WO2005040208A3 - Peptides derived from heat shock proteins binding toll-like receptors 2 and 4 and their use - Google Patents

Peptides derived from heat shock proteins binding toll-like receptors 2 and 4 and their use Download PDF

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Publication number
WO2005040208A3
WO2005040208A3 PCT/US2004/034915 US2004034915W WO2005040208A3 WO 2005040208 A3 WO2005040208 A3 WO 2005040208A3 US 2004034915 W US2004034915 W US 2004034915W WO 2005040208 A3 WO2005040208 A3 WO 2005040208A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptors
heat shock
peptides derived
shock proteins
proteins binding
Prior art date
Application number
PCT/US2004/034915
Other languages
French (fr)
Other versions
WO2005040208A2 (en
Inventor
Albani Salvatore
Original Assignee
Androclus Therapeutics Soa
Albani Salvatore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Androclus Therapeutics Soa, Albani Salvatore filed Critical Androclus Therapeutics Soa
Publication of WO2005040208A2 publication Critical patent/WO2005040208A2/en
Publication of WO2005040208A3 publication Critical patent/WO2005040208A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Toll-like receptor-binding molecules (including peptides and peptidomimetics) are described. Also described are compositions that contain such TLR-binding molecules and methods of using such molecules to modulate immune responses, for example, to treat or prevent certain immune-mediated diseases.
PCT/US2004/034915 2003-10-21 2004-10-21 Peptides derived from heat shock proteins binding toll-like receptors 2 and 4 and their use WO2005040208A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51323103P 2003-10-21 2003-10-21
US60/513,231 2003-10-21

Publications (2)

Publication Number Publication Date
WO2005040208A2 WO2005040208A2 (en) 2005-05-06
WO2005040208A3 true WO2005040208A3 (en) 2005-10-20

Family

ID=34520082

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/034915 WO2005040208A2 (en) 2003-10-21 2004-10-21 Peptides derived from heat shock proteins binding toll-like receptors 2 and 4 and their use

Country Status (1)

Country Link
WO (1) WO2005040208A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1881080A1 (en) 2006-07-18 2008-01-23 Institut Gustave Roussy Toll like receptor 4 dysfunction and the biological applications thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001043691A2 (en) * 1999-12-15 2001-06-21 Peptor Ltd. Fragments and antagonists of heat shock protein 60
WO2002085933A1 (en) * 2001-04-20 2002-10-31 The Institute For Systems Biology Toll-like receptor 5 ligands and methods of use
WO2003070761A1 (en) * 2002-02-19 2003-08-28 Yeda Research And Development Co. Ltd. Dual-effect ligands comprising anti-inflammatory hsp peptide epitopes for immunomodulation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001043691A2 (en) * 1999-12-15 2001-06-21 Peptor Ltd. Fragments and antagonists of heat shock protein 60
WO2002085933A1 (en) * 2001-04-20 2002-10-31 The Institute For Systems Biology Toll-like receptor 5 ligands and methods of use
WO2003070761A1 (en) * 2002-02-19 2003-08-28 Yeda Research And Development Co. Ltd. Dual-effect ligands comprising anti-inflammatory hsp peptide epitopes for immunomodulation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ASEA A ET AL: "Novel signal transduction pathway utilized by extracellular HSP70. Role of toll-like receptor (TLR) 2 and TLR4", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 277, no. 17, 26 April 2002 (2002-04-26), pages 15028 - 15034, XP002971859, ISSN: 0021-9258 *
VABULAS R M ET AL: "Endocytosed HSP60s use Toll-like receptor 2 (TLR2) and TLR4 to activate the Toll/interleukin-1 receptor signaling pathway in innate immune cells", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 33, 17 August 2001 (2001-08-17), pages 31332 - 31339, XP002242849, ISSN: 0021-9258 *
VAN EDEN W ET AL: "Balancing the immune system: Th1 and Th2", ANNALS OF THE RHEUMATIC DISEASES, vol. 61, no. Supplement 2, November 2002 (2002-11-01), pages ii25 - ii28, XP009051927, ISSN: 0003-4967 *
VAN EDEN W ET AL: "Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 21, no. 9-10, 14 February 2003 (2003-02-14), pages 897 - 901, XP004402615, ISSN: 0264-410X *

Also Published As

Publication number Publication date
WO2005040208A2 (en) 2005-05-06

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