BR0315084A - Composição farmacêutica compreendendo hemiidrato cristalino de metanossulfonato de sibutramina - Google Patents
Composição farmacêutica compreendendo hemiidrato cristalino de metanossulfonato de sibutraminaInfo
- Publication number
- BR0315084A BR0315084A BR0315084-4A BR0315084A BR0315084A BR 0315084 A BR0315084 A BR 0315084A BR 0315084 A BR0315084 A BR 0315084A BR 0315084 A BR0315084 A BR 0315084A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- hemihydrate
- sibutramine
- methanesulfonate hemihydrate
- sibutramine methanesulfonate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA COMPREENDENDO HEMIIDRATO CRISTALINO DE METANOSSULFONATO DE SIBUTRAMINA". A presente invenção está relacionada a uma composição farmacêutica para tratar ou prevenir obesidade, compreendendo novo hemiidrato cristalino de metanossulfonato de sibutramina de fórmula (I). O hemiidrato cristalino de metanossulfonato de sibutramina de acordo com a presente invenção tem uma solubilidade muito superior em água, e aprimorada estabilidade sob uma condição de alta umidade/temperatura, como comparada com o monoidrato de cloridrato de sibutramina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20020060798 | 2002-10-05 | ||
KR10-2003-0053752A KR100536750B1 (ko) | 2002-10-05 | 2003-08-04 | 시부트라민 메탄술폰산염의 결정성 반수화물을 포함하는약학 조성물 |
PCT/KR2003/001955 WO2004030663A1 (en) | 2002-10-05 | 2003-09-25 | Pharmaceutical composition comprising crystalline sibutramine methanesulfonate hemihydrate |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0315084A true BR0315084A (pt) | 2005-08-16 |
Family
ID=36147018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0315084-4A BR0315084A (pt) | 2002-10-05 | 2003-09-25 | Composição farmacêutica compreendendo hemiidrato cristalino de metanossulfonato de sibutramina |
Country Status (14)
Country | Link |
---|---|
US (1) | US6900245B2 (pt) |
EP (1) | EP1545484A4 (pt) |
JP (1) | JP4278652B2 (pt) |
AU (1) | AU2003264968B2 (pt) |
BR (1) | BR0315084A (pt) |
CA (1) | CA2501321C (pt) |
HK (1) | HK1083741A1 (pt) |
HR (1) | HRP20050307A2 (pt) |
MX (1) | MXPA05003355A (pt) |
NO (1) | NO20052222L (pt) |
NZ (1) | NZ538966A (pt) |
PL (1) | PL375032A1 (pt) |
RU (1) | RU2290924C2 (pt) |
WO (1) | WO2004030663A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060084636A1 (en) * | 2004-10-18 | 2006-04-20 | Maria Alemany | Methods of using fatty-acid esters of estrogens and serotonin reuptake inhibiting compounds for reducing the body weight of a mammal and compositions containing the same |
US20060084637A1 (en) * | 2004-10-18 | 2006-04-20 | Maria Alemany | Methods of using fatty-acid esters of estrogens and thermogenic compounds for reducing the body weight of a mammal and compositions containing the same |
KR20060080818A (ko) * | 2005-01-06 | 2006-07-11 | 씨제이 주식회사 | 시부트라민의 술폰산염 |
KR20060080817A (ko) * | 2005-01-06 | 2006-07-11 | 씨제이 주식회사 | 시부트라민의 디카복실산염 |
EP1846359A4 (en) * | 2005-01-06 | 2010-03-31 | Cj Cheiljedang Corp | INORGANIC ACID SALTS OF SIBUTRAMINE |
KR100627687B1 (ko) * | 2005-04-20 | 2006-09-25 | 주식회사 씨티씨바이오 | 시부트라민 유리염기 함유 조성물 및 이의 제조방법 |
JP4934293B2 (ja) * | 2005-07-05 | 2012-05-16 | コスモ石油株式会社 | 植物活力剤組成物 |
KR100781882B1 (ko) * | 2005-07-12 | 2007-12-05 | 주식회사유한양행 | 시부트라민을 함유하는 약제학적 조성물 |
KR100806673B1 (ko) | 2006-06-23 | 2008-03-03 | 주식회사 대희화학 | 결정상 시부트라민 프리베이스의 제조방법 |
KR20100088992A (ko) * | 2009-02-02 | 2010-08-11 | 주식회사 대희화학 | (r)-시부트라민 염 및 그의 제조방법 |
WO2011054182A1 (zh) * | 2009-11-03 | 2011-05-12 | Liu Li | 丹参酮ⅱa磺酸钠水合物及其制备方法和用途 |
CN102786444A (zh) * | 2012-07-24 | 2012-11-21 | 上海瑞博化学有限公司 | 一种西布曲明类似物的磺酸盐的制备方法 |
KR102425265B1 (ko) | 2014-08-25 | 2022-07-26 | 에이뮨 테라퓨틱스, 인코퍼레이티드 | 난 단백질 제형 및 이의 제조 방법 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA821577B (en) * | 1981-04-06 | 1983-03-30 | Boots Co Plc | Therapeutic agents |
GB2098302B (en) * | 1981-05-13 | 1985-02-06 | Fort Vale Eng Ltd | Improvements in lids for pressure vessels |
GB8531071D0 (en) * | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
GB2184122B (en) * | 1985-12-17 | 1989-10-18 | Boots Co Plc | N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl butylamine hydrochloride monohydrate |
US20020006963A1 (en) * | 1992-06-23 | 2002-01-17 | Young James W. | Method of using and compositions comprising (-) sibutramine optionally in combination with other pharmacologically active compounds |
US5459164A (en) * | 1994-02-03 | 1995-10-17 | Boots Pharmaceuticals, Inc. | Medical treatment |
GB9619757D0 (en) * | 1996-09-21 | 1996-11-06 | Knoll Ag | Chemical process |
GB9619961D0 (en) * | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
GB9619962D0 (en) * | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
AU3757800A (en) * | 1999-03-19 | 2000-10-09 | Abbott Gmbh & Co. Kg | Method of controlling weight gain associated with therapeutic drugs |
US6376551B1 (en) * | 1999-03-19 | 2002-04-23 | Knoll Pharmaceutical Company | Treatment of chronic fatigue syndrome |
AU3757300A (en) * | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Method of treating anxiety disorders |
CA2367022A1 (en) * | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Method of treating sleep apnoea |
AU3894600A (en) * | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Method of treating sexual dysfunction |
US6399826B1 (en) * | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
US6232347B1 (en) * | 2000-03-17 | 2001-05-15 | Knoll Pharmaceutical Company | Treatment of osteoarthritis |
AU2002210816A1 (en) * | 2000-11-02 | 2002-05-15 | Torrent Pharmaceuticals Ltd | Process for preparation of beta-phenethylamine derivative |
-
2003
- 2003-09-25 BR BR0315084-4A patent/BR0315084A/pt not_active IP Right Cessation
- 2003-09-25 WO PCT/KR2003/001955 patent/WO2004030663A1/en active IP Right Grant
- 2003-09-25 MX MXPA05003355A patent/MXPA05003355A/es active IP Right Grant
- 2003-09-25 AU AU2003264968A patent/AU2003264968B2/en not_active Ceased
- 2003-09-25 RU RU2005109560/15A patent/RU2290924C2/ru not_active IP Right Cessation
- 2003-09-25 JP JP2005500095A patent/JP4278652B2/ja not_active Expired - Fee Related
- 2003-09-25 NZ NZ538966A patent/NZ538966A/en not_active IP Right Cessation
- 2003-09-25 EP EP03799194A patent/EP1545484A4/en not_active Withdrawn
- 2003-09-25 CA CA002501321A patent/CA2501321C/en not_active Expired - Fee Related
- 2003-09-25 PL PL03375032A patent/PL375032A1/xx unknown
- 2003-10-03 US US10/678,325 patent/US6900245B2/en not_active Expired - Fee Related
-
2005
- 2005-04-04 HR HR20050307A patent/HRP20050307A2/xx not_active Application Discontinuation
- 2005-05-06 NO NO20052222A patent/NO20052222L/no not_active Application Discontinuation
-
2006
- 2006-03-24 HK HK06103755A patent/HK1083741A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20040068018A1 (en) | 2004-04-08 |
RU2005109560A (ru) | 2005-09-20 |
HK1083741A1 (en) | 2006-07-14 |
EP1545484A1 (en) | 2005-06-29 |
CA2501321C (en) | 2008-07-08 |
HRP20050307A2 (en) | 2006-12-31 |
EP1545484A4 (en) | 2010-01-13 |
JP2006506449A (ja) | 2006-02-23 |
AU2003264968A1 (en) | 2004-04-23 |
RU2290924C2 (ru) | 2007-01-10 |
AU2003264968B2 (en) | 2006-03-16 |
PL375032A1 (en) | 2005-11-14 |
CA2501321A1 (en) | 2004-04-15 |
NZ538966A (en) | 2006-11-30 |
US6900245B2 (en) | 2005-05-31 |
JP4278652B2 (ja) | 2009-06-17 |
NO20052222L (no) | 2005-05-06 |
MXPA05003355A (es) | 2005-10-18 |
WO2004030663A1 (en) | 2004-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA:INT.CI. A61K 31/13, A61P 3/00 Ipc: A61K 31/13 (2011.01), A61P 3/00 (2011.01) |
|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |