BRPI0316319B8 - derivados de bacterioclorofila aniônicos solúveis em água, composição farmacêutica, usos dos derivados e método para preparo dos mesmos - Google Patents

derivados de bacterioclorofila aniônicos solúveis em água, composição farmacêutica, usos dos derivados e método para preparo dos mesmos

Info

Publication number
BRPI0316319B8
BRPI0316319B8 BRPI0316319A BR0316319A BRPI0316319B8 BR PI0316319 B8 BRPI0316319 B8 BR PI0316319B8 BR PI0316319 A BRPI0316319 A BR PI0316319A BR 0316319 A BR0316319 A BR 0316319A BR PI0316319 B8 BRPI0316319 B8 BR PI0316319B8
Authority
BR
Brazil
Prior art keywords
derivatives
water
preparation
pharmaceutical composition
soluble anionic
Prior art date
Application number
BRPI0316319A
Other languages
English (en)
Portuguese (pt)
Other versions
BR0316319A (pt
BRPI0316319B1 (pt
Inventor
Brandis Alexander
Scherz Avigdor
Scheer Hugo
Mazor Ohad
Salomon Yoram
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30011928&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0316319(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of BR0316319A publication Critical patent/BR0316319A/pt
Publication of BRPI0316319B1 publication Critical patent/BRPI0316319B1/pt
Publication of BRPI0316319B8 publication Critical patent/BRPI0316319B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006—Palladium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006—Palladium compounds
    • C07F15/0066—Palladium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/04—Nickel compounds
    • C07F15/045—Nickel compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06—Zinc compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
BRPI0316319A 2002-11-17 2003-11-17 derivados de bacterioclorofila aniônicos solúveis em água, composição farmacêutica, usos dos derivados e método para preparo dos mesmos BRPI0316319B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL152900 2002-11-17
IL15290002A IL152900A0 (en) 2002-11-17 2002-11-17 Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
PCT/IL2003/000973 WO2004045492A2 (en) 2002-11-17 2003-11-17 Water-soluble anionic bacteriochlorophyll derivatives and their uses

Publications (3)

Publication Number Publication Date
BR0316319A BR0316319A (pt) 2005-09-27
BRPI0316319B1 BRPI0316319B1 (pt) 2017-06-27
BRPI0316319B8 true BRPI0316319B8 (pt) 2021-05-25

Family

ID=30011928

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0316319A BRPI0316319B8 (pt) 2002-11-17 2003-11-17 derivados de bacterioclorofila aniônicos solúveis em água, composição farmacêutica, usos dos derivados e método para preparo dos mesmos

Country Status (23)

Country Link
US (6) US7947672B2 (cg-RX-API-DMAC7.html)
EP (2) EP1567147B1 (cg-RX-API-DMAC7.html)
JP (3) JP4922559B2 (cg-RX-API-DMAC7.html)
CN (2) CN1741801B (cg-RX-API-DMAC7.html)
AU (1) AU2003282354C1 (cg-RX-API-DMAC7.html)
BE (1) BE2018C018I2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0316319B8 (cg-RX-API-DMAC7.html)
CA (1) CA2506296C (cg-RX-API-DMAC7.html)
CY (2) CY1115458T1 (cg-RX-API-DMAC7.html)
DK (1) DK1567147T3 (cg-RX-API-DMAC7.html)
ES (1) ES2489516T3 (cg-RX-API-DMAC7.html)
FR (1) FR18C0002I2 (cg-RX-API-DMAC7.html)
HU (1) HUS1800020I1 (cg-RX-API-DMAC7.html)
IL (2) IL152900A0 (cg-RX-API-DMAC7.html)
LU (1) LUC00073I2 (cg-RX-API-DMAC7.html)
MX (1) MXPA05005262A (cg-RX-API-DMAC7.html)
NL (1) NL300934I2 (cg-RX-API-DMAC7.html)
NO (2) NO334978B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ540790A (cg-RX-API-DMAC7.html)
PL (1) PL216661B1 (cg-RX-API-DMAC7.html)
PT (1) PT1567147E (cg-RX-API-DMAC7.html)
RU (1) RU2353624C2 (cg-RX-API-DMAC7.html)
WO (1) WO2004045492A2 (cg-RX-API-DMAC7.html)

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AU2009219682B2 (en) 2008-02-27 2015-06-18 Yeda Research & Development Co. Ltd RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors
EP2425873A1 (fr) 2010-09-07 2012-03-07 Steba Maor SA Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement
RU2013145501A (ru) 2011-03-11 2015-04-20 Стеба Маор Са Способы фокальной фотодинамической терапии
AU2012298156B2 (en) * 2011-08-23 2017-08-17 Yeda Research And Development Co.Ltd. Method for photodynamic therapy of corneal thinning or scleral weakening with bacteriochlorophyll compounds
DK2971026T3 (da) 2013-03-11 2021-02-15 Tookad Ip Sarl Fremgangsmåde til produktion af bakterieklorofyl a
CN105377862B (zh) 2013-03-15 2019-09-13 希瑞·安·麦克法兰 用作光动力化合物的金属基配合物及其用途
CA3020067A1 (en) * 2016-04-10 2017-10-19 Yeda Research And Development Co. Ltd. Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative
CN107987081B (zh) * 2016-10-26 2019-12-06 刘辉 一种二氢卟吩e6衍生物及其药学上可接受的盐、其制备方法和应用
CN110234760B (zh) * 2016-12-22 2024-08-06 第一三共株式会社 用于治疗年龄相关性黄斑变性的肽
US10933134B2 (en) 2017-03-16 2021-03-02 Memorial Sloan Kettering Cancer Center Combination therapies for treatment of cancer
WO2019116376A1 (en) * 2017-12-17 2019-06-20 Yeda Research And Development Co. Ltd. Cop9 signalosome (csn) complex modulators and uses thereof
CN111848656B (zh) * 2020-06-24 2023-03-14 天津大学 离子修饰的原卟啉镓化合物及其制备方法和应用
EP4190340A4 (en) * 2020-07-29 2024-03-27 Japan Advanced Institute of Science and Technology Therapeutic drug or diagnostic drug for cancer
CN115843960A (zh) * 2022-11-03 2023-03-28 中国农业科学院农产品加工研究所 一种提高叶绿素稳定性的方法
IL311461A (en) * 2024-03-13 2025-10-01 Impact Biotech Ltd Process for preparing bacteriophophorbid derivatives and their alkali metal salts

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Also Published As

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BE2018C018I2 (cg-RX-API-DMAC7.html) 2023-03-07
CA2506296C (en) 2012-09-11
JP5566945B2 (ja) 2014-08-06
US20110117029A1 (en) 2011-05-19
PL216661B1 (pl) 2014-04-30
AU2003282354B2 (en) 2009-04-23
NO20052925D0 (no) 2005-06-15
JP2011148822A (ja) 2011-08-04
HUS1800020I1 (hu) 2018-05-28
NZ540790A (en) 2009-12-24
US20200094069A1 (en) 2020-03-26
AU2003282354B8 (en) 2009-05-14
PL376734A1 (pl) 2006-01-09
NO334978B1 (no) 2014-08-11
IL152900A0 (en) 2003-06-24
FR18C0002I1 (cg-RX-API-DMAC7.html) 2018-06-15
JP2011162551A (ja) 2011-08-25
US20150238773A1 (en) 2015-08-27
RU2353624C2 (ru) 2009-04-27
US20130345417A1 (en) 2013-12-26
FR18C0002I2 (fr) 2020-03-13
PT1567147E (pt) 2014-08-25
CY2018012I2 (el) 2018-09-05
CN1741801B (zh) 2010-12-22
AU2003282354A1 (en) 2004-06-15
WO2004045492A2 (en) 2004-06-03
EP1567147B1 (en) 2014-05-07
HK1081858A1 (en) 2006-05-26
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US20170143988A1 (en) 2017-05-25
CN102002048B (zh) 2012-11-28
JP2006515836A (ja) 2006-06-08
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US20060142260A1 (en) 2006-06-29
DK1567147T3 (da) 2014-08-11
JP4922559B2 (ja) 2012-04-25
IL168480A (en) 2015-01-29
US7947672B2 (en) 2011-05-24
MXPA05005262A (es) 2005-07-25
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CY1115458T1 (el) 2017-01-04
JP5555659B2 (ja) 2014-07-23
NO2018012I1 (no) 2018-04-10
EP1567147A2 (en) 2005-08-31
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WO2004045492A3 (en) 2004-07-08
NO20052925L (no) 2005-06-15
CA2506296A1 (en) 2004-06-03
ES2489516T3 (es) 2014-09-02
LUC00073I2 (en) 2018-06-20
BR0316319A (pt) 2005-09-27
CN102002048A (zh) 2011-04-06
RU2005118771A (ru) 2006-01-20
EP1567147A4 (en) 2008-07-09
US8461142B2 (en) 2013-06-11
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NO2018012I2 (no) 2018-04-10
BRPI0316319B1 (pt) 2017-06-27

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