BRPI0206689B1 - composição de probióticos e uso desta - Google Patents
composição de probióticos e uso desta Download PDFInfo
- Publication number
- BRPI0206689B1 BRPI0206689B1 BRPI0206689A BR0206689A BRPI0206689B1 BR PI0206689 B1 BRPI0206689 B1 BR PI0206689B1 BR PI0206689 A BRPI0206689 A BR PI0206689A BR 0206689 A BR0206689 A BR 0206689A BR PI0206689 B1 BRPI0206689 B1 BR PI0206689B1
- Authority
- BR
- Brazil
- Prior art keywords
- combination
- probiotics
- prebiotic
- bifidobacterium
- probiotic
- Prior art date
Links
- 239000006041 probiotic Substances 0.000 title claims abstract description 67
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims description 32
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 37
- 241000186000 Bifidobacterium Species 0.000 claims abstract description 33
- 241000186660 Lactobacillus Species 0.000 claims abstract description 17
- 229940039696 lactobacillus Drugs 0.000 claims abstract description 16
- 230000036541 health Effects 0.000 claims abstract description 11
- 229920001542 oligosaccharide Polymers 0.000 claims description 13
- 150000002482 oligosaccharides Chemical class 0.000 claims description 12
- 244000005700 microbiome Species 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 7
- 235000013365 dairy product Nutrition 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
- 230000001737 promoting effect Effects 0.000 claims description 5
- 235000013361 beverage Nutrition 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229930014626 natural product Natural products 0.000 claims description 2
- 235000014347 soups Nutrition 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 2
- 235000008452 baby food Nutrition 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract description 22
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract description 14
- 235000019260 propionic acid Nutrition 0.000 abstract description 7
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 abstract description 7
- 210000000987 immune system Anatomy 0.000 abstract description 5
- 230000000529 probiotic effect Effects 0.000 description 40
- 239000000047 product Substances 0.000 description 35
- 230000001580 bacterial effect Effects 0.000 description 26
- 150000003271 galactooligosaccharides Chemical class 0.000 description 19
- 235000010633 broth Nutrition 0.000 description 18
- 235000021255 galacto-oligosaccharides Nutrition 0.000 description 18
- 230000000968 intestinal effect Effects 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 17
- 230000000694 effects Effects 0.000 description 17
- 108090000790 Enzymes Proteins 0.000 description 12
- 102000004190 Enzymes Human genes 0.000 description 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 12
- 241000282414 Homo sapiens Species 0.000 description 11
- 210000001072 colon Anatomy 0.000 description 11
- 210000004698 lymphocyte Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 10
- 241000186429 Propionibacterium Species 0.000 description 9
- 210000000936 intestine Anatomy 0.000 description 9
- 241000894007 species Species 0.000 description 9
- HVDGDHBAMCBBLR-UHFFFAOYSA-N Enterolactone Natural products OC1=CC=CC(CC2C(C(=O)OC2)CC=2C=C(O)C=CC=2)=C1 HVDGDHBAMCBBLR-UHFFFAOYSA-N 0.000 description 8
- 108010074328 Interferon-gamma Proteins 0.000 description 8
- HVDGDHBAMCBBLR-WMLDXEAASA-N enterolactone Chemical compound OC1=CC=CC(C[C@@H]2[C@H](C(=O)OC2)CC=2C=C(O)C=CC=2)=C1 HVDGDHBAMCBBLR-WMLDXEAASA-N 0.000 description 8
- 210000001035 gastrointestinal tract Anatomy 0.000 description 8
- 210000002966 serum Anatomy 0.000 description 8
- 241000194017 Streptococcus Species 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- -1 glucurone compound Chemical class 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 239000013589 supplement Substances 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 6
- 230000000711 cancerogenic effect Effects 0.000 description 6
- 150000001720 carbohydrates Chemical class 0.000 description 6
- 235000014633 carbohydrates Nutrition 0.000 description 6
- 231100000315 carcinogenic Toxicity 0.000 description 6
- 239000004310 lactic acid Substances 0.000 description 6
- 235000014655 lactic acid Nutrition 0.000 description 6
- 239000008101 lactose Substances 0.000 description 6
- 210000003097 mucus Anatomy 0.000 description 6
- 230000035899 viability Effects 0.000 description 6
- 102100037850 Interferon gamma Human genes 0.000 description 5
- 241000218588 Lactobacillus rhamnosus Species 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- 229930006000 Sucrose Natural products 0.000 description 5
- 239000003833 bile salt Substances 0.000 description 5
- 230000000112 colonic effect Effects 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 5
- 235000008504 concentrate Nutrition 0.000 description 5
- 229930182830 galactose Natural products 0.000 description 5
- 230000000813 microbial effect Effects 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- 230000035764 nutrition Effects 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- 206010009944 Colon cancer Diseases 0.000 description 4
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 235000013336 milk Nutrition 0.000 description 4
- 210000004080 milk Anatomy 0.000 description 4
- 239000012466 permeate Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 210000000813 small intestine Anatomy 0.000 description 4
- 230000004936 stimulating effect Effects 0.000 description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 3
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- 241000606125 Bacteroides Species 0.000 description 3
- 241001655328 Bifidobacteriales Species 0.000 description 3
- 241000186016 Bifidobacterium bifidum Species 0.000 description 3
- WNBCMONIPIJTSB-BGNCJLHMSA-N Cichoriin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1)c1c(O)cc2c(OC(=O)C=C2)c1 WNBCMONIPIJTSB-BGNCJLHMSA-N 0.000 description 3
- RFSUNEUAIZKAJO-VRPWFDPXSA-N D-Fructose Natural products OC[C@H]1OC(O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-VRPWFDPXSA-N 0.000 description 3
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 3
- 102000053187 Glucuronidase Human genes 0.000 description 3
- 108010060309 Glucuronidase Proteins 0.000 description 3
- 108090000978 Interleukin-4 Proteins 0.000 description 3
- 244000199866 Lactobacillus casei Species 0.000 description 3
- 235000013958 Lactobacillus casei Nutrition 0.000 description 3
- 241000194036 Lactococcus Species 0.000 description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 3
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 3
- 241000235070 Saccharomyces Species 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 108010046334 Urease Proteins 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 3
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 3
- 239000003613 bile acid Substances 0.000 description 3
- 239000005018 casein Substances 0.000 description 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 3
- 235000021240 caseins Nutrition 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 210000002919 epithelial cell Anatomy 0.000 description 3
- XHCADAYNFIFUHF-TVKJYDDYSA-N esculin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1OC(=O)C=C2 XHCADAYNFIFUHF-TVKJYDDYSA-N 0.000 description 3
- 229940093496 esculin Drugs 0.000 description 3
- AWRMZKLXZLNBBK-UHFFFAOYSA-N esculin Natural products OC1OC(COc2cc3C=CC(=O)Oc3cc2O)C(O)C(O)C1O AWRMZKLXZLNBBK-UHFFFAOYSA-N 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 230000008821 health effect Effects 0.000 description 3
- 208000028774 intestinal disease Diseases 0.000 description 3
- 229940017800 lactobacillus casei Drugs 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 239000003223 protective agent Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 2
- ROWKJAVDOGWPAT-UHFFFAOYSA-N Acetoin Chemical compound CC(O)C(C)=O ROWKJAVDOGWPAT-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000193403 Clostridium Species 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
- QWIZNVHXZXRPDR-UHFFFAOYSA-N D-melezitose Natural products O1C(CO)C(O)C(O)C(O)C1OC1C(O)C(CO)OC1(CO)OC1OC(CO)C(O)C(O)C1O QWIZNVHXZXRPDR-UHFFFAOYSA-N 0.000 description 2
- LKDRXBCSQODPBY-OEXCPVAWSA-N D-tagatose Chemical compound OCC1(O)OC[C@@H](O)[C@H](O)[C@@H]1O LKDRXBCSQODPBY-OEXCPVAWSA-N 0.000 description 2
- 101000874334 Dalbergia nigrescens Isoflavonoid 7-O-beta-apiosyl-glucoside beta-glycosidase Proteins 0.000 description 2
- 241000194033 Enterococcus Species 0.000 description 2
- 101000757733 Enterococcus faecalis (strain ATCC 700802 / V583) Autolysin Proteins 0.000 description 2
- 241000186394 Eubacterium Species 0.000 description 2
- 108010002616 Interleukin-5 Proteins 0.000 description 2
- 229920001202 Inulin Polymers 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 2
- 241000917016 Lactobacillus rhamnosus Lc 705 Species 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000736262 Microbiota Species 0.000 description 2
- 101000757734 Mycolicibacterium phlei 38 kDa autolysin Proteins 0.000 description 2
- 241000191992 Peptostreptococcus Species 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- 241000186428 Propionibacterium freudenreichii Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- NGFMICBWJRZIBI-JZRPKSSGSA-N Salicin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)c1c(CO)cccc1 NGFMICBWJRZIBI-JZRPKSSGSA-N 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 238000001793 Wilcoxon signed-rank test Methods 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- NGFMICBWJRZIBI-UHFFFAOYSA-N alpha-salicin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UHFFFAOYSA-N 0.000 description 2
- 229960000271 arbutin Drugs 0.000 description 2
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
- 229940093761 bile salts Drugs 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 208000029742 colonic neoplasm Diseases 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 235000012041 food component Nutrition 0.000 description 2
- 239000005417 food ingredient Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 244000005709 gut microbiome Species 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 2
- 229940029339 inulin Drugs 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 244000005706 microflora Species 0.000 description 2
- 239000003226 mitogen Substances 0.000 description 2
- 235000021590 normal diet Nutrition 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 2
- 229940120668 salicin Drugs 0.000 description 2
- 235000021391 short chain fatty acids Nutrition 0.000 description 2
- 150000004666 short chain fatty acids Chemical class 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 150000005846 sugar alcohols Chemical class 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 229940104230 thymidine Drugs 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- OUSKVHOYPHDTIA-DBRKOABJSA-N (3s,4s,5r,6r)-3,4,5,6,7-pentahydroxyheptan-2-one Chemical compound CC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO OUSKVHOYPHDTIA-DBRKOABJSA-N 0.000 description 1
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 description 1
- DIIIISSCIXVANO-UHFFFAOYSA-N 1,2-Dimethylhydrazine Chemical compound CNNC DIIIISSCIXVANO-UHFFFAOYSA-N 0.000 description 1
- VOZDNCFKGOLECZ-BTVCFUMJSA-N 2-hydroxypropanoic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O VOZDNCFKGOLECZ-BTVCFUMJSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- 241000186018 Bifidobacterium adolescentis Species 0.000 description 1
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 description 1
- 241000186146 Brevibacterium Species 0.000 description 1
- 108091028026 C-DNA Proteins 0.000 description 1
- 102100035882 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
- 241000208421 Ericaceae Species 0.000 description 1
- 229920001917 Ficoll Polymers 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 108010052764 Fructose-6-phosphate phosphoketolase Proteins 0.000 description 1
- 241000605909 Fusobacterium Species 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 102000005744 Glycoside Hydrolases Human genes 0.000 description 1
- 108010031186 Glycoside Hydrolases Proteins 0.000 description 1
- 229920002488 Hemicellulose Polymers 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- SRBFZHDQGSBBOR-OWMBCFKOSA-N L-ribopyranose Chemical compound O[C@H]1COC(O)[C@@H](O)[C@H]1O SRBFZHDQGSBBOR-OWMBCFKOSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 1
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 description 1
- 241000917009 Lactobacillus rhamnosus GG Species 0.000 description 1
- 241000192132 Leuconostoc Species 0.000 description 1
- 235000019759 Maize starch Nutrition 0.000 description 1
- AYRXSINWFIIFAE-UHFFFAOYSA-N O6-alpha-D-Galactopyranosyl-D-galactose Natural products OCC1OC(OCC(O)C(O)C(O)C(O)C=O)C(O)C(O)C1O AYRXSINWFIIFAE-UHFFFAOYSA-N 0.000 description 1
- 241000192001 Pediococcus Species 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- 101150085390 RPM1 gene Proteins 0.000 description 1
- 241000192031 Ruminococcus Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 208000026723 Urinary tract disease Diseases 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 229940089837 amygdalin Drugs 0.000 description 1
- YZLOSXFCSIDECK-UHFFFAOYSA-N amygdalin Natural products OCC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC(C#N)c3ccccc3 YZLOSXFCSIDECK-UHFFFAOYSA-N 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003217 anti-cancerogenic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 229940009289 bifidobacterium lactis Drugs 0.000 description 1
- 230000001847 bifidogenic effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000014048 cultured milk product Nutrition 0.000 description 1
- 229960002433 cysteine Drugs 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 235000011850 desserts Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- YGHHWSRCTPQFFC-UHFFFAOYSA-N eucalyptosin A Natural products OC1C(O)C(O)C(CO)OC1OC1C(OC(C#N)C=2C=CC=CC=2)OC(CO)C(O)C1O YGHHWSRCTPQFFC-UHFFFAOYSA-N 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- DLRVVLDZNNYCBX-CQUJWQHSSA-N gentiobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-CQUJWQHSSA-N 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229950002441 glucurolactone Drugs 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- GFAZHVHNLUBROE-UHFFFAOYSA-N hydroxymethyl propionaldehyde Natural products CCC(=O)CO GFAZHVHNLUBROE-UHFFFAOYSA-N 0.000 description 1
- 230000015784 hyperosmotic salinity response Effects 0.000 description 1
- 230000005965 immune activity Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940004208 lactobacillus bulgaricus Drugs 0.000 description 1
- 229940059406 lactobacillus rhamnosus gg Drugs 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000012533 medium component Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 235000015927 pasta Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- ZMRUPTIKESYGQW-UHFFFAOYSA-N propranolol hydrochloride Chemical compound [H+].[Cl-].C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 ZMRUPTIKESYGQW-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000012780 rye bread Nutrition 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 208000026775 severe diarrhea Diseases 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- RULSWEULPANCDV-PIXUTMIVSA-N turanose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](C(=O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RULSWEULPANCDV-PIXUTMIVSA-N 0.000 description 1
- 208000014001 urinary system disease Diseases 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/065—Microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/529—Infantis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/61—Propionibacterium
- A23V2400/617—Freudenreichii
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20010157A FI109602B (fi) | 2001-01-25 | 2001-01-25 | Probioottiyhdistelmä |
| PCT/FI2002/000035 WO2002060276A1 (en) | 2001-01-25 | 2002-01-17 | Combination of probiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0206689A BR0206689A (pt) | 2004-02-03 |
| BRPI0206689B1 true BRPI0206689B1 (pt) | 2016-02-10 |
Family
ID=8560139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0206689A BRPI0206689B1 (pt) | 2001-01-25 | 2002-01-17 | composição de probióticos e uso desta |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8309073B2 (enExample) |
| EP (1) | EP1359816B1 (enExample) |
| JP (1) | JP3984546B2 (enExample) |
| KR (1) | KR20040012717A (enExample) |
| CN (1) | CN100400645C (enExample) |
| AT (1) | ATE297664T1 (enExample) |
| AU (1) | AU2002229787B2 (enExample) |
| BR (1) | BRPI0206689B1 (enExample) |
| CA (1) | CA2434337C (enExample) |
| CZ (1) | CZ301673B6 (enExample) |
| DE (1) | DE60204662T2 (enExample) |
| DK (1) | DK1359816T3 (enExample) |
| EE (1) | EE05299B1 (enExample) |
| ES (1) | ES2243697T3 (enExample) |
| FI (1) | FI109602B (enExample) |
| HR (1) | HRP20030586B8 (enExample) |
| HU (1) | HU225790B1 (enExample) |
| NO (1) | NO325463B1 (enExample) |
| NZ (1) | NZ527172A (enExample) |
| PL (1) | PL204245B1 (enExample) |
| PT (1) | PT1359816E (enExample) |
| RU (1) | RU2291899C2 (enExample) |
| WO (1) | WO2002060276A1 (enExample) |
| ZA (1) | ZA200305458B (enExample) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI109602B (fi) * | 2001-01-25 | 2002-09-13 | Valio Oy | Probioottiyhdistelmä |
| US20030175305A1 (en) * | 2002-01-08 | 2003-09-18 | Garner Bryan E. | Compositions and methods for inhibiting pathogenic growth |
| DE10206995B4 (de) * | 2002-02-19 | 2014-01-02 | Orthomol Pharmazeutische Vertriebs Gmbh | Mikronährstoffkombinationsprodukt mit Pro- und Prebiotika |
| ITMI20020399A1 (it) | 2002-02-28 | 2003-08-28 | Ct Sperimentale Del Latte S P | Composizioni dietetiche e/o farmaceutiche per uso umano e/o animale abase di preparati microbici probiotici |
| EP1374878A1 (en) * | 2002-06-20 | 2004-01-02 | N.V. Nutricia | Method and composition for preventing or alleviating symptoms of malabsorption from the gastrointestinal tract |
| US7105336B2 (en) * | 2002-10-07 | 2006-09-12 | Biogaia Ab | Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter |
| FI113057B (fi) * | 2002-11-04 | 2004-02-27 | Valio Oy | Menetelmä hiivojen kasvun estämiseksi |
| US20040208863A1 (en) * | 2003-01-30 | 2004-10-21 | James Versalovic | Anti-inflammatory activity from lactic acid bacteria |
| SE526711C2 (sv) * | 2003-01-31 | 2005-10-25 | Probi Ab | Nya stammar av Bifidobacterium med förmåga att överleva i magtarmkanalen och producera glutamin in vivo, samt kompositioner och användningar därav |
| PL1638415T3 (pl) * | 2003-06-23 | 2011-05-31 | Nestec Sa | Preparat dla niemowląt lub preparat pochodny |
| EP1638414B1 (en) * | 2003-06-23 | 2009-06-17 | Nestec S.A. | Infant or follow-on formula |
| NZ546664A (en) * | 2003-10-24 | 2009-04-30 | Nutricia Nv | Synbiotic composition for infants |
| US20050208034A1 (en) * | 2004-03-17 | 2005-09-22 | Jordan Lazonia V | Natural vaginal yeast infection control |
| EP1597978A1 (en) * | 2004-05-17 | 2005-11-23 | Nutricia N.V. | Synergism of GOS and polyfructose |
| US8252769B2 (en) | 2004-06-22 | 2012-08-28 | N. V. Nutricia | Intestinal barrier integrity |
| US20080126195A1 (en) | 2004-07-22 | 2008-05-29 | Ritter Andrew J | Methods and Compositions for Treating Lactose Intolerance |
| EP1629850B2 (en) * | 2004-08-24 | 2013-05-22 | N.V. Nutricia | Nutritional composition comprising indigestible transgalactooligosaccharides and digestible galactose saccharides |
| ITMI20042189A1 (it) * | 2004-11-16 | 2005-02-16 | Anidral Srl | Composizione a base di batteri probiotici e suo uso nella prevenzione e-o nel trattamento di patologie e-o infezioni respiratorie e nel miglioramento della funzionalita' intestinale |
| PL2805625T5 (pl) * | 2005-02-28 | 2023-03-13 | N.V. Nutricia | Kompozycja odżywcza z prebiotykami i probiotykami |
| US20060233762A1 (en) * | 2005-04-15 | 2006-10-19 | Mcmahon Robert J | Method for treating or preventing systemic inflammation in formula-fed infants |
| US7572474B2 (en) | 2005-06-01 | 2009-08-11 | Mead Johnson Nutrition Company | Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants |
| US8075934B2 (en) * | 2008-10-24 | 2011-12-13 | Mead Johnson Nutrition Company | Nutritional composition with improved digestibility |
| US8287931B2 (en) * | 2005-06-30 | 2012-10-16 | Mead Johnson Nutrition Company | Nutritional composition to promote healthy development and growth |
| KR101411144B1 (ko) | 2005-07-26 | 2014-06-26 | 네스텍 에스.아. | 항비만제 및 항비만 식품 |
| EP1951273B1 (en) * | 2005-10-06 | 2014-02-12 | Probi Ab | Use of lactobacillus for treatment of autoimmune diseases |
| EP1776877A1 (en) * | 2005-10-21 | 2007-04-25 | N.V. Nutricia | Method for stimulating the intestinal flora |
| ES2553636T3 (es) | 2006-03-07 | 2015-12-10 | Nestec S.A. | Mezcla simbiótica |
| ES2459621T3 (es) | 2006-03-10 | 2014-05-12 | N.V. Nutricia | Uso de sacáridos no digeribles para dar a un bebé el mejor comienzo después del nacimiento |
| JP5317954B2 (ja) | 2006-03-16 | 2013-10-16 | ボストン サイエンティフィック リミテッド | 組織壁脱出症を治療するためのシステムおよび方法 |
| WO2007140622A1 (en) * | 2006-06-09 | 2007-12-13 | Nutravital Inc. | Dairy-derived probiotic compositions and uses thereof |
| WO2007140621A1 (en) * | 2006-06-09 | 2007-12-13 | Nutravital Inc. | Probiotic compositions and uses thereof |
| US7387427B2 (en) | 2006-10-20 | 2008-06-17 | Bristol-Myers Squibb Company | Method for blending heat-sensitive material using a conical screw blender with gas injection |
| WO2008054193A1 (en) * | 2006-11-02 | 2008-05-08 | N.V. Nutricia | Nutritional products that comprise saccharide oligomers |
| RU2454239C2 (ru) * | 2007-02-22 | 2012-06-27 | Юрген ШРЕЗЕНМЕИР | Пробиотические грамположительные бактерии для профилактики, подавления или устранения аллергических реакций у человека |
| CN105796607A (zh) * | 2007-02-28 | 2016-07-27 | Mjn 美国控股有限责任公司 | 用于儿童或婴幼儿的含有灭活益生菌的产品 |
| ES2322116B1 (es) | 2007-03-12 | 2010-03-29 | Consejo Superior Investig. Cientificas | Microorganismo productor de anticuerpos, elementos necesarios para su obtencion, anticuerpos asi producidos, composiciones terapeuticas y sus aplicaciones. |
| CN101273737B (zh) | 2007-03-28 | 2011-08-24 | 哈尔滨正方科技有限公司 | 一种在常温下保持高活菌数的发酵乳饮料的制备方法 |
| WO2008153377A1 (en) * | 2007-06-15 | 2008-12-18 | N.V. Nutricia | Nutrition with non-viable bifidobacterium and non-digestible oligosaccharide |
| EP2022502A1 (en) * | 2007-08-10 | 2009-02-11 | Nestec S.A. | Lactobacillus rhamnosus and weight control |
| US20090118228A1 (en) * | 2007-11-07 | 2009-05-07 | Bristol-Myers Squibb Company | Carotenoid-containing compositions and methods |
| FI121912B (fi) * | 2008-02-05 | 2011-06-15 | Valio Oy | Probioottien uusi käyttö |
| WO2009107380A1 (ja) * | 2008-02-29 | 2009-09-03 | 明治乳業株式会社 | 抗アレルギー剤 |
| FI20080321A0 (fi) * | 2008-04-25 | 2008-04-25 | Eino Elias Hakalehto | Menetelmä suoliston bakteeritasapainon ylläpitämiseksi |
| JPWO2009150856A1 (ja) * | 2008-06-13 | 2011-11-10 | 株式会社ヤクルト本社 | 酸素耐性付与遺伝子及びその利用 |
| WO2010002241A1 (en) * | 2008-06-30 | 2010-01-07 | N.V. Nutricia | Nutritional composition for infants delivered via caesarean section |
| FR2933848B1 (fr) | 2008-07-18 | 2019-08-09 | Roquette Freres | Composition de fibres indigestibles solubles et d'organismes eucaryotes dotes d'une paroi polysaccharidique utilisees dans le domaine du bien etre |
| US8986769B2 (en) * | 2008-10-24 | 2015-03-24 | Mead Johnson Nutrition Company | Methods for preserving endogenous TGF-β |
| EP2347661B1 (en) * | 2008-11-21 | 2019-01-09 | José Antonio Cruz Serrano | Method for obtaining a mixture of probiotics, nutrient prebiotics having synergistic symbiotic action |
| US8445426B2 (en) | 2009-02-02 | 2013-05-21 | Valio Ltd. | Peptides and methods for producing them |
| EP2216036A1 (en) * | 2009-02-10 | 2010-08-11 | Nestec S.A. | Lactobacillus rhamnosus NCC4007, a probiotic mixture and weight control |
| EP2216035A1 (en) * | 2009-02-10 | 2010-08-11 | Nestec S.A. | Lactobacillus rhamnosus CNCM I-4096 and weight control |
| US8425955B2 (en) | 2009-02-12 | 2013-04-23 | Mead Johnson Nutrition Company | Nutritional composition with prebiotic component |
| WO2010098822A1 (en) | 2009-02-24 | 2010-09-02 | Ritter Pharmaceuticals, Inc. | Prebiotic formulations and methods of use |
| WO2010103132A1 (es) * | 2009-03-10 | 2010-09-16 | Hero España, S.A. | Aislamiento, identificación y caracterización de cepas con actividad probiótica a partir de heces de lactantes alimentados exclusivamente con leche materna |
| CA2760999A1 (en) * | 2009-03-13 | 2010-09-16 | Mariana Barboza | Prebiotic oligosaccharides |
| US8293264B2 (en) * | 2009-05-11 | 2012-10-23 | Mead Johnson Nutrition Company | Nutritional composition to promote healthy development and growth |
| AU2010254235B2 (en) | 2009-05-26 | 2015-04-02 | Advanced Bionutrition Corporation | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making |
| GB0915315D0 (en) * | 2009-09-03 | 2009-10-07 | Univ Manchester | Use of non-digestible oligosaccharides |
| FI20096058A0 (fi) * | 2009-10-13 | 2009-10-13 | Valio Oy | Koostumuksia ja niihin liittyviä menetelmiä ja käyttöjä |
| WO2011071134A1 (ja) * | 2009-12-10 | 2011-06-16 | 明治乳業株式会社 | インフルエンザ感染症の予防組成物 |
| US9504750B2 (en) | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
| FR2955774A1 (fr) | 2010-02-02 | 2011-08-05 | Aragan | Preparation destinee a traiter l'exces ponderal et les desordres associes et applications de ladite preparation |
| DE102010009582A1 (de) * | 2010-02-05 | 2011-08-11 | Vitacare GmbH & Co. KG, 60318 | Mittel zur Anwendung bei Lactasemangel und Lactoseintoleranz |
| CN101810222A (zh) * | 2010-04-23 | 2010-08-25 | 陕西农产品加工技术研究院 | 一种合生元羊奶粉 |
| EP3202406A1 (en) | 2010-04-28 | 2017-08-09 | Ritter Pharmaceuticals, Inc. | Prebiotic formulations and methods of use |
| US8911348B2 (en) | 2010-09-02 | 2014-12-16 | Boston Scientific Scimed, Inc. | Pelvic implants and methods of implanting the same |
| CN102524391B (zh) * | 2010-12-21 | 2013-11-13 | 内蒙古蒙牛乳业（集团）股份有限公司 | 一种含有复合益生元及益生菌群的发酵乳制品 |
| US8927252B2 (en) | 2011-02-09 | 2015-01-06 | Lavivo Ab | Synbiotic compositions for restoration and reconstitution of gut microbiota |
| US20120269929A1 (en) * | 2011-04-22 | 2012-10-25 | Hugh Lippman | Fortified Milk-Based Nutritional Compositions |
| FR2974512B1 (fr) * | 2011-04-28 | 2013-11-08 | Roquette Freres | Composition anti-inflammatoire de l'intestin comprenant du maltitol |
| US9125935B1 (en) * | 2011-05-31 | 2015-09-08 | Nutech Ventures | Probiotics and methods of obtaining same |
| RU2482176C1 (ru) * | 2012-02-16 | 2013-05-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Тверская государственная медицинская академия" Министерства здравоохранения Российской Федерации"(ГБОУ ВПО Тверская ГМА Минздрава России) | ШТАММ БАКТЕРИЙ Lactobacillus rhamnosus, ОБЛАДАЮЩИЙ ШИРОКИМ СПЕКТРОМ АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТИ ПО ОТНОШЕНИЮ К ПАТОГЕННЫМ И УСЛОВНО-ПАТОГЕННЫМ МИКРООРГАНИЗМАМ |
| CN104394701A (zh) * | 2012-05-21 | 2015-03-04 | 杜邦营养生物科学有限公司 | 丙酸杆菌菌株 |
| KR20150118084A (ko) * | 2012-09-20 | 2015-10-21 | 프로테라 인코포레이티드 | 비만 및 비만 관련 질환을 치료하기 위한 프로바이오틱 조성물 및 방법 |
| CN104936464A (zh) * | 2013-01-21 | 2015-09-23 | 苏黎世联邦理工学院 | 包含产丙酸活细菌的婴儿食物组合物 |
| US11179427B2 (en) | 2013-01-21 | 2021-11-23 | Eth Zurich | Baby food composition comprising viable propionic acid-producing bacteria |
| EP3294308A4 (en) | 2015-05-14 | 2019-03-06 | University of Puerto Rico | PROCESS FOR RECOVERING THE BIOZOOSE OF NEWBORN |
| KR102685914B1 (ko) | 2015-07-29 | 2024-07-16 | 어드밴스드 바이오뉴트리션 코프. | 특수 식이 용도를 위한 안정한 프로바이오틱 건조 조성물 |
| RS57471B1 (sr) | 2015-12-17 | 2018-09-28 | Institut Za Molekularnu Genetiku I Geneticko Inzenjerstvo Univerzitet U Beogradu | Nova probiotička starter kultura za humanu i animalnu primenu |
| WO2017117142A1 (en) | 2015-12-28 | 2017-07-06 | New York University | Device and method of restoring microbiota of newborns |
| ITUA20163807A1 (it) * | 2016-05-25 | 2017-11-25 | Univ Degli Studi Di Foggia | Metodo per la produzione di biofilm microbici probiotici e relativi usi |
| WO2018158450A1 (en) * | 2017-03-03 | 2018-09-07 | Biomillenia Sas | Microparticle for cultivating and testing cells |
| US10695386B2 (en) | 2017-05-11 | 2020-06-30 | Shayne K. Morris | Skin microbiome colonizer formulations and methods for use |
| IT201800003128A1 (it) * | 2018-02-28 | 2019-08-28 | Propharma Soc A Responsabilita Limitata Semplificata | Composizione probiotica |
| US11168299B2 (en) | 2018-04-11 | 2021-11-09 | Shayne Morris | Pairing probiotics and prebiotics, methods for growth and use, separately and in combination |
| US11291696B2 (en) | 2018-04-11 | 2022-04-05 | Shayne Morris | Pairing probiotics and prebiotics, methods for growth and use, separately and in combination |
| GB2590272B (en) | 2018-07-13 | 2022-08-31 | Council Scient Ind Res | Synbiotic composition for improving immune response and antioxidant capacity during aging and a process for the preparation thereof |
| CN109757731A (zh) * | 2019-03-14 | 2019-05-17 | 广州普维君健药业有限公司 | 缓解乳糖不耐的益生菌组合物及其制备方法和应用 |
| EP3760054A1 (en) * | 2019-07-02 | 2021-01-06 | Pepticus s.r.o. | A method of preparing an individual probiotic composition according to analysis of the microbiome and medical history for human or veterinary use |
| CN111450122B (zh) * | 2019-11-02 | 2023-04-25 | 吉安诺惠诚莘科技有限公司 | 一种复合菌剂及其在皮肤修复上的应用 |
| KR102215596B1 (ko) * | 2019-12-11 | 2021-02-15 | 주식회사 에이치이엠 | 신규한 스트렙토코커스 써모필러스 hem 14 균주, 및 상기 균주 또는 이의 배양물을 포함하는 장내 환경 개선용 조성물 |
| KR102254752B1 (ko) | 2020-01-09 | 2021-05-24 | 한국식품연구원 | 신규의 락토바실러스 플란타럼 WiKim87 균주 및 이의 용도 |
| KR102254751B1 (ko) | 2020-01-09 | 2021-05-24 | 한국식품연구원 | 신규의 락토바실러스 플란타럼 WiKim83 균주 및 이의 용도 |
| CN111944727B (zh) * | 2020-08-24 | 2021-12-03 | 汤臣倍健股份有限公司 | 一种短双歧杆菌207-1及其应用 |
| CN113005049B (zh) * | 2020-12-30 | 2022-11-01 | 江南大学 | 一株可缓解腹泻的短双歧杆菌及其应用 |
| KR20220099914A (ko) * | 2021-01-07 | 2022-07-14 | (주)에스앤에이치바이오텍 | 유해균 억제를 통한 프로바이오틱스 활성화용 조성물 |
| EP4373503A1 (en) * | 2021-07-20 | 2024-05-29 | ETH Zurich | Treatment and/or prevention of digestive disorder by a bacterial composition of propionibacterium freudenreichii and bifidobacterium longum |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839281A (en) | 1985-04-17 | 1989-06-13 | New England Medical Center Hospitals, Inc. | Lactobacillus strains and methods of selection |
| CZ281386B6 (cs) * | 1991-01-29 | 1996-09-11 | MILCOM a.s. Výzkumný ústav mlékárenský | Probiotický preparát pro výživu lidí a zvířat a způsob jeho výroby |
| FI92498C (fi) | 1992-06-10 | 1994-11-25 | Valio Meijerien | Uusi mikro-organismikanta, sitä sisältävät bakteerivalmisteet ja näiden käyttö hiivojen ja homeiden torjuntaan |
| US5501857A (en) * | 1992-07-24 | 1996-03-26 | Midwestern Bio-Ag Products & Services, Inc. | Oral nutritional and dietary composition |
| US5529753A (en) * | 1993-07-09 | 1996-06-25 | Dade International Inc. | System for ultrasonic energy coupling by irrigation |
| US5529793A (en) * | 1994-11-16 | 1996-06-25 | Nutrition Physiology Corporation | Compositions for improving the utilization of feedstuffs by ruminants |
| FI104465B (fi) * | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
| EP0880354A1 (en) | 1996-02-14 | 1998-12-02 | The Procter & Gamble Company | Urogenital and intestinal compositions |
| CN1211189A (zh) | 1996-02-14 | 1999-03-17 | 普罗克特和甘保尔公司 | 含衍自杜鹃花科植物的物质和乳酸菌生长因子的,用于泌尿生殖系统和肠道疾病的组合物 |
| AUPN881396A0 (en) | 1996-03-20 | 1996-04-18 | Arnott's Biscuits Limited | Enhancement of microbial colonization of the gastrointestinal tract |
| US5902578A (en) | 1996-03-25 | 1999-05-11 | Abbott Laboratories | Method and formula for the prevention of diarrhea |
| SK281736B6 (sk) * | 1996-12-02 | 2001-07-10 | Jevgenij Anatolievi� Gutkevi� | Zmes na prípravu zmrzliny |
| EP0856259B1 (en) | 1996-12-23 | 1998-08-12 | SITIA-YOMO S.p.A. | Composition for feed use comprising lyophilized live lactic bacteria |
| SK283008B6 (sk) | 1997-08-21 | 2003-01-09 | New Zealand Dairy Board | Biologicky čistá kultúra Lactobacillus rhamnosus, kompozícia s jej obsahom a jej použitie |
| EP0904784A1 (en) | 1997-09-22 | 1999-03-31 | N.V. Nutricia | Probiotic nutritional preparation |
| CN1119154C (zh) * | 1998-01-20 | 2003-08-27 | 上海信谊药业有限公司 | 双歧三联活菌制剂及制备方法 |
| US6080401A (en) | 1998-11-19 | 2000-06-27 | Reddy; Malireddy S. | Herbal and pharmaceutical drugs enhanced with probiotics |
| NL1010770C2 (nl) | 1998-12-09 | 2000-06-13 | Nutricia Nv | Preparaat dat oligosacchariden en probiotica bevat. |
| EP1020123A1 (en) | 1999-01-18 | 2000-07-19 | Sitia-Yomo S.p.A. | Beverages containing live lactic bacteria |
| CA2374937A1 (en) | 1999-05-25 | 2000-11-30 | Gregor Reid | Oral administration of lactobacillus for the maintenance of health in women |
| FI109602B (fi) * | 2001-01-25 | 2002-09-13 | Valio Oy | Probioottiyhdistelmä |
| CN1164186C (zh) * | 2001-04-29 | 2004-09-01 | 上海光明乳业股份有限公司 | 益菌奶及其制造方法 |
| CN1132927C (zh) * | 2001-07-19 | 2003-12-31 | 上海交通大学 | 益生菌真菌共同发酵制备微生态制剂的方法 |
-
2001
- 2001-01-25 FI FI20010157A patent/FI109602B/fi not_active IP Right Cessation
-
2002
- 2002-01-17 JP JP2002560478A patent/JP3984546B2/ja not_active Expired - Fee Related
- 2002-01-17 HR HR20030586A patent/HRP20030586B8/xx not_active IP Right Cessation
- 2002-01-17 DK DK02710896T patent/DK1359816T3/da active
- 2002-01-17 ES ES02710896T patent/ES2243697T3/es not_active Expired - Lifetime
- 2002-01-17 CZ CZ20031915A patent/CZ301673B6/cs not_active IP Right Cessation
- 2002-01-17 NZ NZ527172A patent/NZ527172A/en not_active IP Right Cessation
- 2002-01-17 EE EEP200300351A patent/EE05299B1/xx not_active IP Right Cessation
- 2002-01-17 CN CNB028041178A patent/CN100400645C/zh not_active Expired - Fee Related
- 2002-01-17 CA CA2434337A patent/CA2434337C/en not_active Expired - Fee Related
- 2002-01-17 PL PL363366A patent/PL204245B1/pl unknown
- 2002-01-17 WO PCT/FI2002/000035 patent/WO2002060276A1/en not_active Ceased
- 2002-01-17 KR KR10-2003-7009902A patent/KR20040012717A/ko not_active Ceased
- 2002-01-17 EP EP02710896A patent/EP1359816B1/en not_active Expired - Lifetime
- 2002-01-17 RU RU2003125858/13A patent/RU2291899C2/ru not_active IP Right Cessation
- 2002-01-17 HU HU0401017A patent/HU225790B1/hu not_active IP Right Cessation
- 2002-01-17 PT PT02710896T patent/PT1359816E/pt unknown
- 2002-01-17 US US10/470,151 patent/US8309073B2/en not_active Expired - Fee Related
- 2002-01-17 AT AT02710896T patent/ATE297664T1/de active
- 2002-01-17 BR BRPI0206689A patent/BRPI0206689B1/pt not_active IP Right Cessation
- 2002-01-17 AU AU2002229787A patent/AU2002229787B2/en not_active Ceased
- 2002-01-17 DE DE60204662T patent/DE60204662T2/de not_active Expired - Lifetime
-
2003
- 2003-07-15 ZA ZA200305458A patent/ZA200305458B/en unknown
- 2003-07-21 NO NO20033283A patent/NO325463B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0206689B1 (pt) | composição de probióticos e uso desta | |
| Parracho et al. | Probiotics and prebiotics in infant nutrition | |
| AU2002229787A1 (en) | Combination of probiotics | |
| Kolida et al. | Prebiotic effects of inulin and oligofructose | |
| Hernández-Hernández et al. | Effect of prebiotic carbohydrates on the growth and tolerance of Lactobacillus | |
| CA2706105A1 (en) | Composition with synbiotics | |
| Ogueke et al. | Probiotics and prebiotics: Unfolding prospects for better human health | |
| KR102642548B1 (ko) | 페디오코커스 에시디락티시 WiKim0170을 포함하는 숙취 해소 및 간 기능 개선용 조성물 | |
| Hernandez et al. | Development of probiotics and prebiotics | |
| KR102642547B1 (ko) | 레비락토바실러스 브레비스 WiKim0168을 포함하는 숙취 해소 및 간 기능 개선용 조성물 | |
| KR20210064510A (ko) | 장내 유익균 증가 효과를 가지는 락토바실러스 조성물 | |
| HK1061501B (en) | Combination of probiotics | |
| KR20250175015A (ko) | 근감소증 개선 효능을 갖는 라티락토바실러스 사케이 WiKim0188 및 이의 용도 | |
| KR20250175014A (ko) | 근감소증 개선 효능을 갖는 웨이셀라 시바리아 WiKim0187 및 이의 용도 | |
| WO2025254498A1 (ko) | 근감소증 개선 효능을 갖는 웨이셀라 시바리아 wikim0187 및 이의 용도 | |
| KR20240119903A (ko) | 류코노스톡 메센테로이데스 WiKim0172을 포함하는 숙취 해소 및 간 기능 개선용 조성물 | |
| KR20240119902A (ko) | 락티카제이바실러스 파라카제이 WiKim0171을 포함하는 숙취 해소 및 간 기능 개선용 조성물 | |
| Minj et al. | 10 Beneficial Effects of Dairy | |
| Kumar et al. | Probiotics: biotechnology in prolongation of life | |
| RAJESH | EFFECT OF CHICORY POWDER AND WHEAT BRAN AS NATURAL PREBIOTICS ON THE IMPLANTATION OF WILD STRAINS OF PROBIOTIC CULTURES | |
| Minj et al. | 10 Beneficial Effects of Dairy Foods Enriched with Prebiotics and Probiotics | |
| Devi et al. | Functional Properties of Probiotics and their Beneficial Effects on Human Health | |
| Bruno | The effects of oligosaccharides and probiotic bacteria on the intestinal microflora and vancomycin-resistant enterococcus | |
| HK1104455A (en) | Preventive and/or remedy for inflammatory bowel diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: PAGAR RESTAURACAO. |
|
| B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE RPI 2286 DE 29/10/2014 |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/02/2016, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 35/741 (2015.01), A23L 29/00 (2016.01), A23L |
|
| B25A | Requested transfer of rights approved | ||
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 19A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2613 DE 02-02-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |