EE05557B1 - CTL4 lahustuvad mutantsed molekulid ja nende kasutamine - Google Patents

CTL4 lahustuvad mutantsed molekulid ja nende kasutamine

Info

Publication number
EE05557B1
EE05557B1 EEP201100050A EEP201100050A EE05557B1 EE 05557 B1 EE05557 B1 EE 05557B1 EE P201100050 A EEP201100050 A EE P201100050A EE P201100050 A EEP201100050 A EE P201100050A EE 05557 B1 EE05557 B1 EE 05557B1
Authority
EE
Estonia
Prior art keywords
mutant molecules
amino acid
ctla4
ctl4
molecules
Prior art date
Application number
EEP201100050A
Other languages
English (en)
Estonian (et)
Inventor
J. Peach Robert
R. Naemura Joseph
S. Linsley Peter
Bajorath Jurgen
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of EE201100050A publication Critical patent/EE201100050A/xx
Publication of EE05557B1 publication Critical patent/EE05557B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP201100050A 2000-05-26 2001-05-23 CTL4 lahustuvad mutantsed molekulid ja nende kasutamine EE05557B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
EEP200200659A EE05458B1 (et) 2000-05-26 2001-05-23 CTL4 lahustuvad mutantsed molekulid ja nende kasutamine

Publications (2)

Publication Number Publication Date
EE201100050A EE201100050A (et) 2011-10-17
EE05557B1 true EE05557B1 (et) 2012-08-15

Family

ID=26908652

Family Applications (2)

Application Number Title Priority Date Filing Date
EEP200200659A EE05458B1 (et) 2000-05-26 2001-05-23 CTL4 lahustuvad mutantsed molekulid ja nende kasutamine
EEP201100050A EE05557B1 (et) 2000-05-26 2001-05-23 CTL4 lahustuvad mutantsed molekulid ja nende kasutamine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EEP200200659A EE05458B1 (et) 2000-05-26 2001-05-23 CTL4 lahustuvad mutantsed molekulid ja nende kasutamine

Country Status (41)

Country Link
EP (3) EP1536234B1 (hu)
JP (1) JP4328525B2 (hu)
KR (2) KR100889887B1 (hu)
CN (2) CN101255192A (hu)
AR (1) AR031699A1 (hu)
AT (1) ATE271066T1 (hu)
AU (2) AU6346601A (hu)
BE (1) BE2011C041I2 (hu)
BR (1) BRPI0111191B8 (hu)
CA (1) CA2409748C (hu)
CY (2) CY2011019I2 (hu)
CZ (1) CZ304451B6 (hu)
DE (2) DE60104282T2 (hu)
DK (1) DK1248802T3 (hu)
EC (1) ECSP024365A (hu)
EE (2) EE05458B1 (hu)
EG (1) EG24459A (hu)
ES (2) ES2225549T3 (hu)
FR (1) FR11C0053I2 (hu)
GE (1) GEP20053658B (hu)
HK (2) HK1048126B (hu)
HU (2) HU228137B1 (hu)
IL (1) IL152315A (hu)
LT (1) LT5133B (hu)
LU (1) LU91902I2 (hu)
LV (1) LV12994B (hu)
MX (1) MXPA02011534A (hu)
MY (1) MY136113A (hu)
NO (2) NO330797B1 (hu)
PE (1) PE20011338A1 (hu)
PL (1) PL206267B1 (hu)
PT (1) PT1248802E (hu)
RU (1) RU2283847C2 (hu)
SI (1) SI1248802T1 (hu)
SK (1) SK288131B6 (hu)
TR (1) TR200402703T4 (hu)
TW (2) TWI319405B (hu)
UA (1) UA87432C2 (hu)
UY (1) UY26723A1 (hu)
WO (1) WO2001092337A2 (hu)
ZA (1) ZA200208944B (hu)

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SI1935427T1 (en) * 2000-07-03 2018-05-31 Bristol-Myers Squibb Company USE OF HEATED CTLA4 MUTANT MOLECULES
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
PT1397153E (pt) 2001-05-23 2008-06-12 Bristol Myers Squibb Co Métodos para proteger um transplante alogénico de ilhéus utilizando moléculas mutantes de ctla4 solúveis
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DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
ATE488600T1 (de) 2002-12-23 2010-12-15 Bristol Myers Squibb Co Produktqualitätsverbesserung in säugerzellkulturverfahrenzur proteinproduktion
US7541164B2 (en) 2002-12-23 2009-06-02 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
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AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
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CN116942793A (zh) * 2016-09-19 2023-10-27 昂科医药 Cd80和cd86结合蛋白组合物及其用途
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
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Also Published As

Publication number Publication date
EP1536234A2 (en) 2005-06-01
HK1071931A1 (zh) 2005-08-05
NO2011027I1 (no) 2012-01-09
PL366231A1 (en) 2005-01-24
BRPI0111191B1 (pt) 2019-12-31
SK15702002A3 (sk) 2004-01-08
AU2001263466C1 (en) 2006-10-26
BE2011C041I2 (hu) 2020-08-20
CY2011019I1 (el) 2016-12-14
SK288131B6 (sk) 2013-10-02
HUP0302201A3 (en) 2010-01-28
EE05458B1 (et) 2011-08-15
EE200200659A (et) 2004-06-15
HUS1300012I1 (hu) 2016-08-29
EP1248802B9 (en) 2005-05-11
DE122011100063I1 (de) 2012-06-14
UA87432C2 (uk) 2009-07-27
TWI319405B (en) 2010-01-11
TWI314933B (en) 2009-09-21
ATE271066T1 (de) 2004-07-15
FR11C0053I2 (fr) 2013-01-11
CY1117625T1 (el) 2017-04-26
DE60104282D1 (de) 2004-08-19
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
RU2283847C2 (ru) 2006-09-20
CZ304451B6 (cs) 2014-05-14
KR100889887B1 (ko) 2009-03-24
TW200906857A (en) 2009-02-16
LT2002114A (en) 2003-12-29
MXPA02011534A (es) 2004-08-12
AU2001263466B2 (en) 2006-04-27
GEP20053658B (en) 2005-11-10
KR20030009502A (ko) 2003-01-29
PL206267B1 (pl) 2010-07-30
BRPI0111191B8 (pt) 2021-05-25
CN101255192A (zh) 2008-09-03
ES2225549T3 (es) 2005-03-16
HU228137B1 (en) 2012-12-28
MY136113A (en) 2008-08-29
EP1536234B1 (en) 2016-03-16
CA2409748C (en) 2008-09-16
NO330797B1 (no) 2011-07-18
AR031699A1 (es) 2003-10-01
PE20011338A1 (es) 2002-01-13
JP4328525B2 (ja) 2009-09-09
IL152315A0 (en) 2003-05-29
WO2001092337A3 (en) 2002-05-10
PT1248802E (pt) 2004-11-30
EP1536234A3 (en) 2009-06-03
EE201100050A (et) 2011-10-17
AU6346601A (en) 2001-12-11
LV12994B (en) 2003-08-20
EP1248802B1 (en) 2004-07-14
CA2409748A1 (en) 2001-12-06
EG24459A (en) 2009-07-16
NO2011027I2 (hu) 2011-12-15
NO20025656D0 (no) 2002-11-25
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
LT5133B (lt) 2004-05-25
EP3029062A1 (en) 2016-06-08
CN1309735C (zh) 2007-04-11
HUP0302201A2 (hu) 2003-10-28
ECSP024365A (es) 2003-03-31
ZA200208944B (en) 2004-02-13
UY26723A1 (es) 2001-12-28
NO20025656L (no) 2002-11-25
FR11C0053I1 (hu) 2012-01-13
SI1248802T1 (en) 2005-02-28
KR100895134B1 (ko) 2009-05-04
CN1441810A (zh) 2003-09-10
HK1048126B (zh) 2005-03-04
BR0111191A (pt) 2004-07-06
WO2001092337A2 (en) 2001-12-06
ES2571852T3 (es) 2016-05-27
CZ20023892A3 (cs) 2003-09-17
HK1048126A1 (en) 2003-03-21
DE60104282T2 (de) 2005-10-13
IL152315A (en) 2010-04-15
JP2004511213A (ja) 2004-04-15
TR200402703T4 (tr) 2004-11-22
DK1248802T3 (da) 2004-11-15

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