BRPI0111191B8 - moléculas mutantes de ctla4 solúveis, método para sua produção e seus usos - Google Patents

moléculas mutantes de ctla4 solúveis, método para sua produção e seus usos

Info

Publication number
BRPI0111191B8
BRPI0111191B8 BRPI0111191A BRPI0111191B8 BR PI0111191 B8 BRPI0111191 B8 BR PI0111191B8 BR PI0111191 A BRPI0111191 A BR PI0111191A BR PI0111191 B8 BRPI0111191 B8 BR PI0111191B8
Authority
BR
Brazil
Prior art keywords
mutant molecules
soluble ctla4
production
ctla4
molecules
Prior art date
Application number
Other languages
English (en)
Portuguese (pt)
Inventor
R Naemura Joseph
Bajorath Jurgen
S Linsley Peter
J Peach Robert
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0111191A publication Critical patent/BR0111191A/pt
Publication of BRPI0111191B1 publication Critical patent/BRPI0111191B1/pt
Publication of BRPI0111191B8 publication Critical patent/BRPI0111191B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0111191 2000-05-26 2001-05-23 moléculas mutantes de ctla4 solúveis, método para sua produção e seus usos BRPI0111191B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (3)

Publication Number Publication Date
BR0111191A BR0111191A (pt) 2004-07-06
BRPI0111191B1 BRPI0111191B1 (pt) 2019-12-31
BRPI0111191B8 true BRPI0111191B8 (pt) 2021-05-25

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0111191 BRPI0111191B8 (pt) 2000-05-26 2001-05-23 moléculas mutantes de ctla4 solúveis, método para sua produção e seus usos

Country Status (41)

Country Link
EP (3) EP3029062A1 (hu)
JP (1) JP4328525B2 (hu)
KR (2) KR100889887B1 (hu)
CN (2) CN101255192A (hu)
AR (1) AR031699A1 (hu)
AT (1) ATE271066T1 (hu)
AU (2) AU2001263466C1 (hu)
BE (1) BE2011C041I2 (hu)
BR (1) BRPI0111191B8 (hu)
CA (1) CA2409748C (hu)
CY (2) CY2011019I2 (hu)
CZ (1) CZ304451B6 (hu)
DE (2) DE60104282T2 (hu)
DK (1) DK1248802T3 (hu)
EC (1) ECSP024365A (hu)
EE (2) EE05557B1 (hu)
EG (1) EG24459A (hu)
ES (2) ES2571852T3 (hu)
FR (1) FR11C0053I2 (hu)
GE (1) GEP20053658B (hu)
HK (2) HK1048126B (hu)
HU (2) HU228137B1 (hu)
IL (1) IL152315A (hu)
LT (1) LT5133B (hu)
LU (1) LU91902I2 (hu)
LV (1) LV12994B (hu)
MX (1) MXPA02011534A (hu)
MY (1) MY136113A (hu)
NO (2) NO330797B1 (hu)
PE (1) PE20011338A1 (hu)
PL (1) PL206267B1 (hu)
PT (1) PT1248802E (hu)
RU (1) RU2283847C2 (hu)
SI (1) SI1248802T1 (hu)
SK (1) SK288131B6 (hu)
TR (1) TR200402703T4 (hu)
TW (2) TWI319405B (hu)
UA (1) UA87432C2 (hu)
UY (1) UY26723A1 (hu)
WO (1) WO2001092337A2 (hu)
ZA (1) ZA200208944B (hu)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887471B1 (en) 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
TR201807700T4 (tr) * 2000-07-03 2018-06-21 Squibb Bristol Myers Co Çözünür CTLA4 mutant moleküllerinin kullanımları.
DE60225914T2 (de) 2001-05-23 2009-07-23 Bristol-Myers Squibb Co. Verfahren zum schützen eines allogenen inseltransplantats mit löslichen ctla4-mutationsmolekülen
EP1496931A4 (en) * 2002-04-19 2009-07-01 Bristol Myers Squibb Co METHODS OF TREATING AUTOIMMUNE DISEASE USING SOLUBLE CTLA4 MOLECULE AND ARMM OR NSAID
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
TWI312368B (en) 2002-12-23 2009-07-21 Bristol Myers Squibb Compan Mammalian cell culture processes for protein production
CN100402660C (zh) * 2002-12-23 2008-07-16 布里斯托尔-迈尔斯斯奎布公司 用于蛋白质生产的哺乳动物细胞培养方法中产物质量提高
JP2006517191A (ja) 2002-12-30 2006-07-20 アムジエン・インコーポレーテツド 共刺激因子を用いた併用療法
AU2004287431B2 (en) 2003-10-27 2010-03-11 Amgen Inc. Compositions and methods to modulate an immune response to an immunogenic therapeutic agent
ES2439641T3 (es) 2005-12-20 2014-01-24 Bristol-Myers Squibb Company Composiciones y procedimientos de producción de una composición
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
US7510844B2 (en) 2006-01-24 2009-03-31 Bristol-Myers Squibb Company CD86 and CD80 receptor competition assays
WO2008005290A2 (en) 2006-06-29 2008-01-10 The Trustees Of Columbia University In The City Of New York Methods for testing anti-thrombotic agents
GB0620934D0 (en) 2006-10-20 2006-11-29 Cambridge Antibody Tech Protein variants
CA2673725C (en) 2006-12-20 2016-01-12 Mmr Information Systems, Inc. Antibodies and methods for making and using them
EP2612868B1 (en) 2007-11-01 2018-08-15 Astellas Pharma Inc. Immunosuppressive polypeptides and nucleic acids
MX338825B (es) * 2008-10-02 2016-05-03 Emergent Product Dev Seattle Proteinas de enlace a objetivos multiples de antagonistas de cd86.
US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
CN106432474A (zh) * 2010-03-12 2017-02-22 艾伯维生物医疗股份有限公司 Ctla4蛋白和其用途
US20120214204A1 (en) 2011-02-23 2012-08-23 Amgen Inc. Cell culture media for uvc exposure and methods related thereto
WO2013010537A1 (en) 2011-07-20 2013-01-24 Aarhus Universitet Method of treating morphea
US9758566B2 (en) 2012-03-29 2017-09-12 The General Hospital Corporation Recombinant cytotoxic T-lymphocyte-associated protein 4 (CTLA4)
ES2777778T3 (es) * 2012-05-11 2020-08-06 Medimmune Ltd Variantes de CTLA-4
US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
CA2877986A1 (en) * 2012-06-27 2014-01-03 Orban Biotech Llc Ctla4 fusion proteins for the treatment of diabetes
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
JP6732660B2 (ja) 2014-01-13 2020-07-29 アムジエン・インコーポレーテツド 組換えタンパク質の高マンノースグリコフォーム含有量を操作するためのオルニチン代謝の調節
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
DK3152317T3 (en) 2014-06-04 2019-04-08 Amgen Inc Methods for Harvesting Mammalian Cell Cultures
WO2016089919A1 (en) 2014-12-01 2016-06-09 Amgen Inc. Process for manipulating the level of glycan content of a glycoprotein
US10590457B2 (en) 2015-02-11 2020-03-17 Bristol Myers-Squibb Company Compositions for cell culture and methods of using the same
DK3283508T3 (en) 2015-04-17 2021-05-31 Alpine Immune Sciences Inc Immunomodulatory Proteins with Tunable Affinities
WO2017044807A2 (en) 2015-09-09 2017-03-16 The Trustees Of Columbia University In The City Of New York Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease
CN108350416A (zh) 2015-11-09 2018-07-31 百时美施贵宝公司 操纵在cho细胞中产生的多肽的品质属性的方法
CN116942793A (zh) * 2016-09-19 2023-10-27 昂科医药 Cd80和cd86结合蛋白组合物及其用途
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
CA3077509A1 (en) 2017-10-10 2019-04-18 Alpine Immune Sciences, Inc. Ctla-4 variant immunomodulatory proteins and uses thereof
CN109453383A (zh) * 2018-11-12 2019-03-12 陈慧慧 免疫检查点的抑制剂在制备治疗青光眼及其他眼部免疫损伤机制相关疾病药物中的应用
CA3152665A1 (en) 2019-08-27 2021-03-04 Tonix Pharma Limited Modified tff2 polypeptides
TW202128744A (zh) 2019-12-06 2021-08-01 美商再生元醫藥公司 抗ｖｅｇｆ蛋白組合物及其製備方法
KR20230026434A (ko) 2020-06-18 2023-02-24 리제너론 파아마슈티컬스, 인크. 미처리된 c-말단 리신을 정확하게 측정하기 위한 중질 펩티드 접근법
CN116601279A (zh) 2020-07-28 2023-08-15 思进股份有限公司 用于生产多肽的方法和系统
WO2023115027A2 (en) 2021-12-16 2023-06-22 Bristol-Myers Squibb Company Detergent for viral inactivation
US20230287043A1 (en) 2022-03-02 2023-09-14 Regeneron Pharmaceuticals, Inc. Cell culture methods for antibody production

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5637481A (en) 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
US5851795A (en) 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US5844095A (en) 1991-06-27 1998-12-01 Bristol-Myers Squibb Company CTLA4 Ig fusion proteins
DE69226871T3 (de) 1991-06-27 2009-09-24 Bristol-Myers Squibb Co. CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung
ZA98533B (en) * 1997-01-31 1999-07-22 Bristol Myers Squibb Co Soluble CTLA4 mutant molecules and uses thereof.
JP3521382B2 (ja) * 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
GB9809280D0 (en) * 1998-04-30 1998-07-01 Rpms Technology Ltd Immunosupression
WO2000019988A1 (en) * 1998-10-07 2000-04-13 Millennium Pharmaceuticals, Inc. NOVEL Th2-SPECIFIC MOLECULES AND USES THEREOF
TR201807700T4 (tr) * 2000-07-03 2018-06-21 Squibb Bristol Myers Co Çözünür CTLA4 mutant moleküllerinin kullanımları.

Also Published As

Publication number Publication date
NO2011027I2 (hu) 2011-12-15
EE05458B1 (et) 2011-08-15
IL152315A0 (en) 2003-05-29
JP2004511213A (ja) 2004-04-15
EE200200659A (et) 2004-06-15
GEP20053658B (en) 2005-11-10
TR200402703T4 (tr) 2004-11-22
NO20025656D0 (no) 2002-11-25
PL206267B1 (pl) 2010-07-30
FR11C0053I2 (fr) 2013-01-11
TW200906857A (en) 2009-02-16
ZA200208944B (en) 2004-02-13
ES2225549T3 (es) 2005-03-16
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
CY2011019I1 (el) 2016-12-14
BR0111191A (pt) 2004-07-06
ES2571852T3 (es) 2016-05-27
DK1248802T3 (da) 2004-11-15
UY26723A1 (es) 2001-12-28
NO2011027I1 (no) 2012-01-09
EP1248802B1 (en) 2004-07-14
MXPA02011534A (es) 2004-08-12
BRPI0111191B1 (pt) 2019-12-31
IL152315A (en) 2010-04-15
EP1536234A2 (en) 2005-06-01
CZ304451B6 (cs) 2014-05-14
AU2001263466B2 (en) 2006-04-27
EE201100050A (et) 2011-10-17
AR031699A1 (es) 2003-10-01
CA2409748A1 (en) 2001-12-06
TWI314933B (en) 2009-09-21
EE05557B1 (et) 2012-08-15
DE60104282T2 (de) 2005-10-13
NO20025656L (no) 2002-11-25
HUP0302201A3 (en) 2010-01-28
TWI319405B (en) 2010-01-11
CN1309735C (zh) 2007-04-11
SK15702002A3 (sk) 2004-01-08
CN1441810A (zh) 2003-09-10
RU2283847C2 (ru) 2006-09-20
JP4328525B2 (ja) 2009-09-09
AU2001263466C1 (en) 2006-10-26
KR20030009502A (ko) 2003-01-29
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
HK1048126B (zh) 2005-03-04
LT5133B (lt) 2004-05-25
EP1536234B1 (en) 2016-03-16
LV12994B (en) 2003-08-20
EP1536234A3 (en) 2009-06-03
HU228137B1 (en) 2012-12-28
SI1248802T1 (en) 2005-02-28
FR11C0053I1 (hu) 2012-01-13
EP1248802B9 (en) 2005-05-11
EG24459A (en) 2009-07-16
CA2409748C (en) 2008-09-16
ECSP024365A (es) 2003-03-31
UA87432C2 (uk) 2009-07-27
PT1248802E (pt) 2004-11-30
DE122011100063I1 (de) 2012-06-14
SK288131B6 (sk) 2013-10-02
CZ20023892A3 (cs) 2003-09-17
WO2001092337A2 (en) 2001-12-06
KR100889887B1 (ko) 2009-03-24
HK1071931A1 (zh) 2005-08-05
PL366231A1 (en) 2005-01-24
ATE271066T1 (de) 2004-07-15
AU6346601A (en) 2001-12-11
CY1117625T1 (el) 2017-04-26
PE20011338A1 (es) 2002-01-13
BE2011C041I2 (hu) 2020-08-20
EP3029062A1 (en) 2016-06-08
NO330797B1 (no) 2011-07-18
CN101255192A (zh) 2008-09-03
HUP0302201A2 (hu) 2003-10-28
HUS1300012I1 (hu) 2016-08-29
DE60104282D1 (de) 2004-08-19
WO2001092337A3 (en) 2002-05-10
HK1048126A1 (en) 2003-03-21
KR100895134B1 (ko) 2009-05-04
LT2002114A (en) 2003-12-29
MY136113A (en) 2008-08-29

Similar Documents

Publication Publication Date Title
BRPI0111191B8 (pt) moléculas mutantes de ctla4 solúveis, método para sua produção e seus usos
MX2022009306A (es) Loseta de nucleo de espuma densificada (dfc) con linea de anticuerpos de dominio individual de cd28 y constructos multivalentes y multiespecíficas de los mismos.
BR9910089A (pt) Composições e antìgenos de neisseria meningitidis
BRPI0608144A2 (pt) uso de uma molécula mutante de ctla4
AR036272A1 (es) Genes de metiltransferasas y usos de los mismos
BRPI0314373B8 (pt) produto imunogênico estável para a indução de anticorpos contra uma ou várias proteínas antigênicas em um indivíduo, composições farmacêutica, imunogênica e de vacina e processo de preparação de um produto imunogênico
Bierlmeier et al. Sortase‐Mediated Multi‐Fragment Assemblies by Ligation Site Switching
BR9909639A (pt) Processos para reduzir a alergenicidade de uma proteìna não humana e para produzir uma proteìna tendo reduzida alergenicidade, proteìna mutante tendo reduzida alergenicidade, dna, vetor de expressão, células hospedeiras, composição farmacêutica, e, substilisina humana
BR0015287A (pt) Moléculas recombinantes de fusão
AU2003287115A1 (en) Fluorescent proteins from copepoda species and methods for using same
BR112022026575A2 (pt) Anticorpos de alta afinidade que alvejam tau fosforilado em serina 413
MXPA04005992A (es) Derivados de acido 3-fenil-2-arilalquiltiopropionico como antagonistas selectivos de ppar-alfa.
Tran et al. Novel APC‐cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S
AU4302000A (en) Genome sequence and polypeptides of pyrococcus (abissy), fragment and uses thereof
Law et al. OmpF enhances the ability of BtuB to protect susceptible Escherichia coli cells from colicin E9 cytotoxicity
Morgan et al. Structural and functional characterisation of two proteolytic fragments of the bacterial protein toxin, pneumolysin
Tatu et al. Role of a disulfide cross-link in the conformational stability of a thermostable xylanase
WO2023031943A3 (en) Cd28 shedding blocking agents
Váchová et al. Calcium as a regulator of Bacillus megaterium cytoplasmic proteolytic activity in vitro
Iseki et al. Purification and liposomal reconstitution of the oligopeptide transport activity in rat renal cortex using ceftibuten-affinity chromatography
WO2005040208A3 (en) Peptides derived from heat shock proteins binding toll-like receptors 2 and 4 and their use
TR200401035T2 (tr) Arıtılmış proteinler, rekombinan DNA dizileri ve kahve bitkilerinin olgunlaşmasını kontrol etmek için işlemler

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 31/12/2019, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/05/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 22A ANUIDADE.

B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2724 DE 21/03/2023 POR TER SIDO INDEVIDA.