-11-30
US20050192315A1 (en) 2005-09-01
AP2395A (en) 2012-04-10
DE602005027445D1 (de) 2011-05-26
PL1720531T3 (pl) 2011-09-30
ATE505186T1 (de) 2011-04-15
WO2005074899A2 (en) 2005-08-18
AP2006003674A0 (en) 2006-08-31
KR20120062029A (ko) 2012-06-13
NZ548469A (en) 2010-05-28
SE0400235D0 (sv) 2004-02-06
CA2552463A1 (en) 2005-08-18
HK1105866A1 (en) 2008-02-29
EP1720531A2 (en) 2006-11-15
KR20060130191A (ko) 2006-12-18
DK1720531T3 (da) 2011-08-01
BRPI0506906B1 (pt) 2018-05-15
KR101457463B1 (ko) 2014-11-04
US7589208B2 (en) 2009-09-15
IL176255A (en) 2011-11-30
JP2007520529A (ja) 2007-07-26
CN1980669A (zh) 2007-06-13
AU2005210174B2 (en) 2010-10-07
UA90463C2 (ru) 2010-05-11
SI1720531T1 (sl) 2011-08-31
ZA200605619B (en) 2007-11-28

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